261 research outputs found
Nest cover and faecal glucocorticoid metabolites are linked to hatching success and telomere length in breeding Common Eiders (Somateria mollissima)
Habitat-associated crypsis may affect perceived predation vulnerability, selecting for different predator avoidance strategies. Glucocorticoids could mediate the adjustment of escape responses to the extent of crypsis, introducing an overlooked source of variation in glucocorticoid-fitness relationships. However, prolonged exposure to elevated glucocorticoids may be costly, leading to accelerated telomere loss and, consequently, senescence. Here, we examined how nest cover and immunoreactive faecal glucocorticoid metabolite (fGCM) levels are linked to hatching success and telomere length in breeding female Common Eiders (Somateria mollissima (L., 1758)). We hypothesized that the degree of nest crypsis, reflecting differences in perceived predation risk, would moderate the relationship between reproductive success and fGCM levels. We also expected that telomere length would be shorter in birds with higher glucocorticoid concentration. Results showed that individuals with high fGCM levels had higher hatching success in nests with low cover, while low fGCM levels were more successful in well-concealed nests. We found that shorter telomeres were associated with high fGCM in nesting sites offering little cover and with low fGCM in well-concealed ones. This study provides the first evidence of habitat-dependent moderation of the relationships between stress physiology, telomere length and hatching success.Peer reviewe
Karjalaisuus, karjalainen käsityöperinne ja kulttuuriperintöopetus käsitöitä opettaneiden opettajien muistoja
Controlling crystal symmetries in phase-field crystal models
We investigate the possibility to control the symmetry of ordered states in
phase-field crystal models by tuning nonlinear resonances. In two dimensions,
we find that a state of square symmetry as well as coexistence between squares
and hexagons can be easily obtained. In contrast, it is delicate to obtain
coexistence of squares and liquid. We develop a general method for constructing
free energy functionals that exhibit solid-liquid coexistence with desired
crystal symmetries. As an example, we develop a free energy functional for
square-liquid coexistence in two dimensions. A systematic analysis for
determining the parameters of the necessary nonlinear terms is provided. The
implications of our findings for simulations of materials with simple cubic
symmetry are discussed.Comment: 19 pages, 6 figure
Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression.
Ectodermal organogenesis is regulated by inductive and reciprocal signalling cascades that involve multiple signal molecules in several conserved families. Ectodysplasin-A (Eda), a tumour necrosis factor-like signalling molecule, and its receptor Edar are required for the development of a number of ectodermal organs in vertebrates. In mice, lack of Eda leads to failure in primary hair placode formation and missing or abnormally shaped teeth, whereas mice overexpressing Eda are characterized by enlarged hair placodes and supernumerary teeth and mammary glands. Here, we report two signalling outcomes of the Eda pathway: suppression of bone morphogenetic protein (Bmp) activity and upregulation of sonic hedgehog (Shh) signalling. Recombinant Eda counteracted Bmp4 activity in developing teeth and, importantly, inhibition of BMP activity by exogenous noggin partially restored primary hair placode formation in Eda-deficient skin in vitro, indicating that suppression of Bmp activity was compromised in the absence of Eda. The downstream effects of the Eda pathway are likely to be mediated by transcription factor nuclear factor-kappaB (NF-kappaB), but the transcriptional targets of Edar have remained unknown. Using a quantitative approach, we show in cultured embryonic skin that Eda induced the expression of two Bmp inhibitors, Ccn2/Ctgf (CCN family protein 2/connective tissue growth factor) and follistatin. Moreover, our data indicate that Shh is a likely transcriptional target of Edar, but, unlike noggin, recombinant Shh was unable to rescue primary hair placode formation in Eda-deficient skin explants
DDFT calibration and investigation of an anisotropic phase-field crystal model
The anisotropic phase-field crystal model recently proposed and used by
Prieler et al. [J. Phys.: Condens. Matter 21, 464110 (2009)] is derived from
microscopic density functional theory for anisotropic particles with fixed
orientation. Further its morphology diagram is explored. In particular we
investigated the influence of anisotropy and undercooling on the process of
nucleation and microstructure formation from atomic to the microscale. To that
end numerical simulations were performed varying those dimensionless parameters
which represent anisotropy and undercooling in our anisotropic phase-field
crystal (APFC) model. The results from these numerical simulations are
summarized in terms of a morphology diagram of the stable state phase. These
stable phases are also investigated with respect to their kinetics and
characteristic morphological features.Comment: It contain 13 pages and total of 7 figure
Blood and feather concentrations of toxic elements in a Baltic and an Arctic seabird population
We report blood and feather concentrations of elements in the Baltic Sea and Arctic population of common eiders (Somateria mollissima). The endangered Baltic Sea population of eiders was demonstrably affected by element pollution in the 1990s. While blood concentrations of Hg were higher in Baltic breeding eiders, blood Se, As and Cd concentrations were higher in Arctic eiders. Blood concentrations of Pb, Cr, Zn and Cu did not differ between the two populations. While blood Pb concentrations had declined in Baltic eiders since the 1990s, Hg concentrations had not declined, and were above concentrations associated with adverse oxidative effects in other bird species. Inconsistent with blood concentrations, feather concentrations suggested that Pb, Zn, and Cd exposure was higher in Baltic eiders, and that Hg exposure was higher in Arctic eiders. Our study thus emphasizes the need for comprehensive evaluation of toxic element status, covering the annual cycle of a species. (C) 2016 Elsevier Ltd. All rights reserved.Peer reviewe
Soil methane sink capacity response to a long-term wildfire chronosequence in Northern Sweden
Boreal forests occupy nearly one fifth of the terrestrial land surface and are recognised as globally important regulators of carbon (C) cycling and greenhouse gas emissions. Carbon sequestration processes in these forests include assimilation of CO2 into biomass and subsequently into soil organic matter, and soil microbial oxidation of methane (CH4). In this study we explored how ecosystem retrogression, which drives vegetation change, regulates the important process of soil CH4 oxidation in boreal forests. We measured soil CH4 oxidation processes on a group of 30 forested islands in northern Sweden differing greatly in fire history, and collectively representing a retrogressive chronosequence, spanning 5000 years. Across these islands the build-up of soil organic matter was observed to increase with time since fire disturbance, with a significant correlation between greater humus depth and increased net soil CH4 oxidation rates. We suggest that this increase in net CH4 oxidation rates, in the absence of disturbance, results as deeper humus stores accumulate and provide niches for methanotrophs to thrive. By using this gradient we have discovered important regulatory controls on the stability of soil CH4 oxidation processes that could not have not been explored through shorter-term experiments. Our findings indicate that in the absence of human interventions such as fire suppression, and with increased wildfire frequency, the globally important boreal CH4 sink could be diminished
Alcohol-related cerebellar degeneration: not all down to toxicity?
