3D geometry and architecture of a normal fault zone in poorly lithified sediments: A trench study on a strand of the Baza Fault, central Betic Cordillera, south Spain

Successive excavation of 13 trenches of different orientations reveals the complexity of a normal fault zone in Pliocene-Pleistocene unconsolidated sediments on a strand of the Baza Fault, central Betic Cordillera, south Spain. These trenches and the excavation floor are interpreted and integrated to reconstruct the 3D geometry and internal architecture of the fault zone. The structure consists of two main fault strands: an eastern one with a few hundred metres throw and a western one with at least 15 m throw. These strands interact and gradually merge to the south, bounding a main deformation zone narrowing from ∼7 to 1 m along strike. Fault-bounded rock bodies, clay and sand smears, and clay injections define the structure. These features are highly variable in 3D. In the northern part of the outcrop, deformation is localized around the main strands, brittle in the west and more ductile to the east. As the strands and their fault zones increasingly interact, fault throw, rock deformation and maturity of the structure increase. Mechanical stratigraphy also controls the style of deformation. A realistic representation of this 4D picture of fault deformation is critical for modelling fluid flow in shallow to possibly deep, faulted sedimentary reservoirs.This research was founded by research group VIGROB053 (University of Alicante)

Geometry and kinematics of the Baza Fault (central Betic Cordillera, South Spain): insights into its seismic potential

The geometry and kinematics of active faults have a significant impact on their seismic potential. In this work, a structural characterization of the active Baza Fault (central Betic Cordillera, southern Spain) combining surface and subsurface data is presented. Two sectors are defined based on their surface geometry: a northern sector striking N–S to NNW–SSE with a narrow damage zone and a southern sector striking NW–SE with a wide damage zone. A kinematic analysis shows pure normal fault kinematics along most of the fault. Geometric differences between the northern and southern sectors are caused by i) a heterogeneous basement controlling the fault geometry at depth and in the cover; ii) different orientations of the Baza Fault in the basement with respect to the regional extension direction and iii) interaction with other active faults. We use this structural characterization to analyse the segmentation of the Baza Fault. According to segmentation criteria, the entire Baza Fault should be considered a single fault seismogenic segment. Consequently, the seismic potential of the fault is defined for a complete rupture. Magnitude for the Mmax event is calculated using several scale relationships, obtaining values ranging between Mw 6.6 and Mw 7.1. Recurrence times range between approximately 2,000 and 2,200 years for Mmax events and between 5,300 and 5,400 years for palaeo-events. A geodetic scenario modelled for an Mmax event of Mw 6.7 shows permanent vertical displacements of more than 0.40m and an overall WSW–ENE extension during entire ruptures of the Baza Fault.This work was funded by the research project TASCUB (RTI2018-100737-B-I00) of the Spanish Ministry of Science, Innovation and Universities, the research group VIGROB053 (University of Alicante), the research project AICO/2019/040 of the Generalitat Valenciana (Valencia regional government), and the research group RNM-325 of the Junta de Andalucía (Andalucia regional government). Iván Medina Cascales was funded by Ph.D. contract FPU16/00202 of the Spanish Ministry of Science, Innovation and Universities. Research partially funded by the Programa Operativo FEDER Andalucía 2014-2020-call made by the University of Jaén 2018

Active faulting in the central Betic Cordillera (Spain): Palaeoseismological constraint of the surface-rupturing history of the Baza Fault (Central Betic Cordillera, Iberian Peninsula)

This paper on the Baza Fault provides the first palaeoseismic data from trenches in the central sector of the Betic Cordillera (S Spain), one of the most tectonically active areas of the Iberian Peninsula. With the palaeoseismological data we constructed time-stratigraphic OxCal models that yield probability density functions (PDFs) of individual palaeoseismic event timing. We analysed PDF overlap to quantitatively correlate the walls and site events into a single earthquake chronology. We assembled a surface-rupturing history of the Baza Fault for the last ca. 45,000 years. We postulated six alternative surface rupturing histories including 8–9 fault-wide earthquakes. We calculated fault-wide earthquake recurrence intervals using Monte Carlo. This analysis yielded a 4750–5150 yr recurrence interval. Finally, compared our results with the results from empirical relationships. Our results will provide a basis for future analyses of more of other active normal faults in this region. Moreover, our results will be essential for improving earthquake-probability assessments in Spain, where palaeoseismic data are scarce.This research was founded by the Spanish Ministry of Economics, Industry and Competitiveness (MINECO) research Projects CGL2011-30153-C02-02 and EPILATES (CGL2015-65602-R). Also by the research group VIGROB053 (University of Alicante), the research Project UJA2014/06/17 (Caja Rural de Jaén and University of Jaen) and the research contract 2015CL015 (University of Jaen)

Tectónica de placas, fallas, terremotos y riesgo sísmico. Una estrategia integradora

Los terremotos son uno de los recursos educativos más atractivos en ciencias de la Tierra. El tratamiento integrado de aspectos del currículo como la tectónica de placas, las fallas, los terremotos y el riesgo sísmico permite al alumnado desarrollar un pensamiento crítico. Los terremotos de Turquía de 2023 se han utilizado de ejemplo para que los alumnos y alumnas valoren las causas reales de esta catástrofe humanitaria

Insights of Active Extension Within a Collisional Orogen From GNSS (Central Betic Cordillera, S Spain)

The coexistence of shortening and extensional tectonic regimes is a common feature in orogenic belts. The westernmost end of the Western Mediterranean is an area undergoing shortening related to the 5 mm/yr NNW‒SSE convergence of the Nubia and Eurasia Plates. In this region, the Central Betic Cordillera shows a regional ENE‒WSW extension. Here, we present GNSS-derived geodetic data along a 170 km-long transect orthogonal to the main active normal faults of the Central Betic Cordillera. Our data indicate that the total extension rate along the Central Betic Cordillera is 2.0 ± 0.3 mm/yr. Extension is accommodated in the eastern (0.8 ± 0.3 mm/yr in the Guadix-Baza Basin) and western (1.3 ± 0.3 mm/yr in the Granada Basin) parts of the Central Betic Cordillera, while no extension is recorded in the central part of the study area. Moreover, our data permit us to quantify, for the first time, short-term fault slip rates of the Granada Fault System, which is one of the main seismogenic sources of the Iberian Peninsula. We deduce a fault slip rate of ∼1.3 ± 0.3 mm/yr for the whole Granada Basin, with 0.9 ± 0.3 mm/yr being accommodated in the Granada Fault System and 0.4 ± 0.3 mm/yr being accommodated in the southwestern sector of the Granada Basin, where no active faults have been previously described at the surface. The heterogeneous extension in the Central Betic Cordillera could be accommodated by shallow high-angle normal faults that merge with a detachment at depth. Part of the active extension could be derived from gravitational instability because of underlying over-thickened crust.This research was funded by the Generalitat Valenciana (Valencian Regional Government, Research project AICO/2021/196), Spanish Ministry of Science, Innovation and University (Research Projects RTI2018-100737-B-I00 and PID2021-127967NB-I00), the University of Alicante (Research Project VIGROB053), the University of Jaén (POAIUJA 2021–2022, CEACTEMA and Programa Operativo FEDER Andalucía, 2014–2020—call made by UJA, 2018, Ref. 1263446), P18-RT-3275 (Junta de Andalucía/FEDER), and the Junta de Andalucía regional government (RNM282 and RNM 148 research groups). The Institut Cartogràfic Valencià, Agencia Valenciana de Seguridad y Respuesta a las Emergencias (Generalitat Valenciana), Consorcio Provincial para el Servicio de Prevención y Extinción de Incendios y Salvamento de Alicante, Excelentísimas Diputaciones Provinciales de Alicante y Castellón, and the Ayuntamiento de Almoradí also provided partial funding

Crustal velocity field in Baza and Galera faults: A new estimation from GPS position time series in 2009 - 2018 time span

The Baza and Galera faults are two active geologic structures located in the central area of the Betic Cordillera (Southern Spain). The goal of our research is to constrain the activity of this faults from high quality GPS measurements to obtain precise deformation rates. In 2008 a GPS survey – mode network was installed to monitor this area. In previous works, we presented a velocity field based on the analysis of some GPS campaigns. Here we show the new results computed from nine GPS campaigns in the timespan 2009-2018. The measurements were done in September 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2017 and 2018. The data process and analysis were performed in Precise Point Positioning by using GIPSYX 1.6 software. GIPSY is a GNSS-inferred positioning software developed by the Jet Propulsion Laboratory. Then, the new estimation of the crustal velocity field is computed from the IGb14 time series by SARI software. The model applied to the original time series, using weighted least squares, consists of an intercept, a site rate and an offset to account for an antenna change. The error term is composed of white noise and temporally correlated random error. The colored noise is described by a random-walk process. We have assumed a typical magnitude for this process of 1.0 mm/√yr. Finally, we discuss the implications of the new results for the tectonic setting and seismic hazard assessment of this key tectonic area of the Betic Cordillera.This work has been funded by Programa Operativo FEDER Andalucía 2014-2020 - call made by University of Jaen in 2018, Ref. 1263446, POAIUJA 2021/2022, CEACTEMA, and RNM148 and RNM282 research groups of Junta de Andalucía

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons

Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). There is compelling evidence that mouse and human ALS and ALS/FTD astrocytes can reduce the number of healthy wild-type motoneurons (MNs) in co-cultures or after treatment with astrocyte conditioned media (ACM), independently of their genotype. A growing number of studies have shown that soluble toxic factor(s) in the ACM cause non-cell autonomous MN death, including our recent identification of inorganic polyphosphate (polyP) that is excessively released from mouse primary astrocytes (SOD1, TARDBP, and C9ORF72) and human induced pluripotent stem cells (iPSC)-derived astrocytes (TARDBP) to kill MNs. However, others have reported that astrocytes carrying mutant TDP43 do not produce detectable MN toxicity. This controversy is likely to arise from the findings that human iPSC-derived astrocytes exhibit a rather immature and/or reactive phenotype in a number of studies. Here, we have succeeded in generating a highly homogenous population of functional quiescent mature astrocytes from control subject iPSCs. Using identical conditions, we also generated mature astrocytes from an ALS/FTD patient carrying the TDP43A90V mutation. These mutant TDP43 patient-derived astrocytes exhibit key pathological hallmarks, including enhanced cytoplasmic TDP-43 and polyP levels. Additionally, mutant TDP43 astrocytes displayed a mild reactive signature and an aberrant function as they were unable to promote synaptogenesis of hippocampal neurons. The polyP-dependent neurotoxic nature of the TDP43A90V mutation was further confirmed as neutralization of polyP in ACM derived from mutant TDP43 astrocytes prevented MN death. Our results establish that human astrocytes carrying the TDP43A90V mutation exhibit a cell-autonomous pathological signature, hence providing an experimental model to decipher the molecular mechanisms underlying the generation of the neurotoxic phenotype

