Immunohistochemical characteristics of porcine intrahepatic nerves under physiological conditions and after bisphenol A administration

Background: The neurochemistry of hepatic nerve fibres was investigated in large animal models after dietary exposure to the endocrine disrupting compound known as bisphenol A (BPA).   Materials and methods: Antibodies against neuronal peptides were used to study changes in hepatic nerve fibres after exposure to BPA at varying concentrations using standard immunofluorescence techniques. The neuropeptides investigated were substance P (SP), galanin (GAL), pituitary adenylate cyclase activating polypeptide (PACAP), calcitonin gene regulated peptide (CGRP) and cocaine and amphetamine regulated transcript (CART). Immunoreactive nerve fibres were counted in multiple sections of the liver and among multiple animals at varying exposure levels. The data was pooled and presented as mean ± standard error of the mean.   Results: It was found that all of the nerve fibres investigated showed upregulation of these neural markers after BPA exposure, even at exposure levels currently considered to be safe. These results show very dramatic increases in nerve fibres containing the above-mentioned neuropeptides and the altered neurochemical levels may be causing a range of pathophysiological states if the trend of over-expression is extrapolated to developing humans.   Conclusions: This may have serious implications for children and young adults who are exposed to this very common plastic polymer, if the same trends are occurring in humans

A New Constraint on the Escape Fraction in Distant Galaxies Using Gamma-ray Burst Afterglow Spectroscopy

We describe a new method to measure the escape fraction fesc of ionizing radiation from distant star-forming galaxies using the afterglow spectra of long-duration gamma-ray bursts (GRBs). Optical spectra of GRB afterglows allow us to evaluate the optical depth of the host ISM, according to the neutral hydrogen column density N(HI) observed along the sightlines toward the star-forming regions where the GRBs are found. Different from previous effort in searching for faint, transmitted Lyman continuum photons, our method is not subject to background subtraction uncertainties and does not require prior knowledge of either the spectral shape of the host galaxy population or the IGM Lya forest absorption along these GRB sightlines. Because most GRBs occur in sub-L_* galaxies, our study also offers the first constraint on fesc for distant low-mass galaxies that dominate the cosmic luminosity density. We have compiled a sample of 27 GRBs at redshift z>2 for which the underlying N(HI) in the host ISM are known. These GRBs together offer a statistical sampling of the integrated optical depth to ionizing photons along random sightlines from star-forming regions in the host galaxies, and allow us to estimate the mean escape fraction averaged over different viewing angles. We find =0.02\pm 0.02 and place a 95% c.l. upper limit <= 0.075 for these hosts. We discuss possible biases of our approach and implications of the result. Finally, we propose to extend this technique for measuring at z~0.2 using spectra of core-collapse supernovae.Comment: Five journal pages, including one figure; ApJL in pres

The obscured hyper-energetic GRB 120624B hosted by a luminous compact galaxy at z = 2.20

Gamma-ray bursts are the most luminous explosions that we can witness in the Universe. Studying the most extreme cases of these phenomena allows us to constrain the limits for the progenitor models. In this Letter, we study the prompt emission, afterglow, and host galaxy of GRB 120624B, one of the brightest GRBs detected by Fermi, to derive the energetics of the event and characterise the host galaxy in which it was produced. Following the high-energy detection we conducted a multi-wavelength follow-up campaign, including near-infrared imaging from HAWKI/VLT, optical from OSIRIS/GTC, X-ray observations from the Chandra X-ray Observatory and at sub-millimetre/millimetre wavelengths from SMA. Optical/nIR spectroscopy was performed with X-shooter/VLT. We detect the X-ray and nIR afterglow of the burst and determine a redshift of z = 2.1974 +/- 0.0002 through the identification of emission lines of [OII], [OIII] and H-alpha from the host galaxy of the GRB. This implies an energy release of Eiso = (3.0+/-0.2)x10^54 erg, amongst the most luminous ever detected. The observations of the afterglow indicate high obscuration with AV > 1.5. The host galaxy is compact, with R1/2 < 1.6 kpc, but luminous, at L ~ 1.5 L* and has a star formation rate of 91 +/- 6 Msol/yr as derived from H-alpha. As other highly obscured GRBs, GRB 120624B is hosted by a luminous galaxy, which we also proof to be compact, with a very intense star formation. It is one of the most luminous host galaxies associated with a GRB, showing that the host galaxies of long GRBs are not always blue dwarf galaxies, as previously thought.Comment: 6 pages, 4 figures, 4 tables; accepted for publication in A&

Spectroscopy of superluminous supernova host galaxies. A preference of hydrogen-poor events for extreme emission line galaxies

Superluminous supernovae (SLSNe) are very bright explosions that were only discovered recently and that show a preference for occurring in faint dwarf galaxies. Understanding why stellar evolution yields different types of stellar explosions in these environments is fundamental in order to both uncover the elusive progenitors of SLSNe and to study star formation in dwarf galaxies. In this paper, we present the first results of our project to study SUperluminous Supernova Host galaxIES, focusing on the sample for which we have obtained spectroscopy. We show that SLSNe-I and SLSNe-R (hydrogen-poor) often (~50% in our sample) occur in a class of galaxies that is known as Extreme Emission Line Galaxies (EELGs). The probability of this happening by chance is negligible and we therefore conclude that the extreme environmental conditions and the SLSN phenomenon are related. In contrast, SLSNe-II (hydrogen-rich) occur in more massive, more metal-rich galaxies with softer radiation fields. Therefore, if SLSNe-II constitute a uniform class, their progenitor systems are likely different from those of H-poor SLSNe. Gamma-ray bursts (GRBs) are, on average, not found in as extreme environments as H-poor SLSNe. We propose that H-poor SLSNe result from the very first stars exploding in a starburst, even earlier than GRBs. This might indicate a bottom-light initial mass function in these systems. SLSNe present a novel method of selecting candidate EELGs independent of their luminosity.Comment: Published version, matches proofs. Accepted 2015 February 13. 23 pages, 8 figures, 4 tables. Minor changes with respect to previous versio

Discovery of the broad-lined Type Ic SN 2013cq associated with the very energetic GRB 130427A

Long-duration gamma-ray bursts (GRBs) at z < 1 are in most cases found to be accompanied by bright, broad-lined Type Ic supernovae (SNe Ic-BL). The highest-energy GRBs are mostly located at higher redshifts, where the associated SNe are hard to detect observationally. Here we present early and late observations of the optical counterpart of the very energetic GRB 130427A. Despite its moderate redshift z = 0.3399+/-0.0002, GRB 130427A is at the high end of the GRB energy distribution, with an isotropic-equivalent energy release of Eiso ~ 9.6x10^53 erg, more than an order of magnitude more energetic than other GRBs with spectroscopically confirmed SNe. In our dense photometric monitoring, we detect excess flux in the host-subtracted r-band light curve, consistent with what expected from an emerging SN, ~0.2 mag fainter than the prototypical SN 1998bw. A spectrum obtained around the time of the SN peak (16.7 days after the GRB) reveals broad undulations typical of SNe Ic-BL, confirming the presence of a SN, designated SN 2013cq. The spectral shape and early peak time are similar to those of the high expansion velocity SN 2010bh associated with GRB 100316D. Our findings demonstrate that high-energy long-duration GRBs, commonly detected at high redshift, can also be associated with SNe Ic-BL, pointing to a common progenitor mechanism.Comment: 12 pages, 4 figures, 1 table, accepted for publication in Ap

Low-Luminosity Gamma-Ray Bursts as a Distinct GRB Population:A Firmer Case from Multiple Criteria Constraints

