Modelling twentieth century global ocean circulation and iceberg flux at 48°N: Implications for west Greenland iceberg discharge

We have used a coupled ocean-iceberg model to study the variation in global ocean circulation and North Atlantic iceberg flux from 1900 to 2008. The latter component of the study focused particularly on Greenland icebergs feeding into the Labrador Current and past Newfoundland. The model was forced with daily heat, freshwater and wind fluxes from the Twentieth Century Reanalysis. The reanalysis heat fluxes were shown to be offset from the, shorter, NCEP reanalysis and a grid-point correction was applied to this component of the forcing. The model produces a generally realistic ocean circulation, although with an enhanced Atlantic Meridional Overturning largely due to the forcing. The modelled iceberg flux at 48°N is well correlated with the long-term observed flux when using a modelled iceberg discharge that varies in a similar fashion to the highly variable observed flux at 48°N. From this model we infer changes in the spatial and temporal variability of iceberg calving from western Greenland. During the first third of the twentieth century the majority of modelled icebergs reaching 48°N derive from southern Greenland, while only after 1930 is the traditional perspective of a majority of such icebergs originating from Baffin Bay consistent with model results. Decadal-scale changes in the dominant regional sources are found, with oscillations between western Greenland and northern Baffin Bay. The latter origin was modelled to be most important in the last third of the twentieth century, although west Greenland sources have increased in importance in recent years. The model correctly reproduces the pronounced late spring peak in flux at 48°N for southern Greenland icebergs, but has an approximately six month offset for icebergs from Baffin Bay, most likely due to resolution issues leading to model icebergs not being delayed in shallow coastal waters, whereas in reality they may be grounded for some time or trapped in coastal sea-ice. © 2015 The Authors

The benzene metabolite para-benzoquinone is genotoxic in human, phorbol-12-acetate-13-myristate induced, peripheral blood mononuclear cells at low concentrations

Benzene is one of the most prominent occupational and environmental pollutants. The substance is a proven human carcinogen that induces hematologic malignancies in humans, probably at even low doses. Yet knowledge of the mechanisms leading to benzene-induced carcinogenesis is still incomplete. Benzene itself is not genotoxic. The generation of carcinogenic metabolites involves the production of oxidized intermediates such as catechol, hydroquinone and para-benzoquinone (p-BQ) in the liver. Further activation to the ultimate carcinogenic intermediates is most probably catalyzed by myeloperoxidase (MPO). Yet the products of the MPO pathway have not been identified. If an oxidized benzene metabolite such as p-BQ was actually the precursor for the ultimate carcinogenic benzene metabolite and further activation proceeds via MPO mediated reactions, it should be possible to activate p-BQ to a genotoxic compound in vitro. We tested this hypothesis with phorbol-12-acetate-13-myristate (PMA) activated peripheral blood cells exposed to p-BQ, using the cytokinesis-block micronucleus test. Addition of 20–28 ng/ml PMA caused a significant increase of micronuclei at low and non-cytotoxic p-BQ concentrations between 0.04 and 0.2 μg/ml (0.37–1.85 μM). Thus with PMA or p-BQ alone no reproducible elevation of micronuclei was seen up to toxic concentrations. PMA and p-BQ induce micronuclei when administered jointly. Our results add further support to the hypothesis that MPO is a key enzyme in the activation of benzene

Sea surface temperature control on the distribution of far-traveled Southern Ocean ice-rafted detritus during the Pliocene

The flux and provenance of ice-rafted detritus (IRD) deposited in the Southern Ocean can reveal information about the past instability of Antarctica's ice sheets during different climatic conditions. Here we present a Pliocene IRD provenance record based on the Ar/Ar ages of ice-rafted hornblende grains from Ocean Drilling Program Site 1165, located near Prydz Bay in the Indian Ocean sector of the Southern Ocean, along with the results of modeled sensitivity tests of iceberg trajectories and their spatial melting patterns under a range of sea surface temperatures (SSTs). Our provenance results reveal that IRD and hence icebergs in the Prydz Bay area were mainly sourced from (i) the local Prydz Bay region and (ii) the remote Wilkes Land margin located at the mouth of the low-lying Aurora Subglacial Basin. A series of IRD pulses, reaching up to 10 times background IRD flux levels, were previously identified at Site 1165 between 3.3 and 3.0Ma. Our new results reveal that the average proportion of IRD sourced from distal Wilkes Land margin doubles after 3.3Ma. Our iceberg trajectory-melting models show that slower iceberg melting under cooling SSTs over this middle Pliocene interval allowed Wilkes Land icebergs to travel farther before melting. Hence, declining SSTs can account for a large part of the observed IRD provenance record at Site 1165. In early Pliocene IRD layers, sampled at suborbital resolution around 4.6Ma, we find evidence for significant increases in icebergs derived from Wilkes Land during very warm interglacials. This is suggestive of large-scale destabilization of the East Antarctic Ice Sheet in the Aurora Subglacial Basin, as far-traveled icebergs would have to overcome enhanced melting in warmer SSTs. Our results highlight the importance of considering SSTs when interpreting IRD flux and provenance records in distal locations

Pulmonale Manifestationen bei Patienten mit erworbenem Immunmangelsyndrom (AIDS)

Mülleneisen NK, Höffken G, Lode H, Lichey J, Krämer A. Pulmonale Manifestationen bei Patienten mit erworbenem Immunmangelsyndrom (AIDS). Atemwegs- und Lungenkrankheiten. Diagnostik und Therapie. 1986;12:386-389

High primary productivity in an ice melting hot spot at the eastern boundary of the Weddell Gyre

The Southern Ocean (SO) plays a key role in modulating atmospheric CO 2 via physical and biological processes. However, over much of the SO, biological activity is iron-limited. New in situ data from the Antarctic zone south of Africa in a region centered at ~20°E-25°E reveal a previously overlooked region of high primary production, comparable in size to the northwest African upwelling region. Here, sea ice together with enclosed icebergs is channeled by prevailing winds to the eastern boundary of the Weddell Gyre, where a sharp transition to warmer waters causes melting. This cumulative melting provides a steady source of iron, fuelling an intense phytoplankton bloom that is not fully captured by monthly satellite production estimates. These findings imply that future changes in sea-ice cover and dynamics could have a significant effect on carbon sequestration in the SO