5,135 research outputs found
Towards a Semantic Gas Source Localization under Uncertainty
Towards a Semantic Gas Source Localization under Uncertainty.Communications in Computer and Information Science book series (CCIS, volume 855), doi:10.1007/978-3-319-91479-4_42This work addresses the problem of efficiently and coherently
locating a gas source in a domestic environment with a mobile
robot, meaning efficiently the coverage of the shortest distance as possible
and coherently the consideration of different gas sources explaining
the gas presence. The main contribution is the exploitation, for the
first time, of semantic relationships between the gases detected and the
objects present in the environment to face this challenging issue. Our
proposal also takes into account both the uncertainty inherent in the
gas classification and object recognition processes. These uncertainties
are combined through a probabilistic Bayesian framework to provide a
priority-ordered list of (previously observed) objects to check. Moreover
the proximity of the different candidates to the current robot location
is also considered by a cost function, which output is used for planning
the robot inspection path. We have conducted an initial demonstration
of the suitability of our gas source localization approach by simulating
this task within domestic environments for a variable number of objects,
and comparing it with an greedy approach.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
Universal behavior of crystalline membranes: Crumpling transition and Poisson ratio of the flat phase
We revisit the universal behavior of crystalline membranes at and below the crumpling transition, which pertains to the mechanical properties of important soft and hard matter materials, such as the cytoskeleton of red blood cells or graphene. Specifically, we perform large-scale Monte Carlo simulations of a triangulated two-dimensional phantom network which is freely fluctuating in three-dimensional space. We obtain a continuous crumpling transition characterized by critical exponents which we estimate accurately through the use of finite-size techniques. By controlling the scaling corrections, we additionally compute with high accuracy the asymptotic value of the Poisson ratio in the flat phase, thus characterizing the auxetic properties of this class of systems. We obtain agreement with the value which is universally expected for polymerized membranes with a fixed connectivity.This work was partially supported by Ministerio de
Economía y Competitividad (Spain) through Grants No.
FIS2012-38866-C05-01 and No. FIS2013-42840-P, by Junta
de Extremadura (Spain) through Grant No. GRU10158 (partially
funded by FEDER), and by the European Union through
Grant No. PIRSES-GA-2011-295302. We also made use of
the computing facilities of Extremadura Research Centre
for Advanced Technologies (CETA-CIEMAT), funded by the
European Regional Development Fund (ERDF)
Predictive and criterion validity of the Cervantes-SF menopause quality of life questionnaire.
pre-print384 K
A Multi-Actor Framework Centered around an Assistive Mobile Robot for Elderly People Living Alone
In a social and economic context characterized by a constantly aging population, the research for new technologies able to assist elderly people is getting more and more attention. In this extended abstract we illustrate the main components of the European project MoveCare, a multi-actor framework designed to assist pre-frail elders living alone. The proposed system is centered around an assistive mobile robot that provides the user with a set of functionalities to support cognitive and social stimulation, assistance, and transparent monitoring
Imaging Findings in Patients with Immune Checkpoint Inhibitor-Induced Arthritis
Immune checkpoint inhibitor (ICI)-induced arthritis is an increasingly recognized adverse event in patients with oncologic disease during immunotherapy. Four patterns are well described, including rheumatoid arthritis (RA)-like, polymyalgia rheumatica (PMR)-like, psoriatic arthritis (PsA)-like, and oligo-monoarthritis, among others. Despite better clinical recognition of these syndromes, information about the main imaging findings is limited. Methods: We conducted a retrospective observational study including all adult patients referred to the Rheumatology Department of a single-center due to ICI-induced arthritis who underwent imaging studies [ultrasound (US), magnetic resonance imaging (MRI), and (18)F-FDG PET/CT)] between January 2017 and January 2022. Results: Nineteen patients with ICI-induced arthritis with at least one diagnostic imaging assessment were identified (15 US, 4 MRI, 2 (18)F-FDG PET/CT). Most patients were male (84.2%), with a median age at inclusion of 73 years. The main underlying diagnoses for ICI treatment were melanoma in five cases. The distribution of ICI-induced arthritis was as follows: PMR-like (5, 26.2%), RA-like (4, 21.1%), PsA-like (4, 21.1%), and others (6, 31.6%). All RA-like patients had US findings indistinguishable from conventional RA patients. In addition, 3/5 (60%) of PMR-like patients had significant involvement of the hands and wrists. Abnormal findings on MRI or PET-CT were reported by clinical symptoms. No erosions or myofascitis were seen. Conclusions: ICI-induced arthritis patients present inflammatory patterns on imaging studies similar to conventional inflammatory arthropathies, and therefore these syndromes should be followed carefully and treated according to these findings
Familial hypercholesterolaemia: A study of 36 cases with a phenotype of homozygous familiar hypercholesterolaemia
La hipercolesterolemia familiar homocigótica (HFHo) se caracteriza por niveles muy elevados de cLDL y por enfermedad aterosclerótica temprana. Aunque la frecuencia es baja (1/300.000), las complicaciones son muy severas y pueden ser evitadas. Encontrar y tratar esta población de manera temprana podría reducir la mortalidad. Se describen 36 casos en Colombia, en donde se calcula que haya entre 160 y 200 casos.
