Atlases of globally-predicted small molecule data. 1: Internuclear separation

A table of globally-predicted data of internuclear separation is presented, the first of a series on molecular properties. This paper explores a novel frequency compensation of neural network inputs and a new measure of the asymmetry in the globally-predicted data

An Atlas of Forecasted Molecular Data. 1. Internuclear Separations of Main-Group and Transition-Metal Neutral Gas-Phase Diatomic Molecules in the Ground State

Needed spectroscopic data on diatomic molecules can often be found in the superb critical tables of Huber and Herzberg or in the literature published since 1979. Unfortunately, these sources apply to only a fraction of the diatomic species that can exist and so investigators have had to rely on interpolation, additivity, or ad hoc rules to estimate needed values, all of which require other information that is often lacking. This Atlas presents 1001 additional internuclear separations for use until critical tables are available to fill the needs more precisely. The Atlas was produced by mining the data from Huber and Herzberg for trends with least-squares analysis and with neural network software. There are 162 molecules about whose data Huber and Herzberg had no qualifications and whose data were employed for this work; 248 copies of data with low and high magnitudes were added to reduce the effects of frequency. Internuclear separations for 1001 species not found in Huber and Herzberg are presented, and least-squares predictions supplement some of them. The results, i.e., the Atlas, are presented as Table A, Supporting Information. The average error, based on the average of the absolute differences between the predicted values and tabulated values for the molecules having Huber and Herzberg data, is 0.074 Å; if each error is expressed as a percent of the forecast to which it pertains, the average of these errors is 2.94%. There are 25 “questionable” data from Huber and Herzberg, not used in the preparation of the Atlas, for which predictions are included in the Atlas. Of these, 14 agree with the predicted internuclear separations to within twice the stated errors. Additional atlases for other properties of diatomic molecules are in preparation

The State-Moro Armed Conflict in the Philippines: Unresolved national question or question of governance?

The continuing struggle of the Moro secessionist movement in the Philippines is one of Southeast Asia’s longest armed conflicts. The tenacity of the conflict lies in two competing concerns: the assertion of self-determination rights of the Moro separatist movement; and the affirmation of the Philippines’ sovereign right to territorial integrity. However, beneath these rights are crucial issues that remain unanswered both by the contending forces—problems where internecine violence and conflict emanate from. This article argues that self-determination rights can be adequately exercised by people who have clearly defined their national identity and concept of a nation. Unfortunately, the Moro multi-ethnic national identity has yet to be crystallised while the idea of a Bangsamoro (Bangsa Nation) remains weak. On the other hand, the state has yet to address the Moros’ legitimate demands of political autonomy, socio-economic development, and social justice and discrimination. Without underestimating the ethnic component of secessionism, the article concludes that poor governance has prolonged, complicated, and further justified the Moros’ quest to secede from the Republic

Eisosome proteins assemble into a membrane scaffold

Membrane organization by eisosomes is mediated by self-assembly of its main components into a membrane-bound protein scaffold with lipid-binding specificity

Genotype-Phenotype Correlations in Charcot-Marie-Tooth Disease Due to MTMR2 Mutations and Implications in Membrane Trafficking

