84 research outputs found
New Light Source (NLS) project: conceptual design report
- Author
- Aeppli G
- Allemann R
- Almond A
- Angal-Kalinin D
- Ashfold M
- Averbukh V
- Bagshaw C
- Barahona M
- Barker P
- Bartolini R
- Baumberger F
- Beard C
- Beeby A
- Bisby R
- Blackburn E
- Bliss N
- Bonner P
- Booth P
- Bowler M
- Bressler C
- Brown W
- Bryan W
- Burge F
- Carmichael I
- Catlow C
- Cavalleri A
- Chapman H
- Chattapadhyay S
- Chergui M
- Christou C
- Clarke J
- Cogdell R
- Collier J
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- Corlett J
- Costello J
- Couprie M -E
- Cramer L
- Currell F
- Davis I
- Diakun G
- Dickinson H
- Donovan R
- Dougan C
- Drescher M
- Dunne AM
- Dunning D
- Durr H
- Emma P
- Evans J
- Evans R
- Falcone R
- Feldhaus J
- Fell B
- Ferenczi M
- Ferguson-Smith M
- Fernandez-Hernando J
- Fernig D
- Fielding HH
- Flavell W
- Fraser H
- Frasinski L J
- Froud C
- Gardiner J
- Gensch M
- George M
- Gerricke D
- Gleeson A
- Goddard P
- Gould I
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- Gregori G
- Griffiths S
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- Hamilton B
- Han J -H
- Hanon M
- Hasnain S
- Hatton P
- Hawes C
- Herbert J
- Heron M
- Heyes D
- Hirst G
- Holbourn M
- Holland D
- Humphries M
- Hunter C
- Irving M
- Ivanov M
- Jackson F
- Jamison S
- Jaroszynski D
- Johnson L
- Jones J
- Kadodwala M
- Kalinin A
- Kapanidis A
- Kaplan A
- Kay J
- Kimel A
- Klug D
- Kuske B
- Lammie D
- Lee RW
- Maia F
- Marangos J
- Marsh M
- Martin I
- Martlew B
- Mason N
- Materlik G
- McCombie J
- McCoustra M
- McIntosh P
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- McKenzie S
- McMahon H
- McMahon M
- McNeil B
- Meek K
- Michette A
- Militsyn B
- Molloy J
- Moss A
- Munro A
- Muratori B
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- Nave C
- Ng T
- Nicholson L
- Nilsson A
- O'Neill P
- O'Shea P
- Owen H
- Parker T
- Parmigiani F
- Pattalwar S
- Perutz R
- Pickett C
- Pimblott S
- Poletto L
- Poole M
- Powis I
- Priebe G
- Quiney H
- Quinn F
- Radaelli P
- Raff J
- Rehm G
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- Sankar G
- Schlarb H
- Schroeder S
- Scrutton N
- Seddon E
- Segal D
- Shintake T
- Singleton J
- Smith A
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- Smith S
- Sokolowski-Tinten K
- Somekh M
- Springate E
- Stead T
- Stringer M
- Sutcliffe M
- Tallents G
- Taylor K
- Thompson N
- Thompson R
- Tisch J
- Towns-Andrews E
- Townsend D
- Towrie M
- Ueda K
- Underwood J
- van der Laan G
- van Grondelle R
- van Thor J
- Venkitaraman A
- von Haeften K
- Vrakking M
- Walker R
- Walmsley I
- Wann D
- Wark J
- Weightman P
- Weinstein J
- Wess T
- Wheelhouse A
- Williams P
- Willison K
- Wilson M
- Wishart J
- Wolf A
- Womersley J
- Woodruff P
- Woolsey N
- Yaliraki S
- Yates E
- Zeitler A
- Zepf M
- Zholents A
- Publication venue
- Publication date
- 01/01/2010
- Field of study
Postoperative outcomes in oesophagectomy with trainee involvement
- Author
- A A Syed
- A Ahmad
- A Ahmed
- A Al-Bahrani
- A Ariyarathenam
- A Athanasiou
- A Azizian
- A Bagajevas
- A Bastidas
- A Bekele
- A Bianchi
- A Boddy
- A C Berger
- A C Pinho
- A Charalabopoulos
- A Chaudry
- A Crnjac
- A Da Roit
- A Davies
- A Dingle
- A E Racu
- A Elhadi
- A Elshaer
- A Fekadu
- A G Rendo
- A Gjata
- A Gordon
- A Guner
- A H Memon
- A Harris
- A Hindmarsh
- A Isaza-Restrepo
- A Isik
- A Kechagias
- A Kennedy
- A Kordzadeh
- A M Correia
- A M Leon-Takahashi
- A MacCormick
- A Macdonald
- A Mastrosimone
- A Michalinos
- A Naeem
- A O Shebani
- A Odera
- A Owera
- A P Ainswort
- A Pagan Pomar
- A Pazdro
- A Powell
- A Quinn
- A Raza
- A Reece-Smith
- A Rosat Rodrigo
- A S Sampaio
- A Sarela
- A Schnider
- A Shabbir
- A Shehzadi
- A Singh
- A T Arndt
- A Tamhankar
- A Tizazu
- A Turkyilmaz
- A U Qureshi
- A van der Veen
- A Wajid
- A Wyman
- B Brandt
- B Byrne
- B Chan
- B E Baki
- B Grace
- B Jefferies
- B Johnston
- B Kidane
- B Klarenbeek
- B Knight
- B Lorenzi
- B Morten
- B Nega
- B P L Wijnhoven
- B Salmaso
- B Sevin??
- B Sgromo
- B Smith
- B Stoica
- B Tan
- B Wallner
- C A De Pasqual
- C B ?? S??illeabh??in
- C Baban
- C Baker
- C Ball
- C Bolca
- C Cabalag
- C Cetares
- C Choh
- C Ciubotaru
- C Ciuce
- C Ciuce
- C Collins
- C Cords
- C Craig
- C D Scott
- C D??az L??pez
- C Duong
- C Ekwunife
- C Kelty
- C Krautz
- C Loureiro
- C MacKay
- C Magad??n ??lvarez
- C Mickael
- C Monteiro
- C Mosse
- C Rosman
- C S Vicente
- C Sharp
- C Tinoco Carrasco
- C V Obleaga
- C W Seder
- D Alderson
- D AlShehab
- D Balalis
- D Beardsmore
- D Bennett
- D Bernardi
- D Chan
- D Gunji??
- D Hunter
- D K Manatakis
- D Khoo
- D Mayo
- D Mitton
- D Mukherjee
- D Nepogodiev
- D Nepogodiev
- D P Korkolis
- D P S??nchez
- D Predescu
- D Raptis
- D Reim
- D Schizas
- D Sekhniaidze
- D Theodorou
- D W Kjaer
- D Worku
- D Zanotti
- E A Griffiths
- E A Griffiths
- E A Griffiths
- E Alghunaim
- E Asti
- E Baili
- E Beenen
- E Cheong
- E Choolani Bhojwani
- E Colak
- E Kurnaz
- E L Rosato
- E McLaughlin
- E Mwachiro
- E Okolo
- E P G Santos
- E T Mart??nez
- E Teferra
- E Theophilidou
- F A Elnagar
- F Albadawi
- F Allison
- F Arias-Am??zquita
- F Cabral
- F Di Maggio
- F Gonzalez
- F Lindberg
- F Palazzo
- F R Takeda
- F Rashid
- F van Workum
- F Vargas-Barato
- F Yanni
- G Albanese
- G Beban
