372 research outputs found
Non-invasive prenatal testing of haemoglobin Bart's Using Fetal DNA from the maternal plasma
Ph.DDOCTOR OF PHILOSOPH
SWIFT: Scalable Wasserstein Factorization for Sparse Nonnegative Tensors
Existing tensor factorization methods assume that the input tensor follows
some specific distribution (i.e. Poisson, Bernoulli, and Gaussian), and solve
the factorization by minimizing some empirical loss functions defined based on
the corresponding distribution. However, it suffers from several drawbacks: 1)
In reality, the underlying distributions are complicated and unknown, making it
infeasible to be approximated by a simple distribution. 2) The correlation
across dimensions of the input tensor is not well utilized, leading to
sub-optimal performance. Although heuristics were proposed to incorporate such
correlation as side information under Gaussian distribution, they can not
easily be generalized to other distributions. Thus, a more principled way of
utilizing the correlation in tensor factorization models is still an open
challenge. Without assuming any explicit distribution, we formulate the tensor
factorization as an optimal transport problem with Wasserstein distance, which
can handle non-negative inputs.
We introduce SWIFT, which minimizes the Wasserstein distance that measures
the distance between the input tensor and that of the reconstruction. In
particular, we define the N-th order tensor Wasserstein loss for the widely
used tensor CP factorization and derive the optimization algorithm that
minimizes it. By leveraging sparsity structure and different equivalent
formulations for optimizing computational efficiency, SWIFT is as scalable as
other well-known CP algorithms. Using the factor matrices as features, SWIFT
achieves up to 9.65% and 11.31% relative improvement over baselines for
downstream prediction tasks. Under the noisy conditions, SWIFT achieves up to
15% and 17% relative improvements over the best competitors for the prediction
tasks.Comment: Accepted by AAAI-2
The CO Molecular Outflows of IRAS 16293-2422 Probed by the Submillimeter Array
We have mapped the proto-binary source IRAS 16293-2422 in CO 2-1, 13CO 2-1,
and CO 3-2 with the Submillimeter Array (SMA). The maps with resolution of
1".5-5" reveal a single small scale (~3000 AU) bipolar molecular outflow along
the east-west direction. We found that the blueshifted emission of this small
scale outflow mainly extends to the east and the redshifted emission to the
west from the position of IRAS 16293A. A comparison with the morphology of the
large scale outflows previously observed by single-dish telescopes at
millimeter wavelengths suggests that the small scale outflow may be the inner
part of the large scale (~15000 AU) E-W outflow. On the other hand, there is no
clear counterpart of the large scale NE-SW outflow in our SMA maps. Comparing
analytical models to the data suggests that the morphology and kinematics of
the small scale outflow can be explained by a wide-angle wind with an
inclination angle of ~30-40 degrees with respect to the plane of the sky. The
high resolution CO maps show that there are two compact, bright spots in the
blueshifted velocity range. An LVG analysis shows that the one located 1" to
the east of source A is extremely dense, n(H_2)~10^7 cm^-3, and warm, T_kin >55
K. The other one located 1" southeast of source B has a higher temperature of
T_kin >65 K but slightly lower density of n(H_2)~10^6 cm^-3. It is likely that
these bright spots are associated with the hot core-like emission observed
toward IRAS 16293. Since both two bright spots are blueshifted from the
systemic velocity and are offset from the protostellar positions, they are
likely formed by shocks.Comment: 27 pages, 8 figures, accepted for publication in ApJ, minor typos
correcte
Cultural robotics : The culture of robotics and robotics in culture
Copyright 2013 Samani et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedIn this paper, we have investigated the concept of "Cultural Robotics" with regard to the evolution o social into cultural robots in the 21st Century. By defining the concept of culture, the potential development of culture between humans and robots is explored. Based on the cultural values of the robotics developers, and the learning ability of current robots, cultural attributes in this regard are in the process of being formed, which would define the new concept of cultural robotics. According to the importance of the embodiment of robots in the sense of presence, the influence of robots in communication culture is anticipated. The sustainability of robotics culture based on diversity for cultural communities for various acceptance modalities is explored in order to anticipate the creation of different attributes of culture between robot and humans in the futurePeer reviewe
What Drives Animal Fluency Performance in Cantonese-Speaking Chinese Patients with Adult-Onset Psychosis?
