F3B: A Low-Overhead Blockchain Architecture with Per-Transaction Front-Running Protection

Front-running attacks, which benefit from advanced knowledge of pending transactions, have proliferated in the blockchain space since the emergence of decentralized finance. Front-running causes devastating losses to honest participants and continues to endanger the fairness of the ecosystem. We present Flash Freezing Flash Boys (F3B), a blockchain architecture that addresses front-running attacks by using threshold cryptography. In F3B, a user generates a symmetric key to encrypt their transaction, and once the underlying consensus layer has finalized the transaction, a decentralized secret-management committee reveals this key. F3B mitigates front-running attacks because, before the consensus group finalizes it, an adversary can no longer read the content of a transaction, thus preventing the adversary from benefiting from advanced knowledge of pending transactions. Unlike other mitigation systems, F3B properly ensures that all unfinalized transactions, even with significant delays, remain private by adopting per-transaction protection. Furthermore, F3B addresses front-running at the execution layer; thus, our solution is agnostic to the underlying consensus algorithm and compatible with existing smart contracts. We evaluated F3B on Ethereum with a modified execution layer and found only a negligible (0.026%) increase in transaction latency, specifically due to running threshold decryption with a 128-member secret-management committee after a transaction is finalized; this indicates that F3B is both practical and low-cost

Laparoscopic Splenectomy in Children

BACKGROUND: Laparoscopic splenectomy is being performed more commonly in children, although its advantages are not clear. We sought to determine whether laparoscopic splenectomy was superior to open splenectomy. METHODS: The records of all pediatric patients undergoing splenectomy without significant comorbidities over a 12-year period were examined. The patients were divided into those undergoing laparoscopic splenectomy and those undergoing open splenectomy. Demographics, operative time, estimated blood loss, spleen size, length of stay, and total charges were compared between the groups. RESULTS: Eighty-one (58%) children underwent laparoscopic splenectomy, and 59 (42%) children underwent open splenectomy. The groups were similar in age and sex; hereditary spherocytosis was more common in the LS group. Operating time was longer in the laparoscopic splenectomy group (231 +/- 10 min vs 138 +/- 9 min; P\u3c0.001), but blood loss and complication rates were similar. Twelve (15%) conversions were necessary primarily due to spleen size. Although children undergoing LS had a shorter length of stay (2.4 +/- 0.1 vs 4.1 +/- 0.3 days; P\u3c0.001), they incurred higher charges (dollars 21199 +/- 664 vs dollars 15723 +/- 1737; P\u3c0.002). CONCLUSION: Laparoscopic splenectomy is a safe procedure in children, resulting in shorter hospital stay, which may translate into earlier return to activity and a smaller burden on the child\u27s caretakers

Absorption of high-energy gamma rays in Cygnus X-3

The microquasar Cygnus X-3 was detected at high energies by the gamma-ray space telescopes AGILE and Fermi. The gamma-ray emission is transient, modulated with the orbital period and seems related to major radio flares, i.e. to the relativistic jet. The GeV gamma-ray flux can be substantially attenuated by internal absorption with the ambient X-rays. In this study, we examine quantitatively the effect of pair production in Cygnus X-3 and put constraints on the location of the gamma-ray source. Cygnus X-3 exhibits complex temporal and spectral patterns in X-rays. During gamma-ray flares, the X-ray emission can be approximated by a bright disk black body component and a non-thermal tail extending in hard X-rays, possibly related to a corona above the disk. We calculate numerically the exact optical depth for gamma rays above a standard accretion disk. Emission and absorption in the corona are also investigated. GeV gamma rays are significantly absorbed by soft X-rays emitted from the inner parts of the accretion disk. The absorption pattern is complex and anisotropic. Isotropization of X-rays due to Thomson scattering in the companion star wind tends to increase the gamma-ray opacity. Gamma rays from the corona suffer from strong absorption by photons from the disk and cannot explain the observed high-energy emission, unless the corona is unrealistically extended. The lack of absorption feature in the GeV emission indicates that high-energy gamma rays should be located at a minimum distance ~10^8-10^10 cm from the compact object. The gamma-ray emission is unlikely to have a coronal origin.Comment: 11 pages, 9 figures, accepted for publication in Astronomy and Astrophysic

Weaving Indigenous knowledge systems and Western sciences in terrestrial research, monitoring and management in Canada: A protocol for a systematic map

Human activities and development have contributed to declines in biodiversity across the globe.Understanding and addressing biodiversity loss will require the mobilization of diverse knowledge systems. While calls for interdisciplinary practices in environmental research date back decades, there has been a more recent push for weaving multiple knowledge systems in environmental research and management, specifically Indigenous knowledge systems (IKS) and Western sciences. The use of multiple knowledge systems in environmental research can improve understanding of socio-ecological connections, build trust in research findings and help implement evidence-based action towards biodiversity conservation. Mobilizing multiple types of knowledge in environmental research and management can be beneficial; however, challenges remain. There is a need to understand how and where studies have woven IKS and Western sciences together in order to learn about frameworks and processes used, and identify best practices. Here, we present a protocol for a systematic map that will examine the extent, range and nature of the published literature that weaves IKS and Western sciences in terrestrial ecosystems research, monitoring and management in Canada. The systematic map will aim to capture all available and relevant studies found in the published academic and grey literature. The search will use standardized search terms across four publication databases, four specialized websites and one web-based search engine. Bibliographies of relevant review articles captured by our search strategy will be cross-checked to identify additional studies. Calls for evidence among professional networks will also complement the search strategy. All searches will be conducted in English. Search results will be reviewed in two stages: (1) title and abstract and (2) full text. All screening decisions at the full-text stage will be included into the map database. The systematic map will use a narrative synthesis approach employing descriptive tables, statistics and figures (including a map with geospatially referenced studies) to summarize findings. Results from this mapping exercise can serve to support environmental research and management efforts working across IKS and Western sciences by highlighting best practices, as well as evidence gaps

Transactivation of EGFR by LPS induces COX-2 expression in enterocytes

Necrotizing enterocolitis (NEC) is the leading cause of gastrointestinal morbidity and mortality in preterm infants. NEC is characterized by an exaggerated inflammatory response to bacterial flora leading to bowel necrosis. Bacterial lipopolysaccharide (LPS) mediates inflammation through TLR4 activation and is a key molecule in the pathogenesis of NEC. However, LPS also induces cyclooxygenase-2 (COX-2), which promotes intestinal barrier restitution through stimulation of intestinal cell survival, proliferation, and migration. Epidermal growth factor receptor (EGFR) activation prevents experimental NEC and may play a critical role in LPS-stimulated COX-2 production. We hypothesized that EGFR is required for LPS induction of COX-2 expression. Our data show that inhibiting EGFR kinase activity blocks LPS-induced COX-2 expression in small intestinal epithelial cells. LPS induction of COX-2 requires Src-family kinase signaling while LPS transactivation of EGFR requires matrix metalloprotease (MMP) activity. EGFR tyrosine kinase inhibitors block LPS stimulation of mitogen-activated protein kinase ERK, suggesting an important role of the MAPK/ERK pathway in EGFR-mediated COX-2 expression. LPS stimulates proliferation of IEC-6 cells, but this stimulation is inhibited with either the EGFR kinase inhibitor AG1478, or the selective COX-2 inhibitor Celecoxib. Taken together, these data show that EGFR plays an important role in LPS-induction of COX-2 expression in enterocytes, which may be one mechanism for EGF in inhibition of NEC

A comparative study of knowledge construction within online user support discussion forums in Chinese and English-language cultural contexts

Many IT companies like HP, Dell and Lenovo have established both English language and Chinese user support forums for their consumers to share and construct knowledge. The innovative knowledge generated in these virtual product user communities is valuable for companies enabling them to incorporate users’ innovative insights and problems solving skills. This research compares the knowledge construction processes within such forums in English and Chinese cultural contexts. The research adopts a method combining content analysis of discussion threads where technical problems are solved, complemented by observation and thematic analysis of interviews with forum members. The results show that the cultural and language differences do not cause a big change of users’ knowledge construction patterns. However, the character of Chinese language and culture can indirectly affect the process by including more social information to influence social interactions. The research suggests that more tailored facilitation strategies should be adopted in managing producer sponsored user support forums designed for different cultural regions

L1CAM mutation in association with X-linked hydrocephalus and Hirschsprung’s disease

X-linked hydrocephalus (XLH) is characterized by increased intracranial ventricle size and head circumference secondary to aqueduct of Sylvius congenital stenosis. Exceedingly rare is the concurrence of XLH and Hirschsprung’s disease (HSCR) with a theoretical incidence of 1 in 125–250 million cases. Herein, we are describing a case of a patient with concurrent XLH and HSCR. The patient was delivered via cesarean section at 37 weeks gestation and underwent uneventful ventriculoperitoneal shunt placement. As a part of a workup for constipation, we performed a rectal biopsy, which was consistent with HSCR. Genetics testing showed hemizygous for R558X hemizygous mutation in the L1CAM gene. A C → T nucleotide substitution in exon 13 resulted in replacement of an arginine codon with a stop codon, a nonsense mutation. Although it is widely accepted that HSCR represents the failure of early embryonic neural crest cells to migrate properly, the exact mechanism is not known. The association of HSCR with XLH in the presence of L1CAM mutations remains quite interesting because cell adhesion molecules are involved in the proper migration of neural components throughout the body. Additional studies are necessary to fully elucidate the relationship between XLH and HSCR in the presence of L1CAM mutations

EMPoWER Hybrid Networks: Exploiting Multiple Paths over Wireless and ElectRical Mediums

Several technologies, such as WiFi, Ethernet and power-line communications (PLC), can be used to build residential and enterprise networks. These technologies often co-exist; most networks use WiFi, and buildings are readily equipped with electrical wires that can offer a capacity up to 1 Gbps with PLC. Yet, current networks do not exploit this rich diversity and often operate far below the available capacity. We design, implement, and evaluate EMPoWER, a system that exploits simultaneously several potentially-interfering mediums. It operates at layer 2.5, between the MAC and IP layers, and combines routing (to find multiple concurrent routes) and congestion control (to efficiently balance traffic across the routes). To optimize resource utilization and robustness, both components exploit the heterogeneous nature of the network. They are fair and efficient, and they operate only within the local area network, without affecting remote Internet hosts. We demonstrate the performance gains of EMPoWER, by simulations and experiments on a 22-node testbed. We show that PLC/WiFi, benefiting from the diversity offered by wireless and electrical mediums, provides significant throughput gains (up to 10x) and improves coverage, compared to multi-channel WiFi

Vultures of the Seas: Hyperacidic Stomachs in Wandering Albatrosses as an Adaptation to Dispersed Food Resources, including Fishery Wastes

Animals are primarily limited by their capacity to acquire food, yet digestive performance also conditions energy acquisition, and ultimately fitness. Optimal foraging theory predicts that organisms feeding on patchy resources should maximize their food loads within each patch, and should digest these loads quickly to minimize travelling costs between food patches. We tested the prediction of high digestive performance in wandering albatrosses, which can ingest prey of up to 3 kg, and feed on highly dispersed food resources across the southern ocean. GPS-tracking of 40 wandering albatrosses from the Crozet archipelago during the incubation phase confirmed foraging movements of between 475–4705 km, which give birds access to a variety of prey, including fishery wastes. Moreover, using miniaturized, autonomous data recorders placed in the stomach of three birds, we performed the first-ever measurements of gastric pH and temperature in procellariformes. These revealed surprisingly low pH levels (average 1.50±0.13), markedly lower than in other seabirds, and comparable to those of vultures feeding on carrion. Such low stomach pH gives wandering albatrosses a strategic advantage since it allows them a rapid chemical breakdown of ingested food and therefore a rapid digestion. This is useful for feeding on patchy, natural prey, but also on fishery wastes, which might be an important additional food resource for wandering albatrosses

HST/ACS Multiband Coronagraphic Imaging of the Debris Disk around Beta Pictoris

(Abridged.) We present F435W (B), F606W (Broad V), and F814W (Broad I) coronagraphic images of the debris disk around Beta Pictoris obtained with HST's Advanced Camera for Surveys. We confirm that the previously reported warp in the inner disk is a distinct secondary disk inclined by ~5 deg from the main disk. The main disk's northeast extension is linear from 80 to 250 AU, but the southwest extension is distinctly bowed with an amplitude of ~1 AU over the same region. Both extensions of the secondary disk appear linear, but not collinear, from 80 to 150 AU. Within ~120 AU of the star, the main disk is ~50% thinner than previously reported. The surface-brightness profiles along the spine of the main disk are fitted with four distinct radial power laws between 40 and 250 AU, while those of the secondary disk between 80 and 150 AU are fitted with single power laws. These discrepancies suggest that the two disks have different grain compositions or size distributions. The F606W/F435W and F814W/F435W flux ratios of the composite disk are nonuniform and asymmetric about both projected axes of the disk. Within ~120 AU, the m_F435W-m_F606W and m_F435W-m_F814W colors along the spine of the main disk are ~10% and ~20% redder, respectively, than those of Beta Pic. These colors increasingly redden beyond ~120 AU, becoming 25% and 40% redder, respectively, than the star at 250 AU. We compare the observed red colors within ~120 AU with the simulated colors of non-icy grains having a radial number density ~r^-3 and different compositions, porosities, and minimum grain sizes. The observed colors are consistent with those of compact or moderately porous grains of astronomical silicate and/or graphite with sizes >0.15-0.20 um, but the colors are inconsistent with the blue colors expected from grains with porosities >90%.Comment: 38 pages (including 21 figures and 4 tables) in EmulateApJ format, accepted for publication in The Astronomical Journal. Full-resolution figures and fully processed FITS images (with error maps) are available at http://acs.pha.jhu.edu/~dag/betapic Version 2: Added 4 references and some clarifying text. Basic facts and conclusions are unchange