LMDA Canada: Canadian Newsletter, November 16, 1998

Contents include: Letter from the Editor, Effing the Ineffable, Adapting Theatre History, A Readiness to Receive, The Theatre Center Proudly Presents Body Geometry, Necessary Theatre Manifesto, Writing out Dramaturgy, Report from the Rock, Out of the Blocks and Onto the Track, Rocky Mountain Highs: Dramaturgy and the 1998 playRites Colony, News from the Factory Theatre, Theatre Centre Research Programhttps://soundideas.pugetsound.edu/lmdanewsletter/1030/thumbnail.jp

Degradation par la papa�ne d'oligom�res etales � l'interface air-eau

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Multicenter evaluation of analytical performance of the Liaison((R)) troponin I assay

Objectives: This study evaluated the analytical characteristics of the Liaison(R) immunoassay for cardiac troponin I (cTnI). Design and methods: The protocol consisted of eight sections: evaluation of antibody specificity, linearity, detection limit and imprecision, method comparison, evaluation of endogenous interferents, anticoagulant interference, sample stability, and reference values. Results: The assay equally measured free and complexed cTnI. The minimum detectable cTnI concentration was 0.021 mug/l. The cTnI concentration corresponding to a total CVof 10% was 0.056 mug/l. Linearity of response was demonstrated along the entire dynamic range of the assay. Assay interferences were minimal. cTnI concentrations in serum and heparinized plasma were significantly different. Values in EDTA plasma were on average approximately 5% higher than in matched serum, but this difference was not significant. The 99th percentile cTnI value in healthy subjects was 0.036 mug/l. Conclusions: Being sensitive, specific, and precise, the Liaison(R) cTnI assay meets current requirements to aid in the diagnosis of myocardial necrosis. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved

Diagnosis of acute myocardial infarction from sequential enzyme measurements obtained within 12 hours of admission to hospital.

A prospective study was made of sequential changes in serum creatine kinase (CK) and CK-MB isoenzyme activity within the 12 hours following admission to the coronary care unit on 65 patients with recent chest pain. CK determinations were performed in the laboratory or in the coronary care unit using a dry reagent strip analyser. Slope values for log CK/hour and log CK-MB/hour were calculated, used to confirm or exclude the diagnosis of myocardial infarction, and compared with diagnosis by conventional means. Compared with retrospective diagnosis using all available information, the CK slope had a sensitivity of 100% and a specificity of 94%. This compared with a sensitivity of 94% and specificity of 90% for diagnosis using upper reference limits alone. Determination of CK slope permits very rapid and accurate biochemical confirmation or exclusion of myocardial infarction and the possibility of performing the measurements on the coronary care unit. It additionally offers the prospect of major cost savings resulting from early discharge or transfer from the coronary care unit