Abrupt grain boundary melting in ice

The effect of impurities on the grain boundary melting of ice is investigated through an extension of Derjaguin-Landau-Verwey-Overbeek theory, in which we include retarded potential effects in a calculation of the full frequency dependent van der Waals and Coulombic interactions within a grain boundary. At high dopant concentrations the classical solutal effect dominates the melting behavior. However, depending on the amount of impurity and the surface charge density, as temperature decreases, the attractive tail of the dispersion force interaction begins to compete effectively with the repulsive screened Coulomb interaction. This leads to a film-thickness/temperature curve that changes depending on the relative strengths of these interactions and exhibits a decrease in the film thickness with increasing impurity level. More striking is the fact that at very large film thicknesses, the repulsive Coulomb interaction can be effectively screened leading to an abrupt reduction to zero film thickness.Comment: 8 pages, 1 figur

An internet-based intervention with brief nurse support to manage obesity in primary care (POWeR+): a pragmatic, parallel-group, randomised controlled trial

Background The obesity epidemic has major public health consequences. Expert dietetic and behavioural counselling with intensive follow-up is effective, but resource requirements severely restrict widespread implementation in primary care, where most patients are managed. We aimed to estimate the effectiveness and cost-effectiveness of an internet-based behavioural intervention (POWeR+) combined with brief practice nurse support in primary care. Methods We did this pragmatic, parallel-group, randomised controlled trial at 56 primary care practices in central and south England. Eligible adults aged 18 years or older with a BMI of 30 kg/m2 or more (or ≥28 kg/m2 with hypertension, hypercholesterolaemia, or diabetes) registered online with POWeR+—a 24 session, web-based, weight management intervention lasting 6 months. After registration, the website automatically randomly assigned patients (1:1:1), via computer-generated random numbers, to receive evidence-based dietetic advice to swap foods for similar, but healthier, choices and increase fruit and vegetable intake, in addition to 6 monthly nurse follow-up (control group); web-based intervention and face-to-face nurse support (POWeR+Face-to-face [POWeR+F]; up to seven nurse contacts over 6 months); or web-based intervention and remote nurse support (POWeR+Remote [POWeR+R]; up to five emails or brief phone calls over 6 months). Participants and investigators were masked to group allocation at the point of randomisation; masking of participants was not possible after randomisation. The primary outcome was weight loss averaged over 12 months. We did a secondary analysis of weight to measure maintenance of 5% weight loss at months 6 and 12. We modelled the cost-effectiveness of each intervention. We did analysis by intention to treat, with multiple imputation for missing data. This trial is registered as an International Standard Randomised Controlled Trial, number ISRCTN21244703. Findings Between Jan 30, 2013, and March 20, 2014, 818 participants were randomly assigned to the control group (n=279), the POWeR+F group (n=269), or the POWeR+R group (n=270). Weight loss averaged over 12 months was recorded in 666 (81%) participants. The control group lost almost 3 kg over 12 months (crude mean weight: baseline 104·38 kg [SD 21·11; n=279], 6 months 101·91 kg [19·35; n=136], 12 months 101·74 kg [19·57; n=227]). The primary imputed analysis showed that compared with the control group, patients in the POWeR+F group achieved an additional weight reduction of 1·5 kg (95% CI 0·6–2·4; p=0·001) averaged over 12 months, and patients in the POWeR+R group achieved an additional 1·3 kg (0·34–2·2; p=0·007). 21% of patients in the control group had maintained a clinically important 5% weight reduction at month 12, compared with 29% of patients in the POWeR+F group (risk ratio 1·56, 0·96–2·51; p=0·070) and 32% of patients in the POWeR+R group (1·82, 1·31–2·74; p=0·004). The incremental overall cost to the health service per kg weight lost with the POWeR+ interventions versus the control strategy was £18 (95% CI −129 to 195) for POWeR+F and –£25 (−268 to 157) for POWeR+R; the probability of being cost-effective at a threshold of £100 per kg lost was 88% and 98%, respectively. No adverse events were reported. Interpretation Weight loss can be maintained in some individuals by use of novel written material with occasional brief nurse follow-up. However, more people can maintain clinically important weight reductions with a web-based behavioural program and brief remote follow-up, with no increase in health service costs. Future research should assess the extent to which clinically important weight loss can be maintained beyond 1 year

Lithium-6: A Probe of the Early Universe

I consider the synthesis of 6Li due to the decay of relic particles, such as gravitinos or moduli, after the epoch of Big Bang Nucleosynthesis. The synthesized 6Li/H ratio may be compared to 6Li/H in metal-poor stars which, in the absence of stellar depletion of 6Li, yields significantly stronger constraints on relic particle densities than the usual consideration of overproduction of 3He. Production of 6Li during such an era of non-thermal nucleosynthesis may also be regarded as a possible explanation for the relatively high 6Li/H ratios observed in metal-poor halo stars.Comment: final version, Physical Review Letters, additional figure giving limits on relic decaying particle

Randomised controlled feasibility trial of a web-based weight management intervention with nurse support for obese patients in primary care

