Demagnetization via Nucleation of the Nonequilibrium Metastable Phase in a Model of Disorder

We study both analytically and numerically metastability and nucleation in a two-dimensional nonequilibrium Ising ferromagnet. Canonical equilibrium is dynamically impeded by a weak random perturbation which models homogeneous disorder of undetermined source. We present a simple theoretical description, in perfect agreement with Monte Carlo simulations, assuming that the decay of the nonequilibrium metastable state is due, as in equilibrium, to the competition between the surface and the bulk. This suggests one to accept a nonequilibrium "free-energy" at a mesoscopic/cluster level, and it ensues a nonequilibrium "surface tension" with some peculiar low-T behavior. We illustrate the occurrence of intriguing nonequilibrium phenomena, including: (i) Noise-enhanced stabilization of nonequilibrium metastable states; (ii) reentrance of the limit of metastability under strong nonequilibrium conditions; and (iii) resonant propagation of domain walls. The cooperative behavior of our system may also be understood in terms of a Langevin equation with additive and multiplicative noises. We also studied metastability in the case of open boundaries as it may correspond to a magnetic nanoparticle. We then observe burst-like relaxation at low T, triggered by the additional surface randomness, with scale-free avalanches which closely resemble the type of relaxation reported for many complex systems. We show that this results from the superposition of many demagnetization events, each with a well- defined scale which is determined by the curvature of the domain wall at which it originates. This is an example of (apparent) scale invariance in a nonequilibrium setting which is not to be associated with any familiar kind of criticality.Comment: 26 pages, 22 figure

Differences in the microbial profiles of early stage endometrial cancers between Black and White women

Objective: Black women suffer a higher mortality from endometrial cancer (EC) than White women. Potential biological causes for this disparity include a higher prevalence of obesity and more lethal histologic/molecular subtypes. We hypothesize that another biological factor driving this racial disparity could be the EC microbiome. Methods: Banked tumor specimens of postmenopausal, Black and White women undergoing hysterectomy for early stage endometrioid EC were identified. The microbiota of the tumors were characterized by bacterial 16S rRNA sequencing. The microbial component of endometrioid ECs in The Cancer Genome Atlas (TCGA) database were assessed for comparison. Results: 95 early stage ECs were evaluated: 23 Black (24%) and 72 White (76%). Microbial diversity was increased (p < 0.001), and Firmicutes, Cyanobacteria and OD1 phyla abundance was higher in tumors from Black versus White women (p < 0.001). Genus level abundance of Dietzia and Geobacillus were found to be lower in tumors of obese Black versus obese White women (p < 0.001). Analysis of early stage ECs in TCGA found that microbial diversity was higher in ECs from Black versus White women (p < 0.05). When comparing ECs from obese Black versus obese White women, 5 bacteria distributions were distinct, with higher abundance of Lactobacillus acidophilus in ECs from Black women being the most striking difference. Similarly in TCGA, Dietzia and Geobacillus were more common in ECs from White women compared to Black. Conclusion: Increased microbial diversity and the distinct microbial profiles between ECs of obese Black versus obese White women suggests that intra-tumoral bacteria may contribute to EC disparities and pathogenesis

On the origin and evolution of the material in 67P/Churyumov-Gerasimenko

International audiencePrimitive objects like comets hold important information on the material that formed our solar system. Several comets have been visited by spacecraft and many more have been observed through Earth- and space-based telescopes. Still our understanding remains limited. Molecular abundances in comets have been shown to be similar to interstellar ices and thus indicate that common processes and conditions were involved in their formation. The samples returned by the Stardust mission to comet Wild 2 showed that the bulk refractory material was processed by high temperatures in the vicinity of the early sun. The recent Rosetta mission acquired a wealth of new data on the composition of comet 67P/Churyumov-Gerasimenko (hereafter 67P/C-G) and complemented earlier observations of other comets. The isotopic, elemental, and molecular abundances of the volatile, semi-volatile, and refractory phases brought many new insights into the origin and processing of the incorporated material. The emerging picture after Rosetta is that at least part of the volatile material was formed before the solar system and that cometary nuclei agglomerated over a wide range of heliocentric distances, different from where they are found today. Deviations from bulk solar system abundances indicate that the material was not fully homogenized at the location of comet formation, despite the radial mixing implied by the Stardust results. Post-formation evolution of the material might play an important role, which further complicates the picture. This paper discusses these major findings of the Rosetta mission with respect to the origin of the material and puts them in the context of what we know from other comets and solar system objects