Among the numerous studies investigating semantic factors associated with functioning in psychotic patients, most have been conducted on western populations. By contrast, the current cross-sectional study involved native Cantonese-speaking Chinese participants. Using the category fluency task, we compared performance between patients and healthy participants and examined clinical and sociodemographic correlates. First-episode psychosis patients (n = 356) and gender- and age-matched healthy participants (n = 35) were asked to generate as many ‘animals’ as they could in a minute. As expected, patients generated fewer correct responses (an average of 15.5 vs. 22.9 words), generated fewer clusters (an average of 3.7 vs. 5.4 thematically grouped nouns), switched less between clusters (on average 8.0 vs. 11.9 switches) and, interestingly, produced a larger percentage of Chinese zodiac animals than healthy participants (an average of 37.7 vs. 24.2). However, these significant group differences in the clusters and switches disappeared when the overall word production was controlled for. Within patients, education was the strongest predictor of category fluency performance (namely the number of correct responses, clusters, and switches). The findings suggest that an overall slowness in patients may account for the group differences in category fluency performance rather than any specific abnormality per se
The MALATANG Survey : The L GAS-L IR Correlation on Sub-kiloparsec Scale in Six Nearby Star-forming Galaxies as Traced by HCN J = 4 → 3 and HCO + J = 4 → 3
This is an author-created, un-copyedited version of an article published in The Astrophysical Journal. The Version of Record is available online at https://doi.org/10.3847/1538-4357/aac512.We present HCN J = 4→3 and HCO+ J = 4→3 maps of six nearby star-forming galaxies, NGC 253, NGC 1068, IC 342, M82, M83, and NGC 6946, obtained with the James Clerk Maxwell Telescope as part of the MALATANG survey. All galaxies were mapped in the central 2×2 region at 14 (FWHM) resolution (corresponding to linear scales of ∼0.2-1.0 kpc). The LIR-Ldense relation, where the dense gas is traced by the HCN J = 4→3 and the HCO+ J = 4→3 emission, measured in our sample of spatially resolved galaxies is found to follow the linear correlation established globally in galaxies within the scatter. We find that the luminosity ratio, LIR/Ldense, shows systematic variations with LIR within individual spatially resolved galaxies, whereas the galaxy-integrated ratios vary little. A rising trend is also found between LIR/Ldense ratio and the warm-dust temperature gauged by the 70 μm/100 μm flux ratio. We find that the luminosity ratios of IR/HCN (4-3) and IR/HCO+ (4-3), which can be taken as a proxy for the star formation efficiency (SFE) in the dense molecular gas (SFE dense), appear to be nearly independent of the dense gas fraction ( f dense) for our sample of galaxies. The SFE of the total molecular gas (SFEmol) is found to increase substantially with f dense when combining our data with those on local (ultra)luminous infrared galaxies and high-z quasars. The mean LHCN(4-3) LHCO+(4-3) line ratio measured for the six targeted galaxies is 0.9±0.6. No significant correlation is found for the L'HCN(4-3) L'HCO+(4-3) ratio with the star formation rate as traced by L IR, nor with the warm-dust temperature, for the different populations of galaxies.Peer reviewe
dbDEPC: a database of Differentially Expressed Proteins in human Cancers
