Longitudinal study on transmission of MRSA CC398 within pig herds

Background Since the detection of MRSA CC398 in pigs in 2004, it has emerged in livestock worldwide. MRSA CC398 has been found in people in contact with livestock and thus has become a public health issue. Data from a large-scale longitudinal study in two Danish and four Dutch pig herds were used to quantify MRSA CC398 transmission rates within pig herds and to identify factors affecting transmission between pigs. Results Sows and their offspring were sampled at varying intervals during a production cycle. Overall MRSA prevalence of sows increased from 33% before farrowing to 77% before weaning. Overall MRSA prevalence of piglets was > 60% during the entire study period. The recurrent finding of MRSA in the majority of individuals indicates true colonization or might be the result of contamination. Transmission rates were estimated using a Susceptible-Infectious-Susceptible (SIS-)model, which resulted in values of the reproduction ratio (R0) varying from 0.24 to 8.08. Transmission rates were higher in pigs treated with tetracyclins and ß-lactams compared to untreated pigs implying a selective advantage of MRSA CC398 when these antimicrobials are used. Furthermore, transmission rates were higher in pre-weaning pigs compared to post-weaning pigs which might be explained by an age-related susceptibility or the presence of the sow as a primary source of MRSA CC398. Finally, transmission rates increased with the relative increase of the infection pressure within the pen compared to the total infection pressure, implying that within-pen transmission is a more important route compared to between-pen transmission and transmission through environmental exposure. Conclusion Our results indicate that MRSA CC398 is able to spread and persist in pig herds, resulting in an endemic situation. Transmission rates are affected by the use of selective antimicrobials and by the age of pigs

Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory

Data from the Pierre Auger Observatory are analyzed to search for anisotropies near the direction of the Galactic Centre at EeV energies. The exposure of the surface array in this part of the sky is already significantly larger than that of the fore-runner experiments. Our results do not support previous findings of localized excesses in the AGASA and SUGAR data. We set an upper bound on a point-like flux of cosmic rays arriving from the Galactic Centre which excludes several scenarios predicting sources of EeV neutrons from Sagittarius $A$. Also the events detected simultaneously by the surface and fluorescence detectors (the `hybrid' data set), which have better pointing accuracy but are less numerous than those of the surface array alone, do not show any significant localized excess from this direction.Comment: Matches published versio

The energy spectrum of cosmic rays beyond the turn-down around 10^17 eV as measured with the surface detector of the Pierre Auger Observatory

We present a measurement of the cosmic-ray spectrum above 100 PeV using the part of the surface detector of the Pierre Auger Observatory that has a spacing of 750 m. An inflection of the spectrum is observed, confirming the presence of the so-called second-knee feature. The spectrum is then combined with that of the 1500 m array to produce a single measurement of the flux, linking this spectral feature with the three additional breaks at the highest energies. The combined spectrum, with an energy scale set calorimetrically via fluorescence telescopes and using a single detector type, results in the most statistically and systematically precise measurement of spectral breaks yet obtained. These measurements are critical for furthering our understanding of the highest energy cosmic rays

Reconstruction of events recorded with the surface detector of the Pierre Auger Observatory

Cosmic rays arriving at Earth collide with the upper parts of the atmosphere, thereby inducing extensive air showers. When secondary particles from the cascade arrive at the ground, they are measured by surface detector arrays. We describe the methods applied to the measurements of the surface detector of the Pierre Auger Observatory to reconstruct events with zenith angles less than 60o using the timing and signal information recorded using the water-Cherenkov detector stations. In addition, we assess the accuracy of these methods in reconstructing the arrival directions of the primary cosmic ray particles and the sizes of the induced showers

Transmission of MRSA CC398 strains between pig farms related by trade of animals

Meticillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC) 398 is a genetic lineage associated with livestock, especially pigs. The authors investigated the role of pig trade in the transmission of MRSA CC398 between farms using pulsed-field gel electrophoresis (PFGE), a highly discriminatory method for strain typing. PFGE analysis of 58 MRSA isolates from a retrospective study in the Netherlands and a prospective study in Denmark provided molecular evidence that the strains present in five of the eight recipient farms were indistinguishable from those occurring in the corresponding supplying farm. The molecular typing data confirm the findings of a previous risk-analysis study indicating that trading of colonised pigs is a vehicle for transmission of MRSA CC398

