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Evaluation of scaling-up of HPV self-collection offered by community health workers at home visits to increase screening among socially vulnerable under-screened women in Jujuy Province, Argentina

Author: A Alvarez-Rosete
AB Oyediran
AJ Milat
Alicia Campanera
Alliance for Cervical Cancer Prevention (ACCP)
B Gaglio
E Lazcano-Ponce
E Proctor
F Verdoodt
G Yamey
G Yamey
H Sancho-Garnier
I Zehbe
IARC-WHO
J Cuzick
J Dillner
J Léniz
JM Zulu
K Strasser-Weipp
Laura Thouyaret
M Arbyn
M Gök
M Paolino
Melisa Paolino
N Leon
P Giorgi Rossi
R Atun
R Khresheh
RB Saltman
RC Brownson
RE Glasgow
Rosa Laudi
S Arrossi
S Arrossi
S Arrossi
S Arrossi
S Arrossi
S Arrossi
Silvina Arrossi
U Lehmann
Publication venue: 'Springer Science and Business Media LLC'
Publication date
Field of study

Mapping the human genetic architecture of COVID-19

Author: Abdelrazik M.
Abdullah T.
Abe R.
Abe S.
Abecasis G. R.
Abel L.
Abernathy C.
Abraheem A.
Abul-Husn N. S.
Acosta-Herrera M.
Acquilini D.
Adachi T.
Adachi Y.
Adams C.
Adams K.
Adanini O.
Adeleye O.
Adeniji K.
Adra D.
Afifi N.
Afilalo J.
Afilalo M.
Afolabi D.
Afrasiabi Z.
Afset J. E.
Agasou A.
Aghemo A.
Agranoff D.
Agrawal S.
Aguirre L. A.
Agwuh K.
Ahmad H. F.
Ahmad N.
Ahmed A.
Ahmed C.
Ahmed K. A.
Ai M.
Ail D.
Akeroyd L.
Akhtar M. N.
Akhtar S.
Akinkugbe O.
Aksentijevich A.
Al Thani A.
Al-Muftah W.
Al-Sarraj Y.
Alarcon C.
Alarcon-Riquelme M. E.
Alasdair F.
Alaverdian D.
Alavere H.
Albertos R.
Albillos A.
Albrecht W.
Albrich W.
Albrich W. C.
Aldera E. L.
Aldridge J.
Alegria A.
Alex B.
Alexander P.
Alfonso J.
Algera A. G.
Ali A.
Ali I. A. M.
Ali S.
Aliberti S.
Allan A.
Allan E.
Allan J.
Alldis Z.
Allen L.
Allen S.
Allibone S.
Allison K. S.
Allos R.
Ally S. M.
Almaden-Boyle C.
Altabaibeh A.
Altmuller J.
Alvaro A.
Amar D.
Amin V.
Amitrano S.
Amiya S.
Ampuero J.
Anan R.
Anania S.
Anastasescu E.
Anderson F.
Anderson J.
Anderson M.
Anderson P.
Anderson S.
Anderson S.
Anderson T.
Ando A.
Andolfo I.
Andrade V.
Andretta F.
Andreucci E.
Andrew A.
Andrew B.
Andrew G.
Andrews E.
Andrews S. J.
Andrikopoulos P.
Anedda F.
Aneli S.
Anemoli V.
Angelini C.
Angus B.
Ann Belli M.
Annis A.
Antcliffe D.
Antinori A.
Antoni M. D.
Anumakonda V.
Anwar M.
Anzai T.
Apetri E.
Arai D.
Arana E.
Arbane G.
Archer K.
Arciero E.
Arcos V. T.
Arden T.
Arias S. S.
Arif S.
Arimura K.
Armstrong J.
Armstrong J. A.
Armstrong L.
Armstrong R.
Arning N.
Arnold S.
Arora J.
Artuso R.
Arumugam P.
Asakura T.
Asano K.
Aschard H.
Ascolillo S.
Ashish A.
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Ashraf S.
Ashton L.
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Asiimwe I. G.
Aslibekyan S.
Asselta R.
Astin-Chamberlain R.
Atanasovska B.
Atkinson D.
Atkinson E. G.
Attwood B.
Aucella F.
Augustin M.
Auld D.
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Austin K.
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Zucchi P.
Zyndorf M.
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2021
Field of study

