Switching of Magnetic Moments of Nanoparticles by Surface Acoustic Waves

We report evidence of the magnetization reversal in nanoparticles by surface acoustic waves (SAWs). The experimental system consists of isolated magnetite nanoparticles dispersed on a piezoelectric substrate. Magnetic relaxation from a saturated state becomes significantly enhanced in the presence of the SAW at a constant temperature of the substrate. The dependence of the relaxation on SAW power and frequency has been investigated. The effect is explained by the effective ac magnetic field generated by the SAW in the nanoparticles.Comment: Accepted in Europhysics Letter

Field induced magnetic transition and metastability in Co substituted Mn2SbMn_{2}Sb

A detailed investigation of first order ferrimagnetic (FRI) to antiferromagnetic (AFM) transition in Co (15%) doped $Mn_2Sb$ is carried out. These measurements demonstrate anomalous thermomagnetic irreversibility and glass-like frozen FRI phase at low temperatures. The irreversibility arising between the supercooling and superheating spinodals is distinguised in an ingenious way from the irreversibility arising due to kinetic arrest. Field annealing measurements shows reentrant FRI-AFM-FRI transition with increasing temperature. These measurements also show that kinetic arrest band and supercooling band are anitcorrelated i.e regions which are kinetically arrested at higher temperature have lower supercooling temperature and vice versa.Comment: 10 pages, 8 figure

Tuning Magnetic Avalanches in Mn12-ac

Using micron-sized Hall sensor arrays to obtain time-resolved measurements of the local magnetization, we report a systematic study in the molecular magnet Mn$_{12}$-acetate of magnetic avalanches controllably triggered in different fixed external magnetic fields and for different values of the initial magnetization. The speeds of propagation of the spin-reversal fronts are in good overall agreement with the theory of magnetic deflagration of Garanin and Chudnovsky \cite{Garanin}.Comment: 8 pages, 7 figures; discussion expanded and revise

Coherent radiation by molecular magnets

The possibility of coherent radiation by molecular magnets is investigated. It is shown that to realize the coherent radiation, it is necessary to couple the considered sample to a resonant electric circuit. A theory for describing this phenomenon is developed, based on a realistic microscopic Hamiltonian, including the Zeeman terms, single-site anisotropy, and dipole interactions. The role of hyperfine interactions between molecular and nuclear spins is studied. Numerical solutions of the spin evolution equations are presented.Comment: Latex file, 11 pages, 3 figure

Acoustically driven arrayed waveguide grating

“© 2015 Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited"We demonstrate compact tunable phased-array wavelength-division multiplexers driven by surface acoustic waves (SAWs) in the low GHz range. The devices comprise two couplers, which respectively split and combine the optical signal, linked by an array of single-mode waveguides (WGs). Two different layouts are presented, in which multi-mode interference couplers or free propagating regions were separately employed as couplers. The multiplexers operate on five equally distributed wavelength channels, with a spectral separation of 2 nm. A standing SAW modulates the refractive index of the arrayed WGs. Each wavelength component periodically switches paths between the output channel previously asigned by the design and the adjacent channels, at a fixed applied acoustic power. The devices were monolithically fabricated on (Al, Ga) As. A good agreement between theory and experiment is achieved.The authors thank W. Seidel, and S. Rauwerdink for preparation of the devices. This research has been supported by the international campus of excellence VLC/CAMPUS and by the program INNCIDE from the Spanish Ministry of Economy and Competitiveness (MINECO), through the program "Valoritza i Transfereix" from the Vice-Principal of Research and Scientific Policy of the Universitat de Valencia and through the program INNOVA (grant SP20120860) from the Universitat Politecnica de Valencia. Financial support by the Spanish MINECO Projects TEC2010-21337 and MAT2012-33483 is gratefully acknowledged. A. Crespo-Poveda and B. Gargallo acknowledge financial support through FPI grants BES-2010-036846 and BES-2011-046100, respectively.Crespo-Poveda, A.; Hernandez-Minguez, A.; Gargallo Jaquotot, BA.; Biermann, K.; Tahraoui, A.; Santos, PV.; Munoz, P.... (2015). Acoustically driven arrayed waveguide grating. Optics Express. 23(16):21213-21231. https://doi.org/10.1364/OE.23.021213S21213212312316Dragone, C. (1991). An N*N optical multiplexer using a planar arrangement of two star couplers. IEEE Photonics Technology Letters, 3(9), 812-815. doi:10.1109/68.84502Talahashi, H., Oda, K., Toba, H., & Inoue, Y. (1995). Transmission characteristics of arrayed waveguide N×N wavelength multiplexer. Journal of Lightwave Technology, 13(3), 447-455. doi:10.1109/50.372441Smit, M. K., & Van Dam, C. (1996). PHASAR-based WDM-devices: Principles, design and applications. IEEE Journal of Selected Topics in Quantum Electronics, 2(2), 236-250. doi:10.1109/2944.577370Munoz, P., Pastor, D., & Capmany, J. (2002). Modeling and design of arrayed waveguide gratings. Journal of Lightwave Technology, 20(4), 661-674. doi:10.1109/50.996587Paiam, M. R., & MacDonald, R. I. (1997). Design of phased-array wavelength division multiplexers using multimode interference couplers. Applied Optics, 36(21), 5097. doi:10.1364/ao.36.005097Nakamura, S., Ueno, Y., & Tajima, K. (2001). Femtosecond switching with semiconductor-optical-amplifier-based Symmetric Mach–Zehnder-type all-optical switch. Applied Physics Letters, 78(25), 3929-3931. doi:10.1063/1.1379790Wurtz, G. A., Pollard, R., Hendren, W., Wiederrecht, G. P., Gosztola, D. J., Podolskiy, V. A., & Zayats, A. V. (2011). Designed ultrafast optical nonlinearity in a plasmonic nanorod metamaterial enhanced by nonlocality. Nature Nanotechnology, 6(2), 107-111. doi:10.1038/nnano.2010.278Li, X., Xu, H., Xiao, X., Li, Z., Yu, Y., & Yu, J. (2014). Fast and efficient silicon thermo-optic switching based on reverse breakdown of pn junction. Optics Letters, 39(4), 751. doi:10.1364/ol.39.000751Ishii, M., Hibino, Y., Hanawa, F., Nakagome, H., & Kato, K. (1998). Packaging and environmental stability of thermally controlled arrayed-waveguide grating multiplexer module with thermoelectric device. Journal of Lightwave Technology, 16(2), 258-264. doi:10.1109/50.661019Watanabe, T., Ooba, N., Hayashida, S., Kurihara, T., & Imamura, S. (1998). Polymeric optical waveguide circuits formed using silicone resin. Journal of Lightwave Technology, 16(6), 1049-1055. doi:10.1109/50.681462Xiao, G. Z., Zhao, P., Sun, F. G., Lu, Z. G., Zhang, Z., & Grover, C. P. (2004). Interrogating fiber Bragg grating sensors by thermally scanning a demultiplexer based on arrayed waveguide gratings. Optics Letters, 29(19), 2222. doi:10.1364/ol.29.002222Stabile, R., Rohit, A., & Williams, K. A. (2014). Monolithically Integrated 8 × 8 Space and Wavelength Selective Cross-Connect. Journal of Lightwave Technology, 32(2), 201-207. doi:10.1109/jlt.2013.2290322Asakura, H., Hashimoto, M., Nashimoto, K., Tsuda, H., & Kudzuma, D. (2012). High-speed wavelength selective operation of PLZT-based arrayed-waveguide grating. Electronics Letters, 48(16), 1009-1010. doi:10.1049/el.2012.1292Gorecki, C., Chollet, F., Bonnotte, E., & Kawakatsu, H. (1997). Silicon-based integrated interferometer with phase modulation driven by surface acoustic waves. Optics Letters, 22(23), 1784. doi:10.1364/ol.22.001784De Lima, M. M., Beck, M., Hey, R., & Santos, P. V. (2006). Compact Mach-Zehnder acousto-optic modulator. Applied Physics Letters, 89(12), 121104. doi:10.1063/1.2354411Beck, M., de Lima, M. M., Wiebicke, E., Seidel, W., Hey, R., & Santos, P. V. (2007). Acousto-optical multiple interference switches. Applied Physics Letters, 91(6), 061118. doi:10.1063/1.2768889Beck, M., de Lima, M. M., & Santos, P. V. (2008). Acousto-optical multiple interference devices. 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Immigration and Human Development: Evidence from Lebanon

