The role of learning goals in the design of ILEs: some issues to consider

Part of the motivation behind the evolution of learning environments is the idea of providing students with individualized instructional strategies that allow them to learn as much as possible. It has been suggested that the goals an individual holds create a framework or orientation from which they react and respond to events. There is a large evidence-based literature which supports the notion of mastery and performance approaches to learning and which identifies distinct behavioural patterns associated with each. However, it remains unclear how these orientations manifest themselves within the individual: an important question to address when applying goal theory to the development of a goal-sensitive learner model. This paper exposes some of these issues by describing two empirical studies. They approach the subject from different perspectives, one from the implementation of an affective computing system and the other a classroom-based study, have both encountered the same empirical and theoretical problems: the dispositional/situational aspect and the dimensionality of goal orientation

Role of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and Disease

Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to ligand binding, cellular signaling, and its role in known physiological disorders such as cancer

Validation of an Instrument to Assess Fear Avoidance in Adolescents Who Have Been Diagnosed with a Concussion

Please enjoy Volume 6, Issue 1 of the JSMAHS. In this issue, you will find Professional, Graduate, and Undergraduate research abstracts, and case reports. Thank you for viewing this 6th Annual OATA Special Edition

PARADOX, CONTROVERSY AND NATIONAL SELF-DETERMINATION

Polazište ovog članka je u tvrdnji da doktrina narodnog samoodređenja i dalje ostaje jedna od najparadoksalnijih, najkontroverznijih, ali istodobno i najuspješnijih doktrina, koja i dalje u velikoj mjeri doprinosi oblikovanju postojećeg međunarodnog sustava nacionalnih država. U članku se tvrdi da je ta doktrina, čija je namjera bila da sačuva mir i ljudsko dostojanstvo, uvijek bila u samom srcu mnogih sukoba. Ovaj članak analizira paradokse i kontroverze koji su sadržani u toj doktrini, počevši od napetosti između univerzalnosti doktrine narodnog samoodređenja s jedne, i posebnosti nekog konkretnog zahtjeva za narodno samoodređenje neke nacionalne grupe s druge strane. Ti paradoksi i kontroverze odnose se na širok spektar pitanja: od političkih izazova i pitanja legitimnosti same nacionalne države, koja se na taj način stvara, do činjenice da je doktrina narodnog samoodređenja zapravo stvar međunarodne politike, a ne tek puko unutarnje, tj. nacionalno pitanje. Ne odbacujemo samu doktrinu samoodređenja, nego zaključujemo – u zadnjem (devetom) paradoksu – da se njena uspješnost ili neuspješnost ne smije mjeriti brojem država koje su nastale na taj način, nego u kojoj je mjeri ona uspješna u pretvaranju postojećih država u “sigurne kuće” za sve jasnije definirane nacionalne grupe.This article’s point of departure is that the national self-determination doctrine remains one of the most paradoxical, contested, but successful doctrines which has largely contributed to the shape of our existing international system of nation-states. It argues that the doctrine which is intended to safeguard peace and human dignity is and always has been at the heart of many conflicts. Starting with the tension between the universality of the national self-determination doctrine and the particularity of the national group whose interests it promotes, the article explores other paradoxes contained within this doctrine. They range from political and legitimacy challenges to the very nation-state it creates, through the violations of human rights contrary to its very meaning, to the fact that national self-determination doctrine, far from being a national issue, is actually an international affair. While not rejecting the doctrine, the paper concludes with the final (ninth) paradox that perhaps the success of this doctrine should not be measured by how many states it can produce, but how it can make the existing states a safe home for more self-differentiating national groups

When do children learn from unreliable speakers?

Children do not necessarily disbelieve a speaker with a history of inaccuracy; they take into account reasons for errors. Three- to 5 year-olds (N = 97) aimed to identify a hidden target in collaboration with a puppet. The puppet’s history of inaccuracy arose either from false beliefs, or occurred despite his being fully informed. On a subsequent test trial, children’s realistic expectation about the target was contradicted by the puppet who was fully informed. Children were more likely to revise their belief in line with the puppet’s assertion when his previous errors were due to false beliefs. Children who explained this puppet’s prior inaccuracy in terms of false belief were more likely to believe the puppet than those who did not. As children’s understanding of the mind advances, they increasingly balance the risk of learning falsehoods from unreliable speakers against that of rejecting truths from speakers who made excusable errors

NACIONALNA DRŽAVA I EUROPSKA UNIJA: IZGUBLJENI U BORBI ZA IDENTITET

This article, based on studies of nationalism, discusses identity formation in the European Union and compares it to the nation-state. The starting point is that for all its economic benefits and political innovation, the EU is failing to provide people with the sense of belonging and extract political loyalty. By exploring what function identity serves – for the nation-state in the past and for the EU in the present – it is argued that while there are limits to the EU’s ability to project a meaningful European identity, there are also limits to the nation- -state’s ability to meet the political challenges of contemporary societies. One way, and possibly the only way out of this ‘battle for identity’ is to acknowledge the real impact of the EU on the nation-state and open an honest debate by both European and national elites about which challenges of our time can be met by the EU and which are better kept at the national level. A better understanding of how people’s national aspirations, concerns and political demands are mediated between different levels of governance may lead to adapting their identities accordingly – loyalty and passion for the EU may follow too.Ovaj članak, koji se temelji na proučavanjima nacionalizma, razmatra formiranje identiteta u Europskoj uniji uspoređujući je s nacionalnom državom. Njegovo je polazište da EU, unatoč svim svojim ekonomskim prednostima i političkoj inovaciji, ne uspijeva ljudima pružiti osjećaj pripadnosti ni steći političku lojalnost. Na osnovi ispitivanja koju funkciju identitet obavlja – za nacionalnu državu u prošlosti i za EU u sadašnjosti – ustvrđuje se kako je sposobnost EU-a da projicira značajan europski identitet ograničena, ali da postoje i granice sposobnosti nacionalne države da udovolji političkim izazovima suvremenih društava. Jedan od izlaza, možda i jedini, iz te “borbe za identitet” jest priznavanje zbiljskoga utjecaja EU-a na nacionalnu državu te otvaranje iskrene rasprave i europskih i nacionalnih elita o tome s kojim se izazovima našega vremena može uhvatiti u koštac EU, a koje je bolje zadržati na nacionalnoj razini. Bolje razumijevanje toga kako se nacionalne aspiracije, preokupacije i politički zahtjevi ljudi posreduju među različitim razinama upravljanja moglo bi dovesti do odgovarajuće prilagodbe njihovih identiteta – a za time bi mogli uslijediti i lojalnost i privrženost EU-u

Public outreach: growing and adapting with changing times

Drayton Harbor’s 2016 reopening of 810 acres of commercial, tribal, and recreational shellfish harvesting area marked a significant achievement in the efforts to improve water quality and allow year-round harvest of the productive shellfish growing area. Public outreach over the past 20 years played a critical role in engaging the local community and encouraging on-the-ground actions to reduce pollution throughout the watershed. Bacteria pollution is a complex issue requiring diverse solutions; no single fix exists. In the Drayton Harbor watershed, a variety of organizations, agencies, and community members participated in developing and carrying out a robust and diverse outreach strategy that was adapted over time. We will review the history of these key outreach players and their roles in Drayton Harbor water quality improvements. Successful outreach efforts from Whatcom County’s Pollution Identification and Correction (PIC) Program included the development of online water quality summaries, online interactive results map, community events, video shorts, and the septic system maintenance rebate program. Future outreach goals include the use of social marketing to normalize pollution prevention actions such as routine septic system maintenance. Ultimately, sustaining good water quality and safe, year-round shellfish harvest requires ongoing community engagement

Clinical Use of Insulin Glargine 300 U/mL in Adults with Type 2 Diabetes : Hypothetical Case Studies

Type 2 diabetes (T2D) is a progressive disease, with many individuals eventually requiring basal insulin therapy to maintain glycaemic control. However, there exists considerable therapeutic inertia to the prompt initiation and optimal titration of basal insulin therapy due to barriers that include fear of injections, hypoglycaemia, weight gain, and burdensome regimens. Hypoglycaemia is thought to be a major barrier to optimal glycaemic control and is associated with significant morbidity and mortality. Newer second-generation basal insulin analogues provide comparable glycaemic control with lower risk of hypoglycaemia compared with first-generation basal insulin analogues. The present review article discusses clinical evidence for one such second-generation basal insulin analogue, insulin glargine 300 U/mL (Gla-300), in the context of hypothetical case studies that are representative of individuals who may attend routine clinical practice. These case studies discuss individualised treatment needs for people with T2D who are insulin-naive or pre-treated. Clinical characteristics such as older age, frequent nocturnal hypoglycaemia, and renal impairment, which are known risk factors for hypoglycaemia, are also considered.Peer reviewe

Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling

Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to proteins implicated in endocytosis. For these reasons, it has been proposed that synaptojanin is involved in the recycling of synaptic vesicles. Here, we demonstrate that the unc-26 gene encodes the Caenorhabditis elegans ortholog of synaptojanin. unc-26 mutants exhibit defects in vesicle trafficking in several tissues, but most defects are found at synaptic termini. Specifically, we observed defects in the budding of synaptic vesicles from the plasma membrane, in the uncoating of vesicles after fission, in the recovery of vesicles from endosomes, and in the tethering of vesicles to the cytoskeleton. Thus, these results confirm studies of the mouse synaptojanin 1 mutants, which exhibit defects in the uncoating of synaptic vesicles (Cremona, O., G. Di Paolo, M.R. Wenk, A. Luthi, W.T. Kim, K. Takei, L. Daniell, Y. Nemoto, S.B. Shears, R.A. Flavell, D.A. McCormick, and P. De Camilli. 1999. Cell. 99:179–188), and further demonstrate that synaptojanin facilitates multiple steps of synaptic vesicle recycling