Efecto diferencial del calor en las fases del ciclo de luz-oscuridad en un modelo animal de Anorexia

[ES] Este proyecto estudia los efectos de la aplicación de calor durante las diferentes fases del ciclo de luz-oscuridad en la recuperación de treinta y seis ratas macho sometidas a ABA, considerando el impacto de este tanto en los niveles de actividad en la rueda como en el peso, la ingesta y la temperatura corporal, así como en las tasas de recuperación de la condición. Tras reducir su peso en un 20%, los animales fueron distribuidos aleatoriamente en tres condiciones experimentales: (a) recibir calor de forma continua en las dos fases del ciclo, (b) recibir calor exclusivamente en la fase de luz o (c) recibir calor exclusivamente en la fase de oscuridad. Se encontraron efectos diferenciales del calor en función de las diferentes modalidades de aplicación: en la modalidad de aplicación continua, la actividad disminuyó de forma significativa y duradera, favoreciendo la ganancia de peso y una temperatura corporal superior a la encontrada en las dos modalidades de aplicación alternante de calor. En estas, los efectos beneficiosos del calor fueron transitorios. Los resultados sugieren que la aplicación alternante de calor resulta insuficiente en la recuperación de los animales en ABA. Asimismo, las conclusiones sobre sobre los efectos beneficiosos de la aplicación continua de calor abren la puerta a su establecimiento como una herramienta útil en nuevos tratamientos para la Anorexia Nerviosa en humanos[ENG] This research builds on the studies on ambient temperature as a key influence in the recovery of rodents exposed to the Activity-Based Anorexia (ABA) model. The ABA model is an experimental paradigm in which rodents under a restricted feeding schedule and with free access to an activity wheel show signs that parallel those of Anorexia Nervosa in humans. The present study focuses on the effects of applying heat during the different phases of the dark-light cycle in the activity levels, body weight, food intake and body temperature and recovery rates of 36 male rats submitted to ABA. After reaching a 20% weight loss criterion, animals were randomly assigned to three experimental conditions: (a) continuos warming (b) warming during the light phase or (c) warming during the dark phase. Differential effects were found depending on the modalities of warming: in comparison with either light or dark warming, continuous warming significatively decreased activity, facilitated weight gain and maintained body temperature. Transient effects of warming were found both in the groups warmed during ligt and dark periods. The results suggest that both ligt and dark warming did not promote recovery in animals exposed to ABA. Evidence about the benefitial effects of continuous warming are in line with previous research and reinforces adding external heat as a useful tool in treatment of Anorexia Nervos

Scaling of conductance through quantum dots with magnetic field

Using different techniques, and Fermi-liquid relationships, we calculate the variation with the applied magnetic field (up to second order) of the zero-temperature equilibrium conductance through a quantum dot described by the impurity Anderson model. We focus on the strong-coupling limit U, where U is the Coulomb repulsion and is half the resonant-level width, and consider several values of the dot level energy E d , ranging from the Kondo regime to the intermediate-valence regime F − E d ∼ , where F is the Fermi energy. We have mainly used the density-matrix renormalization group (DMRG) and the numerical renormalization group (NRG) combined with renormalized perturbation theory (RPT). Results for the dot occupancy and magnetic susceptibility from the DMRG and NRG + RPT are compared with the corresponding Bethe ansatz results for U → ∞, showing an excellent agreement once E d is renormalized by a constant Haldane shift. For U low-energy peak in the spectral density of the dot.Fil: Hamad, Ignacio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Gazza, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Andrade Hoyos, Jhon Alejandro. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aligia, Armando Ángel. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cornaglia de la Cruz, Pablo Sebastian. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Roura Bas, Pablo Gines. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

STE-QUEST - Test of the Universality of Free Fall Using Cold Atom Interferometry

In this paper, we report about the results of the phase A mission study of the atom interferometer instrument covering the description of the main payload elements, the atomic source concept, and the systematic error sources

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Ground state of the impurity Anderson model revisited: A projector operator solution