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease

Archivio istituzionale della ricerca - Politecnico di Milano

Archivio della ricerca - Università degli studi di Napoli Federico II

Archivio della Ricerca - Università degli Studi di Siena

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Archivio istituzionale della ricerca - Università di Genova

UTUPub

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

Archivio istituzionale della ricerca - Università di Padova

Environment and Interpretation

Author: Anderson E.
Braun D.
Breslaw D.
Bursik R. J.
Cohen A. K.
Collins P. H.
Creswell J.
Dachter-Lourie L.
Danziger S.
Devine J.
Ellwood D. T.
Fox M.F.
Freeman R. B.
Gans H.
Gans H.
Gephart M.
Glasgow D. G.
Glei D.
Goetz J. P.
Hagedorn J. N.
Haistma M.
Hardy J. B.
Harnez U.
Hoshmand L. T.
Institute of Medicine
Jargowsky P. A.
Jayarante T. E.
JOSEFINA FIGUEIRA-McDONOUGH
Kanter R. M.
Kirschenem J.
Kornhauser R.
Krueger R.
Lehmann N.
Lincoln Y. S.
London K.
Massey D. J.
Massey D. S.
McGahey R.
Merton R. K.
Mincy R.
Moore J.
Moore K.
Orfield G.
Passel H.
Patton M. Q.
Pearson P.
Pratt W.
Reissman L.
Runkel P.
Schram S.
Shaw C. R.
Simmel G.
Skogan W. G.
Stewart D.
Sullivan M.
Suttles G.
Swenson I.
Taifel H.
Warren R. B.
Wilson W. J.
Wilson W. J.
Wilson W.J.
Yin R. K.
Publication venue: 'SAGE Publications'
Publication date
Field of study

Crossref

Intravenous immunoglobulin treatment for mild Guillain-Barré syndrome. An international observational study

