Le goût du court avec Pro Short

Spoutnik et Pro Short, l’association suisse du court métrage, consacrent une projection et discussion au format court. Le court métrage suisse connaît un important succès international avec des participations à de nombreux festivals internationaux d’envergure et en remportant plusieurs prix. La rencontre permettra d’explorer les possibilités offertes par le court mais aussi ses spécificités au niveau de la formation, production, distribution et diffusion. Pro Short regroupe des cinéastes, producteur·rice·s, programmateur·rice·s, institutions et représente les intérêts des courts métrages suisses. L’association s’engage dans la politique cinématographique, les associations et l’industrie du court métrage, pour créer les conditions idéales pour la production, l’évaluation, la mise en réseau et la reconnaissance des courts métrages. Plus d’infos sur les activités de l’association sur www.proshort.ch – PRO SHOR

Modulation of neutrophil NETosis : interplay between infectious agents and underlying host physiology

The ability of neutrophils and other leucocyte members of the innate immune system to expel their DNA into the extracellular environment in a controlled manner in order to trap and kill pathogenic microorganisms lead to a paradigm shift in our understanding of host microbe interactions. Surprisingly, the neutrophil extracellular trap (NET) cast by neutrophils is very wide and extends to the entrapment of viruses as well as multicellular eukaryotic parasites. Not unexpectedly, it has emerged that pathogenic microorganisms can employ a wide array of strategies to avoid ensnarement, including expression of DNAse enzymes that destroy the lattice backbone of NETs. Alternatively, they may use molecular mimicry to avoid detection or trigger events leading to the expression of immune modulatory cytokines such as IL-10, which dampen the NETotic response of neutrophils. In addition, the host microenvironment may contribute to the innate immune response by the production of lectin-like molecules that bind to bacteria and promote their entrapment on NETs. An example of this is the production of surfactant protein D by the lung epithelium. In addition, pregnancy provides a different challenge, as the mother needs to mount an effective response against pathogens, without harming her unborn child. An examination of these decoy and host response mechanisms may open the path for new therapies to treat pathologies mediated by overt NETosis