This paper takes Lebanon as a case study to examine the relationship between human development and immigration. It examines this issue from both ends: the sending and the receiving countries. The author suggests that by developing the concept of a diasporic civil society and a diasporic public sphere, a significant aspect of the relationship between human development and immigration is illuminated especially at the level of political, social and cultural capitals. The paper also argues that the double impact of the home country and that of destination has a lot to say about the influence of immigration on human development in Lebanon. In examining Australia as a destination country, the paper shows the particular impact that globalisation and September 11 have lately had on the capacity of the Lebanese migrants for human development. Finally, the paper concludes by showing the extent to which the diasporic civil society compensates for the ‘negligent’ character of the Lebanese state in the context of human development

Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations

Dravet syndrome is a genetic encephalopathy characterized by severe epilepsy combined with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only partial control of seizures and provide little benefit on the patient’s neurological development. In >80% of cases, the disease is caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of the Nav1.1 voltage-gated sodium channel. Novel therapies aim to restore SCN1A expression in order to address all disease manifestations. We provide evidence that a high-capacity adenoviral vector harboring the 6-kb SCN1A cDNA is feasible and able to express functional Nav1.1 in neurons. In vivo, the best biodistribution was observed after intracerebral injection in basal ganglia, cerebellum, and prefrontal cortex. SCN1A A1783V knockin mice received the vector at 5 weeks of age, when most neurological alterations were present. Animals were protected from sudden death, and the epileptic phenotype was attenuated. Improvement of motor performance and interaction with the environment was observed. In contrast, hyperactivity persisted, and the impact on cognitive tests was variable (success in novel object recognition and failure in Morris water maze tests). These results provide proof of concept for gene supplementation in Dravet syndrome and indicate new directions for improvement

Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset

Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson’s disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully established. Here, we comprehensively assessed the role of mitochondrial function-associated genes in sporadic PD by leveraging improvements in the scale and analysis of PD GWAS data with recent advances in our understanding of the genetics of mitochondrial disease. We calculated a mitochondrial-specific polygenic risk score (PRS) and showed that cumulative small effect variants within both our primary and secondary gene lists are significantly associated with increased PD risk. We further reported that the PRS of the secondary mitochondrial gene list was significantly associated with later age at onset. Finally, to identify possible functional genomic associations we implemented Mendelian randomization, which showed that 14 of these mitochondrial functionassociated genes showed functional consequence associated with PD risk. Further analysis suggested that the 14 identified genes are not only involved in mitophagy, but implicate new mitochondrial processes. Our data suggests that therapeutics targeting mitochondrial bioenergetics and proteostasis pathways distinct from mitophagy could be beneficial to treating the early stage of PD

Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Background Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours.Methods In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186.Findings Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78 center dot 6%] female patients and 4922 [21 center dot 4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1 center dot 4 [IQR 0 center dot 6-3 center dot 4]) compared with the prepandemic phase (2 center dot 0 [0 center dot 9-3 center dot 7]; p<0 center dot 0001) and pandemic decrease phase (2 center dot 3 [1 center dot 0-5 center dot 0]; p<0 center dot 0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69 center dot 0%] of 3704 vs 1515 [71 center dot 5%] of 2119; OR 1 center dot 1 [95% CI 1 center dot 0-1 center dot 3]; p=0 center dot 042), lymph node metastases (343 [9 center dot 3%] vs 264 [12 center dot 5%]; OR 1 center dot 4 [1 center dot 2-1 center dot 7]; p=0 center dot 0001), and tumours at high risk of structural disease recurrence (203 [5 center dot 7%] of 3584 vs 155 [7 center dot 7%] of 2006; OR 1 center dot 4 [1 center dot 1-1 center dot 7]; p=0 center dot 0039).Interpretation Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation.Funding None.Copyright (c) 2023 Published by Elsevier Ltd. All rights reserved

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability

Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and cell-type-specific genomic annotations to connect human genomic PD findings to specific brain cell types. We found that PD heritability attributable to common variation does not enrich in global and regional brain annotations or brain-related cell-type-specific annotations. Likewise, we found no enrichment of PD susceptibility genes in brain-related cell types. In contrast, we demonstrated a significant enrichment of PD heritability in a curated lysosomal gene set highly expressed in astrocytic, microglial, and oligodendrocyte subtypes, and in LoF-intolerant genes, which were found highly expressed in almost all tested cellular subtypes. Our results suggest that PD risk loci do not lie in specific cell types or individual brain regions, but rather in global cellular processes detectable across several cell types