The Effect of Partially Exposed Connective Tissue Graft on Root‐Coverage Outcomes: A Systematic Review and Meta‐Analysis

The aim of this systematic review was to compare the root‐coverage outcomes of using a partially exposed connective tissue graft (CTG) technique with a fully covered CTG technique for root coverage. An electronic search up to February 28th, 2017, was performed to identify human clinical studies with data comparing outcomes of root coverage using CTG, with and without a partially exposed graft. Five clinical studies were selected for inclusion in this review. For each study, the gain of keratinized gingiva, reduction of recession depth, number of surgical sites achieving complete root coverage, percentage of root coverage, gain of tissue thickness, and changes of probing depth and clinical attachment level were recorded. Meta‐analysis for the comparison of complete root coverage between the two techniques presented no statistically significant differences. A statistically significant gain of keratinized tissue in favor of the sites with an exposed CTG and a tendency of greater reduction in recession depth were seen at the sites with a fully covered CTG. Based on the results, the use of a partially exposed CTG in root‐coverage procedures could achieve greater gain in keratinized gingiva, while a fully covered CTG might be indicated for procedures aiming to reduce recession depth

Systematic comparison of the human saliva and plasma proteomes

The proteome of human salivary fluid has the potential to open new doors for disease biomarker discovery. A recent study to comprehensively identify and catalog the human ductal salivary proteome led to the compilation of 1166 proteins. The protein complexity of both saliva and plasma is large, suggesting that a comparison of these two proteomes will provide valuable insight into their physiological significance and an understanding of the unique and overlapping disease diagnostic potential that each fluid provides. To create a more comprehensive catalog of human salivary proteins, we have first compiled an extensive list of proteins from whole saliva (WS) identified through MS experiments. The WS list is thereafter combined with the proteins identified from the ductal parotid, and submandibular and sublingual (parotid/SMSL) salivas. In parallel, a core dataset of the human plasma proteome with 3020 protein identifications was recently released. A total of 1939 nonredundant salivary proteins were compiled from a total of 19 14474 unique peptide sequences identified from whole and ductal salivas[semi] 740 out of the total 1939 salivary proteins were identified in both whole and ductal saliva. A total of 597 of the salivary proteins have been observed in plasma. Gene ontology (GO) analysis showed similarities in the distributions of the saliva and plasma proteomes with regard to cellular localization, biological processes, and molecular function, but revealed differences which may be related to the different physiological functions of saliva and plasma. The comprehensive catalog of the salivary proteome and its comparison to the plasma proteome provides insights useful for future study, such as exploration of potential biomarkers for disease diagnostics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/61527/1/prca_200800140_sm_miscellaneous_information.pd

Early and late studies of EMD use in periodontal intrabony defects

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94589/1/jre1510.pd

Premature Osteoblast Clustering by Enamel Matrix Proteins Induces Osteoblast Differentiation through Up-Regulation of Connexin 43 and N-Cadherin

In recent years, enamel matrix derivative (EMD) has garnered much interest in the dental field for its apparent bioactivity that stimulates regeneration of periodontal tissues including periodontal ligament, cementum and alveolar bone. Despite its widespread use, the underlying cellular mechanisms remain unclear and an understanding of its biological interactions could identify new strategies for tissue engineering. Previous in vitro research has demonstrated that EMD promotes premature osteoblast clustering at early time points. The aim of the present study was to evaluate the influence of cell clustering on vital osteoblast cell-cell communication and adhesion molecules, connexin 43 (cx43) and N-cadherin (N-cad) as assessed by immunofluorescence imaging, real-time PCR and Western blot analysis. In addition, differentiation markers of osteoblasts were quantified using alkaline phosphatase, osteocalcin and von Kossa staining. EMD significantly increased the expression of connexin 43 and N-cadherin at early time points ranging from 2 to 5 days. Protein expression was localized to cell membranes when compared to control groups. Alkaline phosphatase activity was also significantly increased on EMD-coated samples at 3, 5 and 7 days post seeding. Interestingly, higher activity was localized to cell cluster regions. There was a 3 fold increase in osteocalcin and bone sialoprotein mRNA levels for osteoblasts cultured on EMD-coated culture dishes. Moreover, EMD significantly increased extracellular mineral deposition in cell clusters as assessed through von Kossa staining at 5, 7, 10 and 14 days post seeding. We conclude that EMD up-regulates the expression of vital osteoblast cell-cell communication and adhesion molecules, which enhances the differentiation and mineralization activity of osteoblasts. These findings provide further support for the clinical evidence that EMD increases the speed and quality of new bone formation in vivo

Intern marknadsföring och dess påverkan på fullsortimentsbankers uppfattade konkurrensfördelar : - En fallstudie av Svenska Handelsbanken och Nordea

Författarna finner att dagens teori saknar tydliga riktlinjer för hur praktiker i den svenska banksektorn bör använda sig av intern marknadsföring. Bristen av en klar definition av begreppet medför svårigheter att applicera teorin på strategiarbetet och använda de verktyg som finns att tillgå i befintlig forskning. Nuvarande forskning visar på vikten av intern marknadsföring i alla organisationer, och då främst inom servicesektorn. Studierna som har gjorts är emellertid baserade på sektorer utomlands, vilket innebär svårigheter för svenska banker att tillämpa resultatet inom sin egen organisation, menar författarna. Författarna ämnar därför undersöka intern marknadsföring och dess effekt på uppfattade konkurrensfördelar på den svenska banksektorn och författarna har valt att fokusera på svenska fullsortimentsbanker. Det genomförs genom en teoretisk bakgrund kring de begrepp och modeller som finns idag samt genom en kvalitativ undersökning av två aktörer inom den svenska banksektorn. Både ledning och medarbetare på de bägge bankerna har deltagit i undersökningen för att kunna återge en nyanserad bild av problematiken. Studien visar att det råder vissa likheter mellan forskningen och de undersökta fallen, men inom bägge fallstudierna råder det även vissa skillnader i hur den interna marknadsföringen används och vilka konkurrensfördelar den skapar för fullsortimentsbanker. Undersökningen bidrar med rekommendationer för praktiker som kan ge en tydligare bild för hur fullsortimentsbanker inom den svenska banksektorn kan agera för att skapa ytterligare konkurrensfördelar genom den interna marknadsföringen.This paper examines the theoretical area about internal marketing and what competitive advantages it results in. Earlier research shows that internal marketing is vital for successful companies, especially in the service sector. However, there have been no published studies of the Swedish banking sector. That is why the authors have used two case studies within the Swedish bank sector to try to create guidelines that they can use to increase their competitive advantages by using internal marketing in their strategy planning.The theoretical part shows that most of the researchers agree that by using some effective tools and factors in the internal marketing a better and more adaptive organisation will be developed. Even though there are some vital tools, all the tools must be considered and implemented in the organisations. The case studies have been researched using qualitative methods, interviewing both leaders and employees, trying to give a nuanced description of the internal marketing. The result shows that there need to be an open dialogue between the employees and the leaders and that the dialogue will be better by effective use of tools within the internal marketing. The discussion shows that the Swedish banking sector can develop their internal marketing to gain even more competitive advantages

The application of an enamel matrix protein derivative (Emdogain) in regenerative periodontal therapy: a review.

Contains fulltext : 53648.pdf (publisher's version ) (Open Access)Regenerative periodontal therapy aims at reconstitution of the lost periodontal structures such as new formation of root cementum, periodontal ligament and alveolar bone. Findings from basic research indicate that enamel matrix protein derivative (EMD) has a key role in periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. This review aims to present an overview of evidence-based clinical indications for regenerative therapy with EMD