Geogymkhana Alicante: ingenuity games and outdoor skill for learning Geology

La Geoyincana Alicante es una actividad que se realiza anualmente desde el año 2012 en la que han participado casi 10.000 estudiantes de 4º de la ESO y 1º de Bachillerato. Se desarrolla en un itinerario de algo más de 2 km en el que se alternan paradas con explicaciones directas y pruebas de destreza e ingenio al aire libre. En este trabajo se analizan las siete actividades en las que el aprendizaje se basa en juegos: la carrera del Tiempo Geológico, superposición estratigráfica humana, pictionary geológico, en busca de fósiles, geoselfi geomorfológico, geomimic e historia geológica: el enigma final. La actividad alcanza cada año su objetivo principal que es acercar la Geología a estudiantes y profesorado de una forma atractiva, utilizando las actividades de campo como recurso principal. La evaluación realizada al alumnado y profesorado muestra la valoración positiva de las pruebas basadas en juegos y su idoneidad para comprender mejor los conceptos de geología. A pesar de su carácter extracurricular, la actividad favorece la consecución de objetivos del currículo oficial, ya que favorece la participación activa, el trabajo en equipo, el conocimiento sobre la geología local, la motivación por la ciencia y, en general, el interés por el estudio de la Geología.The Geogymkhana-Alicante is a game-based learning activity carried out annually since 2012. During these years around 10,000 students of secondary school (fourth year of the Compulsory Secondary Education and the first year of Bachillerato) have attended Geogymkhana-Alicante. It consists of a 2 km-long walking trip that combines direct explanations and outdoor skill and ingenuity games. In this paper, we analyse seven of the game-based learning activities of Geogymkhana-Alicante: the geological time race, the human stratigraphic superposition, geological Pictionary, find fossils, the geomorphological geoselfie, geomimic, and geological history: Final Enigma. Each year, these games achieved their main goal: to bring geology to students and teachers in an attractive way using field activities as main resource. We performed a quantitative survey to students and teachers. This survey showed a positive approval of the game-based learning field activities, and their suitability to better understand geological concepts. Despite its extracurricular nature, the activity helps to achieve several objectives of the official curriculum, as it favours the understanding of geological concepts, the knowledge of local geology, teamwork, active participation, and motivation for Geology and Science in a broad way

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019 : A systematic analysis for the Global Burden of Disease Study 2019

Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. Methods Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (≥65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0–100 based on the 2·5th and 97·5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UHC effective coverage performance on the basis of pooled health spending per capita, representing UHC effective coverage index levels achieved in 2019 relative to country-level government health spending, prepaid private expenditures, and development assistance for health. To assess current trajectories towards the GPW13 UHC billion target—1 billion more people benefiting from UHC by 2023—we estimated additional population equivalents with UHC effective coverage from 2018 to 2023. Findings Globally, performance on the UHC effective coverage index improved from 45·8 (95% uncertainty interval 44·2–47·5) in 1990 to 60·3 (58·7–61·9) in 2019, yet country-level UHC effective coverage in 2019 still spanned from 95 or higher in Japan and Iceland to lower than 25 in Somalia and the Central African Republic. Since 2010, sub-Saharan Africa showed accelerated gains on the UHC effective coverage index (at an average increase of 2·6% [1·9–3·3] per year up to 2019); by contrast, most other GBD super-regions had slowed rates of progress in 2010–2019 relative to 1990–2010. Many countries showed lagging performance on effective coverage indicators for non-communicable diseases relative to those for communicable diseases and maternal and child health, despite non-communicable diseases accounting for a greater proportion of potential health gains in 2019, suggesting that many health systems are not keeping pace with the rising non-communicable disease burden and associated population health needs. In 2019, the UHC effective coverage index was associated with pooled health spending per capita (r=0·79), although countries across the development spectrum had much lower UHC effective coverage than is potentially achievable relative to their health spending. Under maximum efficiency of translating health spending into UHC effective coverage performance, countries would need to reach $1398 pooled health spending per capita (US$ adjusted for purchasing power parity) in order to achieve 80 on the UHC effective coverage index. From 2018 to 2023, an estimated 388·9 million (358·6–421·3) more population equivalents would have UHC effective coverage, falling well short of the GPW13 target of 1 billion more people benefiting from UHC during this time. Current projections point to an estimated 3·1 billion (3·0–3·2) population equivalents still lacking UHC effective coverage in 2023, with nearly a third (968·1 million [903·5–1040·3]) residing in south Asia. Interpretation The present study demonstrates the utility of measuring effective coverage and its role in supporting improved health outcomes for all people—the ultimate goal of UHC and its achievement. Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. Focusing on effective coverage and accounting for the world's evolving health needs lays the groundwork for better understanding how close—or how far—all populations are in benefiting from UHC