145 research outputs found
Elastic p-3He and n-3H scattering with two- and three-body forces
We report on a microscopic calculation of n-3H and p-3He scattering employing
the Argonne v_{18} and v_8' nucleon-nucleon potentials with and without
additional three-nucleon force. An R-matrix analysis of the p-3He and n-3H
scattering data is presented. Comparisons are made for the phase shifts and a
selection of measurements in both scattering systems. Differences between our
calculation and the R-matrix results or the experimental data can be attributed
to only two partial waves (3P0 and 3P2). We find the effect of the Urbana IX
and the Texas-Los Alamos three-nucleon forces on the phase shifts to be
negligible.Comment: submitted to Phys. Rev.
Microscopic calculation of the spin-dependent neutron scattering lengths on 3He
We report on the spin.dependent neutron scattering length on 3He from a
microscopic calculation of p-3H, n-3He, and d-2H scattering employing the
Argonne v18 nucleon-nucleon potential with and without additional three-nucleon
force. The results and that of a comprehensive R-matrix analysis are compared
to a recent measurement. The overall agreement for the scattering lengths is
quite good. The imaginary parts of the scattering lengths are very sensitive to
the inclusion of three-nucleon forces, whereas the real parts are almost
insensitive.Comment: 9 pages, 1 figur
Moving lattice kinks and pulses: an inverse method
We develop a general mapping from given kink or pulse shaped travelling-wave
solutions including their velocity to the equations of motion on
one-dimensional lattices which support these solutions. We apply this mapping -
by definition an inverse method - to acoustic solitons in chains with nonlinear
intersite interactions, to nonlinear Klein-Gordon chains, to reaction-diffusion
equations and to discrete nonlinear Schr\"odinger systems. Potential functions
can be found in at least a unique way provided the pulse shape is reflection
symmetric and pulse and kink shapes are at least functions. For kinks we
discuss the relation of our results to the problem of a Peierls-Nabarro
potential and continuous symmetries. We then generalize our method to higher
dimensional lattices for reaction-diffusion systems. We find that increasing
also the number of components easily allows for moving solutions.Comment: 15 pages, 5 figure
Against all odds? Forming the planet of the HD196885 binary
HD196885Ab is the most "extreme" planet-in-a-binary discovered to date, whose
orbit places it at the limit for orbital stability. The presence of a planet in
such a highly perturbed region poses a clear challenge to planet-formation
scenarios. We investigate this issue by focusing on the planet-formation stage
that is arguably the most sensitive to binary perturbations: the mutual
accretion of kilometre-sized planetesimals. To this effect we numerically
estimate the impact velocities amongst a population of circumprimary
planetesimals. We find that most of the circumprimary disc is strongly hostile
to planetesimal accretion, especially the region around 2.6AU (the planet's
location) where binary perturbations induce planetesimal-shattering of
more than 1km/s. Possible solutions to the paradox of having a planet in such
accretion-hostile regions are 1) that initial planetesimals were very big, at
least 250km, 2) that the binary had an initial orbit at least twice the present
one, and was later compacted due to early stellar encounters, 3) that
planetesimals did not grow by mutual impacts but by sweeping of dust (the
"snowball" growth mode identified by Xie et al., 2010b), or 4) that HD196885Ab
was formed not by core-accretion but by the concurent disc instability
mechanism. All of these 4 scenarios remain however highly conjectural.Comment: accepted for publication by Celestial Mechanics and Dynamical
Astronomy (Special issue on EXOPLANETS
Photospheric and Subphotospheric Dynamics of Emerging Magnetic Flux
Magnetic fields emerging from the Sun's interior carry information about
physical processes of magnetic field generation and transport in the convection
zone. Soon after appearance on the solar surface the magnetic flux gets
concentrated in sunspot regions and causes numerous active phenomena on the
Sun. This paper discusses some properties of the emerging magnetic flux
observed on the solar surface and in the interior. A statistical analysis of
variations of the tilt angle of bipolar magnetic regions during the emergence
shows that the systematic tilt with respect to the equator (the Joy's law) is
most likely established below the surface. However, no evidence of the
dependence of the tilt angle on the amount of emerging magnetic flux, predicted
by the rising magnetic flux rope theories, is found. Analysis of surface plasma
flows in a large emerging active region reveals strong localized upflows and
downflows at the initial phase of emergence but finds no evidence for
large-scale flows indicating future appearance a large-scale magnetic
structure. Local helioseismology provides important tools for mapping
perturbations of the wave speed and mass flows below the surface. Initial
results from SOHO/MDI and GONG reveal strong diverging flows during the flux
emergence, and also localized converging flows around stable sunspots. The wave
speed images obtained during the process of formation of a large active region,
NOAA 10488, indicate that the magnetic flux gets concentrated in strong field
structures just below the surface. Further studies of magnetic flux emergence
require systematic helioseismic observations from the ground and space, and
realistic MHD simulations of the subsurface dynamics.Comment: 21 pages, 15 figures, to appear in Space Science Review
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Outbreak of severe vomiting in dogs associated with a canine enteric coronavirus, United Kingdom
The lack of population health surveillance for companion animal populations leaves them vulnerable to the effects of novel diseases without means of early detection. We present evidence on the effectiveness of a system that enabled early detection and rapid response to a canine gastroenteritis outbreak in the United Kingdom. In January 2020, prolific vomiting among dogs was sporadically reported in the United Kingdom. Electronic health records from a nationwide sentinel network of veterinary practices confirmed a significant increase in dogs with signs of gastroenteric disease. Male dogs and dogs living with other vomiting dogs were more likely to be affected. Diet and vaccination status were not associated with the disease; however, a canine enteric coronavirus was significantly associated with illness. The system we describe potentially fills a gap in surveillance in neglected populations and could provide a blueprint for other countries
The Origin, Early Evolution and Predictability of Solar Eruptions
Coronal mass ejections (CMEs) were discovered in the early 1970s when space-borne coronagraphs revealed that eruptions of plasma are ejected from the Sun. Today, it is known that the Sun produces eruptive flares, filament eruptions, coronal mass ejections and failed eruptions; all thought to be due to a release of energy stored in the coronal magnetic field during its drastic reconfiguration. This review discusses the observations and physical mechanisms behind this eruptive activity, with a view to making an assessment of the current capability of forecasting these events for space weather risk and impact mitigation. Whilst a wealth of observations exist, and detailed models have been developed, there still exists a need to draw these approaches together. In particular more realistic models are encouraged in order to asses the full range of complexity of the solar atmosphere and the criteria for which an eruption is formed. From the observational side, a more detailed understanding of the role of photospheric flows and reconnection is needed in order to identify the evolutionary path that ultimately means a magnetic structure will erupt
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
The CIELO collaboration: Progress in international evaluations of neutron reactions on Oxygen, Iron, Uranium and Plutonium
The CIELO collaboration has studied neutron cross sections on nuclides that significantly impact criticality in nuclear technologies – 16O, 56Fe, 235,8U and 239Pu – with the aim of improving the accuracy of the data and resolving previous discrepancies in our understanding. This multi-laboratory pilot project, coordinated via the OECD/NEA Working Party on Evaluation Cooperation (WPEC) Subgroup 40 with support also from the IAEA, has motivated experimental and theoretical work and led to suites of new evaluated libraries that accurately reflect measured data and also perform well in integral simulations of criticality
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