Investigation of the Void Coefficient and Other Integral Parameters in the PROTEUS-LWHCR Phase II Program

Comparisons of calculated and measured neutron balance components are reported for the 7. 5% fissile plutonium reference test lattice of the PROTEUS-light water high conversion reactor (LWHCR) phase II program, both wet (with H//2O) and dry (100% void). Special experimental techniques have been developed and applied, particularly for k// infinity , and the range of directly measured reaction rate ratios has been extended. For the two cell codes tested, WIMS-D/1981 library and KARBUS/KEDAK-4, specific shortcomings have been identified; the new measurements have been found to be significantly more representative and accurate than the earlier phase I experiments

COS Ambassadors

A collection of materials and resources for COS ambassadors

Genetic influences on schizophrenia and subcortical brain volumes:Large-scale proof of concept

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders