News narratives and television news editing

This study seeks to understand how and why television news editors impose meanings onto news packages through montage editing. Through a qualitative content analysis and in-depth interviews, this study will advance the notably few past narrative editing studies by investigating the norms and routines of television news editors. While other researchers recognize the significance of studying montage editing in television news, this is the first study to clarify the relationship between montage techniques and the creation of television news narratives

Compromising the Craft: A Mixed-Methodological Analysis of the Products and Processes of Storytelling in Local Television and Digital News

Before the Telecommunications Act of 1996, station ownership was highly restricted to ensure that owners could not dominate in any one market nor own more than a handful of stations across all markets. The Act deregulated station ownership, redefining the role of the station owner from a financial supporter of public communication to an aggressive competitor in the television marketplace. With nearly three quarters of Americans citing local television and digital journalism as their top sources for information, this study serves two purposes: (1) to confirm the existence of storytelling as a professional, value-driven journalistic behavior in local television news and (2) to discuss the current state of the storytelling norm within the context of the larger crisis of journalism. The data from this dissertation come from four methodological approaches to the study of local television news: (1) observations of 18 days of news packaging inside ten local television newsrooms across seven companies and six markets, (2) qualitative comparisons of 32 cases of news packaging for the 6:00 pm newscasts that aired during the observation days, (3) two content analyses of each of the television and web products published in connection to the 32 cases and (4) 62 long-form, semi-structured interviews with the managers, producers, reporters and photographers responsible for those 32 cases. Findings indicate that journalistic norms are indeed vulnerable to corporate demands in particular when combined with a lack of meaningful managerial support. These data show that storytelling in local television news is a performance compromised by the search for economies of scale, where whether an event is covered is primarily the decision of people other than those who determine how an event should be covered

Communicating with the masses from isolation: What happened when local television journalists worked from home

In response to the COVID-19 crises, many local TV newsrooms decided to have employees work from home (WFH) or the field rather than from the newsroom. From a review of research on telework, we identified possible impacts of WFH on worker effectiveness, conceptualized as including output, individual satisfaction and growth, and group well-being. From a case study of a local TV newsroom and interviews with news directors, we found that WFH was successful in creating a newscast, albeit with some concerns about story quality. However, WFH did not seem to satisfy workers individually or as a group. The current lifting of restrictions on gatherings might mitigate some of the experienced problems, but we expect to see challenges to news worker learning with continued WFH

ReelFramer: Co-creating News Reels on Social Media with Generative AI

Short videos on social media are a prime way many young people find and consume content. News outlets would like to reach audiences through news reels, but currently struggle to translate traditional journalistic formats into the short, entertaining videos that match the style of the platform. There are many ways to frame a reel-style narrative around a news story, and selecting one is a challenge. Different news stories call for different framings, and require a different trade-off between entertainment and information. We present a system called ReelFramer that uses text and image generation to help journalists explore multiple narrative framings for a story, then generate scripts, character boards and storyboards they can edit and iterate on. A user study of five graduate students in journalism-related fields found the system greatly eased the burden of transforming a written story into a reel, and that exploring framings to find the right one was a rewarding process

Longitudinal quantile regression in presence of informative drop-out through longitudinal-survival joint modeling

We propose a joint model for a time-to-event outcome and a quantile of a continuous response repeatedly measured over time. The quantile and survival processes are associated via shared latent and manifest variables. Our joint model provides a flexible approach to handle informative drop-out in quantile regression. A general Monte Carlo Expectation Maximization strategy based on importance sampling is proposed, which is directly applicable under any distributional assumption for the longitudinal outcome and random effects, and parametric and non-parametric assumptions for the baseline hazard. Model properties are illustrated through a simulation study and an application to an original data set about dilated cardiomyopathies

Tight-binding parameters for charge transfer along DNA

We systematically examine all the tight-binding parameters pertinent to charge transfer along DNA. The $\pi$ molecular structure of the four DNA bases (adenine, thymine, cytosine, and guanine) is investigated by using the linear combination of atomic orbitals method with a recently introduced parametrization. The HOMO and LUMO wavefunctions and energies of DNA bases are discussed and then used for calculating the corresponding wavefunctions of the two B-DNA base-pairs (adenine-thymine and guanine-cytosine). The obtained HOMO and LUMO energies of the bases are in good agreement with available experimental values. Our results are then used for estimating the complete set of charge transfer parameters between neighboring bases and also between successive base-pairs, considering all possible combinations between them, for both electrons and holes. The calculated microscopic quantities can be used in mesoscopic theoretical models of electron or hole transfer along the DNA double helix, as they provide the necessary parameters for a tight-binding phenomenological description based on the $\pi$ molecular overlap. We find that usually the hopping parameters for holes are higher in magnitude compared to the ones for electrons, which probably indicates that hole transport along DNA is more favorable than electron transport. Our findings are also compared with existing calculations from first principles.Comment: 15 pages, 3 figures, 7 table

Preschool Children’s Memory for Word Forms Remains Stable Over Several Days, but Gradually Decreases after 6 Months

Research on word learning has focused on children’s ability to identify a target object when given the word form after a minimal number of exposures to novel word-object pairings. However, relatively little research has focused on children’s ability to retrieve the word form when given the target object. The exceptions involve asking children to recall and produce forms, and children typically perform near floor on these measures. In the current study, 3- to 5-year-old children were administered a novel test of word form that allowed for recognition memory and manual responses. Specifically, when asked to label a previously trained object, children were given three forms to choose from: the target, a minimally different form, and a maximally different form. Children demonstrated memory for word forms at three post-training delays: 10 mins (short-term), 2–3 days (long-term), and 6 months to 1 year (very long-term). However, children performed worse at the very long-term delay than the other time points, and the length of the very long-term delay was negatively related to performance. When in error, children were no more likely to select the minimally different form than the maximally different form at all time points. Overall, these results suggest that children remember word forms that are linked to objects over extended post-training intervals, but that their memory for the forms gradually decreases over time without further exposures. Furthermore, memory traces for word forms do not become less phonologically specific over time; rather children either identify the correct form, or they perform at chance

The Cytosolic Tail of the Golgi Apyrase Ynd1 Mediates E4orf4-Induced Toxicity in Saccharomyces cerevisiae

The adenovirus E4 open reading frame 4 (E4orf4) protein contributes to regulation of the progression of virus infection. When expressed individually, E4orf4 was shown to induce non-classical transformed cell-specific apoptosis in mammalian cells. At least some of the mechanisms underlying E4orf4-induced toxicity are conserved from yeast to mammals, including the requirement for an interaction of E4orf4 with protein phosphatase 2A (PP2A). A genetic screen in yeast revealed that the Golgi apyrase Ynd1 associates with E4orf4 and contributes to E4orf4-induced toxicity, independently of Ynd1 apyrase activity. Ynd1 and PP2A were shown to contribute additively to E4orf4-induced toxicity in yeast, and to interact genetically and physically. A mammalian orthologue of Ynd1 was shown to bind E4orf4 in mammalian cells, confirming the evolutionary conservation of this interaction. Here, we use mutation analysis to identify the cytosolic tail of Ynd1 as the protein domain required for mediation of the E4orf4 toxic signal and for the interaction with E4orf4. We also show that E4orf4 associates with cellular membranes in yeast and is localized at their cytoplasmic face. However, E4orf4 is membrane-associated even in the absence of Ynd1, suggesting that additional membrane proteins may mediate E4orf4 localization. Based on our results and on a previous report describing a collection of Ynd1 protein partners, we propose that the Ynd1 cytoplasmic tail acts as a scaffold, interacting with a multi-protein complex, whose targeting by E4orf4 leads to cell death

A clinical and molecular characterisation of CRB1-associated maculopathy

To date, over 150 disease-associated variants in CRB1 have been described, resulting in a range of retinal disease phenotypes including Leber congenital amaurosis and retinitis pigmentosa. Despite this, no genotype–phenotype correlations are currently recognised. We performed a retrospective review of electronic patient records to identify patients with macular dystrophy due to bi-allelic variants in CRB1. In total, seven unrelated individuals were identified. The median age at presentation was 21 years, with a median acuity of 0.55 decimalised Snellen units (IQR = 0.43). The follow-up period ranged from 0 to 19 years (median = 2.0 years), with a median final decimalised Snellen acuity of 0.65 (IQR = 0.70). Fundoscopy revealed only a subtly altered foveal reflex, which evolved into a bull’s-eye pattern of outer retinal atrophy. Optical coherence tomography identified structural changes—intraretinal cysts in the early stages of disease, and later outer retinal atrophy. Genetic testing revealed that one rare allele (c.498_506del, p.(Ile167_Gly169del)) was present in all patients, with one patient being homozygous for the variant and six being heterozygous. In trans with this, one variant recurred twice (p.(Cys896Ter)), while the four remaining alleles were each observed once (p.(Pro1381Thr), p.(Ser478ProfsTer24), p.(Cys195Phe) and p.(Arg764Cys)). These findings show that the rare CRB1 variant, c.498_506del, is strongly associated with localised retinal dysfunction. The clinical findings are much milder than those observed with bi-allelic, loss-of-function variants in CRB1, suggesting this in-frame deletion acts as a hypomorphic allele. This is the most prevalent disease-causing CRB1 variant identified in the non-Asian population to date

Charge Transport in DNA-Based Devices

Charge migration along DNA molecules has attracted scientific interest for over half a century. Reports on possible high rates of charge transfer between donor and acceptor through the DNA, obtained in the last decade from solution chemistry experiments on large numbers of molecules, triggered a series of direct electrical transport measurements through DNA single molecules, bundles and networks. These measurements are reviewed and presented here. From these experiments we conclude that electrical transport is feasible in short DNA molecules, in bundles and networks, but blocked in long single molecules that are attached to surfaces. The experimental background is complemented by an account of the theoretical/computational schemes that are applied to study the electronic and transport properties of DNA-based nanowires. Examples of selected applications are given, to show the capabilities and limits of current theoretical approaches to accurately describe the wires, interpret the transport measurements, and predict suitable strategies to enhance the conductivity of DNA nanostructures.Comment: A single pdf file of 52 pages, containing the text and 23 figures. Review about direct measurements of DNA conductivity and related theoretical studies. For higher-resolution figures contact the authors or retrieve the original publications cited in the caption