Review of Varese: A Looking-Glass Diary, Volume 1: 1883-1928 by Louise Varèse

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Exploring unlikely errors using video games: An example in number entry research

A common and important feature of many safety critical interactive devices is number entry. In hospitals, number entry takes the form of setting drug parameters such as doses, volumes, etc. There are several ways a number entry interface can be designed - with different consequences for error and speed. Nurses and healthcare practitioners usually have to interact with different interfaces often under pressure and stress of taking care of patients with different health conditions. Error rates in practice are low, undetected error rates are even lower and obtaining the context in which the errors occur is often incredibly difficult due to poor logging systems in many medical devices and high cost of planning and conducting empirical studies. Laboratory based studies also suffer similar limitations in that, without interventions, error rates are also too low to study. This paper explores the benefits of using a gaming context to study safety critical systems. We argue that a game paradigm provides a way that overcomes many of the problems of studying low error rates in safety critical systems and specifically for number entry in medical contexts

Epstein-Barr viral microRNAs target caspase 3

The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that transforms B cells and causes several malignancies including Burkitt’s lymphoma. EBV differentially expresses at least 49 mature microRNAs (miRNAs) during latency in various infected epithelial and B cells. Recent high-throughput studies and functional assays have begun to reveal the function of the EBV miRNAs suggesting roles in latency, cell cycle control, and apoptosis. In particular, the central executioner of apoptosis, Caspase 3 (CASP3), was proposed as a target of select EBV miRNAs. However, whether CASP3 is truly a target of EBV miRNAs, and if so, which specific miRNAs target CASP3 is still under debate. Based on previously published high-throughput biochemical data and a bioinformatic analysis of the entire CASP3 3′-UTR, we identified 12 EBV miRNAs that have one or more seed binding sites in the CASP3 3′-UTR. We individually tested all 12 miRNAs for repression of CASP3 in luciferase reporter assays, and nine showed statistically significant (P \u3c 0.001) repression of a full-length CASP3 reporter. Further, three EBV miRNAs, including BART22, exhibited repression of endogenous CASP3 protein. These data confirm that CASP3 is a direct target of specific EBV BART miRNAs

Achieving Sustainable Tourism in Hawai'i Using a Sustainability Evaluation System

The WTO defines sustainable tourism as that which meets the needs of present tourists and host regions while protecting and enhancing opportunities for the future of the tourism sector. Hawaii's tourism components (urban, coastal, nature-based, and eco-) are discussed. Systems for evaluating sustainability of tourism are described

Using Learning Collaboratives to Improve Public Health Emergency Preparedness Systems

The U.S. National Health Security Strategy calls for the development and wide-spread implementation of quality improvement (QI) tools in public health emergency preparedness (PHEP), including the development of “learning collaboratives,” a structured way for organizations with common interests to close the gap between potential and practice by learning from each other. To test this approach, we developed and assessed separate learning collaboratives focused on PHEP emergency communications and on the use of Medical Reserve Corps (MRC) volunteers. Although participants carried out improvement projects that they felt were useful, each collaborative struggled to identify a common theme, participation was limited, and leadership buy-in was not strong. This suggests that the learning collaborative model may not be appropriate in this context. Because some of the factors that limited their success are inherent (the lack of an established evidence base and agreed upon outcome and performance measures and the difficulty of carrying out rapid Plan-Do-Study-Act (PDSA) cycles and measuring the results), this suggests that the learning collaborative model may not be appropriate in this context

Evolution of Massive Protostars via Disk Accretion

Mass accretion onto (proto-)stars at high accretion rates > 10^-4 M_sun/yr is expected in massive star formation. We study the evolution of massive protostars at such high rates by numerically solving the stellar structure equations. In this paper we examine the evolution via disk accretion. We consider a limiting case of "cold" disk accretion, whereby most of the stellar photosphere can radiate freely with negligible backwarming from the accretion flow, and the accreting material settles onto the star with the same specific entropy as the photosphere. We compare our results to the calculated evolution via spherically symmetric accretion, the opposite limit, whereby the material accreting onto the star contains the entropy produced in the accretion shock front. We examine how different accretion geometries affect the evolution of massive protostars. For cold disk accretion at 10^-3 M_sun/yr the radius of a protostar is initially small, about a few R_sun. After several solar masses have accreted, the protostar begins to bloat up and for M \simeq 10 M_sun the stellar radius attains its maximum of 30 - 400 R_sun. The large radius about 100 R_sun is also a feature of spherically symmetric accretion at the same accreted mass and accretion rate. Hence, expansion to a large radius is a robust feature of accreting massive protostars. At later times the protostar eventually begins to contract and reaches the Zero-Age Main-Sequence (ZAMS) for M \simeq 30 M_sun, independent of the accretion geometry. For accretion rates exceeding several 10^-3 M_sun/yr the protostar never contracts to the ZAMS. The very large radius of several 100s R_sun results in a low effective temperature and low UV luminosity of the protostar. Such bloated protostars could well explain the existence of bright high-mass protostellar objects, which lack detectable HII regions.Comment: 20 pages, 16 figure

Impact resistance of deflection-hardening fiber reinforced concretes with different mixture parameters

YesThe impact behavior of deflection-hardening High Performance Fiber Reinforced Cementitious Concretes (HPFRCs) was evaluated herein. During the preparation of HPFRCs, fiber type and amount, fly ash to Portland cement ratio and aggregate to binder ratio were taken into consideration. HPFRC beams were tested for impact resistance using free-fall drop-weight test. Acceleration, displacement and impact load vs. time graphs were constructed and their relationship to the proposed mixture parameters were evaluated. The paper also aims to present and verify a nonlinear finite element analysis, employing the incremental nonlinear dynamic analysis, concrete damage plasticity model and contact surface between the dropped hammer and test specimen available in ABAQUS. The proposed modelling provides extensive and accurate data on structural behavior, including acceleration, displacement profiles and residual displacement results. Experimental results which are further confirmed by numerical studies show that impact resistance of HPFRC mixtures can be significantly improved by a proper mixture proportioning. In the presence of high amounts of coarse aggregates, fly ash and increased volume of hybrid fibers, impact resistance of fiberless reference specimens can be modified in a way to exhibit relatively smaller displacement results after impact loading without risking the basic mechanical properties and deflection-hardening response with multiple cracking