299 research outputs found
Evidence for early Pliocene and late Miocene transgressions in southern Patagonia (Argentina): Sr-87/Sr-86 ages of the pectinid "Chlamys" actinodes (Sowerby)
- Publication venue
- Publication date
- 01/11/2013
- Field of study
Numerical ages based on 87Sr/86Sr dating of calcitic shells belonging to the pectinid “Chlamys” actinodes (Sowerby) document the only late Miocene (Tortonian) sea flooding event in the Austral Basin at Cabo Buentiempo (8.95 ± 0.82 Ma, 2 s.e.), and provide evidence of the first documented early Pliocene (Zanclean) transgression in Argentina recorded at Cañadón Darwin (5.15 ± 0.18 Ma, 2 s.e., Austral Basin) and at Terraces of Cerro Laciar (5.10 ± 0.21 Ma, 2 s.e.), southern San Jorge Basin). The sedimentary rocks deposited during the Tortonian are correlated with the youngest beds deposited by the “Entrerriense Sea” that covered northern Patagonia. The Zanclean marine episode is correlated with the long-term cycle represented in the Southern Hemisphere by the flooding events recorded in Cockburn and James Ross Islands (Antarctica) and in North-Central Chile
Correlation between sleep disorder screening and executive dysfunction in children with attention deficit-hyperactivity disorder
- Author
- Accardo JA
- Adrian Poblano
- Beebe DW
- Chervin RD
- Choi J
- Dahl RE
- Elizabeth Zambrano-Sanchez
- Jose A. Martinez-Cortes
- Langberg JM
- Lim W
- Minerva Dehesa-Moreno
- Naëgelé B
- Parkin JR
- Poblano A
- Sawyer AC
- Sergeant JA
- Spruyt K
- Tomás-Vila M
- Verstraeten E
- Yolanda del Rio-Carlos
- Yoon SY
- Zambrano-Sánchez E
- Zambrano-Sánchez E
- Zambrano-Sánchez E
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The Nature of the Dietary Protein Impacts the Tissue-to-Diet 15N Discrimination Factors in Laboratory Rats
- Author
- AC Seila
- AL Waters-Rist
- AM Mekota
- B Lohrke
- BT Fuller
- BT Fuller
- C Boutry
- C Martinez del Rio
- C Martinez del Rio
- C Morens
- C Morens
- C Morens
- CM Kurle
- CT Robbins
- CT Robbins
- Cécile Bos
- DA Schoeller
- Daniel Tomé
- DM O'Brien
- F Dalerum
- François Mariotti
- GE Blakey
- H Fouillet
- H Fouillet
- H Fouillet
- H Sick
- HB Waynforth
- Hélène Fouillet
- J Gaye-Siessegger
- JA Silfer
- JD Roth
- Jean-François Huneau
- JM Hayes
- K Smith
- KA Hobson
- KJ Petzke
- KJ Petzke
- KW Steele
- LS Arneson
- LS Arneson
- LZ Gannes
- M Lacroix
- M Sponheimer
- MA Vanderklift
- MJ DeNiro
- MJ Vander Zanden
- Nathalie Poupin
- NEP Deutz
- OH Gaebler
- PE Sharp
- PS Barboza
- RL DeMots
- S Caut
- S Caut
- S Ponsard
- SA Macko
- SE MacAvoy
- SE MacAvoy
- SH Ambrose
- Stephane Blanc
- T Yoneyama
- V Balter
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Due to the existence of isotope effects on some metabolic pathways of amino acid and protein metabolism, animal tissues are 15N-enriched relative to their dietary nitrogen sources and this 15N enrichment varies among different tissues and metabolic pools. The magnitude of the tissue-to-diet discrimination (Δ15N) has also been shown to depend on dietary factors. Since dietary protein sources affect amino acid and protein metabolism, we hypothesized that they would impact this discrimination factor, with selective effects at the tissue level. To test this hypothesis, we investigated in rats the influence of a milk or soy protein-based diet on Δ15N in various nitrogen fractions (urea, protein and non-protein fractions) of blood and tissues, focusing on visceral tissues. Regardless of the diet, the different protein fractions of blood and tissues were generally 15N-enriched relative to their non-protein fraction and to the diet (Δ15N>0), with large variations in the Δ15N between tissue proteins. Δ15N values were markedly lower in tissue proteins of rats fed milk proteins compared to those fed soy proteins, in all sampled tissues except in the intestine, and the amplitude of Δ15N differences between diets differed between tissues. Both between-tissue and between-diet Δ15N differences are probably related to modulations of the relative orientation of dietary and endogenous amino acids in the different metabolic pathways. More specifically, the smaller Δ15N values observed in tissue proteins with milk than soy dietary protein may be due to a slightly more direct channeling of dietary amino acids for tissue protein renewal and to a lower recycling of amino acids through fractionating pathways. In conclusion, the present data indicate that natural Δ15N of tissue are sensitive markers of the specific subtle regional modifications of the protein and amino acid metabolism induced by the protein dietary source
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
- Author
- Adoue D
- Agard C
- Ahmadi K
- Airo P
- Aizpuru EM
- Akanay-Diesel S
- Albertsson K
- Almeida I
- Alsheimer B
- Alves J
- Andersen M
- Anderson M
- Andresen J
- Angeles Aquirre M
- Antivalle M
- Aries P
- Aslanidis S
- Aslkaksen HK
- Assmann G
- Assous N
- Athanassiou P
- Athiveer P.
- Baguley E
- Bajoochi G
- Bakkeheim V
- Bakland G
- Balquiere S
- Barbado J
- Barca BA
- Barnd A
- Barth S
- Battaglia E
- Baudaoin P
- Baumann C
- Becerra ND
- Becker M
- Becvar R
- Bekou V
- Belin E
- Bellido D
- Bellisai F
- Bellissimo S
- Belloli L
- Belloni B
- Bendvold A
- Beneton N
- Berezne A
- Berthier S
- Bessis D
- Beyer C
- Bezanahary H
- Bijl M
- Bitter H
- Blaise S
- Blanco JJ
- Blanco JS
- Blank N
- Bloching HH
- Blum L
- Blume J
- Boesenberg I
- Bohmova J
- Bootsma H
- Boro D
- Bortoluzzi A
- Boulon C
- Boussely N
- Bracin T
- Brand H
- Bravetti V
- Brodmann M
- Broll H
- Brouwer L
- Brown S
- Bruckner L
- Bruyn G
- Bucci R
- Caamano M
- Cabane J
- Callejas JL
- Calvo J
- Camara I
- Camps MT
- Cantatore F
- Carpentier P
- Cartry O
- Castellvi I
- Castellvi I
- Cazalets-lacoste C
- Chakravarty K
- Charlanne H
- Chatelus E
- Chiffot H
- Choong LM
- Chromik S
- Cipriani P
- Coelho P
- Cohen JD
- Colaci M
- Cole S
- Coleman JV
- collet E
- Colonna L
- Constans J
- Coppere B
- Cordeiro A
- Corteguera M
- Costa J
- Couraud A
- Couret B
- Cozzi F
- Crespo M
- Cruz A
- Cruz J
- Cuomo G
- D'Cruz D
- Dadban A
- De Angeli R
- de Bois M
- De la Puente C
- de la Torre RG
- de Long AJ
- de Ramon E
- de Vicuna RG
- De Vita S
- Deboves O
- Decaux O
- Deininger F
- del Carmen Ortega de la O M
- del Carmen Torres Martin M
- del la Pena Lefebvre PG
- del Mar Ripoll Macias M
- Del Papa N
- del Rio AH
- Delgado EG
- den Hengst C
- Denton C
- Denton CP
- Deppermann N
- Desmurs-Clavel H
- Deuschle K
- Diaz JJ
- Dietl S
- Dimitroulas T
- Diot E
- Distler J
- Distler O
- Dobson J
- Doeffel-hantz V
- Dohse A
- Dolhain R
- Dolnicar AS
- Doutre MS
- Doveri M
- Droitcourt C
- Dumonteil S
- DUO Registry investigators. Collaborators: Stetter M
- Durant C
- Duval-modeste AB
- Dyballa J
- Ebel J
- Eiden E
- Eilbacher P
- Elezoglou A
- Enderlein M
- Erfurt-berge C
- Espinosa G
- Espinposa G
- Ewals J
- Faggioli P
- Faizal A
- Farcas C
- Farge D
- Fauchais AL
- Faustini F
- Federow I
- Feldmann R
- Fell I
- Fernandez AS
- Fernandez C
- Fernandez NC
- Fernandez S
- Ferraccioli G
- Ferrandiz D
- Ferri C
- Fiene M
- Fierlbeck G
- Filloy JA
- Flaig W
- Fojtik Z
- Foti R
- Frambach Y
- Frances C
- Fretter P
- Freundlieb C
- Frey P
- Funkert A
- Fusaro E
- Fuzibet JG
- Gabrielli A
- Gaches F
- Galanopoulo V
- Galanopoulos N
- Galeazzi M
- Galluccio F
- Garcia A
- Garcia PV
- Garyfallos A
- Gatti S
- Gaubitz M
- Gause A
- Gawlik A
- Gerards AH
- Gerber A
- Gerdes V
- Gernot Scheibl E
- Geurts M
- Gil JG
- Gines Martinez F
- Girard-Madoux MH
- Gjessdal CG
- Glaeser R
- Goekoop R
- Gonzales MF
- Gordon P
- Goudran G
- Grandauent B
- Granel B
- Granel-brocard F
- Grassi W
- Greco M
- Grier A
- Groenendael JH
- Groenendael J
