50 research outputs found
Swine Genome Sequencing Consortium (SGSC): A Strategic Roadmap for Sequencing The Pig Genome
The Swine Genome Sequencing Consortium (SGSC) was formed in September
2003 by academic, government and industry representatives to provide international
coordination for sequencing the pig genome. The SGSC’s mission is to advance
biomedical research for animal production and health by the development of DNAbased
tools and products resulting from the sequencing of the swine genome. During
the past 2 years, the SGSC has met bi-annually to develop a strategic roadmap for
creating the required scientific resources, to integrate existing physical maps, and to
create a sequencing strategy that captured international participation and a broad
funding base. During the past year, SGSC members have integrated their respective
physical mapping data with the goal of creating a minimal tiling path (MTP)
that will be used as the sequencing template. During the recent Plant and Animal
Genome meeting (January 16, 2005 San Diego, CA), presentations demonstrated that
a human–pig comparative map has been completed, BAC fingerprint contigs (FPC)
for each of the autosomes and X chromosome have been constructed and that BAC
end-sequencing has permitted, through BLAST analysis and RH-mapping, anchoring
of the contigs. Thus, significant progress has been made towards the creation of a
MTP. In addition, whole-genome (WG) shotgun libraries have been constructed and
are currently being sequenced in various laboratories around the globe. Thus, a
hybrid sequencing approach in which 3x coverage of BACs comprising the MTP
and 3x of the WG-shotgun libraries will be used to develop a draft 6x coverage of
the pig genome
Meeting Report: Validation of Toxicogenomics-Based Test Systems: ECVAM–ICCVAM/NICEATM Considerations for Regulatory Use
This is the report of the first workshop “Validation of Toxicogenomics-Based Test Systems” held 11–12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointly by ECVAM, the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The primary aim of the workshop was for participants to discuss and define principles applicable to the validation of toxicogenomics platforms as well as validation of specific toxicologic test methods that incorporate toxicogenomics technologies. The workshop was viewed as an opportunity for initiating a dialogue between technologic experts, regulators, and the principal validation bodies and for identifying those factors to which the validation process would be applicable. It was felt that to do so now, as the technology is evolving and associated challenges are identified, would be a basis for the future validation of the technology when it reaches the appropriate stage. Because of the complexity of the issue, different aspects of the validation of toxicogenomics-based test methods were covered. The three focus areas include a) biologic validation of toxicogenomics-based test methods for regulatory decision making, b) technical and bioinformatics aspects related to validation, and c) validation issues as they relate to regulatory acceptance and use of toxicogenomics-based test methods. In this report we summarize the discussions and describe in detail the recommendations for future direction and priorities
Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF
The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at
the Fermilab Long-Baseline Neutrino Facility (LBNF) is described
Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 1: The LBNF and DUNE Projects
This document presents the Conceptual Design Report (CDR) put forward by an international neutrino community to pursue the Deep Underground Neutrino Experiment at the Long-Baseline Neutrino Facility (LBNF/DUNE), a groundbreaking science experiment for long-baseline neutrino oscillation studies and for neutrino astrophysics and nucleon decay searches. The DUNE far detector will be a very large modular liquid argon time-projection chamber (LArTPC) located deep underground, coupled to the LBNF multi-megawatt wide-band neutrino beam. DUNE will also have a high-resolution and high-precision near detector
Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF
The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described
Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE): Conceptual Design Report
This volume of the LBNF/DUNE Conceptual Design Report cover the Long-Baseline Neutrino Facility for DUNE and describes the LBNF Project, which includes design and construction of the beamline at Fermilab, the conventional facilities at both Fermilab and SURF, and the cryostat and cryogenics infrastructure required for the DUNE far detector.This volume of the LBNF/DUNE Conceptual Design Report cover the Long-Baseline Neutrino Facility for DUNE and describes the LBNF Project, which includes design and construction of the beamline at Fermilab, the conventional facilities at both Fermilab and SURF, and the cryostat and cryogenics infrastructure required for the DUNE far detector