Guest Editorial Special Issue on Medical Imaging and Image Computing in Computational Physiology

International audienceThe January 2013 Special Issue of IEEE transactions on medical imaging discusses papers on medical imaging and image computing in computational physiology. Aslanid and co-researchers present an experimental technique based on stained micro computed tomography (CT) images to construct very detailed atrial models of the canine heart. The paper by Sebastian proposes a model of the cardiac conduction system (CCS) based on structural information derived from stained calf tissue. Ho, Mithraratne and Hunter present a numerical simulation of detailed cerebral venous flow. The third category of papers deals with computational methods for simulating medical imagery and incorporate knowledge of imaging physics and physiology/biophysics. The work by Morales showed how the combination of device modeling and virtual deployment, in addition to patient-specific image-based anatomical modeling, can help to carry out patient-specific treatment plans and assess alternative therapeutic strategies

DIAMS revisited: Taming the variety of knowledge in fault diagnosis expert systems

The DIAMS program, initiated in 1986, led to the development of a prototype expert system, DIAMS-1 dedicated to the Telecom 1 Attitude and Orbit Control System, and to a near-operational system, DIAMS-2, covering a whole satellite (the Telecom 2 platform and its interfaces with the payload), which was installed in the Satellite Control Center in 1993. The refinement of the knowledge representation and reasoning is now being studied, focusing on the introduction of appropriate handling of incompleteness, uncertainty and time, and keeping in mind operational constraints. For the latest generation of the tool, DIAMS-3, a new architecture has been proposed, that enables the cooperative exploitation of various models and knowledge representations. On the same baseline, new solutions enabling higher integration of diagnostic systems in the operational environment and cooperation with other knowledge intensive systems such as data analysis, planning or procedure management tools have been introduced

Automatically building morphometric anatomical atlases from 3D medical images : Application to a skull atlas

In this article, we present a method for building entirely automatically a morphometric anatomical atlas from 3D medical image s acquired by CT-Scan or MR . We detail each step of the method, including the non-rigid registration algorithm, 3D lines averaging , and statistical analysis processes . We apply the method to obtain a quantitative atlas of crest lines of the skull . Finally, we use the resulting atlas to study a craniofacia l disease : we show how we can obtain qualitative and quantitative results by contrasting a skull affected by a deformation of th e mandible with the atlas .Dans cet article, nous présentons une méthode pour construire de manière automatique des atlas anatomiques morphométriques à partir d'images médicales tridimensionnelles obtenues par scanographie ou imagerie par résonance magnétique. Nous en détaillons les différentes étapes, en particulier les algorithmes de mise en correspondance non-rigide, de moyenne et d'analyse statistique de lignes caractéristiques tridimensionnelles. Nous appliquons la méthode à la construction d'un atlas morphométrique des lignes de crête du crâne. Nous montrons alors comment la comparaison automatique entre l'atlas et un crâne présentant une déformation mandibulaire permet d'obtenir des résultats qualitatifs et quantitatifs utilisables par un médecin

Modelling of the anthropogenic tritium transient and its decay product helium-3 in the Mediterranean Sea using a high-resolution regional model

International audienceThis numerical study provides the first simulation of the anthropogenic tritium invasion and its decay product helium-3 (3 He) in the Mediterranean Sea. The simulation covers the entire tritium (3 H) transient generated by the atmospheric nuclear weapons tests performed in the 1950s and early 1960s and is run till 2011. Tritium, helium-3 and their derived age estimates are particularly suitable for studying intermediate and deep-water ventilation and spreading of water masses at intermediate/deep levels. The simulation is made using a high-resolution regional model NEMO (Nucleus for European Modelling of the Ocean), in a regional configuration for the Mediterranean Sea called MED12, forced at the surface with prescribed tritium evolution derived from observations. The simulation is compared to measurements of tritium and helium-3 performed along large-scale transects in the Mediterranean Sea during the last few decades on cruises of R/V Meteor: M5/6, M31/1, M44/4, M51/2, M84/3, and R/V Poseidon: 234. The results show that the input function used for the tritium generates a realistic distribution of the main hydrographic features of the Mediterranean Sea circulation. In the eastern basin, the results highlight the weak formation of Adriatic Deep Water in the model, which explains its weak contribution to the Eastern Mediterranean Deep Water (EMDW) in the Ionian sub-basin. It produces a realistic representation of the Eastern Mediterranean Transient (EMT) signal, simulating a deep-water formation in the Aegean sub-basin at the beginning of 1993, with a realistic timing of deep-water renewal in the eastern basin