- Guenzel J
- Guertler I
- Guillevin L
- Guillevin L
- Hachulla E
- Hafner F
- Hahn K
- Hak AE
- Hall F
- Hallecker A
- Hallermann C
- Hamberger N
- Hamilton A
- Hampson R
- Han KH
- Hapke S
- Harmuth W
- Harris H
- Hartmann F
- Hassel R
- Hatron PY
- Haust M
- Hazenbiller A
- Hein R
- Hellmich B
- Hellstrom H
- Henkemeier U
- Hermanns G
- Hermansson E
- Hernan MG
- Herr U
- Herrgott I
- Herrick A
- Heurkens AH
- Hildebrandt B
- Hillebrecht C
- Himsel A
- Hirschl M
- Hjertaker SL
- Hoff NP
- Hoffmann-Vold AM
- Holzer G
- Hot A
- Houben H
- Huegel R
- Huertas MP
- Huettig B
- Huizinga TW
- Hulsmans H
- Hundstorfer M
- Hurkens T
- Illmer X
- Imbert B
- Insua SA
- Iversen LV
- Jacobs PJ
- Jahangier de Veen ZN
- Jahnke K
- James J
- Jansen P
- Janssen M
- Jego P
- Jourdain N
- Kaarto A
- Kaasjager HA
- Kaczmarczyk A
- Kaeding U
- Kahl S
- Kalstad S
- Kamali S
- Kampe-Juzak E
- Kanter MD
- Karaenke P
- Karlsmark T
- Karlsson ML
- Katzemich A
- Kayser M
- Kellner C
- Kelsey C
- Kern S
- Keshtmand H
- Kettenbach A
- Keynote A
- Khau van Kien A
- Kirchberg S
- Kirschke J
- Klein E
- Kleiner HJ
- Klings D
- Kneitz C
- Knifjj-Dutmer E
- Knoebel K
- Knudsen JB
- Koch M
- Koldingsnes W
- Kolle H
- Kostrzwewa E
- Koutroumbas A
- Krause Rostock JO
- Kremer K
- Krieg T
- Kritikos I
- Krog B
- Krupp E
- Kuen-Spiegel M
- Kuiper-geertsma DG
- Kunze S
- Kurthen R
- Kyndt X
- Lackner K
- Lamb J
- Lambert M
- Landewe RM
- Lanting P
- Lapadula G
- Launay D
- Laurin CU
- Lauterwein B
- Lazareth I
- Le Quellec A
- Lebrun C
- Leguy-Seguin V
- Letremy A
- Liljequist E
- Lind I
- Lind K
- Linke M
- Loeffler C
- Lok C
- Lombardi S
- Lopez JC
- Lopez MR
- Losada L
- Loustaud-ratti V
- Luethke K
- Lukac J
- Lunardi C
- Lupaschko S
- Maceiras F
- Madaule S
- Madhok F
- Madland TM
- Maglione W
- Magy-Bertrand N
- Maillard H
- Makinen H
- Malavolta N
- Manea P
- Maneiro JR
- Manning J
- Manzanedo VS
- Margeta C
- Marhuenda AR
- Marina P
- Martin I
- Marucci A
- Marx J
- Mascaro JM
- Masolini P
- Mateo FJ
- Matucci-Cerinic M
- Maurer B
- May D
- Mayer L
- Mazzone A
- Mazzuca S
- Mchugh N
- Meier L
- Meier U
- Mendoza AZ
- Mengden T
- Mensing C
- Mensing H
- Mera A
- Merk B
- Mesaric P
- Messall J
- Messer G
- Mettler S
- Metz S
- Metzler C
- Michon-Pasturel U
- Midtvedt O
- Miguelez R
- Minmair G
- Misery L
- Mitchell A
- Mittag M
- Mohammad A
- Moinzadeh P
- Moiton MP
- Molders N
- Moline T
- Monshausen M
- Monshi B
- Montecucco CM
- Montes IC
- Montes J
- Moolenburgh JD
- Moore T
- Moosig F
- Moots R
- Morell S
- Moritz D
- Morrison C
- Mosquera JA
- Mota R
- Moulis G
- Mouthon L
- Mueglich C
- Muhlack A
- Muller WH
- Munoz J
- Murphy K
- Murray M
- Mussi A
- Naderi Y
- Neek G
- Nemec P
- Neul S
- Ngcozana T
- Nichelmann V
- Nicolas GM
- Niedermeier A
- Niefanger K
- Nielen C
- Nigro A
- Ninet J
- Noordzij M
- Nordin A
- Nordvag BY
- O'Rourke M
- Ochiel R
- Ochs W
- Oelsner M
- Ogunbambi G O
- Oliveira S
- Olivieri I
- Olsen AB
- Oltmann-Schroeder J
- Ortego N
- Ostenson A
- Paassen P
- Pallotta S
- Pampin EP
- Parker L
- Pedersen T
- Pellerito R
- Perlat A
- Peters AJ
- Peters J
- Pfeiffer C
- Pflugfelder J
- Pfoehler C
- Pirkhammer D
- Plaumann K
- Podda M
- Podobinska M
- Ponte C
- Prey S
- Priollet P
- Prochazkova L
- Pros A
- Puppo F
- Quemeneur T
- Queyrel V
- Rabaneda EV
- Rabe B
- Raffier B
- Ramos PC
- Rapp P
- Rasche C
- Rauen T
- Reemtsen R
- Reguiai Z
- Reinhart V
- Reischel N
- Remans J
- Resende C
- Riccieri V
- Richez C
- Richter L
- Riemekasten G
- Rintelen B
- Riviere S
- Rizk M
- Robakidze-Torbahn M
- Rodriguez MA
- Rodriguez TR
- Roman Ivorra J
- Ronday K
- Rosato E
- Rosenberg D
- Rubio M
- Ruchenburg J
- Rueda A
- Rullier P
- Rumbaur C
- Rumpel H
- Rushentsova U
- Rydvald Y
- Sadeghlar F
- Saez L
- Sailler L
- Salerno R
- Salsano F
- Sanchez J
- Sanchez MD
- Sanchez PS
- Sancho Alegre JJ
- Sandoval AA
- Santo MP
- Santos C
- Saracco M
- Sardy M
- Sassolas B
- Sautner J
- Schaefer C
- Schanz S
- Schildt K
- Schleenbecker H
- Schmeiser T
- Schmidt K
- Schmidt P
- Schmidt-Bosshard R
- Schneider K
- Scholz J
- Schuart T
- Schuch F
- Schuerwegh A
- Schuetz N
- Schult S
- Schultz L
- Schulze K
- Schuster J
- Schwarting A
- Schweda K
- Schwierin B
- Schwuerzer-Voit M
- Scorza R
- Seidel M
- Seip M
- Semmelweis K
- Semmler M
- Serafino L
- Severino A
- Seys P
- Sheikh N
- Sibillia J
- Siebel C
- Siewertsz van Reesema D
- Silkey M
- Silva I
- Simeon CP
- Skingle S
- Skomsvoll J
- Skowron F
- Skyes H
- SMIT A
- Smrzova A
- Soderlin M
- Sondergaard KH
- Sonnaville PB
- Sordet C
- Soukup T
- Spars A
- Sperling S
- Starz H
- Stein T
- Steinbrink K
- Sticherling M
- Stisi S
- Stoeckl F
- Stolk JN
- Storck-Mueller K
- Stran EK
- Stroes ES
- Suchy D
- Taieb A
- Takacs M
- Tasende JA
- Terlizzi N
- Thomsen RS
- Thonhofer R
- Thorsson C
- Tiev K
- Tiggers C
- Toeller S
- Toledano C
- Tomi N
- Ton E
- Tony HP
- Trautinger F
- Trenado MS
- Triolo G
- Trotta F
- Trummer M
- Tsifetaki N
- Ubels F
- Ughi N
- Uhlig S
- Ullrich-Guenther C
- Unholzer A
- Uson J
- Vacca A
- Valentijn R
- van Hagen M
- van Daele P
- van den Hoogen F
- van der Lubbe P
- van der Veen MJ
- van Gameren I
- Van Guldener C
- Van Krugten M
- Van Neer F
- van Paassen H
- van Woerkom JM
- van Zeben D
- Varcasia G
- Vasilopoulos D
- Vazquez JL
- Vengemyr K
- Vercoutere W
- Verner D
- Victoria Egurbide M
- Vidal E
- Villaverde V
- Vincent R
- Vingren T
- Visser H
- Vlachoyannopoulos P
- von Bildering PB
- von Elling A
- von Oelhafen J
- Vonk M
- Vos P
