21 research outputs found
Climate effects and stature since 1800
During the last 30 years, economic and social historians have collected and analysed large amounts of anthropometric data in order to explore key aspects of the human past. Attention has also been devoted to the examination of factors that can exert an influence on stature. This article outlines the different ways in which climate might influence stature, either directly or indirectly. It then uses Geographical Information System (GIS) software to explore the relationship between variations in temperature and precipitation and the average heights of men in France, India, Mexico, Spain and the United States (US) over the last two centuries. It is possible to observe an influence of climate on stature in some countries, especially during the nineteenth century, but the relationship weakens across time and largely disappears in recent decades. The attenuation of this relationship is attributed to a process of “technophysio evolution” as countries modernised and developed economically
A Moving Boundary Flux Stabilization Method for Cartesian Cut-Cell Grids using Directional Operator Splitting
An explicit moving boundary method for the numerical solution of
time-dependent hyperbolic conservation laws on grids produced by the
intersection of complex geometries with a regular Cartesian grid is presented.
As it employs directional operator splitting, implementation of the scheme is
rather straightforward. Extending the method for static walls from Klein et
al., Phil. Trans. Roy. Soc., A367, no. 1907, 4559-4575 (2009), the scheme
calculates fluxes needed for a conservative update of the near-wall cut-cells
as linear combinations of standard fluxes from a one-dimensional extended
stencil. Here the standard fluxes are those obtained without regard to the
small sub-cell problem, and the linear combination weights involve detailed
information regarding the cut-cell geometry. This linear combination of
standard fluxes stabilizes the updates such that the time-step yielding
marginal stability for arbitrarily small cut-cells is of the same order as that
for regular cells. Moreover, it renders the approach compatible with a wide
range of existing numerical flux-approximation methods. The scheme is extended
here to time dependent rigid boundaries by reformulating the linear combination
weights of the stabilizing flux stencil to account for the time dependence of
cut-cell volume and interface area fractions. The two-dimensional tests
discussed include advection in a channel oriented at an oblique angle to the
Cartesian computational mesh, cylinders with circular and triangular
cross-section passing through a stationary shock wave, a piston moving through
an open-ended shock tube, and the flow around an oscillating NACA 0012 aerofoil
profile.Comment: 30 pages, 27 figures, 3 table
Concert recording 2022-10-12
[Track 1]. Sonata for four trombones / Georg Daniel Speer -- [Track 2]. Scarborough fair / traditional ; arr. Bill Reichenbach -- [Track 3]. Quartet for trombones / Leslie Bassett -- [Track 4]. You made me love you / James Monaco ; arr. Bill Holcombe -- [Track 5]. Fanfare for 8 trombones / Michael P. Terry -- [Track 6]. Andante cantabile from Symphony no. 5, Mtv. II / Pyort IIlich Tchaikovsky ; arr. Nolan Miller -- [Track 7]. Rising tide / Jack Wilds
Concert recording 2022-10-12
[Track 1]. Sonata for four trombones / Georg Daniel Speer -- [Track 2]. Scarborough fair / traditional ; arr. Bill Reichenbach -- [Track 3]. Quartet for trombones / Leslie Bassett -- [Track 4]. You made me love you / James Monaco ; arr. Bill Holcombe -- [Track 5]. Fanfare for 8 trombones / Michael P. Terry -- [Track 6]. Andante cantabile from Symphony no. 5, Mtv. II / Pyort IIlich Tchaikovsky ; arr. Nolan Miller -- [Track 7]. Rising tide / Jack Wilds
A Community-Based Pancreatic Cancer Screening Study in High-Risk Individuals: Preliminary Efficacy and Safety Results
IntroductionPancreatic cancer (PC) screening recommendations have been based on studies performed solely at high-volume academic centers. To make PC screening more widely available, community-based efforts are essential. We implemented a prospective PC screening study in the community of Fairfield County, CT, and report our early safety and efficacy results.MethodsEligible individuals were enrolled into an investigator-initiated study and underwent a baseline and 3 annual magnetic resonance imagings/magnetic resonance cholangiopancreatographies (MRIs/MRCPs) with gadolinium, biannual blood donations for biobanking, and assessments for anxiety and depression. All MRIs were presented at a multidisciplinary board to determine whether further investigation was warranted.ResultsSeventy-five individuals have been enrolled and 201 MRIs performed over a 2.6-year average length of follow-up. Abnormal pancreatic findings (predominantly small cysts) were detected in 58.7% of the participants. Among these, 6.7% underwent endoscopic ultrasound, with 1 case complicated by postprocedural pancreatitis. One surgical resection was performed on a 4.7-cm intraductal papillary mucinous neoplasm with a focus on low-grade pancreatic intraepithelial neoplasia. One incidental finding of fibrosing mediastinitis was detected. Anxiety and depression scores decreased over the course of this study from 21.4% to 5.4% and 10.7% to 3.6%, respectively.DiscussionThis preliminary report supports the feasibility of performing MRI/magnetic resonance cholangiopancreatographies-based PC screening as part of a clinical trial in a community setting. A longer follow-up is needed to better assess safety and efficacy. To the best of our knowledge, this is the first report from a community-based PC screening effort ( clinicaltrials.gov ID: NCT03250078)
Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial
Expanded access to combination antiretroviral therapy (ART) in the resource-poor setting is dependent on “task-shifting” from doctors to other health care providers. We compared “doctor-initiated-nurse-monitored” care to the current standard of care, “doctor-initiated-doctor-monitored” ART