Background: Alcohol-related cerebellar degeneration is one of the commonest acquired forms of cerebellar ataxia. The exact pathogenic mechanisms by which alcohol leads to cerebellar damage remain unknown. Possible autoreactive immune mediated mechanisms have not been explored previously. In this study, we aim to investigate the potential role of alcohol-induced immune mediated cerebellar degeneration.
Methods: Patients with ataxia and a history of alcohol misuse were recruited from the Ataxia and Hepatology tertiary clinics at Sheffield Teaching Hospitals NHS Trust. We determined the pattern of cerebellar involvement both on clinical (SARA score) and imaging (MRI volumetry and MR spectroscopy) parameters. In addition, HLA genotyping, serological markers for gluten-related disorders and serological reactivity on rat cerebellar tissue using indirect immunohistochemistry were assessed.
Results: Thirty-eight patients were included in the study all of whom had ataxia. The gait (97 %), stance (89 %) and heel-shin slide (89 %) were the predominant SARA elements affected. MRI volumetric and spectroscopy techniques demonstrated significant structural, volumetric and functional deficits of the cerebellum with particular involvement of the cerebellar vermis. Circulating anti-gliadin antibodies were detected in 34 % patients vs. 12 % in healthy controls. Antibodies to transglutaminase 6 (TG6) were detected in 39 % of patients and 4 % of healthy control subjects. Using immunohistochemistry, Purkinje cell and/or granular layer reactivity was demonstrated in 71 % of patient sera.
Conclusions: Alcohol induced tissue injury to the CNS leading to cerebellar degeneration may also involve immune mediated mechanisms, including sensitisation to gluten
Comparative analysis on the communication strategies of the forest owners associations in Europe
This research reports a comparative analysis of the communication strategy that forest owners' associations
across Europe use to influence society on one side and the decision-makers on the other, in order to fulfill forest
owners' interests. 60% of Europe's forests are privately owned by an estimated number of 16 million forest
owners, who are represented by forest owners' associations. One of its main functions is to influence the public
perceptions on forests and forestry. In this article it is analyzed how a specific forestry stakeholder fixes its strategies
to communicate with and lobby society in order to get acceptability for their proposals/demands. Open-end
surveys have been used as a source of information in 2006 and repeated in 2012. Besides of the comparison
among countries, a comparison along the time has been also performed. The whole communication frame is
analyzed, considering the objectives, the structure, the messages, the channels, and the evaluation. The main
conclusions that arise are: first, the temporary comparison (2006 2012) results into an improvement in several
issues; second, there is room for improvement of professionalization of communication in forest owners' associations
in Europe; third, social research into public perception of forestry might help to define communication
strategies.Fabra Crespo, M.; Rojas Briales, E. (2015). Comparative analysis on the communication strategies of the forest owners associations in Europe. Forest Policy and Economics. 50:20-30. doi:10.1016/j.forpol.2014.06.004S20305
Mortality and cause of death in hip fracture patients aged 65 or older - a population-based study
<p>Abstract</p> <p>Background</p> <p>The high mortality of hip fracture patients is well documented, but sex- and cause-specific mortality after hip fracture has not been extensively studied. The purpose of the present study was to evaluate mortality and cause of death in patients after hip fracture surgery and to compare their mortality and cause of death to those in the general population.</p> <p>Methods</p> <p>Records of 428 consecutive hip fracture patients were collected on a population-basis and data on the general population comprising all Finns 65 years of age or older were collected on a cohort-basis. Cause of death was classified as follows: malignant neoplasms, dementia, circulatory disease, respiratory disease, digestive system disease, and other.</p> <p>Results</p> <p>Mean follow-up was 3.7 years (range 0-9 years). Overall 1-year postoperative mortality was 27.3% and mortality after hip fracture at the end of the follow-up was 79.0%. During the follow-up, age-adjusted mortality after hip fracture surgery was higher in men than in women with hazard ratio (HR) 1.55 and 95% confidence interval (95% CI) 1.21-2.00. Among hip surgery patients, the most common causes of death were circulatory diseases, followed by dementia and Alzheimer's disease. After hip fracture, men were more likely than women to die from respiratory disease, malignant neoplasm, and circulatory disease. During the follow-up, all-cause age- and sex-standardized mortality after hip fracture was 3-fold higher than that of the general population and included every cause-of-death category.</p> <p>Conclusion</p> <p>During the study period, the risk of mortality in hip fracture patients was 3-fold higher than that in the general population and included every major cause of death.</p
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