- Voskuyl A
- Voss B
- Vosswinkel J
- Wagner N
- Wahl D
- Wahn H
- Waldheim E
- Weiss E
- Welzel J
- Wernitzsch H
- Westedt ML
- Westra R
- White-Alao B
- Wilhelm HU
- Willems H
- Willfort-Ehringer A
- Wipff J
- Wlarvens M
- Woijtasik G
- Wollersdorfer E
- Worm M
- Wragg E
- Wuerzburg I
- Xu Y
- Zabel M
- Zemanova I
- Zeni S
- Zenone T
- Zeuner R
- Ziai M
- Zijlstra TR
- Zimba S
- Zuily S
- Zultak M
- Zuper R
- Zwenger S
- Publication venue
- BMJ Group
- Publication date
- 01/01/2012
- Field of study
OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).
METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.
RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.
CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies
Gender differences in the use of cardiovascular interventions in HIV-positive persons; the D:A:D Study
- Author
- Abeli C
- Abrams DI
- Abrescia N
- Acinapura R
- Ackens RP
- Aho I
- Aksak-Was B
- Albers M
- Alessandrini A
- Amele S
- Ammassari A
- Ammerlaan H
- Andreoni M
- André K
- Ang CW
- Angarano G
- Antinori A
- Arduino R
- Arends JE
- Aubert V
- Baas S
- Back N
- Bagella P
- Baker D
- Bakker Y
- Bakowska E
- Baldelli F
- Baldin G
- Balotta C
- Bandera A
- Barocci V
- Barth RE
- Bartsch G
- Bassetti M
- Battegay M
- Bauer MP
- Bax HI
- Baxter J
- Begovac J
- Bellecave P
- Belvisi V
- Benfield T
- Beniowski M
- Bergsma D
- Berkhout B
- Bermon N
- Bernard E
- Bernard N
- Bernasconi E
- Bezemer DO
- Bezemer M
- Bierman W
- Blaizeau MJ
- Blance A
- Blanco P
- Blaxhult A
- Bloch M
- Bloembergen P
- Blok WL
- Bobbio N
- Boender TS
- Boerg E
- Bogner J
- Bohlius J
- Bojesen A
- Bomers M
- Bonadies G
- Bonfanti P
- Bonnet F
- Bonora S
- Bont LJ
- Bor P
- Borderi M
- Borgia G
- Borodulina E
- Bos JC
- Bosch M
- Bosma AS
- Boucher C
- Bouchet S
- Bouwhuis JW
- Bower M
- Brandt RS
- Branger J
- Braun DL
- Bravo I
- Breilh D
- Brinkman K
- Brokking W
- Brouwer AE
- Brouwer CJ
- Bruinsma-Broekman FB
- Bruun J
- Bucher H
- Buiting A
- Burger D
- Burke M
- Böni J
- Cacopardo B
- Cadafalch J
- Caissotti C
- Calcagno A
- Caldeira L
- Calmy A
- Calvo G
- Calza L
- Capobianchi MR
- Capozzi M
- Caramello P
- Caramma I
- Carletti F
- Carr A
- Carrara S
- Cascio A
- Cassola G
- Castagna A
- Castelli F
- Cattelan AM
- Caubet O
- Cauda R
- Caunegre L
- Cavassini M
- Cazanave C
- Ceccherini-Silberstein F
- Cecchetto M
- Celesia B
- Chiodera A
- Chirianni A
- Chkhartishvili N
- Chossat I
- Chêne G
- Cicalini S
- Cingolani A
- Cinque P
- Ciuffi A
- Claas E
- Claessen E
- Clarke A
- Clotet B
- Clumeck N
- Codina C
- Cohen Stuart J
- Cohn D
- Colomba C
- Conte V
- Cooper D
- Cornelissen M
- Costantini A
- Courjon J
- Courtault C
- Cozzi-Lepri A
- Crane LR
- Cristaudo A
- Cua E
- D'Arminio Monforte A.
