Manure Matters, Volume 9, Number 8

Excerpt from Seabiscuit The halcyon days at the Tijuana track came to a spectacular end. On the backstretch early each morning men guided teams of horses on circuits of the barns, shoveling the mucked-out manure into wagons and driving the teams up the hill behind the backstretch, where they would dump it. The pile had been accumulating since 1917, and because the city received little rain to wash it down, it was enormous. “Oh my gosh.” Remembered trainer Jimmy Jones. “ It was as big as the grandstand.” Inside its depths, the manure fermented, generating scalding heat. To the locals, the mountain of manure was a steaming eyesore. To the jockeys, it was prime sauna country. Every day riders dug holes in the surface and burrowed in, Pollard and Woolf probably included. A few took the precaution of zipping into rubber suits before wiggling in, but most just wore street clothes. It was almost too hot to take, but Mother Nature’s hotbox proved unbeatable for sweating off weight

How humanitarian are Germans towards refugees?

This paper uses data collected in May 2023 to better understand how Germans feel towards Syrian refugees. Generally, while feelings of different types of humanitarian concern (safety, material wellbeing, health, future opportunities) were similar, threat feelings (welfare, safety, culture) were slightly higher with the notable exception of less concern about labour market competition. We find that younger people, people with a university degree, or people with a migration background feel less threatened by the immigration of refugees with the most significant differences in attitudes towards refugees based on people’s social and political values. Respondents with stronger humanitarian orientations, higher trust levels and who do not place themselves on the right side of the political spectrum, show markedly higher levels of humanitarian concerns and lower threat perceptions. In addition to measuring attitudes, we also measured respondents’ solidarity towards refugees. Only 29 percent and 23 percent of respondents are willing to sign a petition in favour of financial aid to refugee camps or admissions to Germany, respectively. Respondents with higher levels of social trust are much more likely to express their support for more camp assistance than less trusting respondents. Regarding refugee admissions, a stark divide emerges along political lines, with individuals on the political left showing much greater openness to admitting refugees than those on the right. We find limited support for housing refugees in Germany, especially when asking for respondents’ willingness to accommodate refugees privately

How humanitarian are Germans towards refugees?

This paper uses data collected in May 2023 to better understand how Germans feel towards Syrian refugees. Generally, while feelings of different types of humanitarian concern (safety, material wellbeing, health, future opportunities) were similar, threat feelings (welfare, safety, culture) were slightly higher with the notable exception of less concern about labour market competition. We find that younger people, people with a university degree, or people with a migration background feel less threatened by the immigration of refugees with the most significant differences in attitudes towards refugees based on people’s social and political values. Respondents with stronger humanitarian orientations, higher trust levels and who do not place themselves on the right side of the political spectrum, show markedly higher levels of humanitarian concerns and lower threat perceptions. In addition to measuring attitudes, we also measured respondents’ solidarity towards refugees. Only 29 percent and 23 percent of respondents are willing to sign a petition in favour of financial aid to refugee camps or admissions to Germany, respectively. Respondents with higher levels of social trust are much more likely to express their support for more camp assistance than less trusting respondents. Regarding refugee admissions, a stark divide emerges along political lines, with individuals on the political left showing much greater openness to admitting refugees than those on the right. We find limited support for housing refugees in Germany, especially when asking for respondents’ willingness to accommodate refugees privately

Accretion Rates for T Tauri Stars Using Nearly Simultaneous Ultraviolet and Optical Spectra

We analyze the accretion properties of 21 low-mass T Tauri stars using a data set of contemporaneous near-UV (NUV) through optical observations obtained with the Hubble Space Telescope Imaging Spectrograph and the ground-based Small and Medium Aperture Research Telescope System, a unique data set because of the nearly simultaneous broad wavelength coverage. Our data set includes accreting T Tauri stars in Taurus, Chamaeleon I, η Chamaeleon, and the TW Hydra Association. For each source we calculate the accretion rate (Ṁ) by fitting the NUV and optical excesses above the photosphere, produced in the accretion shock, introducing multiple accretion components characterized by a range in energy flux (or density) for the first time. This treatment is motivated by models of the magnetospheric geometry and accretion footprints, which predict that high-density, low filling factor accretion spots coexist with low-density, high filling factor spots. By fitting the UV and optical spectra with multiple accretion components, we can explain excesses which have been observed in the near-IR. Comparing our estimates of Ṁ to previous estimates, we find some discrepancies; however, they may be accounted for when considering assumptions for the amount of extinction and variability in optical spectra. Therefore, we confirm many previous estimates of the accretion rate. Finally, we measure emission line luminosities from the same spectra used for the Ṁ estimates, to produce correlations between accretion indicators (Hβ, Ca II K, C II], and Mg II) and accretion properties obtained simultaneously

CSI 2264: Characterizing Accretion-Burst Dominated Light Curves for Young Stars in NGC 2264

Based on more than four weeks of continuous high cadence photometric monitoring of several hundred members of the young cluster NGC 2264 with two space telescopes, NASA's Spitzer and the CNES CoRoT (Convection, Rotation, and planetary Transits), we provide high quality, multi-wavelength light curves for young stellar objects (YSOs) whose optical variability is dominated by short duration flux bursts, which we infer are due to enhanced mass accretion rates. These light curves show many brief -- several hour to one day -- brightenings at optical and near-infrared (IR) wavelengths with amplitudes generally in the range 5-50% of the quiescent value. Typically, a dozen or more of these bursts occur in a thirty day period. We demonstrate that stars exhibiting this type of variability have large ultraviolet (UV) excesses and dominate the portion of the u-g vs. g-r color-color diagram with the largest UV excesses. These stars also have large Halpha equivalent widths, and either centrally peaked, lumpy Halpha emission profiles or profiles with blue-shifted absorption dips associated with disk or stellar winds. Light curves of this type have been predicted for stars whose accretion is dominated by Rayleigh-Taylor instabilities at the boundary between their magnetosphere and inner circumstellar disk, or where magneto-rotational instabilities modulate the accretion rate from the inner disk. Amongst the stars with the largest UV excesses or largest Halpha equivalent widths, light curves with this type of variability greatly outnumber light curves with relatively smooth sinusoidal variations associated with long-lived hot spots. We provide quantitative statistics for the average duration and strength of the accretion bursts and for the fraction of the accretion luminosity associated with these bursts.Comment: Accepted for publication in AJ. 39 pages; 6 tables; 25 figures, many of which are highly degraded to meet size limits. Please download the regular resolution version at http://web.ipac.caltech.edu/staff/amc/staufferetal2014.pd

Toward a Unification of Star Formation Rate Determinations in the Milky Way and Other Galaxies

The star formation rate (SFR) of the Milky Way remains poorly known, with often-quoted values ranging from 1 to 10 solar masses per year. This situation persists despite the potential for the Milky Way to serve as the ultimate SFR calibrator for external galaxies. We show that various estimates for the Galactic SFR are consistent with one another once they have been normalized to the same initial mass function (IMF) and massive star models, converging to 1.9 +/- 0.4 M_sun/yr. However, standard SFR diagnostics are vulnerable to systematics founded in the use of indirect observational tracers sensitive only to high-mass stars. We find that absolute SFRs measured using resolved low/intermediate-mass stellar populations in Galactic H II regions are systematically higher by factors of ~2-3 as compared with calibrations for SFRs measured from mid-IR and radio emission. We discuss some potential explanations for this discrepancy and conclude that it could be allayed if (1) the power-law slope of the IMF for intermediate-mass (1.5 M_sun < m < 5 M_sun) stars were steeper than the Salpeter slope, or (2) a correction factor was applied to the extragalactic 24 micron SFR calibrations to account for the duration of star formation in individual mid-IR-bright H II regions relative to the lifetimes of O stars. Finally, we present some approaches for testing if a Galactic SFR of ~2 M_sun/yr is consistent with what we would measure if we could view the Milky Way as external observers. Using luminous radio supernova remnants and X-ray point sources, we find that the Milky Way deviates from expectations at the 1-3 sigma level, hinting that perhaps the Galactic SFR is overestimated or extragalactic SFRs need to be revised upwards.Comment: Accepted for publication in A

TRAILblazing Strategies for Cancer Treatment

In the late 1990s, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF-family, started receiving much attention for its potential in cancer therapy, due to its capacity to induce apoptosis selectively in tumour cells in vivo. TRAIL binds to its membrane-bound death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5) inducing the formation of a death-inducing signalling complex (DISC) thereby activating the apoptotic cascade. The ability of TRAIL to also induce apoptosis independently of p53 makes TRAIL a promising anticancer agent, especially in p53-mutated tumour entities. Thus, several so-called TRAIL receptor agonists (TRAs) were developed. Unfortunately, clinical testing of these TRAs did not reveal any significant anticancer activity, presumably due to inherent or acquired TRAIL resistance of most primary tumour cells. Since the potential power of TRAIL-based therapies still lies in TRAIL's explicit cancer cell-selectivity, a desirable approach going forward for TRAIL-based cancer therapy is the identification of substances that sensitise tumour cells for TRAIL-induced apoptosis while sparing normal cells. Numerous of such TRAIL-sensitising strategies have been identified within the last decades. However, many of these approaches have not been verified in animal models, and therefore potential toxicity of these approaches has not been taken into consideration. Here, we critically summarise and discuss the status quo of TRAIL signalling in cancer cells and strategies to force tumour cells into undergoing apoptosis triggered by TRAIL as a cancer therapeutic approach. Moreover, we provide an overview and outlook on innovative and promising future TRAIL-based therapeutic strategies