New electronics for the surface detectors of the Pierre Auger Observatory

International audienceThe surface detector array of the Pierre Auger Observatory consists of 1660 water Cherenkov detectors that sample the charged particles and photons of energetic cosmic ray air showers at the ground. In the framework of the planned upgrade of the Auger Observatory, AugerPrime, new electronics has been designed for the surface detectors. The electronics upgrade includes higher sampling frequency, increased dynamic range, increased processing capability, improved timing with up-to-date GPS receivers, and a better calibration and monitoring system. It will also process the data of the additional scintillator detectors planned for the upgrade

The FRAM robotic telescope for atmospheric monitoring at the Pierre Auger Observatory

FRAM (F/Photometric Robotic Atmospheric Monitor) is a robotic telescope operated at the Pierre Auger Observatory in Argentina for the purposes of atmospheric monitoring using stellar photometry. As a passive system which does not produce any light that could interfere with the observations of the fluorescence telescopes of the observatory, it complements the active monitoring systems that use lasers. We discuss the applications of stellar photometry for atmospheric monitoring at optical observatories in general and the particular modes of operation employed by the Auger FRAM. We describe in detail the technical aspects of FRAM, the hardware and software requirements for a successful operation of a robotic telescope for such a purpose and their implementation within the FRAM system

Design, upgrade and characterization of the silicon photomultiplier front-end for the AMIGA detector at the Pierre Auger Observatory

