The times are they a-changing? Evolving attitudes in Australian exercise science students’ attitudes towards sports concussion

The issue of concussion in sport continues to be discussed widely in the community as current and retired players reveal personal experiences, and concerns, about the long-term sequelae of their concussive injuries. This is the first study to examine evolving attitudes and beliefs towards concussion in sport by comparing data in an Australian exercise science student cohort between 2015 and 2020. Using a repeated cross-sectional design 1,013 participants (2020 cohort: n = 751; 21.6 ± 7.1 years; 2015 cohort: n = 312; 22.0 ± 5.2 years) responded to statements about concussion: personal attitudes; the media’s portrayal; elite athletes who continue to play concussed; if participants would continue to play on concussed; and on completing rehabilitation for concussion. Comparisons revealed statistically significant differences between cohorts across the majority of statements. Specifically, more progressive attitudes were found regarding the media presentation (glorification) of concussed athletes (decreased agreement of 14.7%, p < 0.001), admiration of concussed athletes who continued to play (decreased agreement of 10.5%, p < 0.001), and rehabilitation (increased agreement of 13%, p < 0.001). However, participants still presented attitudes of wishing to continue to train or play if they had a concussion for fear of letting team-mates down, or if the injury was not noticeable. While positive attitudes are evolving, more work is required, particularly as attitudes towards concussion still appear to be situation dependent

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.

Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleotide polymorphisms (SNPs) at the HNF1B locus to be associated with endometrial cancer, and now report extensive fine-mapping and in silico and laboratory analyses of this locus. Analysis of 1184 genotyped and imputed SNPs in 6608 Caucasian cases and 37 925 controls, and 895 Asian cases and 1968 controls, revealed the best signal of association for SNP rs11263763 (P = 8.4 × 10(-14), odds ratio = 0.86, 95% confidence interval = 0.82-0.89), located within HNF1B intron 1. Haplotype analysis and conditional analyses provide no evidence of further independent endometrial cancer risk variants at this locus. SNP rs11263763 genotype was associated with HNF1B mRNA expression but not with HNF1B methylation in endometrial tumor samples from The Cancer Genome Atlas. Genetic analyses prioritized rs11263763 and four other SNPs in high-to-moderate linkage disequilibrium as the most likely causal SNPs. Three of these SNPs map to the extended HNF1B promoter based on chromatin marks extending from the minimal promoter region. Reporter assays demonstrated that this extended region reduces activity in combination with the minimal HNF1B promoter, and that the minor alleles of rs11263763 or rs8064454 are associated with decreased HNF1B promoter activity. Our findings provide evidence for a single signal associated with endometrial cancer risk at the HNF1B locus, and that risk is likely mediated via altered HNF1B gene expression

Beyond the Womb and the Tomb: Identity, (Dis)embodiment and the Life Course

Grounded in the authors’ theoretical and ethnographic work on pregnancy and social life after death, this article explores the ways in which the body is involved in processes of identification. With a focus on the embodied nature of social identity, the article nonetheless problematizes a model of the life course that begins at the moments of birth and ends at death. Instead, it offers a more extended temporal perspective and examines other ways in which identity may be claimed, for example, via material objects and practices which evoke the body as imagined or remembered. By documenting pre-birth and post-mortem identity-making of this kind, it demonstrates how the unborn and the dead may come into social existence. In addition, a cultural privileging of both the body and visuality is shown to shore up the capacity of material objects and practices to shape social identities in a highly selective fashion. The article therefore proposes that models of the life course need to accommodate the meanings of pre-birth and post-mortem materialities and so incorporate a conceptualization of social identity as contested, relational and inevitably incomplete

"As soon as you’ve had the baby that’s it…” a qualitative study of 24 postnatal women on their experience of maternal obesity care pathways

Abstract Background Maternal obesity is associated with risks to mother and infant, and has implications for healthcare costs. United Kingdom (UK) levels of maternal obesity are rising, with higher prevalence in North East (NE) England, where this study was set. Pregnancy is often seen as an opportune time for intervention – a ‘teachable moment’ - which is ripe for promoting behaviour change. In response to rising obesity levels, a National Health Service (NHS) Foundation Trust in NE England implemented three maternal obesity care pathways contingent on Body Mass Index (BMI) at time of booking: pathway 1 for those with BMI ≥30 kg/m2; pathway 2 for BMI ≥35 kg/m2; and pathway 3 for BMI ≥40 kg/m2. These incorporated relevant antenatal, intrapartum and postnatal clinical requirements, and included a focus on weight management intervention. This evaluation explored the accounts of postnatal women who had been through one of these pathways in pregnancy. Methods The study used a generic qualitative approach. Semi-structured interviews were carried out to explore the views and experiences of 24 recent mothers (aged 20–42), living in NE England, who had commenced on one of the pathways during pregnancy. Interviews explored experiences of weight management support during and after pregnancy, and perceived gaps in this support. Data were analysed using thematic content analysis. Results Three main themes emerged reflecting women’s views and experiences of the pathways: communication about the pathways; treating obese pregnant women with sensitivity and respect; and appropriate and accessible lifestyle services and information for women during and after pregnancy. An overarching theme: differences in care, support and advice, was evident when comparing the experiences of women on pathways 1 or 2 with those on pathway 3. Conclusions This study indicated that women were not averse to risk management and weight management intervention during and after pregnancy. However, in order to improve reach and effectiveness, such interventions need to be well communicated and offer constructive, individualised advice and support. The postnatal phase may also offer an opportune moment for intervention, suggesting that the simple notion of seeing pregnancy alone as a window of opportunity or a ‘teachable moment’ should be reconsidered

Discourses of cultural heritage in times of crisis:The case of the Parthenon Marbles

The paper focuses on the commodification and politicisation of cultural heritage using as a case study the ongoing debate on the return of the Parthenon Marbles from the U.K. to Greece, recently reignited by the press release for the movie The Monuments Men in 2014. Greece has been in the throes of a severe financial crisis for over six years with the ever imminent threat of Grexit constantly disputed. In parallel with this ongoing turmoil, discourses of Greek antiquity have been persistently prominent in the media. In this context, we problematise the complex nexus of relationships between the financial crisis, national identity and cultural heritage. We combine the Discourse-Historical Approach and Interactional Sociolinguistics drawing data from an online forum, and investigate how the users negotiate pro-/anti-return positions and make the financial crisis relevant in the argumentation process. The analysis shows that history, identity, value, and debt are recontextualised in relation to the Parthenon sculptures. The analysis identifies an underlying process of value trade off and brings the current political and economic environment to the fore. We close the paper by foregrounding the implications of our study and provide directions for further research