Author: 2. Erasmus MC
2. KU Leuven
2. National and Kapodistrian University of Athens
A. Davidson
A. Doets
A. Echaniz-Laguna
A. J. van der Kooi
A. Kohler
A. Magot
A. Pardal
A. Savransky
A. Schenone
A. Spyropoulos (Royal Victoria Infirmary
Aarhus Denmark)
Aarhus Denmark)
Allentown USA)
Amsterdam
Amsterdam
Argentina)
Argentina)
Argentina)
Argentina)
Argentina)
Argentina)
Argentina)
Asturias Spain)
Athens Greece)
b) Dhaka
b) Dhaka
b) Dhaka
B. Islam
B. Stein
B. van den Berg
Baltimore USA)
Bangladesh (icddr
Bangladesh (icddr
Bangladesh (icddr
Bangladesh)
Bangladesh)
Bangladesh)
Barcelona Spain)
Barcelona Spain)
Barcelona Spain)
Barcelona Spain)
Barcelona Spain)
Barcelona Spain)
Barroso F.
Binda D.
Bradford UK)
Buenos Aires
Buenos Aires
Buenos Aires
Buenos Aires
Buenos Aires
Buenos Aires
Buenos Aires
Burlington
Burlington VT
C. Briani
C. Bunschoten
C. C. Chao
C. Casasnovas
C. Dornonville de la Cour
C. Fokke
C. G. Faber
C. Homedes
C. J. Gijsbers
C. J. McDermott
C. L. Sommer
C. Márquez Infante
C. Nascimbene
C. Y. Tan
Calgary Canada)
Cambridge UK)
Canada)
Cape Town
Cape Town
Cavaletti G.
Center
Charlottesville USA)
Chiba Japan)
Chicago USA)
Columbus USA)
Copenhagen Denmark)
Cordoba Spain)
Cornblath D. R.
Delft
Department of Medicine
Department of Medicine
Dhaka Bangladesh)
DO (Lehigh Valley Health Network
DO (Spectrum Health System
Dordrecht
Dordrecht
E. Dardiotis
E. H. Niks
E. Lee Pan
E. Martinez Hernandez
E. Nobile Orazio
F. Eftimov
F. Vermeij
Faculty of Medicine
Faculty of Medicine
Fayetteville USA)
FLENI
France)
France)
FRCP (Ipswich Hospital
FRCP (The Walton Centre
G. A. Marfia
G. Antonini
G. Chavada
G. Gutiérrez-Gutiérrez
G. M. Sachs
G. Mataluni
G. Meekins
G. Morís de la Tassa
G. W. van Dijk
Galassi G.
Genetics and Maternal and Infantile Sciences (DINOGMI)
Genova
Genova Italy)
Glasgow UK)
Glasgow UK)
Glasgow UK)
Glostrup Denmark)
Gorson K. C.
Grand Rapids
H. D. Katzberg
H. J. Willison
H. Kerkhoff
H. Manji
H. Tankisi
Harbo T.
Helmond and Deurne
Homburg Germany)
Homburg Germany)
Hoorn
Hospital Clinic
Hospital of Larissa
Houston USA)
Hughes R. A. C.
Humanitas Clinicala and Research Institute Milan
Humanitas Clinicala and Research Institute Milan
I. Illa
I. Jahan
I. Jericó Pascual
I. R. Bella
I. Rojas-Marcos
Indianapolis USA)
Ipswich UK)
Irvine USA)
Italy 2. IRCCS Policlinico San Martino
Italy)
Italy)
Italy)
Italy)
J. A. L. Miller
J. Bürmann
J. D. Varrato
J. Fehmi (University of Oxford E. A. Fulgenzi
J. Gilhuis
J. K. L. Holt
J. M. Gilchrist
J. M. Goldstein
J. Pardo Fernandez (Hospital Clínico de Santiago
J. Roodbol
J. S. Cosgrove
J. V. Holbech
J. Y. Kwan
Jacksonville USA)
Jacobs B. C. H. Andersen
K. Bateman
K. G. Claeys
K. Jellema
K. Kaida
K. Kimpinski
K. Kuitwaard
K. Sheikh
Kansas City
Kusunoki S.
Kuwabara S.
L. Benedetti
L. H. Visser
L. Kiers
L. Landschoff Lassen
L. Martín-Aguilar
L. Querol Gutierrez
L. Santoro
L. Schwindling
L. Zhou
La Spezia
La Spezia
Larissa Greece)
Leeds UK)
Lehmann H. C.
Leiden
Leiden
Leuven Belgium
Leuven Belgium)
Leuven Belgium)
Leuven Belgium)
LHSC London-Ontario
Liverpool UK)
London UK)
London UK)
Lunn M. P.
M. Bianco (Milan University
M. Busby
M. C. Dalakas
M. Derejko
M. E. Conti
M. G. Mattiazzi
M. Htut
M. J. Sedano Tous
M. Kuwahara
M. M. Dimachkie
M. Mandarakas
M. Osei-Bonsu
M. P. J. Garssen
M. Pulley
M. S. Monges
M. Samukawa
M. V. Vytopil
M. van Woerkom (Erasmus MC
Maastricht
Malaya)
Malaya)
Marseille France)
MBChB
MBChB (Groote Schuur Hospital
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD
MD (1. Thomas Jefferson University
MD (Addenbrooke’s Hospital Cambridge
MD (Barrow Neurology Clinics