none359AMIGA (Auger Muons and Infill for the Ground Array) is an upgrade of the Pierre Auger Observatory to complement the study of ultra-high-energy cosmic rays (UHECR) by measuring the muon content of extensive air showers (EAS). It consists of an array of 61 water Cherenkov detectors on a denser spacing in combination with underground scintillation detectors used for muon density measurement. Each detector is composed of three scintillation modules, with 10 m(2) detection area per module, buried at 2.3 m depth, resulting in a total detection area of 30 m(2). Silicon photomultiplier sensors (SiPM) measure the amount of scintillation light generated by charged particles traversing the modules. In this paper, the design of the front-end electronics to process the signals of those SiPMs and test results from the laboratory and from the Pierre Auger Observatory are described. Compared to our previous prototype, the new electronics shows a higher performance, higher efficiency and lower power consumption, and it has a new acquisition system with increased dynamic range that allows measurements closer to the shower core. The new acquisition system is based on the measurement of the total charge signal that the muonic component of the cosmic ray shower generates in the detector.noneAab A.; Abreu P.; Aglietta M.; Albury J.M.; Allekotte I.; Almela A.; Alvarez-Muniz J.; Alves Batista R.; Anastasi G.A.; Anchordoqui L.; Andrada B.; Andringa S.; Aramo C.; Araujo Ferreira P.R.; Asorey H.; Assis P.; Avila G.; Badescu A.M.; Bakalova A.; Balaceanu A.; Barbato F.; Barreira Luz R.J.; Becker K.H.; Bellido J.A.; Berat C.; Bertaina M.E.; Bertou X.; Biermann P.L.; Bister T.; Biteau J.; Blazek J.; Bleve C.; Bohacova M.; Boncioli D.; Bonifazi C.; Bonneau Arbeletche L.; Borodai N.; Botti A.M.; Brack J.; Bretz T.; Briechle F.L.; Buchholz P.; Bueno A.; Buitink S.; Buscemi M.; Caballero-Mora K.S.; Caccianiga L.; Canfora F.; Caracas I.; Carceller J.M.; Caruso R.; Castellina A.; Catalani F.; Cataldi G.; Cazon L.; Cerda M.; Chinellato J.A.; Choi K.; Chudoba J.; Chytka L.; Clay R.W.; Cobos Cerutti A.C.; Colalillo R.; Coleman A.; Coluccia M.R.; Conceicao R.; Condorelli A.; Consolati G.; Contreras F.; Convenga F.; Covault C.E.; Dasso S.; Daumiller K.; Dawson B.R.; Day J.A.; de Almeida R.M.; de Jesus J.; de Jong S.J.; de Mauro G.; de Mello Neto J.R.T.; de Mitri I.; de Oliveira J.; de Oliveira Franco D.; de Souza V.; de Vito E.; Debatin J.; del Rio M.; Deligny O.; Di Matteo A.; Dobrigkeit C.; D'Olivo J.C.; dos Anjos R.C.; Dova M.T.; Ebr J.; Engel R.; Epicoco I.; Erdmann M.; Escobar C.O.; Etchegoyen A.; Falcke H.; Farmer J.; Farrar G.; Fauth A.C.; Fazzini N.; Feldbusch F.; Fenu F.; Fick B.; Figueira J.M.; Filipcic A.; Fodran T.; Freire M.M.; Fujii T.; Fuster A.; Galea C.; Galelli C.; Garcia B.; Garcia Vegas A.L.; Gemmeke H.; Gesualdi F.; Gherghel-Lascu A.; Ghia P.L.; Giaccari U.; Giammarchi M.; Giller M.; Glombitza J.; Gobbi F.; Gollan F.; Golup G.; Gomez Berisso M.; Gomez Vitale P.F.; Gongora J.P.; Gonzalez J.M.; Gonzalez N.; Goos I.; Gora D.; Gorgi A.; Gottowik M.; Grubb T.D.; Guarino F.; Guedes G.P.; Guido E.; Hahn S.; Hampel M.R.; Hansen P.; Harari D.; Harvey V.M.; Haungs A.; Hebbeker T.; Heck D.; Hill G.C.; Hojvat C.; Horandel J.R.; Horvath P.; Hrabovsky M.; Huege T.; Hulsman J.; Insolia A.; Isar P.G.; Johnsen J.A.; Jurysek J.; Kaapa A.; Kampert K.H.; Keilhauer B.; Kemp J.; Klages H.O.; Kleifges M.; Kleinfeller J.; Kopke M.; Lago B.L.; Lang R.G.; Langner N.; Leigui de Oliveira M.A.; Lenok V.; Letessier-Selvon A.; Lhenry-Yvon I.; Lo Presti D.; Lopes L.; Lopez R.; Luce Q.; Lucero A.; Lundquist J.P.; Machado Payeras A.; Mancarella G.; Mandat D.; Manning B.C.; Manshanden J.; Mantsch P.; Marafico S.; Mariazzi A.G.; Maris I.C.; Marsella G.; Martello D.; Martinez H.; Martinez Bravo O.; Mastrodicasa M.; Mathes H.J.; Matthews J.; Matthiae G.; Mayotte E.; Mazur P.O.; Medina-Tanco G.; Melo D.; Menshikov A.; Merenda K.