- G Blackshaw
- G Bouras
- G Bromley
- G Bryce
- G Buduhan
- G Chmielewski
- G Darling
- G De Manzoni
- G Dobson
- G Emons
- G Fullarton
- G Ga??evski
- G Kim
- G Rosero
- G Sanders
- G van Boxel
- G Weber
- H A Ahmed
- H A Mahendran
- H Ben-Younes
- H Brewer
- H Bui
- H C Aik
- H F Elnagar
- H Faltova
- H Golcher
- H H Ahmed
- H Khizer
- H Liem
- H Matos
- H Medina-Franco
- H N L Basave
- H Samo
- H Sue Ling
- H Warrilow
- I A Makey
- I Cecconello
- I Cordos
- I D??ez del Val
- I D??ez del Val
- I Ganjara
- I Gockel
- I Ivanovski
- I Khan
- I Kruhlikava
- I Martijnse
- I Mohamed
- I Mohamed
- I Nasir
- I Negoi
- I Noaman
- I Wilson
- J A Martinez Corcoles
- J A P Ferrer
- J B Y So
- J Barbosa
- J Bennett
- J Bolger
- J Bundred
- J Bundred
- J Couch
- J D Mitchell
- J D S Coelho
- J Eckardt
- J El Kafsi
- J F Videira
- J Farmanali
- J Fergusson
- J Freire
- J G??mez-Mayorga
- J Gaedcke
- J Gokhale
- J Gossage
- J Gossage
- J Gossage
- J H Egberts
- J Hayden
- J Hedberg
- J Heisterkamp
- J Hesse
- J Hodson
- J Hodson
- J Holm
- J I Moreno
- J I Rossaak
- J Izbicki
- J J B van Lanschot
- J J Reilly
- J L Rodicio Miravalles
- J Leite
- J M Ram??n
- J Mart??n Fern??ndez
- J Ortega
- J P Ruurda
- J Padickakudi
- J R M da Rocha
- J Reynolds
- J S Azagra
- J S Kauppila
- J Saarnio
- J Salim
- J Spillane
- J Vickers
- J W van den Berg
- J Ward
- J Weindelmayer
- J Willem
- J Yeung
- K Akbari
- K Akhtar
- K Dawas
- K E Okonta
- K Exarchou
- K Ishii
- K Loi
- K M I Pal
- K McCormack
- K Patel
- K Pursnani
- K Robertson
- K Shaikh
- K Siaw- Acheampong
- K Supramaniam
- K Wanigasooriya
- L Bonavina
- L C Tan
- L Castilla
- L E P??rez S??nchez
- L F Wong
- L Humphreys
- L Ioannidi
- L Mej??a-Fern??ndez
- L Nino-Torres
- L Provenzano
- L R Lopes
- L S Alvarez
- L Saadeh
- L Sartarelli
- L Tan
- L Volovnik
- L Walls
- L Watson
- M A C??tores Pascual
- M A Noor
- M Abdulrahman
- M Agasiev
- M Baig
- M Bail??n Cuadrado
- M Beuran
- M Bjelovi??
- M Cervellera
- M Cowen
- M Cox
- M Dal Cero
- M Devadas
- M E Ahmed
- M Ebeling
- M Elhadi
- M Forshaw
- M H Jhanzaib
- M H Larsen
- M Haris
- M J Fern??ndez D??az
- M J Liptay
- M J Weyant
- M Johnson
- M K Karush
- M Kelly
- M M A Alasmar
- M M Hennessy
- M Migliore
- M Moreno Gij??n
- M Mpoura
- M Mwachiro
- M Niihara
- M P Achiam
- M P Cerdeira
- M P Gomes
- M Pera
- M Pineda
- M Read
- M Reeh
- M Richardson
- M Rico
- M Ruteg??rd
- M S Trugeda Carrera
- M Saad
- M Scarpa
- M Schiller
- M Sevcikova
- M Shrotri
- M Siemsen
- M Singh
- M Snajdauf
- M Sousa
- M Sundbom
- M Talbot
- M Terashima
- M Tez
- M Thomas
- M Thorsteinsson
- M Vallve-Bernal
- M Valmasoni
- M Verstegen
- M Veselinovi??
