Developpement durable, management ecologique et ethique d’entreprise : Un diagnostic organisationnel des entreprises Algeriennes

Dans un monde où les changements s'accélèrent, où la pression sur les résultats et la responsabilité éthique  s'accentue, les entreprises sont de plus en plus nombreuses à choisir le chemin du Développement Durable. Les entreprises en avance dans le domaine de la protection de l'environnement et dans le respect des normes  sociales se démarquent par rapport aux autres entreprises, ce qui devrait leur assurer un avantage  concurrentiel notamment en leur facilitant l'obtention de contrats ou en leur assurant de meilleures parts de marché. Devant cette obligation d’éthique et de développement durable, où se situent les entreprises   algériennes? Quel constat peuton faire sur les perceptions et les engagements de nos entreprises dans ce sens? Et enfin, quels éclairages apporter sur  d’éventuelles actions de mise en oeuvre?MOTS CLES: Développement durable – Éthique – Gouvernance- Diagnostic organisationnel- Entreprise algérienne

A novel approach to modeling and flooding in ad-hoc wireless networks

This study proposes a new modeling approach for wireless ad-hoc networks. The new approach is based on the construction of fuzzy neighborhoods and essentially consists of assigning a membership or importance degree to each network radio link which reflects the relative quality of this link. This approach is first used to model the flooding problem and then an algorithm is proposed to solve this problem which is of a great importance in ad-hoc wireless networks intrinsically subject to a certain level of node mobility. Simulations carried out in a dynamic environment show promising results and stability compared to the enhanced dominant pruning algorithm. Such an approach is suitable to take into account the volatile aspect of radio links and the physical layer uncertainty when modeling these networks, particularly when the physical layer offers no or insufficient guaranties to high-level protocols as for the flooding

Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6

Although coculture of hematopoietic stem cells (HSCs) with stromal cells is a useful system to study hematopoiesis in the niche, little is known regarding the precise cellular and molecular mechanisms of maintaining HSCs through cell–cell interactions. The murine preadipose stromal cell line MC3T3-G2/PA6 (PA6) has been demonstrated to support HSCs in vitro. In this study, microarray analysis was performed on PA6 cells and HSC-nonsupporting PA6 subclone cells to identify genes responsible for supporting HSC activity. Comparison of gene expression profiles revealed that only 144 genes were down-regulated by more than twofold in PA6 subclone cells. Of these down-regulated genes, we selected 11 candidate genes and evaluated for the maintenance of HSC function by overexpressing these genes in PA6 subclone cells. One unknown gene, 1110007F12Rik (also named as Tmem140), which is predicted to encode an integral membrane protein, demonstrated a partial restoration of the defect in HSC-supporting activity

The HOXB4 Homeoprotein Promotes the Ex Vivo Enrichment of Functional Human Embryonic Stem Cell-Derived NK Cells

Human embryonic stem cells (hESCs) can be induced to differentiate into blood cells using either co-culture with stromal cells or following human embryoid bodies (hEBs) formation. It is now well established that the HOXB4 homeoprotein promotes the expansion of human adult hematopoietic stem cells (HSCs) but also myeloid and lymphoid progenitors. However, the role of HOXB4 in the development of hematopoietic cells from hESCs and particularly in the generation of hESC-derived NK-progenitor cells remains elusive. Based on the ability of HOXB4 to passively enter hematopoietic cells in a system that comprises a co-culture with the MS-5/SP-HOXB4 stromal cells, we provide evidence that HOXB4 delivery promotes the enrichment of hEB-derived precursors that could differentiate into fully mature and functional NK. These hEB-derived NK cells enriched by HOXB4 were characterized according to their CMH class I receptor expression, their cytotoxic arsenal, their expression of IFNγ and CD107a after stimulation and their lytic activity. Furthermore our study provides new insights into the gene expression profile of hEB-derived cells exposed to HOXB4 and shows the emergence of CD34+CD45RA+ precursors from hEBs indicating the lymphoid specification of hESC-derived hematopoietic precursors. Altogether, our results outline the effects of HOXB4 in combination with stromal cells in the development of NK cells from hESCs and suggest the potential use of HOXB4 protein for NK-cell enrichment from pluripotent stem cells

Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested

Prostate cancer stem cells and nanotechnology: a focus on Wnt signaling

Prostate cancer is the most common cancer among men worldwide. However, current treatments for prostate cancer patients in advanced stage often fail because of relapse. Prostate cancer stem cells (PCSCs) are resistant to most standard therapies, and are considered to be a major mechanism of cancer metastasis and recurrence. In this review, we summarized current understanding of PCSCs and their self-renewal signaling pathways with a specific focus on Wnt signaling. Although multiple Wnt inhibitors have been developed to target PCSCs, their application is still limited by inefficient delivery and toxicity in vivo. Recently, nanotechnology has opened a new avenue for cancer drug delivery, which significantly increases specificity and reduces toxicity. These nanotechnology-based drug delivery methods showed great potential in targeting PCSCs. Here, we summarized current advancement of nanotechnology-based therapeutic strategies for targeting PCSCs and highlighted the challenges and perspectives in designing future therapies to eliminate PCSCs

