Advanced Oropharyngeal Cancer Can Be Easily Missed During Esophagogastroduodenoscopy

The case of an elderly man with an advanced oropharyngeal cancer that was missed during esophagogastroduodenoscopy is described. He was referred for endoscopic resection of superficial esophageal squamous cell neoplasms. He died a month after referral due to an advanced oropharyngeal cancer with a metastatic lesion to the brain. Patients with esophageal squamous cell carcinoma are high risk for head and neck cancer. The pharynx is the most common site for cancer in the head and neck region. Consequently, the pharynx should be observed carefully when patients with esophageal squamous cell carcinoma undergo esophagogastroduodenoscopy

Insect-induced daidzein, formononetin and their conjugates in soybean leaves.

In response to attack by bacterial pathogens, soybean (Gylcine max) leaves accumulate isoflavone aglucones, isoflavone glucosides, and glyceollins. In contrast to pathogens, the dynamics of related insect-inducible metabolites in soybean leaves remain poorly understood. In this study, we analyzed the biochemical responses of soybean leaves to Spodoptera litura (Lepidoptera: Noctuidae) herbivory and also S. litura gut contents, which contain oral secretion elicitors. Following S. litura herbivory, soybean leaves displayed an induced accumulation of the flavone and isoflavone aglycones 4',7-dihyroxyflavone, daidzein, and formononetin, and also the isoflavone glucoside daidzin. Interestingly, foliar application of S. litura oral secretions also elicited the accumulation of isoflavone aglycones (daidzein and formononetin), isoflavone 7-O-glucosides (daidzin, ononin), and isoflavone 7-O-(6'-O-malonyl-β-glucosides) (malonyldaidzin, malonylononin). Consistent with the up-regulation of the isoflavonoid biosynthetic pathway, folair phenylalanine levels also increased following oral secretion treatment. To establish that these metabolitic changes were the result of de novo biosynthesis, we demonstrated that labeled (13C9) phenylalanine was incorporated into the isoflavone aglucones. These results are consistent with the presence of soybean defense elicitors in S. litura oral secretions. We demonstrate that isoflavone aglycones and isoflavone conjugates are induced in soybean leaves, not only by pathogens as previously demonstrated, but also by foliar insect herbivory

A Fluid-Dynamical Subgrid Scale Model for Highly Compressible Astrophysical Turbulence

We formulate and implement the Euler equations with SGS dynamics and provide numerical tests of an SGS turbulence energy model that predicts the turbulent pressure of unresolved velocity fluctuations and the rate of dissipation for highly compressible turbulence. We test closures for the turbulence energy cascade by filtering data from high-resolution simulations of forced isothermal and adiabatic turbulence. Optimal properties and an excellent correlation are found for a linear combination of the eddy-viscosity closure that is employed in LES of weakly compressible turbulence and a term that is non-linear in the Jacobian matrix of the velocity. Using this mixed closure, the SGS turbulence energy model is validated in LES of turbulence with stochastic forcing. It is found that the SGS model satisfies several important requirements: 1. The mean SGS turbulence energy follows a power law for varying grid scale. 2. The root mean square (RMS) Mach number of the unresolved velocity fluctuations is proportional to the RMS Mach number of the resolved turbulence, independent of the forcing. 3. The rate of dissipation and the turbulence energy flux are constant. Moreover, we discuss difficulties with direct estimates of the turbulent pressure and the dissipation rate on the basis of resolved flow quantities that have recently been proposed. In combination with the energy injection by stellar feedback and other unresolved processes, the proposed SGS model is applicable to a variety of problems in computational astrophysics. Computing the SGS turbulence energy, the treatment of star formation and stellar feedback in galaxy simulations can be improved. Further, we expect that the turbulent pressure on the grid scale affects the stability of gas against gravitational collapse.Comment: 19 pages, 16 figures, submitted to A&

Refined Holographic Entanglement Entropy for the AdS Solitons and AdS black Holes

We consider the refinement of the holographic entanglement entropy for the holographic dual theories to the AdS solitons and AdS black holes, including the corrected ones by the Gauss-Bonnet term. The refinement is obtained by extracting the UV-independent piece of the holographic entanglement entropy, the so-called renormalized entanglement entropy which is independent of the choices of UV cutoff. Our main results are (i) the renormalized entanglement entropies of the AdS$_{d+1}$ soliton for $d=4,5$ are neither monotonically decreasing along the RG flow nor positive definite, especially around the deconfinement/confinement phase transition; (ii) there is no topological entanglement entropy for AdS$_5$ soliton even with Gauss-Bonnet correction; (iii) for the AdS black holes, the renormalized entanglement entropy obeys an expected volume law at IR regime, and the transition between UV and IR regimes is a smooth crossover even with Gauss-Bonnet correction; (iv) based on AdS/MERA conjecture, we postulate that the IR fixed-point state for the non-extremal AdS soliton is a trivial product state.Comment: 48 pages, 24 figures; v2: few typos corrected; v3: mistake on the choice of dominant phase is corrected, differential subtraction scheme is introduced to remove the UV cutoff-ambiguity, some of the conclusions on RG flow are changed; v4: statement about C theorem revised; v5 Final version to NP

Comprehensive investigation of areae gastricae pattern in gastric corpus using magnifying narrow band imaging endoscopy in patients with chronic atrophic fundic gastritis.

Background:  Barium radiographic studies have suggested the importance of evaluating areae gastricae pattern for the diagnosis of gastritis. Significance of endoscopic appearance of areae gastricae in the diagnosis of chronic atrophic fundic gastritis (CAFG) was investigated by image-enhanced endoscopy. Materials and Methods:  Endoscopic images of the corpus lesser curvature were studied in 50 patients with CAFG. Extent of CAFG was evaluated with autofluorescence imaging endoscopy. The areae gastricae pattern was evaluated with 0.2% indigo carmine chromoendoscopy. Micro-mucosal structure was examined with magnifying chromoendoscopy and narrow band imaging. Results:  In patients with small extent of CAFG, polygonal areae gastricae separated by a narrow intervening part of areae gastricae was observed, whereas in patients with wide extent of CAFG, the size of the areae gastricae decreased and the width of the intervening part of areae gastricae increased (p < 0.001). Most areae gastricae showed a foveola-type micro-mucosal structure (82.7%), while intervening part of areae gastricae had a groove-type structure (98.0%, p < 0.001). Groove-type mucosa had a higher grade of atrophy (p < 0.001) and intestinal metaplasia (p < 0.001) compared with foveola type. Conclusions:  As extent of CAFG widened, multifocal groove-type mucosa that had high-grade atrophy and intestinal metaplasia developed among areae gastricae and increased along the intervening part of areae gastricae. Our observations facilitate our understanding of the development and progression of CAFG

Resonant Photonic Quasicrystalline and Aperiodic Structures

We have theoretically studied propagation of exciton-polaritons in deterministic aperiodic multiple-quantum-well structures, particularly, in the Fibonacci and Thue-Morse chains. The attention is concentrated on the structures tuned to the resonant Bragg condition with two-dimensional quantum-well exciton. The superradiant or photonic-quasicrystal regimes are realized in these structures depending on the number of the wells. The developed theory based on the two-wave approximation allows one to describe analytically the exact transfer-matrix computations for transmittance and reflectance spectra in the whole frequency range except for a narrow region near the exciton resonance. In this region the optical spectra and the exciton-polariton dispersion demonstrate scaling invariance and self-similarity which can be interpreted in terms of the ``band-edge'' cycle of the trace map, in the case of Fibonacci structures, and in terms of zero reflection frequencies, in the case of Thue-Morse structures.Comment: 13 pages, 9 figures, submitted to Phys. Rev.

Entanglement Entropy from a Holographic Viewpoint

The entanglement entropy has been historically studied by many authors in order to obtain quantum mechanical interpretations of the gravitational entropy. The discovery of AdS/CFT correspondence leads to the idea of holographic entanglement entropy, which is a clear solution to this important problem in gravity. In this article, we would like to give a quick survey of recent progresses on the holographic entanglement entropy. We focus on its gravitational aspects, so that it is comprehensible to those who are familiar with general relativity and basics of quantum field theory.Comment: Latex, 30 pages, invited review for Classical and Quantum Gravity, minor correction