Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV

Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]

Direct constraint on the Higgs–charm coupling from a search for Higgs boson decays into charm quarks with the ATLAS detector

A search for the Higgs boson decaying into a pair of charm quarks is presented. The analysis uses proton–proton collisions to target the production of a Higgs boson in association with a leptonically decaying W or Z boson. The dataset delivered by the LHC at a centre-of-mass energy of and recorded by the ATLAS detector corresponds to an integrated luminosity of 139 fb−1. Flavour-tagging algorithms are used to identify jets originating from the hadronisation of charm quarks. The analysis method is validated with the simultaneous measurement of WW, WZ and ZZ production, with observed (expected) significances of 2.6 (2.2) standard deviations above the background-only prediction for the (W/Z)Z(→cc¯) process and 3.8 (4.6) standard deviations for the (W/Z)W(→cq) process. The (W/Z)H(→cc¯) search yields an observed (expected) upper limit of 26 (31) times the predicted Standard Model cross-section times branching fraction for a Higgs boson with a mass of , corresponding to an observed (expected) constraint on the charm Yukawa coupling modifier |κc|<8.5 (12.4), at the 95% confidence level. A combination with the ATLAS (W/Z)H,H→bb¯ analysis is performed, allowing the ratio κc/κb to be constrained to less than 4.5 at the 95% confidence level, smaller than the ratio of the b- and c-quark masses, and therefore determines the Higgs-charm coupling to be weaker than the Higgs-bottom coupling at the 95% confidence level

Observation of electroweak production of two jets in association with an isolated photon and missing transverse momentum, and search for a Higgs boson decaying into invisible particles at 13 TeV with the ATLAS detector

This paper presents the measurement of the electroweak production of two jets in association with a $Z\gamma$ pair with the $Z$ boson decaying into two neutrinos. It also presents the search for invisible or partially invisible decays of a Higgs boson with a mass of 125 GeV produced through vector-boson fusion with a photon in the final state. These results use data from LHC proton-proton collisions at $\sqrt{s}$ = 13 TeV collected with the ATLAS detector corresponding to an integrated luminosity of 139 fb$^{-1}$. The event signature, shared by all benchmark processes considered for measurements and searches, is characterized by a significant amount of unbalanced transverse momentum and a photon in the final state, in addition to a pair of forward jets. For electroweak production of $Z\gamma$ in association with two jets, the background-only hypothesis is rejected with an observed (expected) significance of 5.2 (5.1) standard deviations. The measured fiducial cross-section for this process is 1.31$\pm$0.29 fb. Observed (expected) upper limit of 0.37 (0.34) at 95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to invisible particles, assuming the Standard Model production cross-section. The signature is also interpreted in the context of decays of a Higgs boson to a photon and a dark photon. An observed (expected) 95% CL upper limit on the branching ratio for this decay is set at 0.018 (0.017), assuming the 125 GeV Standard Model Higgs boson production cross-section