Structure and dynamics of the interface between interlacing flux tubes observed at the Earth's magnetopause by MMS mission

La reconnexion magnétique est un processus omniprésent et fondamental dans la physique des plasmas spatiaux. La "Magnetospheric multiscale mission" (MMS) de la NASA, lancée le 12 mars 2015, a été conçue pour fournir des mesures in-situ permettant d'analyser le processus de reconnexion dans la magnétosphère terrestre. Dans ce but, quatre satellites identiquement instrumentés mesurent les champs électromagnétiques et les particules chargées dans les régions de reconnexion, avec une résolution temporelle cent fois meilleure que celle des missions précédentes. MMS permet, pour la première fois, d'étudier les structures microscopiques associées à la reconnexion magnétique et, en particulier, la région de diffusion électronique. Au niveau de la magnétopause terrestre, la reconnexion magnétique a un rôle chef dans le transport de l'énergie du vent solaire vers la magnétosphère terrestre, en convertissant l'énergie magnétique en énergie cinétique et thermique. Les événements à transfert de flux (FTEs) sont considérés comme l'un des produits principaux et les plus typiques de la reconnexion magnétique à la magnétopause terrestre. Cependant, des structures magnétiques 3D plus complexes, avec des signatures similaires à celles des FTEs, peuvent également exister à la magnétopause. On retrouve, par exemple, des tubes de flux entrelacés qui résultent de reconnexions magnétiques ayant eues lieu à des sites différents. La première partie de cette thèse étudie l'un de ces événements, qui a été observé dans des conditions de vent solaire inhabituelles, au voisinage de la magnétopause terrestre par MMS. Malgré des signatures qui, à première vue, semblaient cohérentes avec un FTE classique, cet événement a été interprété comme étant le résultat de l'interaction de deux tubes de flux avec des connectivités magnétiques différentes. La haute résolution temporelle des données MMS a permis d'étudier en détail une fine couche de courant observée à l'interface entre les deux tubes de flux. La couche de courant était associée à un jet d'ions, suggérant ainsi que la couche de courant était soumise à une compression qui a entraîné une reconnexion magnétique à l'origine du jet d'ions. La direction, la vitesse de propagation et la taille de différentes structures ont été déduites en utilisant des techniques d'analyse de données de plusieurs satellites. La deuxième partie de la thèse fournit une étude complémentaire à la précédente et s'intéresse aux ondes observées autour de la couche de courant.Magnetic reconnection is a ubiquitous and fundamental process in space plasma physics. The NASA's Magnetospheric Multiscale mission (MMS) launched on 12 March 2015 was designed to provide in-situ measurements for analyzing the reconnection process at the Earth's magnetosphere. In this aim, four identically instrumented spacecraft measure fields and particles in the reconnection regions with a time resolution which is one hundred times faster than previous missions. MMS allows for the first time to study the microscopic structures associated with magnetic reconnection and, in particular, the thin electron diffusion region. At the Earth's magnetopause, magnetic reconnection governs the transport of energy and momentum from the solar wind plasma into the Earth's magnetosphere through conversion of magnetic energy into kinetic and thermal energies after a rearrangement of magnetic field lines. Flux Transfer Events (FTEs) are considered to be one of the main and most typical products of magnetic reconnection at the Earth's magnetopause. However, more complex 3D magnetic structures with signatures akin to those of FTEs might also occur at the magnetopause like interlaced flux tubes resulting from magnetic reconnection at multiple sites. The first part of the work presented in this thesis consisted of the investigation of one of these events that was observed, under unusual and extreme solar wind conditions, in the vicinity of the Earth's magnetopause by MMS. Despite signatures that, at first glance, appeared consistent with a classic FTE, this event was interpreted to be the result of the interaction of two separate sets of magnetic field lines with different connectivities. The high time resolution of MMS data allowed to resolve a thin current sheet that was observed at the interface between the two sets of field lines. The current sheet was associated with a large ion jet suggesting that the current sheet was submitted to a compression which drove magnetic reconnection and led to the formation of the ion jet. The direction, velocity and scale of different structures were inferred using multi-spacecraft data analysis techniques. This study was completed with a plasma wave analysis that focused on the reconnecting current sheet

Adhesion de cellules macrophagiques (lignee J774). Role regulateur de la proteine kinase A et de propteine kinase C

SIGLEINIST TD 19466 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Problèmes de la modélisation et du flooding dans les réseaux mobiles ad-hoc

Caractérisation des réseaux ad-hoc mobiles -- Modélisation des réseaux ad-hoc : application au flooding