NSF GRFP Information Session, Sept 7, 2022

NSF Graduate Research Fellowship Program (GRFP) Information Sessions Jason Hale, M.S., Director of Research Development, ORSP Robert Doerksen, Ph.D., Associate Dean of the Graduate School Vivian Ibrahim, Ph.D., Associate Professor of History; Director of the Office of National Scholarship Advisement UM Faculty members Nikki Reinemann-Gross (Biomedical Engineering), Rachel Greenspan (Criminal Justice and Legal Studies), Donald Dyer (Associate Dean for Faculty & Academic Affairs, College of Liberal Arts), and Claire Mischker (Writing and Rhetoric) also participated.https://egrove.olemiss.edu/research_presentations/1024/thumbnail.jp

Pharmacognostic and Phytochemical Analysis of Commelina benghalensis L.

Phytochemical and pharmacognostic analysis and thin layer chromatography were carried out on the herb, Commelina benghalensis L. The phytochemical screening revealed the presence of phlobatannins, carbohydrates, tannins, glycosides, volatile oils, resins, balsams, flavonoids and saponins, while terpenes, sterols, anthorquinones and phenols were absent. The pharmacognostic analysis revealed moisture content of 11.60 %, ash value of 6.24%, water soluble extractive value of 22.45 %, alcohol soluble extractive value of 5.99% and acid insoluble ash of 1.21%. The thin layer chromatography development revealed three spots for hexane extract, six spots for ethyl acetate and five spots for methanol

Relationship between Emotional Intelligence and Self-Efficacy with Mathematics Learning Outcomes of MAN Model 1 Manado Students

This study investigates the association between emotional intelligence and self-efficacy in relation to student learning outcomes at MAN Model 1 Manado. This type of study is correlational in nature. The population was comprised of 240 students, and the sample size was 36. The instruments utilized were self-efficacy and emotional intelligence questionnaires. The technique employed for data analysis is partial and multiple correlation analysis. (1) There is a positiveaand significant relationshippbetween emotionallintelligence and student mathematicsslearning outcomes, equaling 0.468; (2) Thereeis a positive andcsignificant relationshippbetween self-efficacy and student mathematicsslearning outcomes, equaling 0.467; and (3) There is a relationship between emotional intelligencesand self-efficacy simultaneously with students'mmathematics learninggoutcomes

Time-dependent viscometry study of endoglucanase action on xyloglucan: A real-time approach

AbstractHydrolysis of xyloglucan from Tamarindus indica and Hymenaea courbaril seeds with endoglucanase (EGII), which randomly breaks the (1→4)-linked β-glycosidic bonds of the polymer chain, was monitored in real time using time-dependent viscometry analysis (TDV). For both samples there was a decrease in the intrinsic viscosity ([η]), viscosity average molar mass (Mv), radius de gyration (Rg) and persistence length (Lp) immediately after the addition of the enzyme. It was observed the formation of oligosaccharides and oligomers composed of ∼2 units, up to 140min. Galactose-containing side chains two positions away from the non-substituted glucose, modulated the action of EGII, and the complete hydrolysis of the XG oligomers occurred after 24h. The results demonstrate for the first time the real-time degradation of xyloglucan as well the macromolecular and oligosaccharide composition during the EGII hydrolysis process

Use of Oleozon in tinea at the General Teaching Hospital, Guantánamo

Se realiza un estudio sobre el uso de Oleozón® en epidermofitosis en 341 pacientes de la consulta de Dermatología del Hospital General Docente “Dr. Agostinho Neto” de Guantánamo, en el período marzo 2009 – febrero 2011, para determinar evolución clínica y aparición de reacciones adversas. Se analizaron variables como: grupo edad, sexo, formas clínicas, evolución clínica, reacciones adversas. Se utilizaron dos grupos de pacientes, a los que se les realizó consulta a la cuarta y final de la sexta semana de tratamiento. El mayor porcentaje de los pacientes perteneció al sexo masculino y al grupo de edades entre 15-32 años. La variedad clínica predominante fue la escamosa, con mejor respuesta al tratamiento. La mayoría de los pacientes mostraron curación clínica, no hubo diferencias en la evolución clínica entre ambos grupos, no se identificaron reacciones adversas. A study on the use of Oleozon in tinea is done in 341 patients from the Dermatology Department at the General Teaching Hospital "Dr.Agostinho Neto "Guantanamo, from March 2009 to February 2011, to determine clinical evolution and adverse reactions. Age group, sex, clinical symptoms, clinical course, adverse reactions were analyzed as variables. Two groups of patients were used, which were treated by consulting the fourth and final of the sixth week of treatment. The highest percentages of patients were males and belonged to the age group between 15-32 years. The predominant clinical form was scaly, with better response to treatment. Most patients showed clinical cure, and there was no difference in clinical evolution between the two groups, no adverse reactions too.

Non-perturbative Euler-Heisenberg Lagrangian and Paraelectricity in Magnetized Massless QED

In this paper we calculate the non-perturbative Euler-Heisenberg Lagrangian for massless QED in a strong magnetic field $H$, where the breaking of the chiral symmetry is dynamically catalyzed by the external magnetic field via the formation of an electro-positron condensate. This chiral condensate leads to the generation of dynamical parameters that have to be found as solutions of non-perturbative Schwinger-Dyson equations. Since the electron-positron pairing mechanism leading to the breaking of the chiral symmetry is mainly dominated by the contributions from the infrared region of momenta much smaller than $\sqrt{eH}$, the magnetic field introduces a dynamical ultraviolet cutoff in the theory that also enters in the non-perturbative Euler-Heisenberg action. Using this action, we show that the system exhibits a significant paraelectricity in the direction parallel to the magnetic field. The nonperturbative nature of this effect is reflected in the non-analytic dependence of the obtained electric susceptibility on the fine-structure constant. The strong paraelectricity in the field direction is linked to the orientation of the electric dipole moments of the pairs that form the chiral condensate. The large electric susceptibility can be used to detect the realization of the magnetic catalysis of chiral symmetry breaking in physical systems.Comment: 18 pages, to be published in NP

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.

OBJECTIVES: HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though efficacy and resistance data for non-B subtypes are limited. Two recent trials have identified the integrase L74I mutation to be associated with integrase inhibitor treatment failure in HIV-1 non-B subtypes. We sought to define the prevalence of integrase resistance mutations, including L74I, in West Africa. METHODS: We studied a Nigerian cohort of recipients prior to and during receipt of second-line PI-based therapy, who were integrase inhibitor-naive. Illumina next-generation sequencing with target enrichment was used on stored plasma samples. Drug resistance was interpreted using the Stanford Resistance Database and the IAS-USA 2019 mutation lists. RESULTS: Of 115 individuals, 59.1% harboured CRF02_AG HIV-1 and 40.9% harboured subtype G HIV-1. Four participants had major IAS-USA integrase resistance-associated mutations detected at low levels (2%-5% frequency). Two had Q148K minority variants and two had R263K (one of whom also had L74I). L74I was detected in plasma samples at over 2% frequency in 40% (46/115). Twelve (26.1%) had low-level minority variants of between 2% and 20% of the viral population sampled. The remaining 34 (73.9%) had L74I present at >20% frequency. L74I was more common among those with subtype G infection (55.3%, 26/47) than those with CRF02_AG infection (29.4%, 20/68) (P = 0.005). CONCLUSIONS: HIV-1 subtypes circulating in West Africa appear to have very low prevalence of major integrase mutations, but significant prevalence of L74I. A combination of in vitro and clinical studies is warranted to understand the potential implications.K.E.B. is supported by Wellcome Trust award number 170461. N.N. is supported by NIH R01 AI147331-01. R.K.G. is supported by a Wellcome Trust Senior Fellowship in Clinical Science (WT108082AIA). This study was supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) under the terms of U2G GH002099-01 and PA GH17-1753 (ACHIEVE)

In‐person interventions to reduce social isolation and loneliness: An evidence and gap map

BackgroundSocial isolation and loneliness can occur in all age groups, and they are linked to increased mortality and poorer health outcomes. There is a growing body of research indicating inconsistent findings on the effectiveness of interventions aiming to alleviate social isolation and loneliness. Hence the need to facilitate the discoverability of research on these interventions.ObjectivesTo map available evidence on the effects of in-person interventions aimed at mitigating social isolation and/or loneliness across all age groups and settings.Search MethodsThe following databases were searched from inception up to 17 February 2022 with no language restrictions: Ovid MEDLINE, Embase, EBM Reviews—Cochrane Central Register of Controlled Trials, APA PsycInfo via Ovid, CINAHL via EBSCO, EBSCO (all databases except CINAHL), Global Index Medicus, ProQuest (all databases), ProQuest ERIC, Web of Science, Korean Citation Index, Russian Science Citation Index, and SciELO Citation Index via Clarivate, and Elsevier Scopus.Selection CriteriaTitles, abstracts, and full texts of potentially eligible articles identified were screened independently by two reviewers for inclusion following the outlined eligibility criteria.Data Collection and AnalysisWe developed and pilot tested a data extraction code set in Eppi-Reviewer. Data was individually extracted and coded. We used the AMSTAR2 tool to assess the quality of reviews. However, the quality of the primary studies was not assessed.Main ResultsA total of 513 articles (421 primary studies and 92 systematic reviews) were included in this evidence and gap map which assessed the effectiveness of in-person interventions to reduce social isolation and loneliness. Most (68%) of the reviews were classified as critically low quality, while less than 5% were classified as high or moderate quality. Most reviews looked at interpersonal delivery and community-based delivery interventions, especially interventions for changing cognition led by a health professional and group activities, respectively. Loneliness, wellbeing, and depression/anxiety were the most assessed outcomes. Most research was conducted in high-income countries, concentrated in the United States, United Kingdom, and Australia, with none from low-income countries. Major gaps were identified in societal level and community-based delivery interventions that address policies and community structures, respectively. Less than 5% of included reviews assessed process indicators or implementation outcomes. Similar patterns of evidence and gaps were found in primary studies. All age groups were represented but more reviews and primary studies focused on older adults (≥60 years, 63%) compared to young people (≤24 years, 34%). Two thirds described how at-risk populations were identified and even fewer assessed differences in effect across equity factors for populations experiencing inequities

Magnetoelectric Effect in Strongly Magnetized Color Superconductivity

The effect of a strong magnetic field on the electric polarization of a three-flavor color superconducting medium is investigated. We found that the electric susceptibility of this strongly magnetized medium is highly anisotropic. In the direction transverse to the applied magnetic field the susceptibility reduces to that of the vacuum, while in the longitudinal direction it depends on the magnetic field and decreases with it. The nature of this behavior is associated with the field's dependence of the Cooper pairs' coherence length, which plays the role of the electric dipole length. The field's dependence of the electric polarization is interpreted as the realization of the magnetoelectric effect in cold-dense quark matter.Comment: 10 pages, 1 figur

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk