Role of endovascular treatment in vascular injuries

OBJECTIVE: To evaluate retrospectively the results, complications and follow-up of patients after endovascular treatment of vascular injuries. METHODS: Fifty transcatheter embolisation procedures (TCE) were performed in 46 patients between 1999 and 2008 at the Aga Khan University Hospital, Karachi. Injuries in 14 (30.4%) patients were due to road traffic accident; iatrogenic in 13 (28%); accidental in 6 (13%). Firearms, bomb blasts and earthquake contributed to injuries in 8(17%), 4(8.8%) and 1(2.2%) patients respectively. All patients underwent angiography and had evidence of either active haemorrhage, pseudo-aneurysm, abnormal vascularity or arteriovenous fistula. Followup ranged from 1 day to 6 years with mean of 10.5 months. Medical record files, lab results and imaging reports were utilised for the study. Procedure was declared as technically successful when there was cessation of extravasation, occlusion of fistula or exclusion of pseudo-aneurysm in the post-embolisation angiograms. Treatment was deemed clinically successful if there was resolution of the indication for which the procedure was done. RESULTS: Transcatheter embolisation was technically successful in occluding vascular lesions in all 46 (100%) patients. Lesions recurred in 4 (9%) patients who underwent initially successful TCE. These patients were treated effectively with repeated TCE. Three patients died during the same hospital stay and 3 patients died after being discharged from the hospital. All these patients were treated successfully with TCE and had factors other then TCE contributing to their mortality. CONCLUSION: Transcatheter embolisation for vascular injuries was found to be a satisfactory procedure, with low morbidity and mortality rates

Investigating the Knowledge Sharing among students in Pakistan

This paper’s goal is to empirically examine the impact of trust, attitude, and ICT Use on knowledge sharing among degree students of universities in Vehari. Self-efficacy theory was used as an underpinning theory to test the suggested model. A sample size of 120 students was selected to collect the primary data through survey from respondents. Correlation and multiple regression analysis were performed to test the hypotheses drawn from this study. The findings show that trust, attitude and ICT Use are the key factors in order to boost knowledge sharing amongst students. The results show that ICT Use is highly significant and correlated predictor of knowledge sharing. The study also discussed implications, limitations and future research recommendation that can be helpful both universities and researchers for further study

THE IMPACT OF NEGATIVE TIES ON TURNOVER INTENTION

Knowledge based industries where human capital is very important are increasingly concerned about retaining human talent. We use a social network perspective to determine the effect of negative ties on an employee’s turnover intentions. Interpersonal dislike ties and conflicting ties are hypothesized to be positively related to turnover intentions, keeping job fit and sacrifice as control variables. Collecting sociometric and conventional data from 100 employees in an organization related to security and information of Pakistani individuals, OLS regression reveled that an employee’s number of dislike ties has a positive and significant impact of employee’s turnover intentions. Whereas an employee’s number of conflicting ties does not significantly impact turnover intentions

THE IMPACT OF NEGATIVE TIES ON TURNOVER INTENTION

Knowledge based industries where human capital is very important are increasingly concerned about retaining human talent. We use a social network perspective to determine the effect of negative ties on an employee’s turnover intentions. Interpersonal dislike ties and conflicting ties are hypothesized to be positively related to turnover intentions, keeping job fit and sacrifice as control variables. Collecting sociometric and conventional data from 100 employees in an organization related to security and information of Pakistani individuals, OLS regression reveled that an employee’s number of dislike ties has a positive and significant impact of employee’s turnover intentions. Whereas an employee’s number of conflicting ties does not significantly impact turnover intentions

Toxicity potential of heartwood extractives from two mulberry species against Heterotermes indicola

Choice and no-choice tests were run to evaluate natural resistance of the woods of two Morus species (Morus alba and Morus nigra) against the subterranean, by Heterotermes indicola under field conditions. Toxicity, antifeedant and repellency potential of the heartwood extractives was also investigated under laboratory conditions. Heartwood extractives were removed from wood shavings by using methanol or an ethanol: toluene (2:1) mixture. Results of choice and no-choice tests with sap and heartwood blocks exposed to termites, showed that both mulberry species were resistant to termites but in comparison. Morus alba wood was more resistant than Morus nigra to termite feeding as it showed <5 % weight loss after 90 days. Termites exhibited a concentration dependent mortality after exposure to either mulberry species’ heartwood extractives. The highest termite mortality occurred after termites were exposed to filter paper treated with Morus alba extractives at a concentration of 5%. . At this concentration, antifeedancy and repellency were calculated to be 91.67 and 84 %respectively. . Our results also showed that extractives from either mulberry species imparted resistance to vacuum-pressure treated non-durable Populus deltoides wood. Termite mortality was greater than 75 % after feeding on Populus deltoides wood treated with extractives from Morus alba. Solvent only (methanol) treated Populus deltoides controls, showed a minimum weight loss of 2.69 % after 28 days. These results suggest that Morus alba extractives have antitermitic properties and may be potentially useful in the development of environment friendly termiticides

Genetic Association of Beta-Myosin Heavy-Chain Gene (MYH7) with Cardiac Dysfunction

Cardiac dysfunction accelerates the risk of heart failure, and its pathogenesis involves a complex interaction between genetic and environmental factors. Variations in myosin affect contractile abilities of cardiomyocytes and cause structural and functional abnormalities in myocardium. The study aims to find the association of MYH7 rs121913642 (c.1594 T>C) and rs121913645 (c.667G>A) variants with cardiac dysfunction in the Punjabi Pakistani population. Patients with heart failure (n = 232) and healthy controls (n = 205) were enrolled in this study. MYH7 variant genotyping was performed using tetra ARMS-PCR. MYH7 rs121913642 TC genotype was significantly more prevalent in the patient group (p < 0.001). However, MYH7 rs121913645 genotype frequencies were not significantly different between the patient and control groups (p < 0.666). Regression analysis also revealed that the rs121913642 C allele increases the risk of cardiac failure by ~2 [OR:1.98, CI: 1.31–2.98, p < 0.001] in comparison to the T allele. High levels of the cardiac enzymes cardiac troponin I (cTnI) and CK-MB were observed in patients. There was also an increase in total cholesterol, LDL cholesterol, and uric acid in patients compared to the healthy control group (p < 0.001). In conclusion, the MYH7 gene variant rs121913642 is genetically associated with cardiac dysfunction and involved in the pathogenesis of HF

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods: We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124. Findings: Between July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid (5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18). Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98). Interpretation: We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial

PENGARUH E-COMMERCE TERHADAP PENGAMBILAN RISIKO BERWIRAUSAHA(Studi pada Mahasiswa Prodi Manajemen Dakwah 2017-2019)

Misbah Milatul Haq (16240032), Skripsi ini berjudul Pengaruh E-Commerce Terhadap Pengambilan Risiko Berwirausaha (Studi pada Mahasiswa Prodi Manajemen Dakwah 2017-2019. Tujuan penelitian ini adalah untuk mengetahui pengaruh e-commerce terhadap pengambilan resiko berwirausaha Mahasiswa Prodi Manajemen Dakwah 2017, 2018 dan 2019. Metode yang digunakan dalam penelitian ini adalah kuantitatif deskriptif, dan populasi dalam penelitian ini adalah Mahasiswa Prodi Manajemen Dakwah 2017-2019 yaitu mahasiswa aktif Fakultas Dakwah dan Komunikasi yang berkosentrasi pada Prodi Manajemen Dakwah yang mendaftar pada tahun ajaran 2017/2018, 2018/2019 dan 2019/2020, dengan jumlah populasi yang didapat yaitu 90 orang. Adapun teknik pengumpulan data dengan menyebar kusioner melalui google formulir kepada Mahasiswa Prodi Manajemen Dakwah angkatan 2017,2018,dan 2019 sedangkan teknik pengambilan sampel dalam penelitian ini adalah dengan menggunakan random sampling. Teknik analisis data dalam penelitian ini menggunakan analisis regresi sederhana, uji validitas, uji reabilitas, analisis deskriptif, uji normalitas, uji linearitas, uji parsial (T) dan uji koofisien determinasi (R ). Hasil penelitian dengan bantuan pada uji parsial (T) 2 menujukkan nilai Thitung>Ttabel yaitu 2,970 > 1,996 dan nilai signifikasi < α yaitu 0,004 < 0,05, yang berarti variabel ECommerce berpengaruh signifikan terhadap pengambilan risiko berwirausaha. Besar pengaruhnya ditunjukkan pada uji koofisien determinasi yaitu pada nilai R Square sebesar 0,110 yang berarti pengaruh E-Commerce terhadap pengambilan risiko berwirausaha sebesar 11% sedangkan 89% dipengaruhi oleh faktor lain