2,716 research outputs found

    Cold gas in the Intra Cluster Medium: implications for flow dynamics and powering optical nebulae

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    We show that the mechanical energy injection rate generated as the intra-cluster medium (ICM) flows around cold clouds may be sufficient to power the optical and near infra-red emission of nebulae observed in the central regions of a sample of seven galaxy clusters. The energy injection rate is extremely sensitive to the velocity difference between the ICM and cold clouds, which may help to explain why optical and infra-red luminosity is often larger than expected in systems containing AGNs. We also find that mass recycling is likely to be important for the dynamics of the ICM. This effect will be strongest in the central regions of clusters where there is more than enough cold gas for its evaporation to contribute significantly to the density of the hot phase.Comment: 8 pages, 2 figures, accepted for publication in MNRA

    Atmospheric Consequences of Cosmic Ray Variability in the Extragalactic Shock Model II: Revised ionization levels and their consequences

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    It has been suggested that galactic shock asymmetry induced by our galaxy's infall toward the Virgo Cluster may be a source of periodicity in cosmic ray exposure as the solar system oscillates perpendicular to the galactic plane. Here we investigate a mechanism by which cosmic rays might affect terrestrial biodiversity, ionization and dissociation in the atmosphere, resulting in depletion of ozone and a resulting increase in the dangerous solar UVB flux on the ground, with an improved ionization background computation averaged over a massive ensemble (about 7 x 10^5) shower simulations. We study minimal and full exposure to the postulated extragalactic background. The atmospheric effects are greater than with our earlier, simplified ionization model. At the lower end of the range effects are too small to be of serious consequence. At the upper end of the range, ~6 % global average loss of ozone column density exceeds that currently experienced due to effects such as accumulated chlorofluorocarbons. The intensity is less than a nearby supernova or galactic gamma-ray burst, but the duration would be about 10^6 times longer. Present UVB enhancement from current ozone depletion ~3% is a documented stress on the biosphere, but a depletion of the magnitude found at the upper end of our range would double the global average UVB flux. For estimates at the upper end of the range of the cosmic ray variability over geologic time, the mechanism of atmospheric ozone depletion may provide a major biological stress, which could easily bring about major loss of biodiversity. Future high energy astrophysical observations will resolve the question of whether such depletion is likely.Comment: 22 pages, 5 figures, to be published in Journal of Geophysical Research--Planets. This is an update and replacement for our 2008 paper, with a much more extensive simulation of air shower ionization. Ionization effects and ozone depletion are somewhat large

    Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart

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    BACKGROUND: Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported that cardiac cardiolipin levels, MLCL AT and cardiolipin synthase activities were all elevated in rats made hyperthyroid by thyroxine treatment. In this study, we examined if cardiac mitochondrial MLCL AT activity was dependent upon the biosynthesis and level of cardiolipin in the heart. Rat heart mitochondrial MLCL AT activity was determined under conditions in which the levels of cardiac cardiolipin and cardiolipin synthase activity were either reduced or unaltered using four different disease models in the rat. In addition, these parameters were examined in a murine model of cardiac cell differentiation. RESULTS: In rats made hypothyroid by treatment with 6-n-propyl-2-thiouracil in the drinking water for 34 days, cardiac cardiolipin content was decreased 29% (p < 0.025) and this was associated with a 32% decrease (p < 0.025) in cardiolipin synthase and a 35% reduction (p < 0.025) in MLCL AT activities. Streptozotocin-induced diabetes or hyperinsulinemia in rats did not affect cardiac cardiolipin content nor MLCL AT and cardiolipin synthase activities. Finally, cardiolipin content, MLCL AT and cardiolipin synthase activities were unaltered during murine P19 teratocarcinoma cell differentiation into cardiac myocytes. In all models, phospholipase A(2) activities were unaltered compared with controls. CONCLUSION: We propose a general model in which the expression of MLCL AT activity is regulated in concert with the biosynthesis and level of cardiolipin in the heart

    Evaluation of the time-activity budgets of captive ducks (Anatidae) compared to wild counterparts

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    This is the final version. Available on open access from Elsevier via the DOI in this recordDucks are commonly housed in captive environments where their abilities for flight are constrained, either temporarily or permanently. The use of flight restraint in modern animal management is contentious and ethically questioned yet any associated impacts on behaviour remain poorly documented and evaluated. Comparison of information on wild ecology and activity of free-living individuals with information from the same species when captive-housed can reliably inform on “naturalness” of behaviour patterns if standardised methods are used. This research aimed to compare the activity of several species of ducks (Order Anseriformes) with information contained in the literature, and that collected from direct observation, to identify differences between the behaviours of captive and wild ducks. Observational data on the state behaviours for 17 duck species were collected at three Wildfowl & Wetland Trust (WWT) centres in the UK from 2015 to 2018, with behavioural data on two species of wild duck also collected via direct observation. A meta-analysis of time spent on key state behaviours (papers published up until 2018) was performed to provide comparison with the information provided on time-activity budgets of the captive birds. Results showed a multitude of factors influenced captive duck behaviour, but resting, maintenance and locomotion behaviours were most commonly observed. Wild birds differed significantly in their time-activity budgets compared to captive individuals and data from the meta-analysis revealed that foraging rates were higher in the wild than in captivity. Records of abnormal behaviour in captive birds were non-existent to very low in performance, suggesting that flight restrained ducks do not fill part of their time budget with stereotypic behaviour. Human presence may potentially influence of the behaviour of both wild and captive ducks living in wetland areas that attract human visitors. Seasonal, temporal and sex differences significantly also affected wild and captive duck behaviour. Further study should continue to investigate behavioural responses of these species to a range of captive housing to determine the most optimal way of providing for good welfare under human care. Research that investigates the behaviour of fully winged captive ducks to extend our evaluation of behaviour patterns in flight restrained birds (and to provide further review against wild data) is recommended