- M W Hii
- M Wadley
- M Wilson
- M Yacob
- M Young
- M Z Sarwar
- N A Andreollo
- N Abbassi
- N Akkapulu
- N Blencowe
- N Carter
- N Colucci
- N Cort??s
- N Damburaci
- N Das
- N Davies
- N Donlon
- N Evenett
- N Katballe
- N Khalil
- N Kreuser
- N M Stilling
- N Maynard
- N Ravi
- N Slim
- N Tewari
- N To
- O Karahan
- O M Fisher
- O McAnena
- O Moussa
- O Shakeel
- O Tucker
- P A Hoara
- P B Mortensen
- P C Lau
- P C Martins
- P Carroll
- P Davis
- P Jain
- P Jambulingam
- P Johnston
- P K Hsu
- P M Schneider
- P Manby
- P McQuillan
- P Mistry
- P Patil
- P Pucher
- P Ramos
- P Safranek
- P Shea
- P Singh
- P Singh
- P Singh
- P Singh
- P Turner
- P V Campos
- P W Soon
- P Wilkerson
- R A A Sallum
- R A Meguid
- R Ackroyd
- R Apostu
- R Babor
- R Bardini
- R Bassari
- R Berrisford
- R Blanco
- R Brown
- R Byrom
- R C T Costa
- R Casaca
- R Chaparala
- R Cort??s-Gonz??lez
- R D Birla
- R da Silva
- R Drasovean
- R E White
- R Evans
- R Gruetzmann
- R Guevara Castro
- R H Sayyed
- R Hardwick
- R Iqbal
- R Jacobs
- R Kennedy
- R Koshy
- R La Mendola
- R Makuuchi
- R Matthijsen
- R McGregor
- R Melhado
- R Nijjar
- R P T Evans
- R P T Evans
- R P T Evans
- R Patel
- R R Scurtu
- R Singhal
- R Skipworth
- R Tomsa
- R van Hillegersberg
- R van Hillegersberg
- R van Hillegersberg
- R Verma
- R Vohra
- R Vohra
- R Vohra
- R Walker
- R Yildirim
- R Young
- R Zheng
- S A Naqi
- S A Pais
- S A Turienzo
- S B A Qudus
- S Bianchini
- S Bouwense
- S Caceres
- S Cheah
- S Constantinoiu
- S Dexter
- S Dikinis
- S Duarte
- S Dwerryhouse
- S Elmahi
- S Er
- S Gananadha
- S Giacopuzzi
- S Gutknecht
- S Higgs
- S Hornby
- S Iftikhar
- S Jaunoo
- S K Kamarajah
- S K Kamarajah
- S K Kamarajah
- S Kapoulas
- S Khattak
- S Kumar
- S Leturio
- S Leturio
- S M Lagarde
- S M??nig
- S McCain
- S McKay
- S McKay
- S Mehta
- S Mercer
- S Merigliano
- S Meril??inen
- S Mukherjee
- S Niebisch
- S Oglesby
- S Paitici
- S Powell-Brett
- S Puig
- S Rif??
- S S Garc??a
- S S Mogoanta
- S Srinathan
- S T Makkai-Popa
- S Thanninalai
- S Triantafyllou
- S Turkyilmaz
- S Vaccari
- S Ward
- T Amalesh
- T B Tirnaksiz
- T Babi??
- T Braga
- T C Beltr??n-Garc??a
- T Dzhendov
- T Gilbert
- T H Wiggins
- T Harustiak
- T Havard
- T Ingemann
- T Irino
- T J Huei
- T Liakakos
- T Murphy
- T Palser
- T S Chin
- T Thorpe
- T Underwood
- T Wheatley
- T Whitehouse
- T Wright
- T Yunrong
- U Boecher
- V Concepci??n Mart??n
- V Koivukangas
- V Menon
- V Negoita
- V Shetty
- V Shneider
- V Sujendran
- V Tercioti
- V Tonini
- V Wills
- V Wong
- W A Jansen
- W Al Khyatt
- W B Robb
- W H Allum
- W Lewis
- X Escofet
- Y K S Viswanath
- Y Tsubosa
- Z Afzal
- Z Butt
- Z U Mirza
- Z Zakir
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND: The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. METHODS: Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. RESULTS: Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). CONCLUSION: Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
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- A Yacoub M.
- A. Adam M.
- A. Nassar M.
- A. Nemer A.
- Aahlin E. K.
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- Abdalla Ahmed Elkamel A.
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- Abdelkader M.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised
The Science Performance of JWST as Characterized in Commissioning
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat RĂŒdeger
- Albert LoĂŻc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Ătienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
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- Baudoz Pierre
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- Beichman Charles
- Bellagama Larry
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- Telfer Randal C.
- Temim Tea
- Texter Scott C.
- Thatte Deepashri G.
- Thompson Christopher Lee
- Thompson Linda M.
- Thomson Shaun R.
- Thronson Harley
- Tierney C. M.
- Tikkanen Tuomo
- Tinnin Lee
- Tippet William Thomas
- Todd Connor William
- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Van Campen Julie
- van de Wetering Inge
- Van Der Marel Roeland P.
- van Dishoeck Ewine F.
- van Haarlem Remy
- Van Tea Mason
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Ălvarez-MĂĄrquez Javier
- Ăstlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
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- Niola Paola
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- O'Toole Ăine
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- OâToole Ăine
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- Pacchiarini Nicole
- Padgett Debra
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- Pandey Sarojini
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- Parker Matthew D
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- Paterson Steve
- Payne Brendan AI
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- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
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- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
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- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
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- Ruis Chris
- Ryan Felicity
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- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Evidence of positive selection associated with placental loss in tiger sharks
- Author
- A Noubhani
- A Stamatakis
- Adam Ciezarek
- AS Afonso
- B Crespi
- B Venkatesh
- B Venkatesh
- BY Choi
- C Kosiol
- Catherine S. Jones
- CG Mull
- CJ Underwood
- CJ Underwood
- CL Conrath
- D Asante
- D Darriba
- D Delsate
- DE Reich
- DG Blackburn
- Dominic G. Swift
- DW Zeh
- ED Grogan
- ED Grogan
- Edward J. Brooks
- EJ Crosley
- Emily Humble
- FM Hunter
- G Tzivion
- G Velo-AntĂłn
- GA Parker
- GJ Pazour
- H Akaike
- H Chang
- H Katagiri
- HW Mossman
- IM Wallace
- J Castresana
- J Probst
- J Roux
- J Zhang
- Javier Igea
- JI Castro
- JL Fitzpatrick
- JP Wourms
- K Howe
- K Inaba
- K Toyo-oka
- KJ Metzger
- L Chapman
- L Compagno
- L Duret
- L Sorenson
- Leslie R. Noble
- LJ Chapman
- LJ Chapman
- Luke T. Dunning
- M Takahashi
- MG Elliot
- MG Elliot
- MG Grabherr
- MJ OâNeill
- MR Heithaus
- MS Brieuc
- NK Dulvy
- NM Whitney
- PJ Motta
- R Maleszka
- R Nielsen
- R Shine
- R Zangerl
- RC Edgar
- S Rashid
- S Tanaka
- S Ziegler
- SF Altshul
- SJ Jorgensen
- SM Lambert
- V Stingo
- Vincent Savolainen
- VP Richards
- W Hamlett
- W Landini
- X Guo
- Y Benjamini
- YP Papastamatiou
- Z Yang
- Z Yang
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background: All vertebrates initially feed their offspring using yolk reserves. In some live-bearing species these yolk
reserves may be supplemented with extra nutrition via a placenta. Sharks belonging to the Carcharhinidae family
are all live-bearing, and with the exception of the tiger shark (Galeocerdo cuvier), develop placental connections
after exhausting yolk reserves. Phylogenetic relationships suggest the lack of placenta in tiger sharks is due to
secondary loss. This represents a dramatic shift in reproductive strategy, and is likely to have left a molecular
footprint of positive selection within the genome.
Results: We sequenced the transcriptome of the tiger shark and eight other live-bearing shark species. From this
data we constructed a time-calibrated phylogenetic tree estimating the tiger shark lineage diverged from the
placental carcharhinids approximately 94 million years ago. Along the tiger shark lineage, we identified five genes
exhibiting a signature of positive selection. Four of these genes have functions likely associated with brain
development (YWHAE and ARL6IP5) and sexual reproduction (VAMP4 and TCTEX1D2).
Conclusions: Our results indicate the loss of placenta in tiger sharks may be associated with subsequent adaptive
changes in brain development and sperm production
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M.
- Abdul Rasheed A.
- Abdul A.
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- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
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- Ahmed R.
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- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; pâ=â0.40). There was no significant effect of DMF on any secondary outcome
Genomic reconstruction of the SARS-CoV-2 epidemic in England.
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- Willford NJ
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- Zamudio ME
- Zarebski AE
- Zhang P
- Publication venue
- Nature
- Publication date
- 01/01/2021
- Field of study
The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M.
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S.Y.
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L.
- Berger Duncan J.
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brooks Tony T.
- Broos Alice
- Brown Julianne Rose
- Brown Paul E.
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K.
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L.
- Caller Laura G.
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Charles Ian G.
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K.J.
- Churcher Carol M.
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M.
- Connor Thomas R.
- Connor Thomas R.
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J.
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J.
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L.
- Fleming Vicki M.
- Forrest Leysa M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Frost Lucy R.
- Fuller William
- Gallagher Eileen
- Gallagher Michael D.
- Garcia-Casado Maria V.
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Gilroy Rachel A.J.
- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Griffith Luke
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- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
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- Halstead Fenella
- Hamilton William L.
- Haque Tanzina
- Harper Katherine L.
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- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Holden Matthew T.G.
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J.
- Howe Robin
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D.
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A.
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu S.
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R.
- Jesudason Natasha
- Jesudason Natasha G.
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Khokhar Fahad A.
- Kidd Stephen
- Kingsley Robert A.
- Kitchen Christine
- Knight Bridget A.
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack C.D.
- Letchford Laura
- Levene Nick
- Levett Lisa J.
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- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
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- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T.
- Masoli Jane A.H.
- Mason Jenifer
- Mather Alison E.
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McCrone John T.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J.
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W.
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F.
- Nascimento Fabricia F.
- Naydenova Plamena
- Neaverson Alexandra S.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M.
- Nichols Jenna
- Niebel Marc O.
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Ăine
- Orton Richard J.
- Osman Husam
- Ott Sascha
- OâGrady Justin
- OâToole Ăine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N.
- Pandey Sarojini
- Park Naomi
- Parker Matthew D.
- Parmar Surendra
- Parr Yasmin A.
- Parsons Paul J.
- Partridge David G.
- Pascall David J.
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan A.I.
- Peacock Sharon J.
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C.
- Rey Sara
- Rey Sara M.
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rogers Hazel A.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M.
- Sang Fei
- Scarlett Garry P.
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K.
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N.
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G.
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Simpson David A.
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Christen
- Smith Colin P.
- Smith Darren
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J.
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben E.W.
- Taylor Graham P.
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P.
- Temperton Ben
- Templeton Kate E.
- Thompson Thomas
- Thomson Emma C.
- Thomson Emma C.
- Thomson Nicholas M.
- Thornton Alicia
- Thurston Scott
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Tutill Helena J.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vamos Edith E.
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B.
- Volz Erik
- Volz Erik M.
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A.
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Willingham Iona
- Wilson Harry D.
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A.
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Elsevier
- Publication date
- 07/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
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