187 research outputs found
Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite Metalloprotease GP63
- Author
- A Brittingham
- A Brittingham
- A Descoteaux
- A Descoteaux
- A Descoteaux
- AS Kristof
- BS McGwire
- BS McGwire
- C Newell
- C Privé
- C Yao
- C Yao
- D Nandan
- David L. Sacks
- DJ Gregory
- FY Liew
- G Cascianelli
- G Chaudhuri
- G Forget
- G Forget
- I Abu-Dayyeh
- IrazĂș Contreras
- J Bouvier
- J Hess
- JA Allen
- JC Mottram
- JE Comer
- K Koike
- K Simons
- K-Y Lee
- LF Pemberton
- M Arnold
- M Ellis
- M Halle
- M Jaramillo
- M Karin
- M Karin
- M Olivier
- MA Gomez
- Marina T. Shio
- Martin Olivier
- MarĂa Adelaida GĂłmez
- MH Macdonald
- MK Tiliang Deng
- Oliver Nguyen
- P Angel
- P Desjeux
- PB Joshi
- PNR Lajoie
- R Alani
- R Wisdom
- Robert W. McMaster
- S Ghosh
- S Ghosh
- TV Piscopo
- VC Foletta
- W-W Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/10/2010
- Field of study
Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-ÎșB. AP-1 regulates pro-inflammatory cytokines, chemokines and nitric oxide production. Herein we show that upon Leishmania infection, AP-1 activity within host cells is abolished and correlates with lower expression of 5 of the 7 AP-1 subunits. Of interest, c-Jun, the central component of AP-1, is cleaved by Leishmania. Furthermore, the cleavage of c-Jun is dependent on the expression and activity of the major Leishmania surface protease GP63. Immunoprecipitation of c-Jun from nuclear extracts showed that GP63 interacts, and cleaves c-Jun at the perinuclear area shortly after infection. Phagocytosis inhibition by cytochalasin D did not block c-Jun down-regulation, suggesting that internalization of the parasite might not be necessary to deliver GP63 molecules inside the host cell. This observation was corroborated by the maintenance of c-Jun cleavage upon incubation with L. mexicana culture supernatant, suggesting that secreted, soluble GP63 could use a phagocytosis-independent mechanism to enter the host cell. In support of this, disruption of macrophage lipid raft microdomains by Methyl ÎČ-Cyclodextrin (MÎČCD) partially inhibits the degradation of full length c-Jun. Together our results indicate a novel role of the surface protease GP63 in the Leishmania-mediated subversion of host AP-1 activity
All the same but different: Understanding family enterprise heterogeneity
- Author
- A Massis De
- A Smith
- A Smith
- A Stewart
- AA Pekerti
- AC Pache
- AW Pearson
- BM Bass
- C Caldwell
- CD Beck
- CM Christensen
- CM Riordan
- D Carter
- D Dierendonck van
- D Dierendonck van
- D Karlan
- D Miller
- D Miller
- D Oyserman
- D Parris
- D Parris
- D Parris
- DJ McAllister
- DL Parris
- DO Neubaum
- DR Ebener
- DT Yoshida
- E Schröder
- EE Joseph
- EL Deci
- EL Deci
- F Hamilton
- F Jaramillo
- F Jaramillo
- FD Schoorman
- FO Walumbwa
- FW Kellermanns
- G Corbetta
- G Martin
- GL Black
- GT Lumpkin
- H He
- H James
- HE Aldrich
- I Breton-Miller Le
- J Cox
- J Fish
- J Graham
- J Greenberg
- J Hu
- J Parolini
- J Whetstone
- JA Laub
- JB Bingham
- JB Craig
- JC Dekker
- JD Lanctot
- JE Barbuto
- JH Astrachan
- JH Chua
- JH Chua
- JH Davis
- JH Davis
- JJ Chrisman
- JL Arregle
- JL Ward
- JL Ward
- JR Hale
- JRP French
- K Madison
- K Moores
- KA Eddleston
- L Spears
- L Spears
- LR GĂłmez-MejĂa
- M Born
- M Duh
- M Granovetter
- M Hernandez
- M Hernandez
- MC Vallejo
- MC Vallejo
- MC Vallejo
- MFR Kets de Vries
- MG Ehrhart
- MJ Neubert
- MM Butts
- MS Blodgett
- N Ashraf
- N Ramamoorthy
- NB Kurland
- P Berrone
- P Blau
- P Marques
- P Sapienza
- P Sharma
- P Sharma
- P Sharma
- PC Early
- PE Bierly
- PJ DiMaggio
- PP Shulka
- PW Dorfman
- R Basco
- R Nieli
- R Russell
- RC Anderson
- RC Liden
- RC Mayer
- RD Putnam
- RK Greenleaf
- RK Greenleaf
- RK Greenleaf
- RK Greenleaf
- RL Heath
- RM Cyert
- RR Washington
- S Kulharni
- S Sendjaya
- S Sendjaya
- SC Muntean
- TG Brashear
- TS Kuhn
- Y Bammens
- Y Cerit
- Y Cerit
- Y Han
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Mortalidad evitable en los estados colindantes de la frontera MĂ©xico-Estados Unidos, 1999-2001 y 2009-2011
- Author
- Ana MarĂa LĂłpez Jaramillo
- Arriaga E
- Arriaga E
- Canales A
- Corona R
- CĂłrdova JA
- Douglas GM
- Franco F
- Franzini L
- Gattini C
- GodĂnez V
- GonzĂĄlez R
- Guillén T
- GĂłmez RD
- GĂłmez RD
- Ham R
- Hoyert DL
- Lara F
- Lozano R
- Lozano R
- LĂłpez AM
- Marcela Agudelo Botero
- Mathers CD
- Molina CA
- Nolte E
- Nolte E
- Nolte E
- Ortega H
- Provencio E
- RaĂșl Sergio GonzĂĄlez RamĂrez
- RodrĂguez J
- Rutstein DD
- Vergara M
- VlÄdescu C
- Ybañez E
- Ybañez E
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Phylogeography of the Spanish Moon Moth Graellsia isabellae (Lepidoptera, Saturniidae)
- Author
- A Cassel-Lundhagen
- A Miraldo
- A Papadopoulou
- A RamĂrez-Soriano
- A Rogers
- A Rubio-Moraga
- A Soto
- A Tsaousis
- B Egger
- B MilĂĄ
- C Darwell
- C Simon
- Carlos Lopez-Vaamonde
- Collectif OPIE
- D Falush
- D Gotzek
- D Zovi
- E Minch
- E Recuero
- EH FernĂĄndez-Vidal
- F Bensettiti
- F Ronquist
- F Rousset
- G Bucci
- G Evanno
- G Jalut
- G Luikart
- G Piganeau
- H Romo
- Horacio Naveira
- I Dupanloup
- J Brown
- J Cipriano
- J Felsenstein
- J FĂŒrstenberg-HĂ€gg
- J Goudet
- J Huelsenbeck
- J Jaramillo-Correa
- J Millar
- J Pritchard
- J Robledo-Arnuncio
- J Rousselet
- J Templado
- J Ylla i Ullastre
- JA HĂłdar
- JI Arce Crespo de
- JR VerdĂș
- K Arunkumar
- K McCracken
- K Naydenov
- KW Matsubayashi
- L Cheng
- L Excoffier
- L Masutti
- M Benito GarzĂłn
- M Benito GarzĂłn
- M Clement
- M Dubreuil
- M Förschler
- M Jakobsson
- M Paiva
- M Simonato
- M Vila
- M Vila
- M Vila
- Marie-Anne Auger-Rozenberg
- Marta Vila
- MR GĂłmez Bustillo
- N Rosenberg
- N Soranzo
- Neus MarĂ-Mena
- O Charrier
- P Dijk Van
- P Librado
- P Mardulyn
- P Quézel
- P Roiron
- R Burton
- R Cheddadi
- R Chefaoui
- R Kass
- R Montoya Moreno
- S Ibåñez Gåzquez
- S Kalinowski
- S Piry
- S Ramos-Onsins
- S Schneider
- T Nyman
- T Powell
- T PyhÀjÀrvi
- T PyhÀjÀrvi
- T Sasaki
- U Kodandaramaiah
- V Dinca
- V Dvornyk
- W Prus-Glowacki
- W Sinclair
- Z Afzal-Rafii
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment
- Author
- Aamodt G
- Abdeen Z
- Abdella NA
- Addo J
- Aekplakorn W
- Afifi MM
- Agabiti Rosei E
- Agyemang C
- Al Nsour M
- Al Nuaim AR
- Ali MK
- Ali MM
- Ambady R
- Aro P
- Azizi F
- Babu BV
- Bahalim AN
- Barbagallo CM
- Barbieri MA
- BarcelĂł A
- Barreto SM
- Barros H
- Bautista LE
- Benetos A
- Bjerregaard P
- Björkelund C
- Bo S
- Bobak M
- BONORA Enzo
- Botana MA
- Bovet P
- Breckenkamp J
- Breteler MM
- Broda G
- Brown IJ
- Bursztyn M
- Campos H
- Cappuccio FP
- Capuano V
- Carnahan E
- Carvajal RG
- Casiglia E
- Castellano M
- Castetbon K
- Cea L
- Chang CJ
- Chaouki N
- Chatterji S
- Chen CJ
- Chen Z
- Choi JS
- Chua L
- Cobiac LJ
- Cooper RS
- Corsi AM
- Costanza MC
- Cowan MJ
- Craig CL
- CĂfkovĂĄ R
- Danaei G
- Dankner RS
- Dastgiri S
- de LeĂłn AC
- Delgado E
- Di Angelantonio E
- Dinc G
- Doi Y
- Dong GH
- Dorsi E
- Dragano N
- Drewnowski A
- Eggertsen R
- Elliott P
- Engeland A
- Erem C
- Esteghamati A
- Ezzati M
- Fall CH
- Fan JG
- Farzadfar F
- Ferreccio C
- Fezeu L
- Finucane MM
- Firmo JO
- Florez HJ
- Fornés NS
- Fowkes FG
- Franceschini G
- Frisk F
- Frisman GH
- Fuchs FD
- Fuller EL
- Getz L
- Giampaoli S
- Gomez Zumaquero JM
- Graff Iversen S
- Grant JF
- Gulliford MC
- Gupta PC
- Gupta R
- Gureje O
- Gutierrez HR
- GĂłmez LF
- Hansen TW
- Hata J
- He J
- Heim N
- Heinrich J
- Hemmingsson T
- Hennis A
- Herman WH
- Herrera VM
- Ho S
- Holdsworth M
- Hoorn SV
- Hopman WM
- Hussain A
- Husseini A
- Ibrahim MM
- Ikeda N
- Jacobsen BK
- Jaddou HY
- Jafar TH
- Janghorbani M
- Jasienska G
- Joffres MR
- Jonas JB
- Kadiki OA
- Kalter Leibovici O
- Kamadjeu RM
- Kaptoge S
- Karalis I
- Kastarinen MJ
- Katz J
- Keinan Boker L
- Kelly P
- Khalilzadeh O
- Khang YH
- Kiechl S
- Kim KW
- Kiyohara Y
- Kobayashi J
- Krause MP
- KubĂnovĂĄ R
- Kurjata P
- Kusuma YS
- Lam TH
- Langhammer A
- Lawes CM
- Le C
- Lee J
- Lewington S
- Li Y
- Li Y
- Lim SS
- Lim TO
- Lin CC
- Lin HH
- Lin JK
- Lin X
- Lind L
- Lissner L
- Liu X
- Lopez Jaramillo P
- Lorbeer R
- Lu Y
- LĂ©vy Marchal C
- Ma G
- Ma S
- MaciĂ F
- MacLean DR
- Maggi S
- Magliano DJ
- Makdisse M
- Mancia G
- Mannami T
- Marques Vidal P
- Mbanya JC
- McFarlane Anderson N
- Miccoli R
- Miettola J
- Minh HV
- Miquel JF
- Miranda JJ
- Mohamed MK
- Mohan V
- Mohanna S
- Mokdad A
- Mollentze WF
- Morales DD
- Morgan K
- Mozaffarian D
- Muiesan LM
- Muntoni S
- Nabipour I
- Nakagami T
- Nangia V
- Nemesure B
- Neovius M
- Nerhus KA
- Nervi F
- Neuhauser H
- Nguyen M
- Ninomiya T
- Noale M
- Oh SW
- Ohkubo T
- OLIVIERI Oliviero
- Onat A
- OrĂłstegui M
- Ouedraogo H
- Pan WH
- Panagiotakos DB
- Panza F
- Park Y
- Passos VM
- Pednekar MS
- Pelizzari PM
- Peres MA
- Phua HP
- Pichardo R
- Pistelli F
- Plans P
- Polakowska M
- Poulter N
- Prabhakaran D
- PĂ©rez C
- PĂ©rez FernĂĄndez R
- Qiao Q
- Rafiei M
- Rahim HF
- Raitakari OT
- Ramos LR
- Rampal L
- Rampal S
- Rao M
- Rasmussen F
- Reddy KK
- Redon J
- Revilla L
- Reyes GarcĂa V
- Riley LM
- Roaeid RB
- Robinson CA
- Rodriguez Artalejo F
- Rojas Martinez R
- Ronkainen K
- Rosero Bixby L
- Roth GA
- Sachdev HS
- Salinas CA
- Sanisoglu SY
- Sans S
- Sarraf Zadegan N
- Scazufca M
- Schaan BD
- Schapochnik N
- Schelleman H
- Schneider IJ
- Schooling CM
- Schwarz B
- Sekuri C
- Sereday MS
- Serra Majem L
- Shaw J
- Shera AS
- Shi Z
- Shiri R
- Shu XO
- Silva DA
- Silva E
- Simons LA
- Singh GM
- Smith M
- Soebardi S
- Solfrizzi V
- Sonestedt E
- Soysal A
- Stattin P
- Stein AD
- Stergiou GS
- Stessman J
- Stevens GA
- Sudo A
- Suka M
- Sundh V
- Sundquist K
- Sundström J
- Swai AB
- SĂĄnchez JR
- Söderberg S
- Tai ES
- Tambs K
- Tesfaye F
- Thomas GN
- Thorogood M
- Tilvis RS
- Tobias M
- Torheim LE
- Trenkwalder P
- Tuomilehto JO
- Tur JA
- Tzourio C
- Uhernik AI
- Ukoli FA
- Unwin N
- Vanderpump MP
- Varo JJ
- VeierĂžd MB
- Velåsquez Meléndez G
- Verschuren M
- Viet L
- Villalpando S
- Vioque J
- Vollenweider P
- Volpato S
- Wang N
- Wang YX
- Ward M
- Ward M.
- Waspadji S
- Welin LX
- Whitlock G
- Wilhelmsen L
- Willeit J
- Woodward M
- Wormser D
- Xavier AJ
- Xu F
- Xu L
- Yamamoto A
- Yang G
- Yang X
- Yeh LC
- Yoon JS
- You Q
- Yu Z
- Zhang J
- Zhang L
- Zheng W
- Zhou M
- Ănal AE
- Publication venue
- 'Lancet XXI STORIChChYa, LLC'
- Publication date
- 01/01/2014
- Field of study
Background High blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular
diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four
cardiometabolic risk factors for all countries and regions from 1980 to 2010.
Methods We used data for exposure to risk factors by country, age group, and sex from pooled analyses of populationbased health surveys. We obtained relative risks for the eff ects of risk factors on cause-specifi c mortality from metaanalyses
of large prospective studies. We calculated the population attributable fractions for- each risk factor alone,
and for the combination of all risk factors, accounting for multicausality and for mediation of the eff ects of BMI by the other three risks. We calculated attributable deaths by multiplying the cause-specifi c population attributable fractions by the number of disease-specifi c deaths. We obtained cause-specifi c mortality from the Global Burden of Diseases, Injuries, and Risk Factors 2010 Study. We propagated the uncertainties of all the inputs to the fi nal estimates.
Findings In 2010, high blood pressure was the leading risk factor for deaths due to cardiovascular diseases, chronic kidney disease, and diabetes in every region, causing more than 40% of worldwide deaths from these diseases; high BMI and glucose were each responsible for about 15% of deaths, and high cholesterol for more than 10%. After
accounting for multicausality, 63% (10\ub78 million deaths, 95% CI 10\ub71\u201311\ub75) of deaths from these diseases in 2010 were attributable to the combined eff ect of these four metabolic risk factors, compared with 67% (7\ub71 million deaths,
6\ub76\u20137\ub76) in 1980. The mortality burden of high BMI and glucose nearly doubled from 1980 to 2010. At the country
level, age-standardised death rates from these diseases attributable to the combined eff ects of these four risk factors
surpassed 925 deaths per 100 000 for men in Belarus, Kazakhstan, and Mongolia, but were less than 130 deaths per 100 000 for women and less than 200 for men in some high-income countries including Australia, Canada, France,
Japan, the Netherlands, Singapore, South Korea, and Spain.
Interpretation The salient features of the cardiometabolic disease and risk factor epidemic at the beginning of
the 21st century are high blood pressure and an increasing eff ect of obesity and diabetes. The mortality burden
of cardiometabolic risk factors has shifted from high-income to low-income and middle-income countries. Lowering
cardiometabolic risks through dietary, behavioural, and pharmacological interventions should be a part of the globalresponse to non-communicable diseases
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A DĂĄvalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L BarabĂĄsi
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
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- AE Heazell
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- AEC Ihekwaba
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- AH Berg
- AH Koeppen
- AH Koeppen
- AH Tong
- AI Bush
- AI Bush
- AI Bush
- AI Bush
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- AJ Ghio
- AJ Ghio
- AJ Ghio
- AJ Hulbert
- AJ Kowaltowski
- AJ Lusis
- AJ Matthews
- AJ Reyes
- AJ van Oostrom
- AJ Watson
- AJ White
- AJ Williams
- AK Junk
- AL Beal
- AL Hemdahl
- AL Hopkins
- AL Hopkins
- AL Lagan
- AL Mark
- AL Sirén
- AL Sirén
- AL Sirén
- AL Takeda
- AM Abeles
- AM Borzychowski
- AM Choi
- AM Dolga
- AM Elneihoum
- AM Elneihoum
- AM Feist
- AM Harvey
- AM Jenkinson
- AM Lin
- AM Samuni
- AM Snyder
- AN Crowson
- AN Tabah
- AP Bolger
- AP Breen
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- AR Kallianpur
- AR Kallianpur
- AR Martin
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- AS Baldwin Jr
- AS Binbrek
- AS Kaprelyants
- AS Wierzbicki
- AT McKie
- AV Lebedev
- AV Perkins
- AV Rao
- AW Maresso
- AY Andreyev
- AY Sun
- B Chakravarti
- B Chance
- B Cronin
- B de Valk
- B De Vries
- B Desoize
- B Drayer
- B Faller
- B Goodell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Huppertz
- B Jayawardhana
- B Kwak
- B Lachili
- B Lipinski
- B Mackenzie
- B Marshall
- B Mignotte
- B Oldenburg
- B Poeggeler
- B Pradines
- B Pradines
- B Regland
- B Russell
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- B Shipley
- B Skibska
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- B Thorand
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- B Wolozin
- B Xu
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- BA Maddux
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- BP Leung
- BP Oberg
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- BR Kwak
- BR Otto
- BS Chen
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- BT Mossman
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- BY Tung
- BĂ Palsson
- C Arnaud
- C Beaumont
- C Behl
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- C Breymann
- C Brooksbank
- C Bubici
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- C Burdon
- C Camaschella
- C Camaschella
- C Caris
- C Cavdar
- C Chen
- C Delaby
- C Demougeot
- C Finch
- C Fleury
- C GarcĂa-Ruiz
- C Gasche
- C Gasche
- C GerhÀuser
- C Goble
- C Henry
- C Herce-Pagliai
- C Herder
- C Hershko
- C Hershko
- C Hershko
- C Hershko
- C Jacob
- C Kenyon
- C Knox
- C Kretz-Remy
- C Kunsch
- C Köhle
- C Leadbeater
- C Li
- C Lu
- C Manach
- C Manach
- C Manach
- C Mancuso
- C Moon
- C Moon
- C Mouralian
- C Muscoli
- C Peyssonnaux
- C Peyssonnaux
- C Peyssonnaux
- C Pigeon
- C Popa
- C Quintana
- C Ramassamy
- C Ramassamy
- C Ratledge
- C Rigamonti
- C Ritter
- C Ritter
- C Ritter
- C Savino
- C Savoia
- C Savoia
- C Schmeer
- C Shirky
- C Singh
- C Smith
- C Thrasivoulou
- C Trenkwalder
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
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- Zuolo D
- Zygala L
- Ălvarez FernĂĄndez A
- Ăsterberg K
- Ăzçelik Ă
- Ć irokĂœ J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Rhodnius barretti, a new species of Triatominae (Hemiptera: Reduviidae) from western Amazonia
- Author
- Abad-Franch F
- Abad-Franch F
- Abad-Franch F
- Abad-Franch F
- Abad-Franch F
- Abad-Franch F
- Aguilar HM
- Aguilar VHM
- AmunĂĄrriz M
- AmunĂĄrriz M
- Barrett TV
- Bickford D
- BĂ©renger J-M
- Calzada JE
- Carcavallo R
- Carolina Dale
- Chico HM
- Coura JR
- da Rosa JA
- Dayrat B
- Drummond AJ
- Duverney Chaverra
- Fernando A Monteiro
- Fernando Abad-Franch
- Fitzpatrick S
- Francisco S Palomeque
- Gaston KJ
- Grijalva MJ
- Guevara AG
- Gurgel-Gonçalves R
- GĂłmez-Palacio A
- Harry M
- Hornik K
- Jurberg J
- Justi SA
- Lent H
- Marcio G Pavan
- MartĂnez A
- Monteiro FA
- Monteiro FA
- Monteiro FA
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- MĂĄrquez E
- Nicolas Jaramillo-O
- Noireau F
- Olson D
- Palomeque FS
- Pavan MG
- Pavan MG
- Pfeiler E
- Posada D
- Rohlf FJ
- Rohlf FJ
- Rohlf FJ
- Schofield CJ
- Schofield CJ
- Tamura K
- Valente SAS
- Valente VC
- Wiemers M
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2013
- Field of study
Observation of a New Excited Beauty Strange Baryon Decaying to Îb- Ï+Ï-
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Abu Zeid S
- Acharya H
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- Agarwal G
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- Albergo S
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- Alcaraz Maestre J
- Aldaya Martin M
- AldĂĄ JĂșnior WL
- Aleksandrov A
- Alexander J
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- Alison J
- Almond J
- Alvarez Gonzalez B
- Alverson G
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- Amendola C
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- Amram O
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- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Atakisi IO
- Atanasov I
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydogmus Sen F
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- Azhgirey I
- Aziz T
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- Baarmand MM
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- Banerjee S
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- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
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- Barnes VE
- Barney D
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- Yusli MN
- Zabi A
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- Zahid S
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- Zalewski P
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- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
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- Zorbilmez C
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- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Îb-Ï+Ï- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Îb- is reconstructed via its decays to J/ÏÎ- and J/ÏÎK-. A narrow resonance, labeled Îb(6100)-, is observed at a Îb-Ï+Ï- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Îb-) MeV, where the last uncertainty reflects the precision of the Îb- baryon mass. The upper limit on the Îb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Îb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Îc baryon states, the new Îb(6100)- resonance and its decay sequence are consistent with the orbitally excited Îb- baryon, with spin and parity quantum numbers JP=3/2-
Observation of the B-s(0) -> X(3872)phi Decay
- Author
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- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
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