How Not to Lie with Judicial Votes: Misconceptions, Measurement, and Models

In Part I, we describe the formal spatial theory often invoked to justify the statistical approach. While spatial theory has the nice feature of synthesizing theory and empirics, legal scholars may remain skeptical of its strong assumptions. Fortunately, measurement models can be illuminating even if the spatial theory is questionable. To illustrate this, Part II provides a nontechnical overview of the intuition behind measurement models that take merits votes as an input and return a summary score of Justice-specific behavior as an output. Such scores provide clear and intuitive descriptive summaries of differences in judicial voting. Confusion abounds, however, and in Part III we clarify prevailing misconceptions of such scores. We discuss how these scores relate to ideology, explain how such models grapple with the complexity and dimensionality of judicial decisionmaking, illustrate the problems of intertemporal extrapolation and cardinal interpretation of the scores, and highlight other common abuses of such measures. In Part IV, we demonstrate how modern measurement methods are useful precisely because they empower meaningful examination, data collection, and incorporation of doctrine and jurisprudence. We argue that existing uses are simply a special case of a much more general measurement approach that works synergistically with the qualitative study of case law. We demonstrate in Part V how such measurement approaches-when augmented with jurisprudentially meaningful data-----can advance our understanding of courts, with case studies of the constitutional revolution of 1937, the dimensionality of the Supreme Court, the historical origins of the standing doctrine, statutory interpretation, and backlash against Supreme Court opinions. We conclude with thoughts on the chief virtues of model-based measurement and the study of law

The Role of Theory and Evidence in Media Regulation and Law: A Response to Baker and a Defense of Empirical Legal Studies

We thank Professor Baker for a stimulating response to an Article in which we offered empirical evidence of editorial viewpoint diversity in the face of media consolidation. We appreciate his praise of the Article as apply[ing] innovative statistical techniques and as far superior methodologically to most empirical studies he has seen. At the same time, Baker denies the policy relevance to our Article because empirical evidence is entirely irrelevant to the field of media regulation under his preferred normative theory. Baker argues sweepingly that the legal academy\u27s increased willingness to consider the perspectives of quantitative empiricists and positive theorists is malignant, and that law is best confined to normative theory and value-based inquiries - to the exclusion of positive investigation. Because of the provocative nature of the specific critiques of our Article and the general across-the-board indictment of positive scholarship and empirical legal studies, we respond

Calibration of Nebular Emission-line Diagnostics: II. Abundances

(Abridged) We examine standard methods of measuring nebular chemical abundances, including estimates based on direct T_e measurements, and also bright-line diagnostics. We use observations of 4 LMC HII regions whose ionizing stars have classifications ranging from O7 to WN3. We assume a 2-zone T_e structure to compute ionic abundances. We compare with photoionization models tailored to the properties of the individual objects, and emphasize the importance of correctly relating T_e in the two zones, which can otherwise cause errors of ~0.2 dex in abundance estimates. There are no spatial variations to within 0.1 - 0.15 dex in any of the objects, even one hosting 3 WR stars. Our data agree with the modeled R23 and S23 diagnostics of O and S. We present the first theoretical tracks for S23, which are in excellent agreement with a larger dataset. However, contrary to earlier suggestions, S23 is much more sensitive to the ionization parameter than is R23, because S23 does not sample S IV. We therefore introduce S234 = ([SII]+[SIII]+[SIV])/H-beta. Predicted and observed spatial variations in S234 are dramatically reduced in contrast to S23. The intensity of [SIV]10.5 microns is easily estimated from a simple relation between [SIV]/[SIII] and [OIII]/[OII]. This method of estimating S234 yields excellent agreement with our models, hence we give a theoretical calibration for S234. The double-valued structure of S23 and S234 remains an important problem as for R23, and presently we consider the S diagnostics reliable only at Z < 0.5 Z_sol. However, the slightly larger dynamic range and excellent compatibility with theoretical predictions suggest the S diagnostics to be more effective abundance indicators than R23.Comment: Accepted to ApJ. 24 pages, 11 figures, uses emulateapj.st

Increased Population Prevalence of Low Pertussis Toxin Antibody Levels in Young Children Preceding a Record Pertussis Epidemic in Australia