Cancer-related investigations have long been in the limelight of biomedical research. Years of effort from scientists and doctors worldwide have generated large amounts of data at the genome, transcriptome, proteome and even metabolome level, and DNA and RNA cancer signature databases have been established. Here we present a database of differentially expressed proteins in human cancers (dbDEPC), with the goal of collecting curated cancer proteomics data, providing a resource for information on protein-level expression changes, and exploring protein profile differences among different cancers. dbDEPC currently contains 1803 proteins differentially expressed in 15 cancers, curated from 65 mass spectrometry (MS) experiments in peer-reviewed publications. In addition to MS experiments, low-throughput experiment data from the same literatures and cancer-associated genes from external databases were also integrated to provide some validation information. Furthermore, dbDEPC associates differential proteins with important structural variations in the human genome, such as copy number variations or single nucleotide polymorphisms, which might be helpful for explaining changes in protein expression at the DNA level. Data in dbDEPC can be queried by protein identifier, description or sequence; the retrieved protein entry provides the differential expression pattern seen in cancers, along with detailed annotations. dbDEPC is expected to be a reference database for cancer signatures at the protein level. This database is provided at http://dbdepc.biosino.org/index/
Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development
Non-proteolytic ubiquitin signaling mediated by Lys63 ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells. Our previous work indicates that GPS2 (G-protein Pathway Suppressor 2) is a multifunctional protein regulating TNF signaling and lipid metabolism in the adipose tissue through modulation of Lys63 ubiquitination events. However, the full extent of GPS2-mediated regulation of ubiquitination and the underlying molecular mechanisms are unknown. Here, we report that GPS2 is required for restricting the activation of TLR and BCR signaling pathways and the AKT/FOXO1 pathway in immune cells based on direct inhibition of Ubc13 enzymatic activity. Relevance of this regulatory strategy is confirmed in vivo by B cell-targeted deletion of GPS2, resulting in developmental defects at multiple stages of B cell differentiation. Together, these findings reveal that GPS2 genomic and non-genomic functions are critical for the development and cellular homeostasis of B cells
Efeitos do tratamento com captopril e losartan em ratos Wistar e ratos espontaneamente hipertensos submetidos a hipertensão arterial pulmonar com monocrotalina
A hipertensão arterial pulmonar (HAP) é uma doença que se inicia com o aumento da resistência das arteríolas pulmonares. Após a sua instalação, sucedem-se várias alterações sobre os sistemas cardiovascular, respiratório e autonômico. Apesar dos trabalhos disponíveis na literatura, o desenvolvimento desta doença em modelos experimentais de hipertensão arterial sistêmica permanece ainda por ser estudado, bem como os efeitos terapêuticos de bloqueadores do sistema renina-angiotensina na reversão desta doença. Os objetivos deste estudo foram avaliar os efeitos cardiovasculares, autonômicos e respiratórios promovidos pela HAP induzida pela monocrotalina (MCT) em ratos Wistar e SHR e os efeitos terapêuticos do tratamento crônico com captopril e losartan na reversão da HAP. Para tanto, foram utilizados ratos Wistar (150-180g) e SHR (150-180g), divididos nos seguintes grupos: Wistar controle tratado com salina ou MCT (WIS-CON-SAL e WIS-CON-MCT, respectivamente), SHR controle tratado com salina ou MCT (SHR-CON-SAL e SHR-CON-MCT, respectivamente), Wistar tratados com Captopril + salina ou MCT (WIS-CPT-SAL e WIS-CPT-MCT, respectivamente), SHR tratados com Captopril + salina ou MCT (SHR-CPT-SAL e SHR-MCT-CPT, respectivamente), Wistar tratados com Losartan + salina ou MCT (WIS-LOS-SAL e WIS-LOS-MCT, respectivamente), SHR tratados com Losartan + salina ou MCT (SHR-LOS-SAL e SHR-LOS-MCT, respectivamente). Os animais tratados com MCT receberam uma única injeção subcutânea (60 mg/Kg SC) e os controles receberam o mesmo volume de salina (~0,8 mL). Ao término da 3ª senama, quando os animais MCTs controle apresentaram HAP, foi feito o tratamento com captopril (100 mg/Kg/mL) ou losartan (30 mg/Kg/mL) na água de beber por 2 semanas no