BeppoSAX-WFC monitoring of the Galactic Center region

We review the results obtained with the Galactic center campaigns of the BeppoSAX Wide Field X-ray Cameras (WFCs). This pertains to the study of luminous low-mass X-ray binaries (LMXBs). When pointed at the Galactic center, the WFC field of view contains more than half of the Galactic LMXB population. The results exemplify the excellent WFC capability to detect brief X-ray transients. Firstly, the WFCs expanded the known population of Galactic thermonuclear X-ray bursters by 50%. At least half of all LMXBs are now established to burst and, thus, to contain a neutron star as compact accretor rather than a black hole candidate. We provide a complete list of all 76 currently known bursters, including the new case 1RXS J170854.4-321857. Secondly, the WFCs have uncovered a population of weak transients with peak luminosities up to ~10^37 erg/s and durations from days to weeks. One is the first accretion-powered millisecond pulsar SAX J1808.4-3658. Thirdly, the WFCs contributed considerably towards establishing that nearly all (12 out of 13) luminous low-mass X-ray binaries in Galactic globular clusters contain neutron stars rather than black holes. Thus, the neutron star to black hole ratio in clusters differs from that in the Galactic disk at a marginal confidence level of 97%.Comment: 10 pages 6 figures, to appear in Proc. "The Restless High-Energy Universe" (2nd BeppoSAX Symposium), eds. E.P.J. van den Heuvel, J.J.M. in 't Zand & R.A.M.J. Wijers, Nucl. Instrum. Meth. B Suppl. Se

Gender (in)equity in global mental health research: A call to action

In this commentary, we build on work by Gurung and colleagues which highlighted gender inequity in the global mental health research workforce in Nepal (Gurung et al., 2021). We seek to increase awareness of the under-representation of women in global mental health research and its consequences, and we call for change. By women, we refer to all people who identify as women, including trans people. The commentary is informed by conversations with women who are global mental health researchers in the Global North and South at various stages of their careers

Euphonia:reflecting on the design of an AI-powered voice-controlled narrative game

This paper reflects on the design process for a work-in-progress AI-powered voice-controlled narrative game created by Innovation for Games and Media Enterprise (InGAME). This paper describes the steps which led to the final design decisions, and how the background research, research questions and initial prototyping may be traced through to the work-in-progress game. The design process is then reviewed for its suitability as a practice-based research and development workflow, before finally suggesting next steps the project will take

Orbital parameters of supergiant fast X-ray transients

Supergiant fast X-ray transient (SFXT) is a new class of the high mass X-ray binary that shows short X-ray flares. The physical mechanism of SFXT short flares is still open for discussion. The accretion process of dense clumps in stellar wind onto neutron star (NS) has been proposed as the origin of such short flares. In order to examine the applicability of the clumpy wind scenario, we focus on the accretion mode that depends on orbital parameters. Our goal is to impose restrictions on the orbital parameters of SFXT. Assuming a simple analytic model of clumpy wind, we investigate the condition where the size of accretion cylinder overcomes the clump size. The allowed parameter region for SFXT is restricted in a relatively narrow window in $P_{\rm{orb}} - e$ diagram. Binary systems with large eccentricities (e \ga 0.4) and moderate orbital periods ($P_{\rm{orb}} \sim 10$ d) are prone to show periodic X-ray outbursts which are characteristic for SFXT. We confirm that systems with a long orbital period of more than 100 days cannot produce bright X-ray flares in the simple clumpy wind scenario.Comment: 6 pages, accepted for publication in A&

Medical oncology patients' preferences with regard to health care: development of a patient-driven questionnaire

BACKGROUND: To improve quality of care for cancer patients, it is important to have an insight on the patient's view on health care and on their specific wishes, needs and preferences, without restriction and without influence of researchers and health care providers. The aim of this study was to develop a questionnaire assessing medical oncology patients' preferences for health care based on their own input. PATIENTS AND METHODS: Items were generated using 10 focus group interviews with 51 cancer patients. A preliminary questionnaire was handed out to 681 patients of seven Dutch departments of medical oncology. Explorative factor analysis was carried out on the 386 returned questionnaires (response 57%). RESULTS: Focus group interviews resulted in a preliminary questionnaire containing 136 items. Explorative factor analysis resulted in a definitive questionnaire containing 123 items (21 scales and eight single items). Patients rated expertise, safety, performance and attitude of physicians and nurses as the most important issues in cancer care. CONCLUSION: This questionnaire may be used to assess preferences of cancer patients and to come to a tailored approach of health care that meets patients' wishes and needs

Uneven progress in reducing exposure to violence at home for New Zealand adolescents 2001–2012: a nationally representative cross‐sectional survey series

Objective: To explore trends, and identify risk factors, that may explain changes in adolescent exposure to family violence over time.Methods: Data for this study was drawn from the Youth 2000 series of cross‐sectional surveys, carried out with New Zealand high school students in 2001, 2007 and 2012. Latent class analysis was used to understand different patterns of exposure to multiple risks for witnessing violence at home among adolescents.Results: Across all time periods, there was no change in witnessing emotional violence and a slight decline in witnessing physical violence at home. However, significant differences were noted between 2001 and 2007, and 2007 and 2012, in the proportion of adolescents who reported witnessing emotional and physical violence. Four latent classes were identified in the study sample; these were characterised by respondents' ethnicity, concerns about family relationships, food security and alcohol consumption. For two groups (characterised by food security, positive relationships and lower exposure to physical violence), there was a reduction in the proportion of respondents who witnessed physical violence but an increase in the proportion who witnessed emotional violence between 2001 and 2012. For the two groups characterised by poorer food security and higher exposure to physical violence, there were no changes in witnessing of physical violence in the home.Implications for public health: In addition to strategies directly aimed at violence, policies are needed to address key predictors of violence exposure such as social disparities, financial stress and alcohol use. These social determinants of health cannot be ignored

Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes

Our aims were (1) by computed tomography (CT) to establish a population database for pancreas volume (parenchyma and fat) from birth to age 100 years, (2) in adults, to establish the impact of gender, obesity, and the presence or absence of type-2 diabetes on pancreatic volume (parenchyma and fat), and (3) to confirm the latter histologically from pancreatic tissue obtained at autopsy with a particular emphasis on whether pancreatic fat is increased in type-2 diabetes. We measured pancreas volume in 135 children and 1,886 adults (1,721 nondiabetic and 165 with type-2 diabetes) with no history of pancreas disease who had undergone abdominal CT scan between 2003 and 2006. Pancreas volume was computed from the contour of the pancreas on each CT image. In addition to total pancreas volume, parenchymal volume, fat volume, and fat/parenchyma ratio (F/P ratio) were determined by CT density. We also quantified pancreatic fat in autopsy tissue of 47 adults (24 nondiabetic and 23 with type-2 diabetes). During childhood and adolescence, the volumes of total pancreas, pancreatic parenchyma, and fat increase linearly with age. From age 20–60 years, pancreas volume reaches a plateau (72.4 ± 25.8 cm3 total; 44.5 ± 16.5 cm3 parenchyma) and then declines thereafter. In adults, total (∼32%), parenchymal (∼13%), and fat (∼68%) volumes increase with obesity. Pancreatic fat content also increases with aging but is not further increased in type-2 diabetes. We provide lifelong population data for total pancreatic, parenchymal, and fat volumes in humans. Although pancreatic fat increases with aging and obesity, it is not increased in type-2 diabetes. Clin. Anat. 20:933–942, 2007. © 2007 Wiley-Liss, Inc

Effects of Preoperative Anxiety on Gastric Fluid Acidity and Volume

The aim of this study was to evaluate the effect of preoperative anxiety on the gastric pH and volume. We studied 96 female patients aged 16-60 yr who underwent elective gynecological surgery. We classified the subjects into 2 groups, those presenting preoperative anxiety scores using visual analogue scale (VAS, 0-10) less than 5 (L-group, n=59), and those with 5 and more (H-group, n=37). Immediately after tracheal intubation, gastric contents were aspirated using a 14-F multiorifice nasogastric tube. The gastric acidity and volume of the two groups were not statistically different. Mean pH were 3.0±1.8 and 3.0±2.0 in each group (L-group and H-group) and mean gastric volume (mL) were 15.3±11.7 and 11.8±11.8, respectively. Nine (15.3%) patients in the L-group were considered to be 'at risk i.e. gastric pH <2.5 and volume >25 mL' and one patient (2.7%) in the H-group (p<0.05). The mean serum gastrin concentrations in both groups were similar (21.6±9.8 vs. 20.2±11.0 pg/mL). The pH and volume of preoperative gastric contents were not correlated with the preoperative anxiety. The results suggest that a low level of preoperative anxiety can be considered a risk factor for aspiration pneumonitis

Outcomes from a pilot psychological therapies service for UK military veterans

Aim: To evaluate the outcomes of participants attending a psychological therapies service for military veterans. Background: The UK Military Veterans’ Improving Access to Psychological Therapies Service (North West) (MV IAPT) provided a clinical psychological therapies service for military veterans. Outcomes of depression, anxiety and social adjustment were assessed after treatment in the service's pilot phase. Design: An observational, prospective cohort study examined changes in depression, anxiety and social adjustment during receipt of the service. Methods: Changes in depression (PHQ-9), anxiety (GAD-7) and social adjustment (WSAS) were examined in 952 veterans referred over 20 months from September 2011. Data were collected using the IAPT clinical information system plus additional fields. Changes for patients who completed treatment, remained in treatment and dropped out were compared. Results: Seven hundred and seven veterans received an initial assessment, from which 505 received two or more appointments. Of these, 156 completed treatments, 179 remained in treatment and 170 dropped out. The majority of veterans had been operationally deployed and were similar in risk characteristics to those in other military cohort studies. There were highly significant improvements on all measures (p<.01), with completers improving more and having higher rates of recovery from depression and anxiety than those remaining and drop outs. Recovery rates compared favourably with evaluations of general IAPT services and also exceeded reported natural recovery rates

The impact of predation by marine mammals on Patagonian toothfish longline fisheries

Predatory interaction of marine mammals with longline fisheries is observed globally, leading to partial or complete loss of the catch and in some parts of the world to considerable financial loss. Depredation can also create additional unrecorded fishing mortality of a stock and has the potential to introduce bias to stock assessments. Here we aim to characterise depredation in the Patagonian toothfish (Dissostichus eleginoides) fishery around South Georgia focusing on the spatio-temporal component of these interactions. Antarctic fur seals (Arctocephalus gazella), sperm whales (Physeter macrocephalus), and orcas (Orcinus orca) frequently feed on fish hooked on longlines around South Georgia. A third of longlines encounter sperm whales, but loss of catch due to sperm whales is insignificant when compared to that due to orcas, which interact with only 5% of longlines but can take more than half of the catch in some cases. Orca depredation around South Georgia is spatially limited and focused in areas of putative migration routes, and the impact is compounded as a result of the fishery also concentrating in those areas at those times. Understanding the seasonal behaviour of orcas and the spatial and temporal distribution of “depredation hot spots” can reduce marine mammal interactions, will improve assessment and management of the stock and contribute to increased operational efficiency of the fishery. Such information is valuable in the effort to resolve the human-mammal conflict for resources