-D.; Michal S.; Micheletti M.I.; Miramonti L.; Mollerach S.; Montanet F.; Morello C.; Mostafa M.; Muller A.L.; Muller M.A.; Mulrey K.; Mussa R.; Muzio M.; Namasaka W.M.; Nellen L.; Niculescu-Oglinzanu M.; Niechciol M.; Nitz D.; Nosek D.; Novotny V.; Nozka L.; Nucita A.; Nunez L.A.; Palatka M.; Pallotta J.; Papenbreer P.; Parente G.; Parra A.; Pech M.; Pedreira F.; Pekala J.; Pelayo R.; Pena-Rodriguez J.; Perez Armand J.; Perlin M.; Perrone L.; Petrera S.; Pierog T.; Pimenta M.; Pirronello V.; Platino M.; Pont B.; Pothast M.; Privitera P.; Prouza M.; Puyleart A.; Querchfeld S.; Rautenberg J.; Ravignani D.; Reininghaus M.; Ridky J.; Riehn F.; Risse M.; Ristori P.; Rizi V.; Rodrigues de Carvalho W.; Rodriguez Rojo J.; Roncoroni M.J.; Roth M.; Roulet E.; Rovero A.C.; Ruehl P.; Saffi S.J.; Saftoiu A.; Salamida F.; Salazar H.; Salina G.; Sanabria Gomez J.D.; Sanchez F.; Santos E.M.; Santos E.; Sarazin F.; Sarmento R.; Sarmiento-Cano C.; Sato R.; Savina P.; Schafer C.M.; Scherini V.; Schieler H.; Schimassek M.; Schimp M.; Schluter F.; Schmidt D.; Scholten O.; Schovanek P.; Schroder F.G.; Schroder S.; Schulte J.; Sciutto S.J.; Scornavacche M.; Shellard R.C.; Sigl G.; Silli G.; Sima O.; Smida R.; Sommers P.; Soriano J.F.; Souchard J.; Squartini R.; Stadelmaier M.; Stanca D.; Stanic S.; Stasielak J.; Stassi P.; Streich A.; Suarez-Duran M.; Sudholz T.; Suomijarvi T.; Supanitsky A.D.; Supik J.; Szadkowski Z.; Taboada A.; Tapia A.; Timmermans C.; Tkachenko O.; Tobiska P.; Todero Peixoto C.J.; Tome B.; Travaini A.; Travnicek P.; Trimarelli C.; Trini M.; Tueros M.; Ulrich R.; Unger M.; Vaclavek L.; Vacula M.; Valdes Galicia J.F.; Valore L.; Varela E.; Varma V.K.C.; Vasquez-Ramirez A.; Veberic D.; Ventura C.; Vergara Quispe I.D.; Verzi V.; Vicha J.; Vink J.; Vorobiov S.; Wahlberg H.; Watson A.A.; Weber M.; Weindl A.; Wiencke L.; Wilczynski H.; Winchen T.; Wirtz M.; Wittkowski D.; Wundheiler B.; Yushkov A.; Zapparrata O.; Zas E.; Zavrtanik D.; Zavrtanik M.; Zehrer L.; Zepeda A.Aab, A.; Abreu, P.; Aglietta, M.; Albury, J. M.; Allekotte, I.; Almela, A.; Alvarez-Muniz, J.; Alves Batista, R.; Anastasi, G. A.; Anchordoqui, L.; Andrada, B.; Andringa, S.; Aramo, C.; Araujo Ferreira, P. R.; Asorey, H.; Assis, P.; Avila, G.; Badescu, A. M.; Bakalova, A.; Balaceanu, A.; Barbato, F.; Barreira Luz, R. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Bister, T.; Biteau, J.; Blazek, J.; Bleve, C.; Bohacova, M.; Boncioli, D.; Bonifazi, C.; Bonneau Arbeletche, L.; Borodai, N.; Botti, A. M.; Brack, J.; Bretz, T.; Briechle, F. L.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, L.; Canfora, F.; Caracas, I.; Carceller, J. M.; Caruso, R.; Castellina, A.; Catalani, F.; Cataldi, G.; Cazon, L.; Cerda, M.; Chinellato, J. A.; Choi, K.; Chudoba, J.; Chytka, L.; Clay, R. W.; Cobos Cerutti, A. C.; Colalillo, R.; Coleman, A.; Coluccia, M. R.; Conceicao, R.; Condorelli, A.; Consolati, G.; Contreras, F.; Convenga, F.; Covault, C. E.; Dasso, S.; Daumiller, K.; Dawson, B. R.; Day, J. A.; de Almeida, R. M.; de Jesus, J.; de Jong, S. J.; de Mauro, G.; de Mello Neto, J. R. T.; de Mitri, I.; de Oliveira, J.; de Oliveira Franco, D.; de Souza, V.; de Vito, E.; Debatin, J.; del Rio, M.; Deligny, O.; Di Matteo, A.; Dobrigkeit, C.; D'Olivo, J. C.; dos Anjos, R. C.; Dova, M. T.; Ebr, J.; Engel, R.; Epicoco, I.; Erdmann, M.; Escobar, C. O.; Etchegoyen, A.; Falcke, H.; Farmer, J.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Feldbusch, F.; Fenu, F.; Fick, B.; Figueira, J. M.; Filipcic, A.; Fodran, T.; Freire, M. M.; Fujii, T.; Fuster, A.; Galea, C.; Galelli, C.; Garcia, B.; Garcia Vegas, A. L.; Gemmeke, H.; Gesualdi, F.; Gherghel-Lascu, A.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Glombitza, J.; Gobbi, F.; Gollan, F.; Golup, G.; Gomez Berisso, M.; Gomez Vitale, P. F.; Gongora, J. P.; Gonzalez, J. M.; Gonzalez, N.; Goos, I.; Gora, D.; Gorgi, A.; Gottowik, M.; Grubb, T. D.; Guarino, F.; Guedes, G. P.; Guido, E.; Hahn, S.; Hampel, M. R.; Hansen, P.; Harari, D.; Harvey, V. M.; Haungs, A.; Hebbeker, T.; Heck, D.; Hill, G. C.; Hojvat, C.; Horandel, J. R.; Horvath, P.; Hrabovsky, M.; Huege, T.; Hulsman, J.; Insolia, A.; Isar, P. G.; Johnsen, J. A.; Jurysek, J.; Kaapa, A.; Kampert, K. H.; Keilhauer, B.; Kemp, J.