MD (Bellvitge University Hospital - IDIBELL Neurometabolic Diseases Group. CIBERER
MD (Bicêtre University Hospital
MD (Buffalo Jacobs School of Medicine S. Sindrup
MD (Canisius Wilhelmina Hospital
MD (Columbia University
MD (Dokkyo Medical University
MD (Franciscus Gasthuis
MD (Franciscus Gasthuis
MD (Gelre Hospital
MD (Glostrup Hospital
MD (Hospital Britanico
MD (Hospital Cesar Milstein Buenos Aires
MD (Hospital Clínico de Santiago
MD (Hospital de la Santa Creu i Sant Pau
MD (Hospital de Pediatría J. P. Garrahan
MD (Hospital Militar Central
MD (Hospital Universitario Infanta Sofia
MD (Hospital Universitario Marques de Valdecilla
MD (Hospital Universitario Virgen del Rocio
MD (Hospital UniversitarioCentral de Asturias
MD (Hospital Univesitario Reina Sofia
MD (Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
MD (Instituto de Investigaciones Neurológicas Raúl Carrea
MD (Leeds General Infirmary
MD (Leeds General Infirmary
MD (Maasstad Hospital
MD (Mental Health and Sensory Organs (NESMOS)
MD (Montefiore Medical
MD (National Hospital Copenhagen
MD (Neurological Clinic
MD (Neurology Unit
MD (Northwestern University Feinberg
MD (Odense University Hospital
MD (Ospedale Sant’ Andrea La Spezia
MD (Pinderfields Hospital
MD (Reference Centre for NMD
MD (Royal Hallamshire Hospital
MD (Scientific Institute San Raffaele
MD (Soulthern Illinois University School of Medicine
MD (St. George’s Hospital
MD (St. Joseph’s Regional Medical Center
MD (The University of Tennessee Health Science Center (UTHSC)
MD (Toho University Medical Center
MD (University Hospital
MD (University Hospital Clinicas
MD (University Hospital/ University of Texas Health Science Center
MD (University of Arkansas
MD (University of Calgary
MD (University of California
MD (University of Florida
MD (University of Glasgow
MD (University of Indiana School of Medicine
MD (University of Kansas Medical Center
MD (University of Maryland School of Medicine
MD (University of Mass Medical School
MD (University of Melbourne
MD (University of Minnesota
MD (University of Padova
MD (University of Rhode Island
MD (University of Thessaly
MD (University of Toronto
MD (University of Utah School of Medicine
MD (University of Vermont
MD (University of Vermont Medical Center
MD (University of Virginia
MD (Universitätsklinikum des Saarlandes
MD (Universitätsklinikum des Saarlandes
MD (Universitätsklinikum Würzburg
MD (Vlietland Hospital
MD (Westfriesgasthuis
MD (Wexner Medical Center at The Ohio State University
MD (Yale University School of Medicine
MD (Yale University School of Medicine
Memphis USA)
Middlesbrough UK)
Milan Italy)
Milan Italy)
MRCP (Neurology Unit
N. A. Goyal
N. J. Silvestri
N. Kokubun
N. Kolb
N. Shahrizaila
Nantes University Hospital
Nantes University Hospital
Napels Italy)
New Brunswick
New Haven
New Haven
New York
New York City
Newcastle UK)
Newcastle UK)
NIHR Clinical
Nijmegen
Odense Denmark)
Odense Denmark)
Odense Denmark)
Osaka Japan)
Osaka Japan)
P. Twydell
P. Van Damme
P. Van den Bergh
Padova Italy)
Pamplona Spain)
Paris France)
Parkville Australia)
Paterson USA)
PhD
PhD (1. Albert Schweitzer Hospital
PhD (1. Department of Neurosciences
PhD (1. University Hospitals Leuven
PhD (Aarhus University Hospital
PhD (Aarhus University Hospital
PhD (Albert Schweitzer Hospital
PhD (Amsterdam University Medical Centre
PhD (Amsterdam University Medical Centre
PhD (Bellvitge University Hospital - IDIBELL Neurometabolic Diseases Group. CIBERER
PhD (Chiba University
PhD (CHU Timone
PhD (Complejo Hospitalario de Navarra
PhD (Concord Repatriation General Hospital
PhD (Elisabeth-TweeSteden Hospital
