Characterizing the Effect of Videophone Conversations on Intersection Driving Performance

The present study examined the efficacy of videophone conversations for enhancing conversation partner situational awareness and mitigating cell phone distraction during intersection drives. Younger and older drivers drove through simulated intersections in four conditions: undistracted, with an in-car passenger, with a remote partner who could see the driver and a subset of the driving scene via a videophone, and with a remote partner on a cell phone. Relative to the cell phone condition, passenger and videophone conversations enhanced situational awareness and mitigated distraction. Younger and older drivers showed similar benefits, although there were age-related costs to driving performance overall. Videophone information offers a simple and promising potential strategy to enhance partner situational awareness during cell phone conversations, even when the conversation partner can see only a subset of the driving scene

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

CHARACTERIZING THE EFFECT OF VIDEOPHONE CONVERSATIONS ON INTERSECTION DRIVING PERFORMANCE

Summary: The present study examined the efficacy of videophone conversations for enhancing conversation partner situational awareness and mitigating cell phone distraction during intersection drives. Younger and older drivers drove through simulated intersections in four conditions: undistracted, with an in-car passenger, with a remote partner who could see the driver and a subset of the driving scene via a videophone, and with a remote partner on a cell phone. Relative to the cell phone condition, passenger and videophone conversations enhanced situational awareness and mitigated distraction. Younger and older drivers showed similar benefits, although there were age-related costs to driving performance overall. Videophone information offers a simple and promising potential strategy to enhance partner situational awareness during cell phone conversations, even when the conversation partner can see only a subset of the driving scene

Are Gamers Better Crossers? An Examination Of Action Video Game Experience And Dual Task Effects In A Simulated Street Crossing Task

Objective: A high-fidelity street crossing simulator was used to test the hypothesis that experienced action video game players are less vulnerable than nongamers to dual task costs in complex tasks. Background: Previous research has shown that action video game players outperform nonplayers on many single task measures of perception and attention. It is unclear, however, whether action video game players outperform nonplayers in complex, divided attention tasks. Method: Experienced action video game players and nongamers completed a street crossing task in a high-fidelity simulator. Participants walked on a manual treadmill to cross the street. During some crossings, a cognitively demanding working memory task was added. Results: Dividing attention resulted in more collisions and increased decision making time. Of importance, these dual task costs were equivalent for the action video game players and the nongamers. Conclusion: These results suggest that action video game players are equally susceptible to the costs of dividing attention in a complex task. Application: Perceptual and attentional benefits associated with action video game experience may not translate to performance benefits in complex, realworld tasks. Copyright © 2013, Human Factors and Ergonomics Society

ALICE on the Eightfold Way: Exploring Curved Spaces in an Enclosed Virtual Reality Theatre

We describe a collaboration between mathematicians interested in visualizing curved three-dimensional spaces and researchers building next-generation virtual-reality environments such as ALICE, a six-sided, rigid-walled virtual-reality chamber. This environment integrates active-stereo imaging, wireless motion-tracking and wireless-headphone sound. To reduce cost, the display is driven by a cluster of commodity computers instead of a traditional graphics supercomputer. The mathematical application tested in this environment is an implementation of Thurston’s eight-fold way; these eight three-dimensional geometries are conjectured to suffice for describing all possible three-dimensional manifolds or universes