Identification of common genetic risk variants for autism spectrum disorder

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.Peer reviewe

Observations and Numerical Simulations of Subrotor Vortices during T-REX

High-resolution observations from scanning Doppler and aerosol lidars, wind profiler radars, as well as surface and aircraft measurements during the Terrain-induced Rotor Experiment (T-REX) provide the first comprehensive documentation of small-scale intense vortices associated with atmospheric rotors that form in the lee of mountainous terrain. Although rotors are already recognized as potential hazards for aircraft, it is proposed that these small-scale vortices, or subrotors, are the most dangerous features because of strong wind shear and the transient nature of the vortices. A life cycle of a subrotor event is captured by scanning Doppler and aerosol lidars over a 5-min period. The lidars depict an amplifying vortex, with a characteristic length scale of 500–1000 m, that overturns and intensifies to a maximum spanwise vorticity greater than 0.2 s−1. Radar wind profiler observations document a series of vortices, characterized by updraft/downdraft couplets and regions of enhanced reversed flow, that are generated in a layer of strong vertical wind shear and subcritical Richardson number. The observations and numerical simulations reveal that turbulent subrotors occur most frequently along the leading edge of an elevated sheet of horizontal vorticity that is a manifestation of boundary layer shear and separation along the lee slopes. As the subrotors break from the vortex sheet, intensification occurs through vortex stretching and in some cases tilting processes related to three-dimensional turbulent mixing. The subrotors and ambient vortex sheet are shown to intensify through a modest increase in the upstream inversion strength, which illustrates the predictability challenges for the turbulent characterization of rotors

In Beam Tests of Implanted Helium Targets

Targets consisting of 3,4He implanted into thin aluminum foils (approximately 100, 200 or 600 ug/cm^2) were prepared using intense (a few uA) helium beams at low energy (approximately 20, 40 or 100 keV). Uniformity of the implantation was achieved by a beam raster across a 12 mm diameter tantalum collimator at the rates of 0.1 Hz in the vertical direction and 1 Hz in the horizontal direction. Helium implantation into the very thin (approximately 80-100 ug/cm^2) aluminum foils failed to produce useful targets (with only approximately 10% of the helium retained) due to an under estimation of the range by the code SRIM. The range of low energy helium in aluminum predicted by Northcliffe and Shilling and the NIST online tabulation are observed on the other hand to over estimate the range of low energy helium ions in aluminum. An attempt to increase the amount of helium by implanting a second deeper layer was also carried out, but it did not significantly increase the helium content beyond the blistering limit (approximately 6 x 10^17 helium/cm^2). The implanted targets were bombarded with moderately intense 4He and 16O beams of 50-100 particle nA . Rutherford Back Scattering of 1.0 and 2.5 MeV proton beams and recoil helium from 15.0 MeV oxygen beams were used to study the helium content and profile before, during and after bombardments. We observed the helium content and profile to be very stable even after a prolonged bombardment (up to two days) with moderately intense beams of 16O or 4He. Helium implanted into thin (aluminum) foils is a good choice for thin helium targets needed, for example, for a measurement of the 3he(a,g)7Be reaction and the associated S34 astrophysical cross section factor (S-factor). Comment: Submitted to the New Online Journal of Instrumentation, JINST. Work Supported by USDOE Grant Nos: DE-FG02-94ER40870, DE-FG02-91ER40609, DE-FG02-97ER41033, and DE-FG02-97ER4104