PhD (Elkerliek Hospital
PhD (Erasmus University Medical Centre
PhD (Glasgow University
PhD (Groote Schuur Hospital
PhD (Haaglanden Medisch Centrum
PhD (HagaZiekenhuis
PhD (Hospital de la Santa Creu i Sant Pau
PhD (Hospital de la Santa Creu i Sant Pau
PhD (Hospital de Pediatría J. P. Garrahan
PhD (Icahn School
PhD (International Centre for Diarrhoeal Disease Research
PhD (International Centre for Diarrhoeal Disease Research
PhD (James Cook University Hospital
PhD (Jeroen Bosch Hospital
PhD (Kindai University
PhD (Kindai University
PhD (King’s College Hospital
PhD (Leiden University Medical Centre
PhD (Leiden University Medical Centre
PhD (Luigi Sacco Hospital
PhD (Maastricht University Medical Centre
PhD (Milan University
PhD (National Defense Medical College
PhD (National Institute of Neurosciences and Hospital
PhD (National Taiwan University Hospital
PhD (National Taiwan University Hospital
PhD (Neurological Clinic
PhD (Odense University Hospital
PhD (Odense University Hospital
PhD (Ospedale Sant’ Andrea La Spezia
PhD (Reference Centre for NMD
PhD (Reinier de Graaf Gasthuis
PhD (Royal Victoria Infirmary
PhD (Rutgers
PhD (The University of Texas Health Science Center at Houston
PhD (Tufts University School of Medicine Lahey Hospital P. W. Wirtz
PhD (University Clinic St. Luc
PhD (University Federico II
PhD (University Hospital Leuven
PhD (University of Glasgow
PhD (University of Oxford J. P. A. Samijn
PhD candidate (Erasmus University Medical Centre
PhD candidate (Erasmus University Medical Centre
PhD candidate (Erasmus University Medical Centre
PhD candidate (Erasmus University Medical Centre
PhD candidate (International Centre for Diarrhoeal Disease Research
Philadelphia USA
Phoenix Arizona
Policlinico Tor Vergata
Policlinico Tor Vergata
Providence USA)
Q. D. Mohammad
R. Bhavaraju-Sanka
R. C. Roberts
R. D. M. Hadden
R. Fazio
R. J. Nowak
R. M. Pascuzzi
R. van Koningsveld
Rehabilitation Ophthalmology
Reisin R. C.
Robert Wood Johnson University Hospital
Rome Italy)
Rome Italy)
Rome Italy)
Rotterdam
Rotterdam
Rotterdam
Rotterdam
Rotterdam
Rotterdam
Rotterdam
Rotterdam
Rotterdam
Rotterdam
Royal Melbourne Hospital
S. A. Rudnicki
S. Ajroud-Driss
S. Attarian
S. Butterworth
S. Chen
S. E. Leonhard
S. Grisanti
S. Karafiath
S. Rinaldi
S. S. Ladha
S. T. Hsieh
S. W. Reddel
Saitama Japan)
Salt Lake City
San Antonio Texas
San Sebastian
Santander Cantabria
Santiago de Compostela (A Coruña)
Santiago de Compostela (A Coruña)
Sant’Andrea Hospital
Sapienza University
Schiedam
Seville Spain)
Sheffield UK)
South-Africa)
South-Africa)
Spain)
Spain)
Spain)
Spain)
Springfield USA)
Sydney Australia)
T. E. Bertorini
T. E. Feasby
T. Fujioka
T. García-Sobrino
T. H. Brannagan
T. van der Ree
Taipei Taiwan)
Taipei Taiwan)
The Hague
The Hague
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
the Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
The Netherlands)
the Netherlands)
the Netherlands)
The Netherlands)
the Netherlands)
The Netherlands)
the Netherlands)
Tilburg and Waalwijk
Tochigi Japan)
Tokyo Japan)
Toronto Canada)
U. A. Badrising
Universitat Autònoma de Barcelona
Universitat Autònoma de Barcelona
Universitat Autònoma de Barcelona
University of Genova
University of Malaya
University of Malaya
USA)
USA)
USA)
USA)
USA)
USA)
USA)
USA)
USA)
USA)
USA)
USA)
USA). Other collaborators were:J. M. Addington
V. Granit
V. Lawson
Van Doorn P. A.
Verboon C.
W. Waheed
Wakefield UK)
Worcester USA)
Würzburg Germany)
Y. Péréon
Y. Sekiguchi
Z. Islam
Zutphen and Apeldoorn
’s Hertogenbosch
Publication venue: 'BMJ'
Publication date: 01/01/2021
Field of study

