Investigating Nonlinearity: A Note on the Estimation of Hamilton’s Random Field Regression Model

This is a revised and extended version of the authors’ 2003 Trinity Economic Paper. It describes Hamilton’s (2001) approach to nonlinear econometric modelling and some of the methods of nonlinear optimization, as before, but adds significantly to the investigation of Hamilton’s Gauss program for the implementation of his methodology. Specifically, it reports on the performance of this program using data relating to Hamilton’s US Phillips curve example, the use of two versions of the Gauss software and a range of numerical optimization options. It also examines the impact of changes in initial parameter estimates, the use of algorithm switching strategies, and the e?ects of changes in the sample data on the results produced by Hamilton’s procedure. The new results presented suggest some further clear conclusions that will be of value to those using Hamilton’s method.

Rational preferential reasoning for datalog

Datalog is a powerful language that can be used to represent explicit knowledge and compute inferences in knowledge bases. Datalog cannot represent or reason about contradictory rules, though. This is a limitation as contradictions are often present in domains that contain exceptions. In this paper, we extend datalog to represent contradictory and defeasible information. We define an approach to efficiently reason about contradictory information in datalog and show that it satisfies the KLM requirements for a rational consequence relation. Finally, we introduce an implementation of this approach in the form of a defeasible datalog reasoning tool and evaluate the performance of this tool

The United States 1989 military intervention in Panama: a just cause?

American involvement in Panama dates back to 1903 when the United States helped bring independence to the Republic and soon after began construction of the Panama Canal. As the guarantor of Panamanian sovereignty, the U.S in the ensuing decades contributed to a non-democratic environment in Panama by supporting a series of dictators who promised stability in the region. The U.S. National Security policy just before Operation JUST CAUSE finally acknowledged the brutality of the Panamanian dictator, Manuel Noriega, forcing Washington to attempt numerous unsuccessful diplomatic maneuvers in an effort to avoid military intervention. Once combat operations commenced, the justification, necessity and amount of force committed in Panama came under critical review by some lawmakers and the public. However, military leaders task organized U.S. forces against Panamanian units and significant key locations in accordance with Army doctrinal correlation of forces and means for a deliberate attack. A comprehensive assessment of force ratios and insights on conduct during JUST CAUSE displays the successful application of a measured military force in adherence with strict rules of engagement. History bound the United States with Panama ultimately forcing military intervention in order to restore democracy. The response, executed with measured force and conducted appropriately, resulted in all of the National Security objectives met and ensured democracy returned to the Republic of Panama and its people. The 1989 military intervention in Panama was a just cause

A Review of Recent Developments in Atomic Processes for Divertors and Edge Plasmas

The most promising concepts for power and particle control in tokamaks and other fusion experiments rely upon atomic processes to transfer the power and momentum from the edge plasma to the plasma chamber walls. This places a new emphasis on processes at low temperatures (1-200 eV) and high densities (10^20-10^22 m^-3). The most important atomic processes are impurity and hydrogen radiation, ionization, excitation, recombination, charge exchange, radiation transport, molecular collisions, and elastic scattering of atoms, molecules and ions. Important new developments have occurred in each of these areas. The best available data for these processes and an assessment of their role in plasma wall interactions are summarized, and the major areas where improved data are needed are reviewed.Comment: Preprint for the 11th PSI meeting, postscript with 22 figures, 40 page

A Comparative Profile Study of the Industrial Arts Major at North Texas State University

The problem of this study is to determine a profile of the typical industrial arts major at North Texas State University, based on scores made on the American College Testing Program Battery, and to compare this profile with profiles of four other local subgroups. ACT scores representing nine categories of student information were analyzed from a total sampling of 286 North Texas State University students of the Industrial Arts Department, School of Business Administration, School of Education, and College of Arts and Sciences. Data were from tests administered during regular ACT testing sessions in 1966-67

Poly(ADP-Ribose) glycohydrolase (PARG) vs. poly(ADP-Ribose) polymerase (PARP) – function in genome maintenance and relevance of inhibitors for anti-cancer therapy

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins. PARPs are known to function in a large range of cellular processes including DNA repair, DNA replication, transcription and modulation of chromatin structure. Inhibition of PARP holds great potential for therapy, especially in cancer. Several PARP1/2/3 inhibitors (PARPi) have had success in treating ovarian, breast and prostate tumors harboring defects in the homologous recombination (HR) DNA repair pathway, especially BRCA1/2 mutated tumors. However, treatment is limited to specific sub-groups of patients and resistance can occur, limiting the use of PARPi. Poly(ADP-ribose) glycohydrolase (PARG) reverses the action of PARP enzymes, hydrolysing the ribose-ribose bonds present in poly(ADP-ribose). Like PARPs, PARG is involved in DNA replication and repair and PARG depleted/inhibited cells show increased sensitivity to DNA damaging agents. They also display an accumulation of perturbed replication intermediates which can lead to synthetic lethality in certain contexts. In addition, PARG is thought to play an important role in preventing the accumulation of cytoplasmic PAR and therefore parthanatos, a caspase-independent PAR-mediated type of cell death. In contrast to PARP, the therapeutic potential of PARG has been largely ignored. However, several recent papers have demonstrated the exciting possibilities that inhibitors of this enzyme may have for cancer treatment, both as single agents and in combination with cytotoxic drugs and radiotherapy. This article discusses what is known about the functions of PARP and PARG and the potential future implications of pharmacological inhibition in anti-cancer therapy

Optimising care for patients with cognitive impairment and dementia following hip fracture

The global shift in demographics towards aging populations is leading to a commensurate increase in age-related disease and frailty. It is essential to optimise health services to meet current needs and prepare for anticipated future demands. This paper explores issues impacting on people living with cognitive impairment and/or dementia who experience a hip fracture and are cared for in acute settings. This is important given the high mortality and morbidity associated with this population. Given the current insufficiency of clear evidence on optimum rehabilitation of this patient group, this paper explored three key themes namely: recognition of cognitive impairment, response by way of training and education of staff to optimise care for this patient group and review of the importance of outcomes measures. Whilst there is currently insufficient evidence to draw conclusions about the optimal ways of caring for patients living with dementia following hip fracture, this paper concludes that future research should improve understanding of healthcare staff education to improve the outcomes for this important group of patients

Trichotillometry: the reliability and practicality of hair pluckability as a method of nutritional assessment

<p>Abstract</p> <p>Background</p> <p>A nutritional assessment method that is quick and easy to conduct would be extremely useful in a complex emergency, where currently there is no agreed practical and acceptable method. Hair pluckability has been suggested to be a useful method of assessing protein nutritional status. The aim was to investigate the reliability of the trichotillometer and to explore the effects of patient characteristics on hair epilation force.</p> <p>Methods</p> <p>Three observers plucked hair from twelve participants to investigate the within- and between-observer reliability. To investigate the effect of patient characteristics on hair pluckability, 12 black African and 12 white volunteers were recruited. Participants completed a short questionnaire to provide basic information on their characteristics and hair.</p> <p>Results</p> <p>Mean hair pluckability measurements for the 12 participants obtained by the three observers (39.5 g, 41.2 g and 32.7 g) were significantly different (p < 0.001). Significant variation between patients was also found (p < 0.001). None of the patient characteristics significantly affected hair pluckability, with the exception of age, although this relationship was not consistent.</p> <p>Conclusion</p> <p>Due to significant variation in measurements, hair pluckability does not appear to be a reliable method for assessing adult nutritional status. Hair pluckability could be a useful method of nutritional assessment in complex humanitarian emergencies but only if the reliability was improved.</p