「中国の脅威」を解剖する : インドと日本の認識変化の分析

安全保障・国際問題プログラム / Security and International Studies Program政策研究大学院大学 / National Graduate Institute for Policy Studies論文審査委員: 道下 徳成（主査）, 白石 隆, 恒川 惠市, 植木 千可子(早稲田大学大学院アジア太平洋研究科教授), 園部 哲史, 広瀬 崇子（専修大学法学部教授

Voluntad de verdad y principio de veracidad en el apredizaje. Una conversación entre Descartes, Rancière y Deleuze

Se trata, en este artículo, de carear las filosofías de la educación de René Descartes, Jacques Rancière y Gilles Deleuze para poder analizar cierta «imagen» del aprender. Lo que se propone en este trabajo es, en gran parte, dar cuenta del modo en que cada pensador problematiza la relación entre la voluntad y la verdad en el aprendizaje, y, así, ver si es posible pensar el aprender de otra forma que como un pasaje del no-saber al saber.Palabras clave: voluntad, verdad, aprender, Descartes, Rancière, Deleuze.AbstractThe purpose of this paper is to bring René Descartes, Jacques Rancière and Gilles Deleuze’s philosophies of education face to face in order to analyze a certain «image» of learning. What is proposed in this work is, mainly, to report the way in which each thinker problematizes the relation between will and truth in learning, and therefore to see if it is possible to think learning in another way than as a passage from ignorance to knowledge.Keywords: will, truth, learning, Descartes, Rancière, Deleuze.</p

Oral polio vaccine response in the MAL-ED birth cohort study: Considerations for polio eradication strategies

Background: Immunization programs have leveraged decades of research to maximize oral polio vaccine (OPV) response. Moving toward global poliovirus eradication, the WHO recommended phased OPV-to-IPV replacement on schedules in 2012. Using the MAL-ED prospective birth cohort data, we evaluated the influence of early life exposures impacting OPV immunization by measuring OPV response for serotypes 1 and 3.Methods: Polio neutralizing antibody assays were conducted at 7 and 15 months of age for serotypes 1 and 3. Analyses were conducted on children receiving ≥3 OPV doses (n = 1449). History of vaccination, feeding patterns, physical growth, home environment, diarrhea, enteropathogen detection, and gut inflammation were examined as risk factors for non-response [Log2(titer) \u3c 3] and Log2(titer) by serotype using multivariate regression.Findings: Serotype 1 seroconversion was significantly higher than serotype 3 (96.6% vs. 89.6%, 15 months). Model results indicate serotypes 1 and 3 failure was minimized following four and six OPV doses, respectively; however, enteropathogen detection and poor socioeconomic conditions attenuated response in both serotypes. At three months of age, bacterial detection in stool reduced serotype 1 and 3 Log2 titers by 0.34 (95% CI 0.14–0.54) and 0.53 (95% CI 0.29–0.77), respectively, and increased odds of serotype 3 failure by 3.0 (95% CI 1.6–5.8). Our socioeconomic index, consisting of Water, Assets, Maternal education, and Income (WAMI), was associated with a 0.79 (95% CI 0.15–1.43) and 1.23 (95% CI 0.34–2.12) higher serotype 1 and 3 Log2 titer, respectively, and a 0.04 (95% CI 0.002–0.40) lower odds of serotype 3 failure. Introduction of solids, transferrin receptor, and underweight were differentially associated with serotype response. Other factors, including diarrheal frequency and breastfeeding practices, were not associated with OPV response.Interpretation: Under real-world conditions, improved vaccination coverage and socio-environmental conditions, and reducing early life bacterial exposures are key to improving OPV response and should inform polio eradication strategies

Stereo-PIV measurements of spatio-temporal turbulence correlations in an axisymmetric jet

Stereoscopic three-component particle image velocimetry (3C-PIV) measurements have been made in a turbulent round jet to investigate the spatio-temporal correlations that are the origin of aerodynamic noise. Restricting attention to subsonic, isothermal jets, measurements were taken in a water flow experiment where, for the same Reynolds number and nozzle size, the shortest time scale of the dynamically important turbulent structures is more than an order of magnitude greater that in equivalent airflow experiments, greatly facilitating time-resolved PIV measurements. Results obtained (for a jet nozzle diameter and velocity of 40 mm and 1 m s\u1000001, giving Re D 4 104) show that, on the basis of both single-point statistics and two-point quantities (correlation functions, integral length scales) the present incompressible flow data are in excellent agreement with published compressible, subsonic airflow measurements. The 3C-PIV data are first compared to higher-spatial-resolution 2C-PIV data and observed to be in good agreement, although some deterioration in quality for higher-order correlations caused by high-frequency noise in the 3C-PIV data is noted. A filter method to correct for this is proposed, based on proper orthogonal decomposition (POD) of the 3C-PIV data. The corrected data are then used to construct correlation maps at the second- and fourth-order level for all velocity components. The present data are in accordance with existing hot-wire measurements, but provide significantly more detailed information on correlation components than has previously been available. The measured relative magnitudes of various components of the two-point fourth-order turbulence correlation coefficient (Rij;kl) – the fundamental building block for free shear flow aerodynamic noise sources – are presented and represent a valuable source of validation data for acoustic source modelling. The relationship between fourth-order and second-order velocity correlations is also examined, based on an assumption of a quasi-Gaussian nearly normal p.d.f. for the velocity fluctuations. The present results indicate that this approximation shows reasonable agreement for the measured relative magnitudes of several correlation components; however, areas of discrepancy are identified, indicating the need for work on alternative models such as the shell turbulence concept of Afsar (Eur. J. Mech. (B/Fluids), vol. 31, 2012, pp. 129–139)

Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction†

To determine whether risk stratification tests can predict serious arrhythmic events after acute myocardial infarction (AMI) in patients with reduced left ventricular ejection fraction (LVEF <= 0.40). A total of 5869 consecutive patients were screened in 10 European centres, and 312 patients (age 65 +/- 11 years) with a mean LVEF of 31 +/- 6% were included in the study. Heart rate variability/turbulence, ambient arrhythmias, signal-averaged electrocardiogram (SAECG), T-wave alternans, and programmed electrical stimulation (PES) were performed 6 weeks after AMI. The primary endpoint was ECG-documented ventricular fibrillation or symptomatic sustained ventricular tachycardia (VT). To document these arrhythmic events, the patients received an implantable ECG loop-recorder. There were 25 primary endpoints (8.0%) during the follow-up of 2 years. The strongest predictors of primary endpoint were measures of heart rate variability, e.g. hazard ratio (HR) for reduced very-low frequency component ( <5.7 ln ms(2)) adjusted for clinical variables was 7.0 (95% CI: 2.4-20.3, P <0.001). Induction of sustained monomorphic VT during PES (adjusted HR = 4.8, 95% CI, 1.7-13.4, P = 0.003) also predicted the primary endpoint. Fatal or near-fatal arrhythmias can be predicted by many risk stratification methods, especially by heart rate variability, in patients with reduced LVEF after AM

Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study

Background Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populations. A theory-driven systems model to critically evaluate pathways through which enteropathogens, gut permeability, and intestinal and systemic inflammation affect child growth was conducted within the framework of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) birth cohort study that included children from eight countries. Methods Non-diarrheal stool samples (N = 22,846) from 1253 children from multiple sites were evaluated for a panel of 40 enteropathogens and fecal concentrations of myeloperoxidase, alpha-1-antitrypsin, and neopterin. Among these same children, urinary lactulose:mannitol (L:M) (N = 6363) and plasma alpha-1-acid glycoprotein (AGP) (N = 2797) were also measured. The temporal sampling design was used to create a directed acyclic graph of proposed mechanistic pathways between enteropathogen detection in non-diarrheal stools, biomarkers of intestinal permeability and inflammation, systemic inflammation and change in length- and weight- for age in children 0–2 years of age. Findings Children in these populations had frequent enteric infections and high levels of both intestinal and systemic inflammation. Higher burdens of enteropathogens, especially those categorized as being enteroinvasive or causing mucosal disruption, were associated with elevated biomarker concentrations of gut and systemic inflammation and, via these associations, indirectly associated with both reduced linear and ponderal growth. Evidence for the association with reduced linear growth was stronger for systemic inflammation than for gut inflammation; the opposite was true of reduced ponderal growth. Although Giardia was associated with reduced growth, the association was not mediated by any of the biomarkers evaluated. Interpretation The large quantity of empirical evidence contributing to this analysis supports the conceptual model of EE. The effects of EE on growth faltering in young children were small, but multiple mechanistic pathways underlying the attribution of growth failure to asymptomatic enteric infections had statistical support in the analysis. The strongest evidence for EE was the association between enteropathogens and linear growth mediated through systemic inflammation

Early life child micronutrient status, maternal reasoning, and a nurturing household environment have persistent influences on child cognitive development at age 5 years: Results from MAL-ED

Background: Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is unknown. Objective: The aim of this study was to examine the relation between early-life factors (birth to 2 y) and cognitive development at 5 y. Methods: Observational follow-up visits were made of children at 5 y, previously enrolled in the community-based MAL-ED longitudinal cohort. The burden of enteropathogens, prevalence of illness, complementary diet intake, micronutrient status, and household and maternal factors from birth to 2 y were extensively measured and their relation with the Wechsler Preschool Primary Scales of Intelligence at 5 y was examined through use of linear regression. Results: Cognitive T-scores from 813 of 1198 (68%) children were examined and 5 variables had significant associations in multivariable models: mean child plasma transferrin receptor concentration (β: −1.81, 95% CI: −2.75, −0.86), number of years of maternal education (β: 0.27, 95% CI: 0.08, 0.45), maternal cognitive reasoning score (β: 0.09, 95% CI: 0.03, 0.15), household assets score (β: 0.64, 95% CI: 0.24, 1.04), and HOME child cleanliness factor (β: 0.60, 95% CI: 0.05, 1.15). In multivariable models, the mean rate of enteropathogen detections, burden of illness, and complementary food intakes between birth and 2 y were not significantly related to 5-y cognition. Conclusions: A nurturing home context in terms of a healthy/clean environment and household wealth, provision of adequate micronutrients, maternal education, and cognitive reasoning have a strong and persistent influence on child cognitive development. Efforts addressing aspects of poverty around micronutrient status, nurturing caregiving, and enabling home environments are likely to have lasting positive impacts on child cognitive development.publishedVersio