Objective: To compare the disease course in patients with mild Guillain-Barré syndrome (GBS) who were treated with intravenous immunoglobulin (IVIg) or supportive care only. Methods: We selected patients from the prospective observational International GBS Outcome Study (IGOS) who were able to walk independently at study entry (mild GBS), treated with one IVIg course or supportive care. The primary endpoint was the GBS disability score four weeks after study entry, assessed by multivariable ordinal regression analysis. Results: Of 188 eligible patients, 148 (79%) were treated with IVIg and 40 (21%) with supportive care. The IVIg group was more disabled at baseline. IVIg treatment was not associated with lower GBS disability scores at 4 weeks (adjusted OR (aOR) 1.62, 95% CI 0.63 to 4.13). Nearly all secondary endpoints showed no benefit from IVIg, although the time to regain full muscle strength was shorter (28 vs 56 days, p=0.03) and reported pain at 26 weeks was lower (n=26/121, 22% vs n=12/30, 40%, p=0.04) in the IVIg treated patients. In the subanalysis with persistent mild GBS in the first 2 weeks, the aOR for a lower GBS disability score at 4 weeks was 2.32 (95% CI 0.76 to 7.13). At 1 year, 40% of all patients had residual symptoms. Conclusion: In patients with mild GBS, one course of IVIg did not improve the overall disease course. The certainty of this conclusion is limited by confounding factors, selection bias and wide confidence limits. Residual symptoms were often present after one year, indicating the need for better treatments in mild GBS