The intriguing observations of Swift/BAT X-ray flash XRF 060218 and the BATSE-BeppoSAX gamma-ray burst GRB 980425, both with much lower luminosity and redshift compared to other observed bursts, naturally lead to the question of how these low-luminosity (LL) bursts are related to high-luminosity (HL) bursts. Incorporating the constraints from both the flux-limited samples observed with CGRO/BATSE and Swift/BAT and the redshift-known GRB sample, we investigate the luminosity function for both LL- and HL-GRBs through simulations. Our multiple criteria, including the log N - log P distributions from the flux-limited GRB sample, the redshift and luminosity distributions of the redshift-known sample, and the detection ratio of HL- and LL- GRBs with Swift/BAT, provide a set of stringent constraints to the luminosity function. Assuming that the GRB rate follows the star formation rate, our simulations show that a simple power law or a broken power law model of luminosity function fail to reproduce the observations, and a new component is required. This component can be modeled with a broken power, which is characterized by a sharp increase of the burst number at around L < 10^47 erg s^-1}. The lack of detection of moderate-luminosity GRBs at redshift ~0.3 indicates that this feature is not due to observational biases. The inferred local rate, rho_0, of LL-GRBs from our model is ~ 200 Gpc^-3 yr^-1 at ~ 10^47 erg s^-1, much larger than that of HL-GRBs. These results imply that LL-GRBs could be a separate GRB population from HL-GRBs. The recent discovery of a local X-ray transient 080109/SN 2008D would strengthen our conclusion, if the observed non-thermal emission has a similar origin as the prompt emission of most GRBs and XRFs.Comment: 22 pages, 9 figures, 3 tables; MNRAS, in press; Updated analysis and figure

Looking Into the Fireball: ROTSE-III and Swift Observations of Early GRB Afterglows

We report on a complete set of early optical afterglows of gamma-ray bursts (GRBs) obtained with the ROTSE-III telescope network from March 2005 through June 2007. This set is comprised of 12 afterglows with early optical and Swift/XRT observations, with a median ROTSE-III response time of 45 s after the start of gamma-ray emission (8 s after the GCN notice time). These afterglows span four orders of magnitude in optical luminosity, and the contemporaneous X-ray detections allow multi-wavelength spectral analysis. Excluding X-ray flares, the broadband synchrotron spectra show that the optical and X-ray emission originate in a common region, consistent with predictions of the external forward shock in the fireball model. However, the fireball model is inadequate to predict the temporal decay indices of the early afterglows, even after accounting for possible long-duration continuous energy injection. We find that the optical afterglow is a clean tracer of the forward shock, and we use the peak time of the forward shock to estimate the initial bulk Lorentz factor of the GRB outflow, and find 100<Gamma_0<1000, consistent with expectations.Comment: 31 pages, 5 figures, submitted to Ap

Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions

It is controversially discussed whether immune-deficient mice experience severity in the absence of infection. Because a comprehensive analysis of the well-being of immune-deficient mice under specific pathogen free conditions is missing, we used a multi-parametric test analyzing, corticosterone, weight, nest building and facial expression over a period of 9 month to determine the well-being of two immune-deficient mouse lines (recombination activating gene 2- and interferon gamma receptor-deficient mice). We do not find evidence for severity when comparing immune-deficient mice to their heterozygous immune-competent littermates. Our data challenge the assumption that immune-deficiency per se regardless of housing conditions causes severity. Based on our study we propose to use objective non-invasive parameters determined by laboratory animal science for decisions concerning severity of immune-deficient mice

Long-term X-ray variability of Swift J1644+57

We studied the X-ray timing and spectral variability of the X-ray source Sw J1644+57, a candidate for a tidal disruption event. We have separated the long-term trend (an initial decline followed by a plateau) from the short-term dips in the Swift light-curve. Power spectra and Lomb-Scargle periodograms hint at possible periodic modulation. By using structure function analysis, we have shown that the dips were not random but occurred preferentially at time intervals ~ [2.3, 4.5, 9] x 10^5 s and their higher-order multiples. After the plateau epoch, dipping resumed at ~ [0.7, 1.4] x 10^6 s and their multiples. We have also found that the X-ray spectrum became much softer during each of the early dip, while the spectrum outside the dips became mildly harder in its long-term evolution. We propose that the jet in the system undergoes precession and nutation, which causes the collimated core of the jet briefly to go out of our line of sight. The combined effects of precession and nutation provide a natural explanation for the peculiar patterns of the dips. We interpret the slow hardening of the baseline flux as a transition from an extended, optically thin emission region to a compact, more opaque emission core at the base of the jet.Comment: 16 pages, 12 figures. Accepted by MNRAS on 2012 Feb 11; minor improvements in the introduction and discussion from the previous arXiv versio