Effects of Sc and Zr on the texture and mechanical anisotropy of high strength Al - Zn - Mg alloy sheets

Texture, mechanical anisotropy and microstructure of aged Al–Zn–Mg, Al–Zn–Mg–0.1Sc–0.1Zr and Al–Zn–Mg–0.25Sc–0.1Zr (wt.%) alloy sheets were investigated by tensile tests and electron microscopy. Sc and Zr additions do not change the texture of homogenized and cold rolled alloys, but transfer the cube texture of the aged Al–Zn–Mg alloy into -fiber rolling texture. With increasing Sc and Zr additions, the strength significantly increases, and mechanical anisotropy is enhanced. The strength is highest parallel to the rolling direction, whereas it is lowest at a 45° angle to the rolling direction. The higher strength is mainly due to grain boundary strengthening and precipitation strengthening caused by Al₃ScxZr₁₋x nano-particles. The stronger mechanical anisotropy is ascribed to the rolling texture, due to the inhibitory effect of Al₃ScxZr₁₋x on recrystallization. A new model was successfully established to reveal the interrelation between Sc and Zr additions, texture and yield strength anisotropy of Al–Zn–Mg sheets

Physics with the KLOE-2 experiment at the upgraded DAϕ\phiNE

Investigation at a $\phi$--factory can shed light on several debated issues in particle physics. We discuss: i) recent theoretical development and experimental progress in kaon physics relevant for the Standard Model tests in the flavor sector, ii) the sensitivity we can reach in probing CPT and Quantum Mechanics from time evolution of entangled kaon states, iii) the interest for improving on the present measurements of non-leptonic and radiative decays of kaons and eta/eta$^\prime$ mesons, iv) the contribution to understand the nature of light scalar mesons, and v) the opportunity to search for narrow di-lepton resonances suggested by recent models proposing a hidden dark-matter sector. We also report on the $e^+ e^-$ physics in the continuum with the measurements of (multi)hadronic cross sections and the study of gamma gamma processes.Comment: 60 pages, 41 figures; added affiliation for one of the authors; added reference to section

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Involvement of Peripheral Beta-Endorphin and MU, Delta, Kappa Opioid Receptors in Electro Acupuncture Analgesia for Prolonged Inflammatory Pain of Rats

Acupuncture is commonly used to relieve chronic pain worldwide. Accumulating evidence shows that peripheral opioid system plays an important role in inhibiting inflammatory pain. This study aimed to investigate the involvement of peripheral opioid system in electroacupuncture (EA) analgesia for prolonged inflammatory pain. Inflammatory pain was induced by an intraplantar injection of complete Freund's adjuvant (CFA) into the right hind paw. EA (2/100 Hz, 2 mA) was applied to the ipsilateral Zusanli (ST36) and Kunlun (BL 60) acupoints for 30 min once everyday. Block studies on EA analgesia were performed on day 18 after CFA injection by using α-helical corticotrophin-releasing factor (CRF), a CRF antagonist, and naloxone methiodide, a peripherally restricted opioid receptor antagonist. Paw withdrawal latency (PWL) to a noxious thermal stimulus was measured as the pain behavioral change. Radioimmunoassay for beta-endorphin (beta-END), Met-enkephalin (Met-ENK), and dynorphin A (DYN A) in paw inflammatory tissue and immunohistochemistry study for mu, delta, kappa opioid receptors in dorsal root ganglion (DRG) were carried out. A subsequent validation experiment by locally delivered exogenous beta-END was also performed. We found that EA significantly increased the PWL of rats injected with CFA from day 4 to day 18. Locally administered α-helical CRF or naloxone blocked EA-produced analgesia. EA increased beta-END level in the paw inflammatory tissues, while CFA raised the local levels of Met-ENK and DYN A. The increased beta-END level by EA was fully reversed by α-helical CRF. Intraplantar injection of exogenous beta-END alleviated prolonged inflammatory pain. EA also up-regulated the expressions of mu, delta, kappa opioid receptors in rat L5 DRG. In conclusion, peripheral local beta-END and three subtypes of opioid receptors may be involved in EA analgesia for prolonged inflammatory pain

Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China.

&lt;p&gt;Mycobacterium tuberculosis can acquire resistance to rifampin (RIF) through mutations in the rpoB gene. This is usually accompanied by a fitness cost, which, however, can be mitigated by secondary mutations in the rpoA or rpoC gene. This study aimed to identify rpoA and rpoC mutations in clinical M. tuberculosis isolates in northern China in order to clarify their role in the transmission of drug-resistant tuberculosis (TB). The study collection included 332 RIF-resistant and 178 RIF-susceptible isolates. The majority of isolates belonged to the Beijing genotype (95.3%, 486/510 isolates), and no mutation was found in rpoA or rpoC of the non-Beijing genotype strains. Among the Beijing genotype strains, 27.8% (89/320) of RIF-resistant isolates harbored nonsynonymous mutations in the rpoA (n = 6) or rpoC (n = 83) gene. The proportion of rpoC mutations was significantly higher in new cases (P = 0.023) and in strains with the rpoB S531L mutation (P &lt; 0.001). In addition, multidrug-resistant (MDR) strains with rpoC mutations were significantly associated with 24-locus mycobacterial interspersed repetitive-unit-variable-number tandem-repeat clustering (P = 0.016). In summary, we believe that these findings indirectly suggest an epistatic interaction of particular mutations related to RIF resistance and strain fitness and, consequently, the role of such mutations in the spread of MDR M. tuberculosis strains.&lt;/p&gt;</p

Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains.

&lt;p&gt;Mycobacterium tuberculosis Beijing genotype strains increasingly circulate in different world regions, either as historical endemic, e.g. in East Asia, or recently imported, e.g. in South America, and this family is regarded as the most successful lineage of the global tuberculosis (TB) epidemic. Here we analysed the transmission capacity of these strains in the context of their phylogenetic background and drug resistance mutations. The study collection included all multidrug resistant (MDR) strains of Beijing genotype isolated in Beijing Chest Hospital, the largest tertiary TB facility in North China, in 2011-2013 (n = 278). Strains were subjected to NTF/IS6110 and 24-loci MIRU-VNTR analysis. Drug resistance mutations were detected in rpoB, katG, inhA and oxyR-ahpC. A total of 58 and 220 strains were assigned to the ancient and modern Beijing sublineages, respectively. 24-MIRU-VNTR clustering was higher in modern versus ancient Beijing strains (35.9% vs. 12.1%; P &lt;0.001). After taking into consideration the presence of rpoB and katG mutations, clustering decreased to 15.9% in modern and 0% in ancient strains. The most frequent combination of mutations (rpoB531-TTG and katG315-ACC) was more prevalent in clustered versus non-clustered isolates in the modern sublineage (23/35 vs. 47/185; P &lt;0.0001). To conclude, a combination of the known low-fitness-cost rpoB531-TTG and katG315-ACC mutations likely facilitates the increased transmission ability of MDR strains of the modern but not ancient Beijing sublineage. Accordingly, positive epistasis of major low-cost drug resistance-conferring mutations is influenced by the phylogenetic background of M. tuberculosis strains.&lt;/p&gt;</p