By means of a projector operator formalism we study the ground state properties of the Anderson Impurity Hamiltonian. The non-perturbative treatment of the model agrees with the previous one, obtained by Inagaki [Prog. Theor. Phys. 62, 1441 (1979)] by means of a perturbation expansion with respect the hybridization term. We go beyond the Inagaki's formalism to the next leading order. It provides a very accurate calculation of the energy spectrum in the total spin ST=0 sector and, in particular, the ground state energy in the whole parameter space. For a one body spinless system, the dependence of the ground state energy as a function of the impurity level obtained by this procedure remarkably agrees with analytical results. For the many body case the occupancy of the impurity as a function of the parameters is studied and it agrees with the corresponding one obtained by using the Bethe ansatz and the Numerical Renormalization Group solution of the Hamiltonian. The magnetization and susceptibility of the impurity is analyzed by studying the response of the system to an external magnetic field, from which it is possible to extract the Kondo temperature. The dependence of the Kondo scale with the parameters of the model is in excellent agreement with well-known results.Fil: Roura Bas, Pablo Gines. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hamad, Ignacio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Anda, E.V.. Pontifícia Universidade Católica do Rio de Janeiro PUC-Rio. Centro de Estudos em Telecomunicaciones. Laboratorio de Semiconductores; Brasi

Air movement in the ventilated façade: analysis of cases in Barcelona, Spain

The Ventilated Façade (VF) supposes an improvement compared with a conventional façade –single layerin terms of thermal comfort, through the ventilation of the wall cavity, limited by an inner and an outer layer, usually of open joints. However, in buildings with VF the constructions characteristics in the wall cavity are often different from that considered in academic studies, performed by simulations or prototype measurements. The present work analyses the air movement in the VF wall cavity of existing buildings built in Barcelona city. In situ measurements were made in summer in 10 buildings, using a Testo405i thermal anemometer with management via a smartphone. The methodology consisted in the monitoring of the cases in periods of 30 minutes in the morning and 30 minutes in the afternoon. The data were recorded every two seconds, according to the sequence: 5 minutes outside, 20 minutes inside the wall cavity and 5 minutes outside. The extensible telescope (400mm long) of the anemometer was introduced by the open joints of the outer sheets, so that the sensor is perpendicular to the vertical air flow in the wall cavity. The results show two determining factors for the adequate performance of the air movement in the VF chamber: on the one hand, the increase in the incidence of solar radiation on the facade, and on the other hand, the increase of the entrance and exit apertures of air in the chamber. Besides, temperatures tend to increase in the wall cavity, that is to say that there are always gains of heat in the air chamber

Air movement in the ventilated façade: analysis of cases in Barcelona, Spain

The Ventilated Façade (VF) supposes an improvement compared with a conventional façade –single layerin terms of thermal comfort, through the ventilation of the wall cavity, limited by an inner and an outer layer, usually of open joints. However, in buildings with VF the constructions characteristics in the wall cavity are often different from that considered in academic studies, performed by simulations or prototype measurements. The present work analyses the air movement in the VF wall cavity of existing buildings built in Barcelona city. In situ measurements were made in summer in 10 buildings, using a Testo405i thermal anemometer with management via a smartphone. The methodology consisted in the monitoring of the cases in periods of 30 minutes in the morning and 30 minutes in the afternoon. The data were recorded every two seconds, according to the sequence: 5 minutes outside, 20 minutes inside the wall cavity and 5 minutes outside. The extensible telescope (400mm long) of the anemometer was introduced by the open joints of the outer sheets, so that the sensor is perpendicular to the vertical air flow in the wall cavity. The results show two determining factors for the adequate performance of the air movement in the VF chamber: on the one hand, the increase in the incidence of solar radiation on the facade, and on the other hand, the increase of the entrance and exit apertures of air in the chamber. Besides, temperatures tend to increase in the wall cavity, that is to say that there are always gains of heat in the air chamber.Postprint (published version

Air movement in the ventilated façade: analysis of cases in Barcelona, Spain

The Ventilated Façade (VF) supposes an improvement compared with a conventional façade –single layerin terms of thermal comfort, through the ventilation of the wall cavity, limited by an inner and an outer layer, usually of open joints. However, in buildings with VF the constructions characteristics in the wall cavity are often different from that considered in academic studies, performed by simulations or prototype measurements. The present work analyses the air movement in the VF wall cavity of existing buildings built in Barcelona city. In situ measurements were made in summer in 10 buildings, using a Testo405i thermal anemometer with management via a smartphone. The methodology consisted in the monitoring of the cases in periods of 30 minutes in the morning and 30 minutes in the afternoon. The data were recorded every two seconds, according to the sequence: 5 minutes outside, 20 minutes inside the wall cavity and 5 minutes outside. The extensible telescope (400mm long) of the anemometer was introduced by the open joints of the outer sheets, so that the sensor is perpendicular to the vertical air flow in the wall cavity. The results show two determining factors for the adequate performance of the air movement in the VF chamber: on the one hand, the increase in the incidence of solar radiation on the facade, and on the other hand, the increase of the entrance and exit apertures of air in the chamber. Besides, temperatures tend to increase in the wall cavity, that is to say that there are always gains of heat in the air chamber