Resultados
Un total de 36 pacientes con fenotipo sugestivo de HFHo fueron identificados y tratados en un período de observación de cuatro años. La media de edad fue 27 años (24 mujeres). 34 pacientes tuvieron un puntaje según la Red de Clínicas de Lípidos de Holanda (RCLH) mayor de 8 (diagnóstico definitivo) y los restantes 2 tenían puntaje equivalente a diagnóstico probable. Un cuarto de los casos procedían de la costa norte colombiana. En las pruebas genéticas, 14 fueron homocigóticos verdaderos para mutación del gen que codifica para el receptor de LDL (LDLR), 12 heterocigóticos compuestos, 2 heterocigóticos dobles y uno autosómico recesivo (LDLRAP1); 5 pacientes fueron heterocigóticos simples (LDLR) y 2 pacientes no autorizaron la prueba. En los homocigóticos verdaderos, la variante más frecuente encontrada fue la c.11G>A. 14 pacientes cursaron con enfermedad coronaria, 9 con estenosis carotídea, 8 con estenosis aórtica y 2 tuvieron ataques cerebrovasculares (ACV). 34 pacientes recibían estatinas (24 rosuvastatina), 30 recibían ezetimibe, 2 recibían evolocumab y 20 recibían lomitapide (dosis promedio 12,7mg). Ninguno recibió aféresis de cLDL. Los medicamentos, en general, fueron bien tolerados y la reducción promedio de cLDL con la terapia fue de 533,7mg/dl a 245,1mg/dl (54%).
Conclusiones
Todos los pacientes recibieron tratamiento hipolipemiante y se encontraron alteraciones genéticas diagnósticas en todos aquellos que autorizaron el examen. Los niveles elevados de cLDL conllevan tanto riesgo que el tratamiento debe establecerse aún sin conocer el diagnóstico genético.Homozygous familial hypercholesterolemia (HoFH) is characterized for very high levels of cLDL and early cardiovascular disease. Although incidence is low (1/300 000), complications are very severe and can be avoided. Finding and treating this population promptly could reduce mortality. We describe 36 cases in Colombia, where 160 to 200 cases are expected.
Results
36 patients with phenotype of HoHF were identified and treated in a follow-up of 4 years. The mean age was 27 years (24 women). 34 of them had at least 8 points in the FH Dutch Lipid Clinic Criteria (definitive diagnosis) and two had probable diagnosis. A quarter of the cases came from the Colombian North Coast. In molecular tests, 14 were true homozygous for LDLR, 12 were compound heterozygous for LDLR, 2 double heterozygous and one was autosomal recessive; 5 were heterozygous and 2 patients did not authorized genetic test. In true homozygous subjects, the most frequent variant was c.11G>A. 14 patients had coronary disease, 9 carotid stenosis, 8 aortic stenosis and 2 had stroke. 34 patients were on statins (25 rosuvastatin), 30 were receiving ezetimibe, 2 were receiving a PSCK9 inhibitor (evolocumab) and 20 were on lomitapide with mean doses of 12.7mg. None received lipoprotein apheresis. Medications were very well tolerated. Changes in cLDL after therapy was from 533.7 mg/dL to 245 mg/dL, (54%).
Conclusions
Treatment was started in all patients. We found genetic mutations in all patients with genetic tests. The high levels of cLDL mean such a high risk that treatment must be started promptly, even without a genetic test
Early-Career Coordinated Distributed Experiments: Empowerment Through Collaboration
Este artículo contiene 7 páginas, 1 tabla, 3 figuras.Coordinated distributed experiments (CDEs) enable the study of large-scale ecological
patterns in geographically dispersed areas, while simultaneously providing broad
academic and personal benefits for the participants. However, the effective involvement
of early-career researchers (ECRs) presents major challenges. Here, we analyze the
benefits and challenges of the first CDE exclusively led and conducted by ECRs (i.e.
ECR-CDE), which sets a baseline for similar CDEs, and we provide recommendations
for successful CDE execution. ECR-CDEs achieve most of the outcomes identified in
conventional CDEs as well as extensive benefits for the young cohort of researchers,
including: (i) receiving scientific credit, (ii) peer-training in new concepts and methods, (iii)
developing leadership and communication skills, (iv) promoting a peer network among
ECRs, and (v) building on individual engagement and independence. We also discuss
the challenges of ECR-CDEs, which are mainly derived from the lack of independence
and instability of the participants, and we suggest mechanisms to address them, such
as resource re-allocation and communication strategies. We conclude that ECR-CDEs
can be a relevant tool to empower ECRs across disciplines by fostering their training,
networking and personal well-being.The authors were supported by the following founding: NC
the support of the Beatriu de Pinós postdoctoral program of
the Government of Catalonia’s Secretariat for Universities and
Research of the Ministry of Economy and Knowledge (BP2016-
00215), EE by a predoctoral grant from the Basque Government
(2014-2017), AB by a Generalitat de Catalunya—Beatriu de
Pinós (BP-00385-2016), AMG-F by a predoctoral research grant
(BES-2013-065770) from the Spanish Ministry of Economy and
Competitiveness, MAr by a postdoctoral grant from the Basque
Government, MIA by a Juan de la Cierva postdoctoral grant
(FJCI-2015-26192), PR-L by a Margalida Comas postdoctoral
contract (PD/031/2018) funded by the Government of the
Balearic Islands and the European Social Fund, AP by a Ramón
Areces Foundation Postdoctoral Scholarship, and AL by a Kempe
Foundation stipend. DOMIPEX project was founded by the First
Call of Collaborative Projects among Young Researchers of the
Iberian Association of Limnology (AIL; 2013-2015).Peer reviewe
A simple biogeochemical model for estuaries with high sediment loads: Application to the Guadalquivir River (SW Iberia)
Measurement of the branching fraction ratio
Using collision data collected by LHCb at center-of-mass energies
= 7 TeV and 8 TeV, corresponding to an integrated luminosity of 3
fb, the ratio of the branching fraction of the decay relative to that of the
decay is measured to be 0.268 0.032 (stat) 0.007 (syst) 0.006
(BF). The first uncertainty is statistical, the second is systematic, and the
third is due to the uncertainties on the branching fractions of the and decays. This
measurement is consistent with the previous LHCb result, and the statistical
uncertainty is halved.Comment: 17 pages including author list, 2 figure
Observation of resonances consistent with pentaquark states in decays
Observations of exotic structures in the channel, that we refer to
as pentaquark-charmonium states, in decays are
presented. The data sample corresponds to an integrated luminosity of 3/fb
acquired with the LHCb detector from 7 and 8 TeV pp collisions. An amplitude
analysis is performed on the three-body final-state that reproduces the
two-body mass and angular distributions. To obtain a satisfactory fit of the
structures seen in the mass spectrum, it is necessary to include two
Breit-Wigner amplitudes that each describe a resonant state. The significance
of each of these resonances is more than 9 standard deviations. One has a mass
of MeV and a width of MeV, while the second
is narrower, with a mass of MeV and a width of MeV. The preferred assignments are of opposite parity, with one
state having spin 3/2 and the other 5/2.Comment: 48 pages, 18 figures including the supplementary material, v2 after
referee's comments, now 19 figure
- …