<b>Background</b><p></p> There is a need for cost-effective weight management interventions that primary care can deliver to reduce the morbidity caused by obesity. Automated web-based interventions might provide a solution, but evidence suggests that they may be ineffective without additional human support. The main aim of this study was to carry out a feasibility trial of a web-based weight management intervention in primary care, comparing different levels of nurse support, to determine the optimal combination of web-based and personal support to be tested in a full trial.<p></p> <b>Methods</b><p></p> This was an individually randomised four arm parallel non-blinded trial, recruiting obese patients in primary care. Following online registration, patients were randomly allocated by the automated intervention to either usual care, the web-based intervention only, or the web-based intervention with either basic nurse support (3 sessions in 3 months) or regular nurse support (7 sessions in 6 months). The main outcome measure (intended as the primary outcome for the main trial) was weight loss in kg at 12 months. As this was a feasibility trial no statistical analyses were carried out, but we present means, confidence intervals and effect sizes for weight loss in each group, uptake and retention, and completion of intervention components and outcome measures.<p></p> <b>Results</b><p></p> All randomised patients were included in the weight loss analyses (using Last Observation Carried Forward). At 12 months mean weight loss was: usual care group (n = 43) 2.44 kg; web-based only group (n = 45) 2.30 kg; basic nurse support group (n = 44) 4.31 kg; regular nurse support group (n = 47) 2.50 kg. Intervention effect sizes compared with usual care were: d = 0.01 web-based; d = 0.34 basic nurse support; d = 0.02 regular nurse support. Two practices deviated from protocol by providing considerable weight management support to their usual care patients.<p></p> <b>Conclusions</b><p></p> This study demonstrated the feasibility of delivering a web-based weight management intervention supported by practice nurses in primary care, and suggests that the combination of the web-based intervention with basic nurse support could provide an effective solution to weight management support in a primary care context

OVII and OVIII line emission in the diffuse soft X-ray background: heliospheric and galactic contributions

We study the 0.57 keV (O VII triplet) and 0.65 keV (O VIII) diffuse emission generated by charge transfer collisions between solar wind (SW) oxygen ions and interstellar H and He neutral atoms in the inner Heliosphere. These lines which dominate the 0.3-1.0 keV energy interval are also produced by hot gas in the galactic halo (GH) and possibly the Local Interstellar Bubble (LB). We developed a time-dependent model of the SW Charge-Exchange (SWCX) X-ray emission, based on the localization of the SW Parker spiral at each instant. We include input SW conditions affecting three selected fields, as well as shadowing targets observed with XMM-Newton, Chandra and Suzaku and calculate X-ray emission fot O VII and O VIII lines. We determine SWCX contamination and residual emission to attribute to the galactic soft X-ray background. We obtain ground level intensities and/or simulated lightcurves for each target and compare to X-ray data. The local 3/4 keV emission (O VII and O VIII) detected in front of shadowing clouds is found to be entirely explained by the CX heliospheric emission. No emission from the LB is needed at these energies. Using the model predictions we subtract the heliospheric contribution to the measured emission and derive the halo contribution. We also correct for an error in the preliminary analysis of the Hubble Deep Field North (HDFN).Comment: 21 pages (3 on-line), 10 figures (4 on-line), accepted for publication in Astronomy and Astrophysic

Pulsar Results with the Fermi Large Area Telescope

The launch of the Fermi Gamma-ray Space Telescope has heralded a new era in the study of gamma-ray pulsars. The population of confirmed gamma-ray pulsars has gone from 6-7 to more than 60, and the superb sensitivity of the Large Area Telescope (LAT) on Fermi has allowed the detailed study of their spectra and light curves. Twenty-four of these pulsars were discovered in blind searches of the gamma-ray data, and twenty-one of these are, at present, radio quiet, despite deep radio follow-up observations. In addition, millisecond pulsars have been confirmed as a class of gamma-ray emitters, both individually and collectively in globular clusters. Recently, radio searches in the direction of LAT sources with no likely counterparts have been highly productive, leading to the discovery of a large number of new millisecond pulsars. Taken together, these discoveries promise a great improvement in the understanding of the gamma-ray emission properties and Galactic population of pulsars. We summarize some of the results stemming from these newly-detected pulsars and their timing and multi-wavelength follow-up observations.Comment: 21 pages, 9 figures, to appear in Proceedings of ICREA Workshop on The High-Energy Emission from Pulsars and their Systems, Sant Cugat, Spain, 2010 April 12-16 (Springer

Measurements of the Isotopic Ratio 6Li/7Li in Stars with Planets

High-resolution (R = 143,000), high signal-to-noise (S/N = 700-1100) Gemini-S bHROS spectra have been analyzed in a search for 6Li in 5 stars which host extrasolar planets. The presence of detectable amounts of 6Li in these mature, solar-type stars is a good monitor of accretion of planetary disk material, or solid bodies themselves, into the outer layers of the parent stars. Detailed profile-fitting of the Li I resonance doublet at lambda 6707.8 A reveals no detectable amounts of 6Li in any star in our sample. The list of stars analyzed includes HD 82943 for which 6Li has been previouly detected at the level of 6Li/7Li = 0.05 +/- 0.02. The typical limits in the derived isotopic fraction are 6Li/7Li <= 0.00-0.02. These upper limits constrain the amount of accreted material to less than ~ 0.02 to 0.5 Jovian masses. The presence of detectable amounts of 6Li would manifest itself as a red asymmetry in the Li I line-profile and the derived upper limits on such asymmetries are discussed in light of three-dimensional hydrodynamic model atmospheres, where convective motions also give rise to slight red asymmetries in line profiles.Comment: 33 pages, 7 figures, 6 tables, accepted for publication in Ap