Off-axis electron holography of bacterial cells and magnetic nanoparticles in liquid

The mapping of electrostatic potentials and magnetic fields in liquids usingelectron holography has been considered to be unrealistic. Here, we showthat hydrated cells ofMagnetospirillum magneticumstrain AMB-1 and assem-blies of magnetic nanoparticles can be studied using off-axis electronholography in a fluid cell specimen holder within the transmission electronmicroscope. Considering that the holographic object and reference waveboth pass through liquid, the recorded electron holograms show sufficientinterference fringe contrast to permit reconstruction of the phase shift ofthe electron wave and mapping of the magnetic induction from bacterialmagnetite nanocrystals. We assess the challenges of performingin situmagne-tization reversal experiments using a fluid cell specimen holder, discussapproaches for improving spatial resolution and specimen stability, and outlinefuture perspectives for studying scientific phenomena, ranging from interpar-ticle interactions in liquids and electrical double layers at solid–liquidinterfaces to biomineralization and the mapping of electrostatic potentialsassociated with protein aggregation and folding

Correlations between the mechanical loss and atomic structure of amorphous TiO2-doped Ta2O5 coatings

<p>Highly reflective dielectric mirror coatings are critical components in a range of precision optics applications including frequency combs, optical atomic clocks, precision interferometry and ring laser gyroscopes. A key limitation to the performance in these applications is thermal noise, arising from the mechanical loss of the coatings. The origins of the mechanical loss from these coatings is not well understood.</p> <p>Recent work suggests that the mechanical loss of amorphous Ta2O5 coatings can drop by as much as 40% when it is doped with TiO2. We use a combination of electron diffraction data and atomic modelling using molecular dynamics to probe the atomic structure of these coatings, and examine the correlations between changes in the atomic structure and changes in the mechanical loss of these coatings. Our results show the first correlation between changes in the mechanical loss and experimentally measured changes in the atomic structure resulting from variations in the level of TiO2 doping in TiO2-doped Ta2O5 coatings, in that increased homogeneity at the nearest-neighbour level appears to correlate with reduced mechanical loss. It is demonstrated that subtle but measurable changes in the nearest-neighbour homogeneity in an amorphous material can correlate with significant changes in macroscopic properties.</p&gt

Topological dynamics of an intrinsically disordered N-terminal domain of the human androgen receptor

ACKNOWLEDGEMENTS We are thankful to Eugene Shakhnovich (Harvard University) for critical reading of the manuscript, and to Peter Bolhuis and Ioana Ilie (University of Amsterdam) for technical discussions. The research in Mashaghi lab is supported by funding from Muscular Dystrophy Association (USA), Grant Number MDA628071, and Dutch Research Council (Nederlandse Organisatie voor Wetenschappelijk Onderzoek) through NWA-IDG (NWA.1228.192.309) and Open Competition XS (OCENW.XS.076).Peer reviewedPublisher PD

Retarding Sub- and Accelerating Super-Diffusion Governed by Distributed Order Fractional Diffusion Equations

We propose diffusion-like equations with time and space fractional derivatives of the distributed order for the kinetic description of anomalous diffusion and relaxation phenomena, whose diffusion exponent varies with time and which, correspondingly, can not be viewed as self-affine random processes possessing a unique Hurst exponent. We prove the positivity of the solutions of the proposed equations and establish the relation to the Continuous Time Random Walk theory. We show that the distributed order time fractional diffusion equation describes the sub-diffusion random process which is subordinated to the Wiener process and whose diffusion exponent diminishes in time (retarding sub-diffusion) leading to superslow diffusion, for which the square displacement grows logarithmically in time. We also demonstrate that the distributed order space fractional diffusion equation describes super-diffusion phenomena when the diffusion exponent grows in time (accelerating super-diffusion).Comment: 11 pages, LaTe