Archivio della ricerca- Università di Roma La Sapienza

Ezetimibe added to statin therapy after acute coronary syndromes

Author: Aagnes I
Aambakk MB
Aase O
Aaser E
Abdel-Latief A
Abell T
Aboufakher R
Abramson B
Abrantes J
Achilli A
Adams A
Adams K
Adamus J
Addington J
Adgey A
Adjei A
Agarwal J
Aggarwal A
Aggarwal K
Aggarwal R
Agocha A
Agraou B
Aguirre O
Ahmed A
Ahmed O
Ahsan A
Airaksinen J
Airoldi F
Aji J
Akkad H
Akubzanova E
Al-Ani R
Al-Jumaily J
Alameda J
Albirini A
Albuquerque A
Albuquerque D
Alcasena S
Alexander J
Alfonso F
Ali MI
Alings MA
Allall O
Allen J
Allen RP
Allred S
Almeira AS
Alonso L
Alsagheer S
Alshaher M
Altschuller A
Alvarez J
Alvarez J
Alvarez Y
Alves A
Amidon T
Amos M
Anaszewicz M
Andersen M
Andersen O
Andersson E
Andersson G
Andrade G
Andrade M
Andrea B
Andreou C
Antonangelo A
Antorrena I
Appel K
Arana C
Aranda M
Araujo J
Arce R
Ardito RV
Ardito W
Arend C
Arias V
Armada E
Armstrong P
Arnold A
Arnold M
Arntsen BI
Arora P
Aros F
Arriagada G
Arriagada G
Artaecheverria J
Arvesen K
Arvigo L
Ash Y
Aske R
Ata N
Atar D
Atar S
Atassi K
Atieh M
Atkinson C
Atzenhofer-Baumgartner K
Auer J
Aug L
Ausen K
Aycock G
Aylward P
Aylward P
Ayres T
Azize G
Azrin M
Azzolini P
Babu R
Bach R
Badings EA
Baeza N
Baig M
Baiz A
Bajcsi É
Balaguera J
Balcells E
Baldari D
Baldus S
Bali H
Ballantyne C
Ballmer P
Banerjee S
Bang-Hansen T
Banikova A
Bankowski D
Banks K
Bansal M
Baraona F
Barber C
Barber C
Barbir M
Barillas O
Barnes D
Barnett O
Barr C
Barrett J
Barringhaus K
Barron M
Bartels GL
Basilio E
Bass M
Bassand J
Bassand JP
Bassand JP
Basso V
Bata I
Battikadi S
Battin D
Bauer B
Baumanns S
Bautista J
Bayat J
Bayer M
Bayer M
Bayles A
Bazzi A
Beaudry M
Bedoya R
Been M
Belicova M
Bell K
Belle L
Beloscar J
Beltran R
Beltrano MC
Ben-Aharon J
Ben-Yehuda O
Benetar J
Bengtsson PO
Bennermo M
Bennett J
Benyahya L
Beresford P
Berezniakov I
Berger M
Berger-Kucza A
Bergeron J
Berglund M
Berglund R
Bergsten J
Berk M
Berli M
Bernardi D
Berra F
Berrospi P
Bertolet B
Bescos L
Bethea C
Bethencourt A
Betti I
Betzu R
Bhalla H
Bhalodkar N
Bhargava M
Bhargava R
Bhargavi M
Bhesania T
Biasucci L
Biedermann B
Bikkina M
Bilazarian S
Bilodeau N
Bin Ismail O
Binaghi G
Birkemeyer R
Birnbaum Y
Bishop A
Bishop B
Bishop C
Bissett J
Bissett J
Bittel B
Bitzer V
Bjornstad H
Blacher MG
Blais D
Blank E
Blazing M
Blazing M
Blazing M
Blazing Michael A.
Blessing E
Block D
Bluguermann J
Blumberg E
Bobek M
Bocconcelli P
Bocconcelli P
Bodanese L
Bodenstein W
Boehm S
Bogomolny N
Bohle D
Bohlscheid V
Bohorquez R
Bohula Erin A.
Boliek W
Bolli R
Bolsman C
Bonatti S
Bondi L
Bondio M
Bone C
Bonnet J
Bono J
Book K
Boomer L
Boos C
Botero R
Bottzauw J
Botwin S
Boudriot E
Bouvier JM
Bowden W
Bozek B
Bradford L
Bradford L
Brady A
Brady A
Brady A
Braga J
Branca G
Branny M
Branzi A
Braun P
Braunwald Eugene
Breen J
Brike C
Britto F
Britto F
Britto F
Broadwater S
Bronnum-Schou J
Brossoit R
Brown C
Brown C
Brown C
Brown J
Brunelli C
Brunelli C
Brunk S
Bruno N
Brunvand H
Brussee H
Bryniarski L
Budzon S
Bueno M
Buerke M
Buerke M
Bugos V
Buijs EM
Buijs F
Bullivant M
Burgess L
Burghard S
Burley T
Burton J
Buss I
Bustamante G
Butcher R
Butkus E
Butter C
Buzetti C
Byfuglien A
Cabrera-Santamaria A
Calderón MJ
Calic S
Califf
Calpar I
Calzolari D
Campbell C
Campbell T
Campos C
Cannon C
Cannon C
Cannon Christopher P.
Canto J
Cappelen H
Capucci A
Capucci A
Cardillo MT
Cardinal F
Cardoso A
Carell E
Carell E
Carey C
Carlessi C
Carlevaro O
Carling-Chambers L
Carlsson F
Carmelo M
Carr K
Carrageta M
Carrageta M
Carrageta M
Carrié D
Carswell BS
Cartasegna L
Caruso O
Casalins M
Casares G
Caso P
Caspi A
Cassadonte F
Cassavar D
Cassel G
Castoldi M
Castro P
Castro R
Catarino C
Caussin C
Cauthren T
Cavallini C
Ceder-Brolin K
Centeno E
Centurion C
Cepeda M
Cequier A
Chadwyn D
Chae SC
Chalavarya G
Chambers J
Chandler G
Chandna H
Chandna H
Chandna H
Chandra P
Chandraratna P
Chandrasekaran S
Chang D
Chang G
Chang K
Chang K
Chang M
Charng M
Chattree K
Chavarri M
Chavez V
Chee K
Chernick R
Chessa P
Cheung S
Chew D
Chhabra A
Chian-Yi W
Chiariello M
Chilakamarri V
Childs A
Childs C
Chiodi L
Chiu A
Cho M
Choi Y
Cholewa M
Chopra A
Chopra V
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Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2015
Field of study

BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit

Archivio istituzionale della ricerca - Università di Genova

Archivio della ricerca- Università di Roma La Sapienza

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease