The Influence of Religiosity, Zakat Literacy and Trust on Muzakki's Interest in Paying Professional Zakat at Baznas Jakarta Province

This study aims to understand the factors that influence individual interest as muzakki in paying professional zakat through BAZNAS Jakarta Province. The method used is a field study with a quantitative approach. The sample consisted of 97 muzakki who had or had never paid zakat through BAZNAS Jakarta Province. Primary data were collected through questionnaires distributed to respondents. Regression analysis shows that zakat literacy and belief have a positive and significant influence on individual interest as muzakki to pay professional zakat to BAZNAS Jakarta Province, while religiosity has no effect on muzakki interest in paying professional zakat at BAZNAS Jakarta province

Analisis Persepsi Anggota Terhadap Hukum Pembiayaan Murābahah Di Bmt Amanah Ummah Sukoharjo

ABSTRACT The problem studied in this research is the analysis of members' perception of murābahah financing law in BMT Amanah Ummah Sukoharjo. Thus, the purpose of this study was to find out how the BMT Amanah Ummah members' perception of murābahah financing law in BMT Amanah Ummah. To achieve that goal, the researcher uses field research with the method of collecting data by interview, documentation, and observation. The data that the source is BMT Amanah Ummah. The data analysis is done by using qualitative descriptive method that describes and analyzes the issues raised. From the research that has been done the following results are obtained, that the member's perception of murābahah financing law on BMT Amanah Ummah Sukoharjo states murābahah financing conducted by BMT Amanah Ummah Sukoharjo already in accordance with Islamic Law. This can be seen in the filing procedure when members begin to apply for financing until receipt of financing. Keywords: Murābahah, BMT, Perceptions, Member

Agama dan relasi sosial : konstruksi santri tentang multikulturalisme dan relevansinya terhadap model pembelajaran agama berwawasan kebangsaan dalam tradisi pesantren di Yogyakarta

Penelitian ini bertujuan untuk mengungkapkan konstruksi para santri tentang multikulturalisme di Indonesia yang dihubungkan dengan pemahaman ideologi keagamaan mereka. Penelitian ini menggunakan metode penelitian deskriptif-analitif yang berupaya untuk mengungkapkan berbagai konstruksi santri dalam memahami multikulturalisme. Dari hasil paparan konstruksi para santri mengenai multikulturalisme tersebut penelitian ini bermaksud menemukan model pembelajaran agama yang dikembangkan di lingkungan pesantren yang mengedepankan semangat multikulturalisme. Penelitian deskriptif ini dilakukan dengan wawancara mendalam kepada santri dan pengelola pesantren di Yogyakarta tentang realitas multikultural di Indonesia. Para santri yang dijadikan sebagai informan penelitian adalah santri di lingkungan pesantren yang berafiliasi pada organisasi massa Nahdlatul Ulama. Hasil penelitian menunjukkan bahwa pemahaman para santri tentang keberagaman di Indonesia sangat erat kaitannya dengan pemahaman keagamaan yang dimilikinya. Pesantren-pesantren NU di Yogyakarta yang menjadi obyek penelitian ini menunjukkan sikap terbuka dalam menerima keberagaman. Para santri di pesantren-pesantren itu memiliki pandangan bahwa multikulturalisme merupakan keniscayaan dalam masyarakat yang harus diterima dengan segala konsekuensinya. Keragaman agama dan budaya adalah fakta sosial yang tidak bisa ditolak kehadirannya. Itulah sebabnya, pemahaman keagamaan yang menurut mereka perlu dikembangkan adalah yang menghargai keragaman dan keterbukaan menerima perbedaan tersebut. Lingkungan Yogyakarta dengan Kasultanan sebagai perekat tradisi Jawa dianggap para santri memberikan pengaruh kepada sikap dan perilaku keberagamaan mereka. Di Yogyakarta relasi sosial dibarigun secara dinamis dengfm kekuatan tradisi sebagai media perekat sosial antar agama. Pengungkapan atas konstruksi multikulturalisme tersebut menjadi titik pijak dirumuskannya model pembelajaran agama bewawasan kebangsaaan

De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development

Bosma arhinia microphthalmia syndrome (BAMS) is an extremely rare and striking condition characterized by complete absence of the nose with or without ocular defects. We report here that missense mutations in the epigenetic regulator SMCHD1 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied. All mutations were de novo where parental DNA was available. Biochemical tests and in vivo assays in Xenopus laevis embryos suggest that these mutations may behave as gain-of-function alleles. This finding is in contrast to the loss-of-function mutations in SMCHD1 that have been associated with facioscapulohumeral muscular dystrophy (FSHD) type 2. Our results establish SMCHD1 as a key player in nasal development and provide biochemical insight into its enzymatic function that may be exploited for development of therapeutics for FSHD