- D'Ivernois C
- Dabis F.
- Damen M
- Dauchy FA
- de Boer M
- de Groot J
- de Groot L
- de Jong A
- de Lang A
- De Luca A
- de Munnik E
- de Oude-Lubbers A
- De Ruyter Ziekenhuis A
- De Salvador-Guillouet F
- de Vocht J
- de Weerd DA
- De Wit S.
- de Zeeuw-de Man M
- Decoin M
- Degen O
- Deiman B
- Del Cacho E
- Delforge M
- Dellamonica P
- Delsing CE
- Delveaux S
- den Berg JF
- den Berk G
- den Hollander JG
- Desjardin S
- Di Biagio A
- Di Caro A
- Di Giuli C
- Di Martino F
- Di Perri G
- Diarra F
- Diederen B
- Dijkstra K
- Dofferhoff A
- Dollenmaier G
- Dollet K
- Domingo P
- Donati V
- Dondia D
- Dorama W
- Driessen G
- Duffau P
- Dupon M
- Durant J
- Dutronc H
- Duvivier C
- Edwards S
- Egger M
- El Berkaoui A
- El Moussaoui R
- El-Sadr W.
- Elbirt D
- Elinav H
- Ellerbroek PM
- Elsenburg L
- Elzi L
- Esposito R
- Etienne C
- Faber S
- Falasca K
- Falconer K
- Fanti I
- Farbos S
- Faure I
- Fehr J
- Fellay J
- Ferrand H
- Ferrando S
- Fischer AH
- Fisher E
- Flamholc L
- Fleury H
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- 01/01/2018
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Peer reviewe
Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
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- Aasly JO
- Ahmad-Annuar A
- Akpalu A
- Albin R
- Alcalay R
- Alvarez I
- Amod F
- Amouri R
- Anderson TJ
- Arboleda G
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- Chahine LM
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- Cheung NY-F
- Chowdhury S
- Coker D
- Comart C
- Cornejo-Olivas M
- Corvol J-C
- Cruchaga C
- Cubo E
- Dadiotis E
- Dagklis I
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- Dean M
- del Rio MJ
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- Dhamija D
- Divya KP
- Doquenia ML
- Dumanis S
- El-Sadig S
- Ellis M
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- Ertan S
- Espay A
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- Publication venue
- Springer Nature
- Publication date
- Field of study
\ua9 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations
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- Alizadeh J
- Almacellas E
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- Alzaharna MM
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- Ambrosio S
- Amer AO
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- Andersen SU
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- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Abicht NJ
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- Zhemchugov A
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- Zimine NI
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
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- Abbott B
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- Abicht NJ
- Abidi SH
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- Windischhofer PJ
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- Zenger DT
- Zenin O
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- Zerradi S
- Zerwas D
- Zhai M
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- Zhang DF
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- Zhang J
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- Zhang R
- Zhang S
- Zhang T
- Zhang X
- Zhang X
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- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Corrigendum to "Search for flavour-changing neutral-current couplings between the top quark and the photon with the ATLAS detector at √s=13 TeV" (Physics Letters B, 842 (2023), 137379)
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- Abbott B
- Abbott Dc
- Abed Abud A
- Abeling K
- Abidi Sh
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman Ac
- Acharya Bs
- Achkar B
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- Scanlon T
- Schaarschmidt J
- Schacht P
- Schaefer D
- Schaffer Ac
- Schaile D
- Schamberger Rd
- Schanet E
- Scharf C
- Schäfer U
- Schegelsky Va
- Scheirich D
- Schenck F
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- Scheulen C
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- Schlag B
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- Schmitt C
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- Schoeffel L
- Schoening A
- Scholer Pg
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- Schumm Ba
- Schune P
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- Schwemling P
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- Sciandra A
- Sciolla G
- Scuri F
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- Sebastiani Cd
- Sedlaczek K
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- Seidel Sc
- Seiden A
- Seidlitz Bd
- Seiss T
- Seitz C
- Seixas Jm
- Sekhniaidze G
- Sekula Sj
- Selem L
- Semprini-Cesari N
- Sen S
- Senthilkumar V
- Serin L
- Serkin L
- Sessa M
- Severini H
- Sevova S
- Sforza F
- Sfyrla A
- Shabalina E
- Shaheen R
- Shahinian Jd
- Shaikh Nw
- Shaked Renous D
- Shan Ly
- Shapiro M
- Sharma A
- Sharma As
- Sharma P
- Sharma S
- Shatalov Pb
- Shaw K
- Shaw Sm
- Sherwood P
- Shi L
- Shimmin Co
- Shimogama Y
- Shinner Jd
- Shipsey Ipj
- Shirabe S
- Shiyakova M
- Shlomi J
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- Shope Dr
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- Sideras Haddad E
- Sidiropoulou O
- Sidoti A
- Siegert F
- Sijacki D
- Sikora R
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- Silverstein Sb
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- Simpson El
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- Sindhu S
- Sinervo P
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- Sjölin J
- Skaf A
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- Slawinska M
- Smakhtin V
- Smart Bh
- Smiesko J
- Smirnov Sy
- Smirnov Y
- Smirnova Ln
- Smirnova O
- Smith Ea
- Smith Ha
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- Smizanska M
- Smolek K
- Smykiewicz A
- Snesarev Aa
- Snoek Hl
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- Solans Sanchez Ca
- Soldatov Ey
- Soldevila U
- Solodkov Aa
- Solomon S
- Soloshenko A
- Solovieva K
- Solovyanov Ov
- Solovyev V
- Sommer P
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- Song Wy
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- Soualah R
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- Stanislaus B
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- Starovoitov P
- Staszewski R
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- Steinhebel Al
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- Stoicea G
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- Strizenec P
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- Su X
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- Sulin Vv
- Sullivan Mj
- Sultan Dms
- Sultanaliyeva L
- Sultansoy S
- Sumida T
- Sun S
- Sun S
- Sunneborn Gudnadottir O
- Sutton Mr
- Svatos M
- Swiatlowski M
- Swirski T
- Sykora I
- Sykora M
- Sykora T
- Ta D
- Tackmann K
- Taffard A
- Tafirout R
- Tafoya Vargas Js
- Taibah Rhm
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- Talyshev Aa
- Tam Kc
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- Tanaka A
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- Tanaka R
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- Tang J
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- Tapprogge S
- Tarek Abouelfadl Mohamed A
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- Thielmann O
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- Thompson Pd
- Thomson E
- Thorpe Ej
- Tian Y
- Tikhomirov V
- Tikhonov Ya
- Timoshenko S
- Ting Exl
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- Togawa M
- Tojo J
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- Tokushuku K
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- Tomoto M
- Tompkins L
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- Torró Pastor E
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- Tsulaia V
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- Veloce Lm
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- Ventura A
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- Verducci M
- Vergis C
- Verissimo De Araujo M
- Verkerke W
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- Villhauer Em
- Vilucchi E
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- Vivarelli I
- Vladimirov V
- Voevodina E
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- Vukotic I
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- Wahdan S
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- Wiedenmann W
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- Wilkens Hg
- Williams Dm
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- Wosiek Bk
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- Yeletskikh I
- Yexley Mr
- Yin P
- Yorita K
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- Zaid E
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- Zakharchuk N
- Zambito S
- Zang J
- Zanzi D
- Zaplatilek O
- Zeitnitz C
- Zeißner Sv
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- Zenger Dt
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- Zerradi S
- Zerwas D
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhulanov V
- Zimine Ni
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- Zou W
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- Ženiš T
- Živković L
- Publication venue
- ELSEVIER
- Publication date
- 01/01/2023
- Field of study
- …