Supporting Catholic Education through Effective School/University Partnerships: Two Models from the 2012 Catholic Higher Education Collaborative Conference

This essay was developed from a panel presentation by Henk and Maney, as well as other key professional colleagues, delivered at the 2012 CHEC Conference. The essay describes the formation and initial work of a consortium of five institutions of higher education in the greater Milwaukee area, including Alverno College, Cardinal Stritch University, Marian University, Marquette University, and Mount Mary College

Higher Education Working Together to Help Catholic Schools: The Greater Milwaukee Catholic Education Consortium

This essay was developed from a panel presentation by Henk and Maney, as well as other key professional colleagues, delivered at the 2012 CHEC Conference. The essay describes the formation and initial work of a consortium of five institutions of higher education in the greater Milwaukee area, including Alverno College, Cardinal Stritch University, Marian University, Marquette University, and Mount Mary College

Family Leave

Includes bibliographical references.Millions of American workers who qualify for family or medical leave don't take it because they cannot afford to go without pay. Family and work patterns have shifted dramatically in recent decades, yet workplace policies have not kept pace with these changes. The vast majority of employers find that the benefits of providing leave under FMLA offset or outweighed the costs

Dyadic reciprocity in the emerging relationship between low-income African American mothers and their toddlers

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.Title from title screen of research.pdf file viewed on (April 25, 2007)Vita.Thesis (Ph.D.) University of Missouri-Columbia 2006.The present study will adopt a dual focus: on the description of dyadic reciprocity among mother-child dyads and on the antecedents proposed to influence its development. As research on the nature of dyadic reciprocity as the means of parent-child interaction among African American families is lacking, the first set of goals will be to provide descriptive data on reciprocity in a comprehensive framework for this sample. The second set of goals examined questions regarding individual differences in the development of early reciprocity. Child characteristics, such as temperament, maternal characteristics, such as personality and depression, and dyadic characteristics, such as attachment, were all expected to impact the development of reciprocal interactions. Results are discussed in the contexts of the cultural validity of the dyadic reciprocity construct and potential uses of dyadic reciprocity in early intervention services.Includes bibliographical reference

Supporting Catholic Education through Effective School/University Partnerships: Two Models from the 2012 Catholic Higher Education Collaborative Conference

The following article contains two essays based on presentations to the 2012 CHEC conference on Catholic school governance held at Marquette University in October 2012. The essays outline two models of deep collaboration between Catholic institutions of higher education and Catholic K-12 schools designed to support and foster improvements in Catholic education. The first essay, “Higher Education Working Together to Help Catholic Schools: The Greater Milwaukee Catholic Education Consortium,” written by William A. Henk and Jennifer A. Maney, provides an overview of the Greater Milwaukee Catholic Education Consortium (GMCEC), an ongoing collaborative effort between the archdiocese of Milwaukee and the region’s five Catholic colleges and universities. Building a strong partnership among multiple institutions has allowed the GMCEC to leverage the individual strengths of each member institution to provide a variety of supports to Catholic schools within the diocese. The essay outlines the early history of the collaboration, the key areas of engagement, and some emerging outcomes and ongoing challenges associated with efforts to scaffold supports for diocesan schools. Following this essay are excerpts from a panel discussion among the five presidents of the institutions of higher education that are part of the consortium

Attachment Predicts College Students’ Knowledge, Attitudes, and Skills for Working with Infants, Toddlers, and Families

Research Findings:Adults’ attitudes about attachment relationships are central to how they perceive and respond to children. However, little is known about how attachment styles are related to teachers’ attitudes toward and interactions with infants and toddlers. From a survey of 207 students taking early childhood (EC) courses at 4 U.S. universities, we report relations among students’ attachment styles and their (a) career goals, (b) attitudes about caring for and educating infants and young children, and (c) interaction skills for responding in developmentally supportive ways. Overall, attachment security was positively associated with career goals focused on working with younger children, knowledge about infant/toddler development, attitudes that acknowledge the importance of adult support in children’s development, and developmentally supportive interaction skills. Students who scored high on attachment fearfulness minimized the importance of adults in children’s lives, minimized the importance of the early years for later learning, and endorsed strict and controlling forms of child guidance. Practice or Policy: A conceptual mediation model linking a path from attachment to caregiving skill through knowledge and attitudes is articulated. We propose a person-centered pedagogy for infant/toddler professional preparation that provides opportunities for reflection on one’s own attachment and its effects on work with young childre

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin\u27s I-band: the cardiomyopathy-linked mutation T2580I

Missense single-nucleotide polymorphisms (mSNPs) in titin are emerging as a main causative factor of heart failure. However, distinguishing between benign and disease-causing mSNPs is a substantial challenge. Here, we research the question of whether a single mSNP in a generic domain of titin can affect heart function as a whole and, if so, how. For this, we studied the mSNP T2850I, seemingly linked to arrhythmogenic right ventricular cardiomyopathy (ARVC). We used structural biology, computational simulations and transgenic muscle in vivo methods to track the effect of the mutation from the molecular to the organismal level. The data show that the T2850I exchange is compatible with the domain three-dimensional fold, but that it strongly destabilizes it. Further, it induces a change in the conformational dynamics of the titin chain that alters its reactivity, causing the formation of aberrant interactions in the sarcomere. Echocardiography of knock-in mice indicated a mild diastolic dysfunction arising from increased myocardial stiffness. In conclusion, our data provide evidence that single mSNPs in titin\u27s I-band can alter overall muscle behaviour. Our suggested mechanisms of disease are the development of non-native sarcomeric interactions and titin instability leading to a reduced I-band compliance. However, understanding the T2850I-induced ARVC pathology mechanistically remains a complex problem and will require a deeper understanding of the sarcomeric context of the titin region affected