Charcot-Marie-Tooth type 4 (CMT4) is an autosomal recessive severe form of neuropathy with genetic heterogeneity. CMT4B1 is caused by mutations in the myotubularin-related 2 (MTMR2) gene and as a member of the myotubularin family, the MTMR2 protein is crucial for the modulation of membrane trafficking. To enable future clinical trials, we performed a detailed review of the published cases with MTMR2 mutations and describe four novel cases identified through whole-exome sequencing (WES). The four unrelated families harbor novel homozygous mutations in MTMR2 (NM_016156, Family 1: c.1490dupC; p.Phe498IlefsTer2; Family 2: c.1479+1G>A; Family 3: c.1090C>T; p.Arg364Ter; Family 4: c.883C>T; p.Arg295Ter) and present with CMT4B1-related severe early-onset motor and sensory neuropathy, generalized muscle atrophy, facial and bulbar weakness, and pes cavus deformity. The clinical description of the new mutations reported here overlap with previously reported CMT4B1 phenotypes caused by mutations in the phosphatase domain of MTMR2, suggesting that nonsense MTMR2 mutations, which are predicted to result in loss or disruption of the phosphatase domain, are associated with a severe phenotype and loss of independent ambulation by the early twenties. Whereas the few reported missense mutations and also those truncating mutations occurring at the C-terminus after the phosphatase domain cause a rather mild phenotype and patients were still ambulatory above the age 30 years. Charcot-Marie-Tooth neuropathy and Centronuclear Myopathy causing mutations have been shown to occur in proteins involved in membrane remodeling and trafficking pathway mediated by phosphoinositides. Earlier studies have showing the rescue of MTM1 myopathy by MTMR2 overexpression, emphasize the importance of maintaining the phosphoinositides equilibrium and highlight a potential compensatory mechanism amongst members of this pathway. This proved that the regulation of expression of these proteins involved in the membrane remodeling pathway may compensate each other's loss- or gain-of-function mutations by restoring the phosphoinositides equilibrium. This provides a potential therapeutic strategy for neuromuscular diseases resulting from mutations in the membrane remodeling pathway

Membrane curvature in cell biology: An integration of molecular mechanisms.

Curving biological membranes establishes the complex architecture of the cell and mediates membrane traffic to control flux through subcellular compartments. Common molecular mechanisms for bending membranes are evident in different cell biological contexts across eukaryotic phyla. These mechanisms can be intrinsic to the membrane bilayer (either the lipid or protein components) or can be brought about by extrinsic factors, including the cytoskeleton. Here, we review examples of membrane curvature generation in animals, fungi, and plants. We showcase the molecular mechanisms involved and how they collaborate and go on to highlight contexts of curvature that are exciting areas of future research. Lessons from how membranes are bent in yeast and mammals give hints as to the molecular mechanisms we expect to see used by plants and protists

The afterlife of colonial radio in Christian missionary broadcasting of the Philippines

The article explores Christian missionary radio broadcasting as part of a wider sonic colonization of the Philippines under US colonial rule. Specifically, I explore how some post-Second World War faith-based broadcasters shaped the listening practices of Filipino audiences through programming tactics such as blocktiming. Furthermore, I consider how missionary broadcasters cultivated direct relationships with listeners through the imagined ‘shared experiences’ of aural space. As a case study, I explore the activities of the US-based Far East Broadcasting Company (FEBC), which began its operations in the Philippines in 1948. Since then, the organization has used the country as a hub for its expanding domestic and international radio network, which now includes broadcasts to South East Asia, China and other parts of the world. In addition to exploring how FEBC’s localized approach to programming has cultivated specific listening audiences, I explore how programmes have been received by listeners in the Philippines, many of whom continue to tune in via terrestrial radio

Integration of Synaptic Vesicle Cargo Retrieval with Endocytosis at Central Nerve Terminals

Central nerve terminals contain a limited number of synaptic vesicles (SVs) which mediate the essential process of neurotransmitter release during their activity-dependent fusion. The rapid and accurate formation of new SVs with the appropriate cargo is essential to maintain neurotransmission in mammalian brain. Generating SVs containing the correct SV cargo with the appropriate stoichiometry is a significant challenge, especially when multiple modes of endocytosis exist in central nerve terminals, which occur at different locations within the nerve terminals. These endocytosis modes include ultrafast endocytosis, clathrin-mediated endocytosis (CME) and activity-dependent bulk endocytosis (ADBE) which are triggered by specific patterns of neuronal activity. This review article will assess the evidence for the role of classical adaptor protein complexes in SV retrieval, discuss the role of monomeric adaptors and how interactions between specific SV cargoes can facilitate retrieval. In addition it will consider the evidence for preassembled plasma membrane cargo complexes and their role in facilitating these endocytosis modes. Finally it will present a unifying model for cargo retrieval at the presynapse, which integrates endocytosis modes in time and space

The 'Unfinished Revolution' in Philippine Political Discourse

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