16 research outputs found

    Diversification for sustainable and resilient agricultural landscape systems

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    This virtual issue comprises papers that address diversification for providing sustainable solutions at different scales from cropping and grassland to food systems. The authors investigated processes in case studies at the landscape scale where synergies and trade-offs between social and environmental objectives become the most tangible. Contributions from all continents highlighted regional specificities related to diversification and include research from natural and social sciences, with inter- and transdisciplinary approaches including synthesis of knowledge (reviews), empirical studies with experiments as well as assessments with interviews in case studies: Model-based design of crop diversification, the role of digitalization for achieving sustainability in the European context, ecological engineering for rice pest suppression in China, the role of cereal species mixtures in Ethiopian smallholder farmers, diversified planting in arid irrigation areas in northwestern China, integration of legumes in European and Canadian cropping systems, screening of native forage legumes for northern Swedish grassland systems, cropping system diversification of smallholder farmers in south-central Bangladesh, identification of how farmers imagine diversified landscapes in southern Idaho in the US, farm diversification affecting impacts from COVID-19 across Europe, the role of diversified farming in Mato Grosso Brazil, diversification and soil management measures in Germany, value chain formation for the scaling of crop diversification, and the design process with farmers and scientists for the transition toward legume-supported farming in Europe. A key finding from these examples is that agricultural intensification has led to the simplification of cropping systems and landscapes in terms of species diversity and ecosystem function. To instead move towards sustainable transformation, all system levels (i.e. from the plot, farm, landscape, governance and overall food systems) need to interact and reinforce each other for diversification to deliver the desired outcomes

    Great apes and human children rationally monitor their decisions

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    Several species can detect when they are uncertain about what decision to make –revealed by opting out of the choice, or by seeking more information before deciding. But we do not know whether any nonhuman animals recognize when they need more information to make a decision because new evidence contradicts an already-formed belief. Here we explore this ability in great apes and human children. First, we show that after great apes saw new evidence contradicting a prior belief about which of two rewards was greater, they stopped to look for more information before deciding. They did not just register their own uncertainty, but attempted to resolve the contradiction between their belief and the new evidence, indicating rational monitoring of the decision-making process. Children did the same at five years of age, but not at three. In a second study, participants formed a belief about a reward’s location, but then a social partner contradicted them, by picking the opposite location. This time even three-year old children looked for more information, while apes ignored the disagreement. While apes were sensitive only to the conflict in physical evidence, the youngest children were more sensitive to peer disagreement than conflicting physical evidence.PostprintPeer reviewe

    A protocol to develop shared socio-economic pathways for European agriculture

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    Moving towards a more sustainable future requires concerted actions, particularly in the context of global climate change. Integrated assessments of agricultural systems (IAAS) are considered valuable tools to provide sound information for policy and decision-making. IAAS use storylines to define socio-economic and environmental framework assumptions. While a set of qualitative global storylines, known as the Shared Socio-economic Pathways (SSPs), is available to inform integrated assessments at large scales, their spatial resolution and scope is insufficient for regional studies in agriculture. We present a protocol to operationalize the development of Shared Socio-economic Pathways for European agriculture – Eur-Agri-SSPs – to support IAAS. The proposed design of the storyline development process is based on six quality criteria: plausibility, vertical and horizontal consistency, salience, legitimacy, richness and creativity. Trade-offs between these criteria may occur. The process is science-driven and iterative to enhance plausibility and horizontal consistency. A nested approach is suggested to link storylines across scales while maintaining vertical consistency. Plausibility, legitimacy, salience, richness and creativity shall be stimulated in a participatory and interdisciplinary storyline development process. The quality criteria and process design requirements are combined in the protocol to increase conceptual and methodological transparency. The protocol specifies nine working steps. For each step, suitable methods are proposed and the intended level and format of stakeholder engagement are discussed. A key methodological challenge is to link global SSPs with regional perspectives provided by the stakeholders, while maintaining vertical consistency and stakeholder buy-in. We conclude that the protocol facilitates systematic development and evaluation of storylines, which can be transferred to other regions, sectors and scales and supports inter-comparisons of IAAS

    Shared Socio-economic Pathways for European agriculture and food systems: the Eur-Agri-SSPs

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    Scenarios describe plausible and internally consistent views of the future. They can be used by scientists, policymakers and entrepreneurs to explore the challenges of global environmental change given an appropriate level of spatial and sectoral detail and systematic development. We followed a nine-step protocol to extend and enrich a set of global scenarios – the Shared Socio-economic Pathways (SSPs) – providing regional and sectoral detail for European agriculture and food systems using a one-to-one nesting participatory approach. The resulting five Eur-Agri-SSPs are titled (1) Agriculture on sustainable paths, (2) Agriculture on established paths, (3) Agriculture on separated paths, (4) Agriculture on unequal paths, and (5) Agriculture on high-tech paths. They describe alternative plausible qualitative evolutions of multiple drivers of particular importance and high uncertainty for European agriculture and food systems. The added value of the protocol-based storyline development process lies in the conceptual and methodological transparency and rigor; the stakeholder driven selection of the storyline elements; and consistency checks within and between the storylines. Compared to the global SSPs, the five Eur-Agri-SSPs provide rich thematic and regional details and are thus a solid basis for integrated assessments of agriculture and food systems and their response to future socio-economic and environmental change

    31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

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    Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

    Great apes and human children rationally monitor their decisions

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    Several species can detect when they are uncertain about what decision to make –revealed by opting out of the choice, or by seeking more information before deciding. But we do not know whether any nonhuman animals recognize when they need more information to make a decision because new evidence contradicts an already-formed belief. Here we explore this ability in great apes and human children. First, we show that after great apes saw new evidence contradicting a prior belief about which of two rewards was greater, they stopped to look for more information before deciding. They did not just register their own uncertainty, but attempted to resolve the contradiction between their belief and the new evidence, indicating rational monitoring of the decision-making process. Children did the same at five years of age, but not at three. In a second study, participants formed a belief about a reward’s location, but then a social partner contradicted them, by picking the opposite location. This time even three-year old children looked for more information, while apes ignored the disagreement. While apes were sensitive only to the conflict in physical evidence, the youngest children were more sensitive to peer disagreement than conflicting physical evidence
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