Unravelling interactions between asymmetric tidal turbulence, residual circulation and salinity dynamics in short, periodically weakly stratified estuaries

Asymmetric tidal turbulence (ATT) strongly influences estuarine health and functioning. However, its impact on the three-dimensional estuarine dynamics and the feedback of water motion and salinity distribution on ATT remain poorly understood, especially for short estuaries (estuarine length ≪ tidal wavelength). This study systematically investigates the above-mentioned interactions in a short estuary for the first time, considering periodically weakly stratified conditions. This is done by developing a three-dimensional semi-analytical model (combining perturbation method with finite element method) that allows a dissection of the contributions of different processes to ATT, estuarine circulation, and salt transport. The generation of ATT is dominated by (i) strain-induced periodic stratification and (ii) asymmetric bottom shear generated turbulence, and their contributions to ATT are different both in amplitude and phase. The magnitude of the residual circulation related to ATT and the eddy viscosity-shear covariance (ESCO) is about half of that of the gravitational circulation (GC) and shows a ‘reversed’ pattern as compared to GC. ATT generated by (i) contributes to an ESCO circulation with a spatial structure similar to GC. This circulation reduces the longitudinal salinity gradients and thus weakens GC. Contrastingly, the ESCO circulation due to (ii) shows patterns opposite to GC and acts to enhance GC. Concerning the salinity dynamics at steady state, GC and tidal pumping are equally important to salt import, whereas ESCO circulation yields a significant seaward salt transport. These findings highlight the importance of identifying the sources of ATT to understand its impact on estuarine circulation and salt distribution

A risk prediction model for the assessment and triage of women with hypertensive disorders of pregnancy in low-resourced settings: the miniPIERS (Pre-eclampsia Integrated Estimate of RiSk) multi-country prospective cohort study.

BACKGROUND: Pre-eclampsia/eclampsia are leading causes of maternal mortality and morbidity, particularly in low- and middle- income countries (LMICs). We developed the miniPIERS risk prediction model to provide a simple, evidence-based tool to identify pregnant women in LMICs at increased risk of death or major hypertensive-related complications. METHODS AND FINDINGS: From 1 July 2008 to 31 March 2012, in five LMICs, data were collected prospectively on 2,081 women with any hypertensive disorder of pregnancy admitted to a participating centre. Candidate predictors collected within 24 hours of admission were entered into a step-wise backward elimination logistic regression model to predict a composite adverse maternal outcome within 48 hours of admission. Model internal validation was accomplished by bootstrapping and external validation was completed using data from 1,300 women in the Pre-eclampsia Integrated Estimate of RiSk (fullPIERS) dataset. Predictive performance was assessed for calibration, discrimination, and stratification capacity. The final miniPIERS model included: parity (nulliparous versus multiparous); gestational age on admission; headache/visual disturbances; chest pain/dyspnoea; vaginal bleeding with abdominal pain; systolic blood pressure; and dipstick proteinuria. The miniPIERS model was well-calibrated and had an area under the receiver operating characteristic curve (AUC ROC) of 0.768 (95% CI 0.735-0.801) with an average optimism of 0.037. External validation AUC ROC was 0.713 (95% CI 0.658-0.768). A predicted probability ≥25% to define a positive test classified women with 85.5% accuracy. Limitations of this study include the composite outcome and the broad inclusion criteria of any hypertensive disorder of pregnancy. This broad approach was used to optimize model generalizability. CONCLUSIONS: The miniPIERS model shows reasonable ability to identify women at increased risk of adverse maternal outcomes associated with the hypertensive disorders of pregnancy. It could be used in LMICs to identify women who would benefit most from interventions such as magnesium sulphate, antihypertensives, or transportation to a higher level of care

NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy

Nemaline myopathy (NM) is one of the most common non-dystrophic genetic muscle disorders. NM is often associated with mutations in the NEB gene. Even though the exact NEB-NM pathophysiological mechanisms remain unclear, histological analyses of patients' muscle biopsies often reveal unexplained accumulation of glycogen and abnormally shaped mitochondria. Hence, the aim of the present study was to define the exact molecular and cellular cascade of events that would lead to potential changes in muscle energetics in NEB-NM. For that, we applied a wide range of biophysical and cell biology assays on skeletal muscle fibres from NM patients as well as untargeted proteomics analyses on isolated myofibres from a muscle-specific nebulin-deficient mouse model. Unexpectedly, we found that the myosin stabilizing conformational state, known as super-relaxed state, was significantly impaired, inducing an increase in the energy (ATP) consumption of resting muscle fibres from NEB-NM patients when compared with controls or with other forms of genetic/rare, acquired NM. This destabilization of the myosin super-relaxed state had dynamic consequences as we observed a remodeling of the metabolic proteome in muscle fibres from nebulin-deficient mice. Altogether, our findings explain some of the hitherto obscure hallmarks of NM, including the appearance of abnormal energy proteins and suggest potential beneficial effects of drugs targeting myosin activity/conformations for NEB-NM.Peer reviewe