volume diário de 30 mL. Após o tratamento com captopril ou losartan, foram realizados os registros cardiovasculares, respiratórios, gasométricos e a histologia pulmonar. Os resultados mostraram um significativo aumento do Índice Pulmonar nos animais controles tratados com MCT (Wistar e SHR) quando comparados com seus respectivos controles. As pressões ventriculares (PSmáx, PDI e PDF) também foram significativamente aumentadas nos grupos MCTs, bem como os valores de pressão arterial sistólica and diastólica, frequência cardíaca, pressão de pulso e labilidade da pressão arterial média. O tratamento com captopril normalizou todos os parâmetros estudados, no entanto, o losartan se mostrou ineficiente em normalizar os parâmetros hemodinâmicos. As análises morfométricas mostraram um espessamento da camada média dos dos ramos distais da artéria pulmonar e uma diminuição do lúmen nos grupos tratados com MCT. O tratamento com captopril e losartan normalizou estes parâmetros, embora o grupo tratado com losartan tenha sido menos eficaz que o captopril, pois os tratamentos mostraram diferenças significativas entre si. Quanto a avaliação autonômica, os animais MCT mostraram aumento do tônus simpático cardíaco e redução do tônus parassimpático cardíaco. Novamente, o tratamento com captopril normalizou estes parâmetros, enquanto que o losartan foi ineficaz em normalizá-los. Quanto aos parâmetros respiratórios, observamos aumentos no volume corrente, na frequência respiratória, na ventilação minuto e na ventilação alveolar dos animais controles tratados com MCT. Apenas o tratamento com captopril normalizou estes parâmetros. A avaliação gasométrica mostrou que os grupos controles tratados com MCT apresentaram redução da pressão parcial de O2 (hipóxia), aumento da pressão parcial de CO2 (hipercapnia), queda da porcentagem de saturação da hemoglobina (% Hb), aumento do bicarbonato (HCO3-) e acidose. O tratamento com captopril normalizou todos os parâmetros gasométricos, enquanto que o mesmo não foi observado com o losartan para os animais SHR submetidos a HAP. Nossos resultados mostraram que a MCT induziu ao quadro de HAP nos animais Wistar e SHR, bem como importantes alterações cardiovasculares, autonômicas, respiratórias, gasométricas e morfológicas pulmonares. Os tratamentos com captopril e losartan foram capazes de reverter a HAP em animais Wistar e SHR, porém, o captopril se mostrou mais eficiente em normalizar esses parâmetros quando comparados ao losartan. Estes resultados sugerem que o uso de bloqueadores do sistema renina angiotensina pode ser uma opção terapêutica para o tratamento da HAP.
Palavras chave: hipertensão arterial pulmonar; monocrotalina; SHR; captopril; losartan
All-Electrical Skyrmionic Bits in a Chiral Magnetic Tunnel Junction
Topological spin textures such as magnetic skyrmions hold considerable
promise as robust, nanometre-scale, mobile bits for sustainable computing. A
longstanding roadblock to unleashing their potential is the absence of a device
enabling deterministic electrical readout of individual spin textures. Here we
present the wafer-scale realization of a nanoscale chiral magnetic tunnel
junction (MTJ) hosting a single, ambient skyrmion. Using a suite of electrical
and multi-modal imaging techniques, we show that the MTJ nucleates skyrmions of
fixed polarity, whose large readout signal - 20-70% relative to uniform states
- corresponds directly to skyrmion size. Further, the MTJ exploits
complementary mechanisms to stabilize distinctly sized skyrmions at zero field,
thereby realizing three nonvolatile electrical states. Crucially, it can write
and delete skyrmions using current densities 1,000 times lower than
state-of-the-art. These results provide a platform to incorporate readout and
manipulation of skyrmionic bits across myriad device architectures, and a
springboard to harness chiral spin textures for multi-bit memory and
unconventional computing.Comment: 8 pages, 5 figure
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