    Localized Basis for Effective Lattice Hamiltonians: Lattice Wannier Functions

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    A systematic method is presented for constructing effective Hamiltonians for general phonon-related structural transitions. The key feature is the application of group theoretical methods to identify the subspace in which the effective Hamiltonian acts and construct for it localized basis vectors, which are the analogue of electronic Wannier functions. The results of the symmetry analysis for the perovskite, rocksalt, fluorite and A15 structures and the forms of effective Hamiltonians for the ferroelectric transition in PbTiO3PbTiO_3 and BaTiO3BaTiO_3, the oxygen-octahedron rotation transition in SrTiO3SrTiO_3, the Jahn-Teller instability in La1−x(Ca,Sr,Ba)xMnO3La_{1-x}(Ca,Sr,Ba)_xMnO_3 and the antiferroelectric transition in PbZrO3PbZrO_3 are discussed. For the oxygen- octahedron rotation transition in SrTiO3SrTiO_3, this method provides an alternative to the rotational variable approach which is well behaved throughout the Brillouin zone. The parameters appearing in the Wannier basis vectors and in the effective Hamiltonian, given by the corresponding invariant energy expansion, can be obtained for individual materials using first- principles density-functional-theory total energy and linear response techniques, or any technique that can reliably calculate force constants and distortion energies. A practical approach to the determination of these parameters is presented and the application to ferroelectric PbTiO3PbTiO_3 discussed.Comment: extensive revisions in presentation, 32 pages, Revtex, 7 Postscript figure

    Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections

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    Importance Evidence indicates that preexisting neuropsychiatric conditions confer increased risks of severe outcomes from COVID-19 infection. It is unclear how this increased risk compares with risks associated with other severe acute respiratory infections (SARIs).Objective To determine whether preexisting diagnosis of and/or treatment for a neuropsychiatric condition is associated with severe outcomes from COVID-19 infection and other SARIs and whether any observed association is similar between the 2 outcomes.Design, Setting, and Participants Prepandemic (2015-2020) and contemporary (2020-2021) longitudinal cohorts were derived from the QResearch database of English primary care records. Adjusted hazard ratios (HRs) with 99% CIs were estimated in April 2022 using flexible parametric survival models clustered by primary care clinic. This study included a population-based sample, including all adults in the database who had been registered with a primary care clinic for at least 1 year. Analysis of routinely collected primary care electronic medical records was performed.Exposures Diagnosis of and/or medication for anxiety, mood, or psychotic disorders and diagnosis of dementia, depression, schizophrenia, or bipolar disorder.Main Outcomes and Measures COVID-19–related mortality, or hospital or intensive care unit admission; SARI-related mortality, or hospital or intensive care unit admission.Results The prepandemic cohort comprised 11 134 789 adults (223 569 SARI cases [2.0%]) with a median (IQR) age of 42 (29-58) years, of which 5 644 525 (50.7%) were female. The contemporary cohort comprised 8 388 956 adults (58 203 severe COVID-19 cases [0.7%]) with a median (IQR) age of 48 (34-63) years, of which 4 207 192 were male (50.2%). Diagnosis and/or treatment for neuropsychiatric conditions other than dementia was associated with an increased likelihood of a severe outcome from SARI (anxiety diagnosis: HR, 1.16; 99% CI, 1.13-1.18; psychotic disorder diagnosis and treatment: HR, 2.56; 99% CI, 2.40-2.72) and COVID-19 (anxiety diagnosis: HR, 1.16; 99% CI, 1.12-1.20; psychotic disorder treatment: HR, 2.37; 99% CI, 2.20-2.55). The effect estimate for severe outcome with dementia was higher for those with COVID-19 than SARI (HR, 2.85; 99% CI, 2.71-3.00 vs HR, 2.13; 99% CI, 2.07-2.19).Conclusions and Relevance In this longitudinal cohort study, UK patients with preexisting neuropsychiatric conditions and treatments were associated with similarly increased risks of severe outcome from COVID-19 infection and SARIs, except for dementia

    Emissions of nitrogen-containing organic compounds from the burning of herbaceous and arboraceous biomass: Fuel composition dependence and the variability of commonly used nitrile tracers

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    Volatile organic compounds (VOCs) emitted from residential wood and crop residue burning were measured in Colorado, U.S. When compared to the emissions from crop burning, residential wood burning exhibited markedly lower concentrations of acetonitrile, a commonly used biomass burning tracer. For both herbaceous and arboraceous fuels, the emissions of nitrogen-containing VOCs (NVOCs) strongly depend on the fuel nitrogen content; therefore, low NVOC emissions from residential wood burning result from the combustion of low-nitrogen fuel. Consequently, the emissions of compounds hazardous to human health, such as HNCO and HCN, and the formation of secondary pollutants, such as ozone generated by NOx, are likely to depend on fuel nitrogen. These results also demonstrate that acetonitrile may not be a suitable tracer for domestic burning in urban areas. Wood burning emissions may be best identified through analysis of the emissions profile rather than reliance on a single tracer species
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