Background: Cross-sectional serosurveys using IgG antibody to pertussis toxin (IgG-PT) are increasingly being used to estimate trends in recent infection independent of reporting biases. Methods/Principal Findings: We compared the age-specific seroprevalence of various levels of IgG-PT in cross-sectional surveys using systematic collections of residual sera from Australian diagnostic laboratories in 1997/8, 2002 and 2007 with reference to both changes in the pertussis vaccine schedule and the epidemic cycle, as measured by disease notifications. A progressive decline in high-level ($62.5 EU/ml) IgG-PT prevalence from 19 % (95 % CI 16–22%) in 1997/98 to 12 % (95 % CI 11–14%) in 2002 and 5 % (95 % CI 4–6%) in 2007 was consistent with patterns of pertussis notifications in the year prior to each collection. Concomitantly, the overall prevalence of undetectable (,5 EU/ml) levels increased from 17 % (95 % CI 14– 20%) in 1997/98 to 38 % (95 % CI 36–40%) in 2007 but among children aged 1–4 years, from 25 % (95 % CI 17–34%) in 1997/98 to 62 % (95 % CI 56–68%) in 2007. This change followed withdrawal of the 18-month booster dose in 2003 and preceded record pertussis notifications from 2008 onwards. Conclusions/Significance: Population seroprevalence of high levels of IgG-PT is accepted as a reliable indicator of pertussis disease activity over time within and between countries with varying diagnostic practices, especially in unimmunised age groups. Our novel findings suggest that increased prevalence of undetectable IgG-PT is an indicator of waning immunit

A classification system to guide physical therapy management in Huntington’s disease: a case series

Background and Purpose: Individuals with Huntington’s disease (HD), a rare neurological disease, experience impairments in mobility and cognition throughout their disease course. The Medical Research Council Framework (MRC) provides a framework that can be applied to the development and evaluation of complex interventions, such as those provided by physical therapists. Treatment-based classifications, based on expert consensus and available literature are helpful in guiding physical therapy management across the stages of HD and contributing to the development and further evaluation of well-defined complex interventions in this highly variable and complex neurodegenerative disease. The purpose of this case series was to illustrate the use of these classifications in the management of two individuals with late-stage HD. Case Description: Two females, ages 40 and 55, with late-stage HD participated in this study. Both experienced progressive declines in ambulatory function and balance as well as falls or fear of falling. Both individuals received daily care in the home for ADLs. Intervention: Physical Therapy Treatment based classifications for HD guided the interventions and outcomes. Eight weeks of in-home balance training, strength training, task-specific practice of functional activities including transfers and walking tasks, and family/carer education was provided. Outcomes: Both individuals demonstrated improvements that met or exceeded the established minimal detectible change (MDC) values for gait speed and Timed Up and Go performance. Both also demonstrated improvements on Berg Balance Scale and Physical Performance Test performance, with one of the two exceeding the established MDCs for both tests. Reductions in fall risk were evident in both cases. Discussion: These cases provide proof-of-principle to support usage of Treatment Based Classifications for physical therapy management for individuals with HD. Traditional classification of early-, mid-, and late-stage disease progression may not reflect patients’ true capabilities; those with late-stage HD may be as responsive to interventions as those at an earlier disease stage

Genetic interaction between two VNTRs in the MAOA gene is associated with the nicotine dependence

Nicotine dependence is an addiction to tobacco products and a global public health concern that in part would be influenced by our genetics. Smokers are reported to have reduced MAOA activity, but the results from genetic associations with this gene have been inconclusive. Two functionally relevant variable number tandem repeat (VNTR) domains, termed uVNTR and dVNTR, in the MAOA gene are well characterized transcriptional regulatory elements. In the present study, we analyzed uVNTR and dVNTR polymorphisms in the MAOA gene in the Vietnamese male population of smokers and non-smokers in order to assess the association of MAOA with the nicotine dependence measured by the Fagerström Test for Nicotine Dependence (FTND). Individual analysis of VNTRs separately identified uVNTR to be associated with the F6 question of the FTND indicating the stronger addiction to nicotine. No associations were found between the dVNTR and smoking behavior. The combination of dVNTR and uVNTR, that predicts low expression of MAOA (10–3 haplotypes), was significantly associated with the higher nicotine dependence (FTND score), longer smoking duration, and more persistent smoking behavior (fewer quit attempts). In conclusion, our study confirms that low MAOA expression is genetically predictive to the higher nicotine dependence

A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl

A sclerosing stromal tumor of the ovary is an extremely rare benign tumor; it usually is found during the second and third decades of life. Patients present with pelvic pain or a palpable abdominal mass. Hormonal effects such as masculinization are uncommon. Here, an 11-year old premenarchal girl presented with deepening of the voice. In addition, clitoromegaly and hirsutism with a male suprapubic hair pattern were observed. The laboratory findings showed that the testosterone level was elevated to 3.67 ng/mL, andostenedione to above 10 ng/mL, dehydroepiandrosterone-sulfate to 346 µg/dL and 17-hydroxy progesterone (17-OHP) to 11.28 ng/mL. The chromosome evaluation revealed a 46,XX female karyotype. An adrenocorticotropic hormone stimulation test was performed. The 17-OHP to cortisol ratio in 30 minutes was 0.045, which suggested a heterozygote for the 21-hydroxylase deficiency. However, the CYP21A2 gene encoding steroid 21-hydroxylase showed normal. The pelvic ultrasound showed a heterogeneous mass consisting of predominantly solid tissue in the pelvic cavity. The pelvic magnetic resonance imaging revealed an 8.9×6.2×6.6 cm mass of the left ovary. A left oophrectomy was performed and microscopic examination confirmed a sclerosing stromal tumor. Immunohistochemical studies showed that the tumor was positive for smooth muscle actin and vimentin, but negative for S-100 protein and cytokeratin. Following surgery, the hormone levels returned to the normal range and the hirsutism resolved

HST/ACS observations of shell galaxies: inner shells, shell colours and dust

AIM:Learn more about the origin of shells and dust in early type galaxies. METHOD: V-I colours of shells and underlying galaxies are derived, using HST Advanced Camera for Surveys (ACS) data. A galaxy model is made locally in wedges and subtracted to determine shell profiles and colours. We applied Voronoi binning to our data to get smoothed colour maps of the galaxies. Comparison with N-body simulations from the literature gives more insight to the origin of the shell features. Shell positions and dust characteristics are inferred from model galaxy subtracted images. RESULT: The ACS images reveal shells well within the effective radius in some galaxies (at 1.7 kpc in the case of NGC 5982). In some cases, strong nuclear dust patches prevent detection of inner shells. Most shells have colours which are similar to the underlying galaxy. Some inner shells are redder than the galaxy. All six shell galaxies show out of dynamical equilibrium dust features, like lanes or patches, in their central regions. Our detection rate for dust in the shell ellipticals is greater than that found from HST archive data for a sample of normal early-type galaxies, at the 95% confidence level. CONCLUSIONS: The merger model describes better the shell distributions and morphologies than the interaction model. Red shell colours are most likely due to the presence of dust and/or older stellar populations. The high prevalence and out of dynamical equilibrium morphologies of the central dust features point towards external influences being responsible for visible dust features in early type shell galaxies. Inner shells are able to manifest themselves in relatively old shell systems.Comment: accepted by A&A; 36 Figures, 25 pages. A version with full resolution Figures can be found here: http://www.astro.rug.nl/~sikkema/shells.p

Exophytic Benign and Malignant Hepatic Tumors: CT Imaging Features

Our objective is to describe the CT features of exophytic hepatic tumors those may pose a diagnostic challenge because of the uncertainty of tumor origin. The beak sign and the feeding artery of a tumor are useful diagnostic indicators of exophytic hepatic tumors. Two- or three-dimensional reformation images are also helpful for diagnosis. The CT features of exophytic hepatic tumors are similar to those of the usual intrahepatic tumors except for their location

The psychological correlates of distinct neural states occurring during wakeful rest

When unoccupied by an explicit external task, humans engage in a wide range of different types of self-generated thinking. These are often unrelated to the immediate environment and have unique psychological features. Although contemporary perspectives on ongoing thought recognise the heterogeneity of these self-generated states, we lack both a clear understanding of how to classify the specific states, and how they can be mapped empirically. In the current study, we capitalise on advances in machine learning that allow continuous neural data to be divided into a set of distinct temporally re-occurring patterns, or states. We applied this technique to a large set of resting state data in which we also acquired retrospective descriptions of the participants' experiences during the scan. We found that two of the identified states were predictive of patterns of thinking at rest. One state highlighted a pattern of neural activity commonly seen during demanding tasks, and the time individuals spent in this state was associated with descriptions of experience focused on problem solving in the future. A second state was associated with patterns of activity that are commonly seen under less demanding conditions, and the time spent in it was linked to reports of intrusive thoughts about the past. Finally, we found that these two neural states tended to fall at either end of a neural hierarchy that is thought to reflect the brain's response to cognitive demands. Together, these results demonstrate that approaches which take advantage of time-varying changes in neural function can play an important role in understanding the repertoire of self-generated states. Moreover, they establish that important features of self-generated ongoing experience are related to variation along a similar vein to those seen when the brain responds to cognitive task demands