Dietary tuna hydrolysate modulates growth performance, immune response, intestinal morphology and resistance to Streptococcus iniae in juvenile barramundi, Lates calcarifer

This study investigated the effects of tuna hydrolysate (TH) inclusion in fishmeal (FM) based diets on the growth performance, innate immune response, intestinal health and resistance to Streptococcus iniae infection in juvenile barramundi, Lates calcarifer. Five isonitrogenous and isoenergetic experimental diets were prepared with TH, replacing FM at levels of 0% (control) 5%, 10%, 15% and 20%, and fed fish to apparent satiation three times daily for 8 weeks. The results showed that fish fed diets containing 5% and 10% TH had significantly higher final body weight and specific growth rate than the control. A significant reduction in blood glucose was found in fish fed 10%, 15% and 20% TH compared to those in the control whereas none of the other measured blood and serum indices were influenced by TH inclusion. Histological observation revealed a significant enhancement in goblet cell numbers in distal intestine of fish fed 5 to 10% TH in the diet. Moreover, fish fed 10% TH exhibited the highest resistance against Streptococcus iniae infection during a bacterial challenge trial. These findings therefore demonstrate that the replacement of 5 to 10% FM with TH improves growth, immune response, intestinal health and disease resistance in juvenile barramundi

Mitragynine Attenuates Withdrawal Syndrome in Morphine-Withdrawn Zebrafish

A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to mitigate the harshness of drug withdrawal. A series of experiments was conducted to investigate the effect of mitragynine on anxiety behavior, cortisol level and expression of stress pathway related genes in zebrafish undergoing morphine withdrawal phase. Adult zebrafish were subjected to two weeks chronic morphine exposure at 1.5 mg/L, followed by withdrawal for 24 hours prior to tests. Using the novel tank diving tests, we first showed that morphine-withdrawn zebrafish display anxiety-related swimming behaviors such as decreased exploratory behavior and increased erratic movement. Morphine withdrawal also elevated whole-body cortisol levels, which confirms the phenotypic stress-like behaviors. Exposing morphine-withdrawn fish to mitragynine however attenuates majority of the stress-related swimming behaviors and concomitantly lower whole-body cortisol level. Using real-time PCR gene expression analysis, we also showed that mitragynine reduces the mRNA expression of corticotropin releasing factor receptors and prodynorphin in zebrafish brain during morphine withdrawal phase, revealing for the first time a possible link between mitragynine's ability to attenuate anxiety during opiate withdrawal with the stress-related corticotropin pathway

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

publishersversionPeer reviewe

Linear and Branched Glyco-Lipopeptide Vaccines Follow Distinct Cross-Presentation Pathways and Generate Different Magnitudes of Antitumor Immunity

Glyco-lipopeptides, a form of lipid-tailed glyco-peptide, are currently under intense investigation as B- and T-cell based vaccine immunotherapy for many cancers. However, the cellular and molecular mechanisms of glyco-lipopeptides (GLPs) immunogenicity and the position of the lipid moiety on immunogenicity and protective efficacy of GLPs remain to be determined.We have constructed two structural analogues of HER-2 glyco-lipopeptide (HER-GLP) by synthesizing a chimeric peptide made of one universal CD4(+) epitope (PADRE) and one HER-2 CD8(+) T-cell epitope (HER(420-429)). The C-terminal end of the resulting CD4-CD8 chimeric peptide was coupled to a tumor carbohydrate B-cell epitope, based on a regioselectively addressable functionalized templates (RAFT), made of four alpha-GalNAc molecules. The resulting HER glyco-peptide (HER-GP) was then linked to a palmitic acid moiety, attached either at the N-terminal end (linear HER-GLP-1) or in the middle between the CD4+ and CD8+ T cell epitopes (branched HER-GLP-2). We have investigated the uptake, processing and cross-presentation pathways of the two HER-GLP vaccine constructs, and assessed whether the position of linkage of the lipid moiety would affect the B- and T-cell immunogenicity and protective efficacy. Immunization of mice revealed that the linear HER-GLP-1 induced a stronger and longer lasting HER(420-429)-specific IFN-gamma producing CD8(+) T cell response, while the branched HER-GLP-2 induced a stronger tumor-specific IgG response. The linear HER-GLP-1 was taken up easily by dendritic cells (DCs), induced stronger DCs maturation and produced a potent TLR- 2-dependent T-cell activation. The linear and branched HER-GLP molecules appeared to follow two different cross-presentation pathways. While regression of established tumors was induced by both linear HER-GLP-1 and branched HER-GLP-2, the inhibition of tumor growth was significantly higher in HER-GLP-1 immunized mice (p<0.005).These findings have important implications for the development of effective GLP based immunotherapeutic strategies against cancers