Babelomics 5.0: functional interpretation for new generations of genomic data

This article has been accepted for publication in Nucleic Acids Research Published by Oxford University Press.Babelomics has been running for more than one decade offering a user-friendly interface for the functional analysis of gene expression and genomic data. Here we present its fifth release, which includes support for Next Generation Sequencing data including gene expression (RNA-seq), exome or genome resequencing. Babelomics has simplified its interface, being now more intuitive. Improved visualization options, such as a genome viewer as well as an interactive network viewer, have been implemented. New technical enhancements at both, client and server sides, makes the user experience faster and more dynamic. Babelomics offers user-friendly access to a full range of methods that cover: (i) primary data analysis, (ii) a variety of tests for different experimental designs and (iii) different enrichment and network analysis algorithms for the interpretation of the results of such tests in the proper functional context. In addition to the public server, local copies of Babelomics can be downloaded and installed. Babelomics is freely available at: http://www.babelomics.org.Spanish Ministry of Economy and Competitiveness [BIO2011-27069], Conselleria d'Educacio of the Valencian Community [PROMETEOII/2014/025]; EU FP7-PEOPLE Project MLPM [316861]; Fundació la Marató TV3 [151/C/2013]. Funding for open access charge: Spanish Ministry of Economy and Competitiveness [BIO2011-27069]

A comparison of mechanistic signaling pathway activity analysis methods

This is a pre-copyedited, author-produced version of an article accepted for publication in Briefings in Bioinformatics following peer review. The version of record Amadoz, A., et al. (2018). "A comparison of mechanistic signaling pathway activity analysis methods." Briefings in Bioinformatics. is available online at: https://doi.org/10.1093/bib/bby040This work was supported by grants SAF2017-88908-R from the Spanish Ministry of Economy and Competitiveness and “Plataforma de Recursos Biomoleculares y Bioinformáticos” PT13/0001/0007 from the ISCIII, both co-funded with European Regional Development Funds (ERDF), and EU H2020-INFRADEV-1-2015-1 ELIXIR-EXCELERATE (ref. 676559)

Computing with biological switches and clocks

The complex dynamics of biological systems is primarily driven by molecular interactions that underpin the regulatory networks of cells. These networks typically contain positive and negative feedback loops, which are responsible for switch-like and oscillatory dynamics, respectively. Many computing systems rely on switches and clocks as computational modules. While the combination of such modules in biological systems leads to a variety of dynamical behaviours, it is also driving development of new computing algorithms. Here we present a historical perspective on computation by biological systems, with a focus on switches and clocks, and discuss parallels between biology and computing. We also outline our vision for the future of biological computing

Computing with biological switches and clocks

The complex dynamics of biological systems is primarily driven by molecular interactions that underpin the regulatory networks of cells. These networks typically contain positive and negative feedback loops, which are responsible for switch-like and oscillatory dynamics, respectively. Many computing systems rely on switches and clocks as computational modules. While the combination of such modules in biological systems leads to a variety of dynamical behaviours, it is also driving development of new computing algorithms. Here we present a historical perspective on computation by biological systems, with a focus on switches and clocks, and discuss parallels between biology and computing. We also outline our vision for the future of biological computing

La Biblioteca-Archivo de la Escuela de Estudios Árabes, un servicio con proyección cultural y educativa

Sección especial para la "Home" de la Web de la Red de Bibliotecas y Archivos del CSIC para dar a conocer de manera visual y textual aspectos representativos de las bibliotecas y archivos que constituyen la Red CSICTener como sede la Casa morisca del Chapiz, monumento del siglo XVI cuyo origen remontan algunos especialistas al período nazarí, convierte a la Escuela de Estudios Árabes del CSIC en un instituto de investigación de indudable singularidad. Excepcionales son también el Albaicín, barrio en el que está enclavada, su entorno paisajístico y patrimonial, frente a la Alhambra y la propia ciudad de Granada en la que todos ellos se asientan. No hay mejores elementos para enmarcar las actividades científicas que en él se desarrollan: la historia de al-Andalus y de sus textos, la arqueología y la arquitectura Islámicas.N