Nuorten päihteiden käyttö ja vanhempien saama tuki

Nuorten päihteiden käyttö on lisääntynyt viime vuosina. Nuoret eivät yleensä ole päihteistä riippuvaisia, mutta satunnainenkin kokeilu ja käyttö ovat haitallisia. Päihteiden käyttö voi olla yksittäinen ongelma, mutta myös osa suurempaa ongelmakokonaisuutta. Tämän vuoksi nuoren tilannetta tulee tarkastella kokonaisvaltaisesti. Päihteiden käyttöä ei aina huomata, ja sen ilmeneminen voi olla sokki läheisille. Päihteiden käyttö on ongelma käyttäjälle, mutta voi sairastuttaa myös läheiset. Läheiset, usein nuorten vanhemmat, tarvitsevat myös tukea ja neuvoa tilanteessa. Vanhempien oma asenne ja päihdekäyttäytyminen sekä nuoren asioista perillä oleminen ovat tärkeitä ehkäiseviä tekijöitä nuoren päihteiden käytölle. Myös nuoren oma asenne päihteisiin sekä sosiaaliset suhteet ja onnistumisen kokemukset ovat päihteiltä suojaavia tekijöitä. Tämä opinnäytetyö on tehty kokoamalla kattavasti teoriatietoa päihteistä, niiden käytöstä ja haitoista. Etelä-Karjalan sosiaali- ja terveyspiirin (Eksoten) internet-sivuilta selvitettiin, mistä ja miten voi hakea apua ja neuvoja läheisen päihteiden käytön ongelmiin. Lisäksi tehtiin kysely päihdenuorten vanhemmille. Kyselyllä selvitettiin päihdenuorten vanhempien omaa kokemusta saamastaan tuesta sosiaali- ja terveysalan ammattilaisilta. Tulokset analysoitiin empiirisesti. Tulosten mukaan osa vanhemmista on tyyty-väisiä saamaansa tukeen, osa taas kokee, ettei ole saanut tarpeeksi tukea ja tietoa. Päihdepalvelujen parempi ja määrällisesti laajempi saatavuus on kyse-lyyn vastanneiden vanhempien toiveissa. Tästä voidaan päätellä, että päih-denuorten vanhemmat otetaan huomioon ja tukea on tarjolla, mutta kaikkia tuki ei tavoita. Jatkotutkimuksessa voisi selvittää millaiseksi päihdenuoret kokevat saamansa hoidon. Lisäksi voisi selvittää miten sosiaali- ja terveysalan ammattilaiset koke-vat voivansa vaikuttaa nuorten päihdekäyttäytymiseen ja miten sosiaali- ja ter-veysalan ammattilaiset voisivat ottaa päihdenuorten vanhemmat paremmin huomioon. Kirjallisen nuorten päihdeasioita käsittelevän oppaan tekeminen ja jakaminen vanhemmille voisi olla hyödyllinen.Intoxicant use and abuse in young people has increased in recent years. Young people are generally not dependent on intoxicants, but occasional experimentation and use are harmful. Intoxicant use can be a single problem or part of a larger set of problems. Because of this, the situation of the young people should be considered from a broad perspective. Intoxicant use is not always noticed and its appearance may be a shock to those close to the user. Intoxicant use is a problem in the user, but can cause problems for families and friends, as well. Closely related, commonly parents, also need support and counsel in these situations. Parent's own attitudes and customs to use intoxicants, and knowing well issues about young people are important preventive factors for young people's intoxicant use. Also young people's attitude to intoxicant use and social affairs and experience of success are protective factors for intoxicant use. This thesis has been done by collecting comprehensive information on theory of intoxicant consumption and drawbacks of them. With the help of South Karelia District of Social and Health Service's websites, information about where and how to get help and advice for those close to young people with problems was found. In addition to this has been done an inquiry to parents of young people who use intoxicants. By the inquiry, the parents own experiences of having support from professionals in social and health care were examined. The results were analyzed empirically. According to the results, a proportion of parents are satisfied for support they have got, whereas part of parents find that they have not had enough support and information. The parents hope for better and wider availability of services for intoxicant users. Parents of young intoxicant abusers were taken into ac-count, and support services are available, but they do not reach all who need them. For further study, the opinions of the young people, and also of the health professionals about care of intoxicant abusers would be of interest

Tools for estimating fake/non-prompt lepton backgrounds with the ATLAS detector at the LHC

International audienceMeasurements and searches performed with the ATLAS detector at the CERN LHC often involve signatures with one or more prompt leptons. Such analysesare subject to `fake/non-prompt' lepton backgrounds, where either a hadron or a lepton from a hadron decay or an electron from a photon conversion satisfies the prompt-leptonselection criteria. These backgrounds often arise within a hadronic jet because of particle decays in the showering process, particle misidentification or particleinteractions with the detector material. As it is challenging to model these processes with high accuracy in simulation, their estimation typically uses data-driven methods.Three methods for carrying out this estimation are described, along with their implementation in ATLAS and their performance