1,956 research outputs found

    Volunteer studies replacing animal experiments in brain research - Report and recommendations of a Volunteers in Research and Testing workshop

    Get PDF

    Expanding the role of morality and public policy in European patent law

    Get PDF
    This is the author accepted manuscript. The final version is available from Wolters Kluwer via the link in this recordEconomic and Social Research Council (ESRC

    Fabrication and Characterization of a NIR-FIR Dichroic for the Infrared Interferometer BETTII

    Get PDF
    BETTII is a balloon-borne far infra-red (FIR: 30-100 m) interferometer that also uses a near-infrared (NIR: 1-2.5 m) channel for fine pointing sensing using stars. We have developed an inductive grid dichroic to divide the incoming beam into two components, by reflecting FIR light and transmitting NIR light. The dichroic is fabricated using focused electron beam technology to produce a 1 m period, 100 nm width metal grid on a sapphire substrate in order to have high reflectance for FIR wavelengths. Here we discuss the design and the detailed manufacturing process for such a dichroic. The transmission and reflectance characteristics are also presented. We discuss them in context of the BETTII requirements

    Production and perception of speaker-specific phonetic detail at word boundaries

    Get PDF
    Experiments show that learning about familiar voices affects speech processing in many tasks. However, most studies focus on isolated phonemes or words and do not explore which phonetic properties are learned about or retained in memory. This work investigated inter-speaker phonetic variation involving word boundaries, and its perceptual consequences. A production experiment found significant variation in the extent to which speakers used a number of acoustic properties to distinguish junctural minimal pairs e.g. 'So he diced them'—'So he'd iced them'. A perception experiment then tested intelligibility in noise of the junctural minimal pairs before and after familiarisation with a particular voice. Subjects who heard the same voice during testing as during the familiarisation period showed significantly more improvement in identification of words and syllable constituents around word boundaries than those who heard different voices. These data support the view that perceptual learning about the particular pronunciations associated with individual speakers helps listeners to identify syllabic structure and the location of word boundaries

    Perturbations during gait: A systematic review of methodologies and outcomes

    Get PDF
    Background: Despite extensive literature regarding laboratory-based balance perturbations, there is no up-to-date systematic review of methods. This systematic review aimed to assess current perturbation methods, and outcome variables used to report participant biomechanical responses during walking. ​​​​​​​Methods: Web of Science, CINAHL and PubMed online databases were searched, for records from 2015, the last search was on 30th of May 2022. Studies were included where participants were 18+ years, with or without clinical conditions, conducted in non-hospital settings. Reviews were excluded. Participant descriptive, perturbation method, outcome variables and results were extracted and summarised. Bias was assessed using the Appraisal tool for Cross-sectional Studies risk of bias assessment tool. Qualitative analysis was performed as the review aimed to investigate methods used to apply perturbations. Results: 644 records were identified and 33 studies were included, totaling 779 participants. The most frequent method of balance perturbation during gait was by means of a treadmill translation. The most frequent outcome variable collected was participant step width, closely followed by step length. Most studies reported at least one spatiotemporal outcome variable. All included studies showed some risk of bias, generally related to reporting of sampling approaches. Large variation in perturbation type, duration and intensity and outcome variables were reported. Conclusions: This review shows the wide variety of published laboratory perturbation methods. Also demonstrating the significant impact on outcome measures of a study based on the type of perturbation used. Registration: PROSPERO ID: CRD4202021187

    Intellectual Property Rights and Access in Crisis

    Get PDF
    This is the final version. Available on open access from Springer via the DOI in this recordThe importance of access to intellectual property rights (IPR) protected subject-matter in two crucial areas – public health, and educational and cultural engagement – has been extensively demonstrated during the COVID-19 pandemic. Although they implicate separate legal areas, patent and copyright, the common thread linking the two is intellectual property’s difficult relationship with access in the public interest. This paper examines the tensions caused by access barriers, the tools used to reduce them and their effectiveness. It is clear that the access barriers magnified by COVID-19 are not restricted to narrow or specific contexts but are widespread. They are created by, and a feature of, our existing IPR frameworks. Open movements provide limited remedies because they are not designed to, nor can, adequately address the wide range of access barriers necessary to promote the public interest. Existing legislative mechanisms designed to remove access barriers similarly fail to effectively remedy access needs. These existing options are premised on the assumption that there is a singular ‘public’ motivated by homogenous ‘interests’ which fails to reflect the plurality and cross-border reality of the public(s) interest(s) underpinning the welfare goals of IPR. We conclude that a systemic re-evaluation is required and call for positive and equitable legal measures protective of the public(s) interest(s) to be built within IPR frameworks that also address non-IPR barriers. The current pandemic and development of a ‘new normal’ provides a crucial opportunity to comprehensively consider the public(s) interest(s), not just during a global health crisis, but on an ongoing basis.Research Englan

    Structure function of the UV variability of Q0957+561

    Full text link
    We present a detailed structure function analysis of the UV variability of Q0957+561. From new optical observations, we constructed normalized structure functions of the quasar luminosity at restframe wavelengths of 2100 and 2600 \AA. Old optical records also allow the structure function to be obtained at 2100 \AA, but 10 years ago in the observer's frame. These three structure functions are then compared to predictions of both simple and relatively sophisticated (incorporating two independent variable components) Poissonian models. We do not find clear evidence of a chromatic mechanism of variability. From the recent data, 100-d time-symmetric and 170-d time-asymmetric flares are produced at both restframe wavelengths. Taking into account measurements of time delays and the existence of an EUV/radio jet, reverberation is probably the main mechanism of variability. Thus, two types of EUV/X-ray fluctuations would be generated within or close to the jet and later reprocessed by the disc gas in the two emission rings. The 100-d time-symmetric shots are also responsible for most of the 2100 \AA variability detected in the old experiment. However, there is no evidence of asymmetric shots in the old UV variability. If reverberation is the involved mechanism of variability, this could mean an intermittent production of high-energy asymmetric fluctuations. The old records are also consistent with the presence of very short-lifetime (10 d) symmetric flares, which may represent additional evidence of time evolution. We also discuss the quasar structure that emerges from the variability scenario.Comment: 7 pages, 4 figures. Accepted for publication in A&A (based on the brightness records at http://arxiv.org/abs/0810.4619
    corecore