Measurement of Radio-Frequency Radiation Pressure

We perform measurements of the radiation pressure of a radio-frequency (RF) electromagnetic field which may lead to a new SI-traceable power calibration. There are several groups around the world investigating methods to perform more direct SI traceable measurement of RF power (where RF is defined to range from 100s of MHz to THz). A measurement of radiation pressure offers the possibility for a power measure traceable to the kilogram and to Planck's constant through the redefined SI. Towards this goal, we demonstrate the ability to measure the radiation pressure/force carried in a field at 15~GHz.Comment: 2 pages 4 figure

Turbulent drag reduction by spanwise wall forcing. Part 2: High-Reynolds-number experiments

Here, we present measurements of turbulent drag reduction at high friction Reynolds numbers in the range of $4500 \le Re_\tau \le 15000$. The efficacy of the approach, using streamwise travelling waves of spanwise wall oscillations, is studied for two actuation regimes: (i) inner-scaled actuation (ISA), as investigated in Part 1 of this study, which targets the relatively high-frequency structures of the near-wall cycle, and (ii) outer-scaled actuation (OSA), which was recently presented by Marusic et al. (Nat. Commun., vol. 12, 2021) for high-$Re_\tau$ flows, targeting the lower-frequency, outer-scale motions. Multiple experimental techniques were used, including a floating-element balance to directly measure the skin-friction drag force, hot-wire anemometry to acquire long-time fluctuating velocity and wall-shear stress, and stereoscopic-PIV (particle image velocimetry) to measure the turbulence statistics of all three velocity components across the boundary layer. Under the ISA pathway, drag reduction of up to 25% was achieved, but mostly with net power saving losses due to the high-input power cost associated with the high-frequency actuation. The low-frequency OSA pathway, however, with its lower input power requirements, was found to consistently result in positive net power savings of 5 - 10%, for moderate drag reductions of 5 - 15%. The results suggest that OSA is an attractive pathway for energy-efficient drag reduction in high Reynolds number applications. Both ISA and OSA strategies are found to produce complex inter-scale interactions, leading to attenuation of the turbulent fluctuations across the boundary layer for a broad range of length and time scales

Τεχνικές Σχολές και εργαστήρια στα Ιωάννινα

Data on incidence of resistance to phosphine over the last 20 years and factors associated with insect sample collection are stored in the Australian Grain Insect Resistance Database. The database was analysed using descriptive statistics, linear trend analysis and Bayesian hurdle modelling to gain insights into factors contributing to the development of strong resistance in Rhyzopertha dominica. Descriptive statistics indicated that strong resistance was significantly more common in central storages, particularly bunker storages, than on farms. Strong resistance in R. dominica was also associated with wheat, barley and sorghum but there was no significant link to any grain protectant or storage treatment chemical, other than phosphine. Highest frequency of strong resistance was found in northern New South Wales and no detections were made in Western Australia. In eastern Australia, trend analysis indicated that strong resistance detections increased steadily from the first detection in 1997 to about 8% of samples containing resistant insects in 2014. Weak resistance was detected in about 10% of samples in eastern Australia in the early 1990s but this increased rapidly to 40–50% by 1990, at the same time that industry use of phosphine greatly increased, and then to about 80% in 1995. Strong resistance was first detected in this species when weak resistance was diagnosed in close to 80% of population samples. The Bayesian hurdle model identified bunkers, silos and unsealed storages as being associated with development of strong resistance and sheds with a lower frequency. This model also identified an accelerated increase in resistance frequency of strong resistance from 2011 to present. The information gained from this analysis is being used to inform current and future management of resistance to phosphine

Swift: primary data analysis for the Illumina Solexa sequencing platform

Motivation: Primary data analysis methods are of critical importance in second generation DNA sequencing. Improved methods have the potential to increase yield and reduce the error rates. Openly documented analysis tools enable the user to understand the primary data, this is important for the optimization and validity of their scientific work

UK Kidney association clinical practice guideline: sodium-glucose co-transporter-2 (SGLT-2) inhibition in adults with kidney disease 2023 UPDATE

Large placebo-controlled trials have demonstrated kidney and cardiovascular clinical benefits of SGLT-2 inhibitors. Data from the EMPA-KIDNEY and DELIVER trials and associated meta-analyses triggered an update to the UK Kidney Association Clinical Practice Guideline on Sodium-Glucose Co-transporter-2 (SGLT-2) Inhibition in Adults with Kidney Disease. We provide a summary of the full guideline and highlight the rationale for recent updates. The use of SGLT-2 inhibitors in people with specific medical conditions, including type 1 diabetes, kidney transplants, and people admitted to hospital with heart failure is also considered, along with Recommendations for future research and Recommendations for implementation. A full “lay” summary of the guidelines is provided as an appendix to ensure that these guidelines are accessible and understandable to people who are not medical professionals

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P-Bonferroni <1.06 x 10(-7)). In additional analyses in 7,278 participants,Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Resistance to phosphine in Sitophilus oryzae in Australia: A national analysis of trends and frequencies over time and geographical spread

In Australia, along with many other parts of the world, fumigation with phosphine is a vital component in controlling stored grain insect pests. However, resistance is a factor that may limit the continued efficacy of this fumigant. While strong resistance to phosphine has been identified and characterised, very little information is available on the causes of its development and spread. Data obtained from a unique national resistance monitoring and management program were analysed, using Bayesian hurdle modelling, to determine which factors may be responsible. Fumigation in unsealed storages, combined with a high frequency of weak resistance, were found to be the main criteria that led to the development of strong resistance in Sitophilus oryzae. Independent development, rather than gene flow via migration, appears to be primarily responsible for the geographic incidence of strong resistance to phosphine in S. oryzae. This information can now be utilised to direct resources and education into those areas at high risk and to refine phosphine resistance management strategies