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Kopke, M.; Lago, B. L.; Lang, R. G.; Langner, N.; Leigui de Oliveira, M. A.; Lenok, V.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Lo Presti, D.; Lopes, L.; Lopez, R.; Luce, Q.; Lucero, A.; Lundquist, J. P.; Machado Payeras, A.; Mancarella, G.; Mandat, D.; Manning, B. C.; Manshanden, J.; Mantsch, P.; Marafico, S.; Mariazzi, A. G.; Maris, I. C.; Marsella, G.; Martello, D.; Martinez, H.; Martinez Bravo, O.; Mastrodicasa, M.; Mathes, H. J.; Matthews, J.; Matthiae, G.; Mayotte, E.; Mazur, P. O.; Medina-Tanco, G.; Melo, D.; Menshikov, A.; Merenda, K. -D.; Michal, S.; Micheletti, M. I.; Miramonti, L.; Mollerach, S.; Montanet, F.; Morello, C.; Mostafa, M.; Muller, A. L.; Muller, M. A.; Mulrey, K.; Mussa, R.; Muzio, M.; Namasaka, W. M.; Nellen, L.; Niculescu-Oglinzanu, M.; Niechciol, M.; Nitz, D.; Nosek, D.; Novotny, V.; Nozka, L.; Nucita, A.; Nunez, L. A.; Palatka, M.; Pallotta, J.; Papenbreer, P.; Parente, G.; Parra, A.; Pech, M.; Pedreira, F.; Pekala, J.; Pelayo, R.; Pena-Rodriguez, J.; Perez Armand, J.; Perlin, M.; Perrone, L.; Petrera, S.; Pierog, T.; Pimenta, M.; Pirronello, V.; Platino, M.; Pont, B.; Pothast, M.; Privitera, P.; Prouza, M.; Puyleart, A.; Querchfeld, S.; Rautenberg, J.; Ravignani, D.; Reininghaus, M.; Ridky, J.; Riehn, F.; Risse, M.; Ristori, P.; Rizi, V.; Rodrigues de Carvalho, W.; Rodriguez Rojo, J.; Roncoroni, M. J.; Roth, M.; Roulet, E.; Rovero, A. C.; Ruehl, P.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Salina, G.; Sanabria Gomez, J. D.; Sanchez, F.; Santos, E. M.; Santos, E.; Sarazin, F.; Sarmento, R.; Sarmiento-Cano, C.; Sato, R.; Savina, P.; Schafer, C. M.; Scherini, V.; Schieler, H.; Schimassek, M.; Schimp, M.; Schluter, F.; Schmidt, D.; Scholten, O.; Schovanek, P.; Schroder, F. G.; Schroder, S.; Schulte, J.; Sciutto, S. J.; Scornavacche, M.; Shellard, R. C.; Sigl, G.; Silli, G.; Sima, O.; Smida, R.; Sommers, P.; Soriano, J. F.; Souchard, J.; Squartini, R.; Stadelmaier, M.; Stanca, D.; Stanic, S.; Stasielak, J.; Stassi, P.; Streich, A.; Suarez-Duran, M.; Sudholz, T.; Suomijarvi, T.; Supanitsky, A. D.; Supik, J.; Szadkowski, Z.; Taboada, A.; Tapia, A.; Timmermans, C.; Tkachenko, O.; Tobiska, P.; Todero Peixoto, C. J.; Tome, B.; Travaini, A.; Travnicek, P.; Trimarelli, C.; Trini, M.; Tueros, M.; Ulrich, R.; Unger, M.; Vaclavek, L.; Vacula, M.; Valdes Galicia, J. F.; Valore, L.; Varela, E.; Varma, V. K. C.; Vasquez-Ramirez, A.; Veberic, D.; Ventura, C.; Vergara Quispe, I. D.; Verzi, V.; Vicha, J.; Vink, J.; Vorobiov, S.; Wahlberg, H.; Watson, A. A.; Weber, M.; Weindl, A.; Wiencke, L.; Wilczynski, H.; Winchen, T.; Wirtz, M.; Wittkowski, D.; Wundheiler, B.; Yushkov, A.; Zapparrata, O.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zehrer, L.; Zepeda, A

Search for magnetically-induced signatures in the arrival directions of ultra-high-energy cosmic rays measured at the Pierre Auger Observatory

We search for signals of magnetically-induced effects in the arrival directions of ultra-high-energy cosmic rays detected at the Pierre Auger Observatory. We apply two different methods. One is a search for sets of events that show a correlation between their arrival direction and the inverse of their energy, which would be expected if they come from the same point-like source, they have the same electric charge and their deflection is relatively small and coherent. We refer to these sets of events as "multiplets". The second method, called "thrust", is a principal axis analysis aimed to detect the elongated patterns in a region of interest. We study the sensitivity of both methods using a benchmark simulation and we apply them to data in two different searches. The first search is done assuming as source candidates a list of nearby active galactic nuclei and starburst galaxies. The second is an all-sky blind search. We report the results and we find no statistically significant features. We discuss the compatibility of these results with the indications on the mass composition inferred from data of the Pierre Auger Observatory. © 2020 IOP Publishing Ltd and Sissa Medialab