136 research outputs found
Performance analysis of contention based bandwidth request mechanisms in WiMAX networks
This article is posted here with the permission of IEEE. The official version can be obtained from the DOI below - Copyright @ 2010 IEEEWiMAX networks have received wide attention as they support high data rate access and amazing ubiquitous connectivity with great quality-of-service (QoS) capabilities. In order to support QoS, bandwidth request (BW-REQ) mechanisms are suggested in the WiMAX standard for resource reservation, in which subscriber stations send BW-REQs to a base station which can grant or reject the requests according to the available radio resources. In this paper we propose a new analytical model for the performance analysis of various contention based bandwidth request mechanisms, including grouping and no-grouping schemes, as suggested in the WiMAX standard. Our analytical model covers both unsaturated and saturated traffic load conditions in both error-free and error-prone wireless channels. The accuracy of this model is verified by various simulation results. Our results show that the grouping mechanism outperforms the no-grouping mechanism when the system load is high, but it is not preferable when the system load is light. The channel noise degrades the performance of both throughput and delay.This work was supported by the U.K. Engineering and Physical Sciences Research Council (EPSRC) under Grant EP/G070350/1 and
by the Brunel University’s BRIEF Award
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Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
Combined hepatocellular-cholangiocarcinoma (cHCC-ICC) is an uncommon and aggressive form of primary liver cancer. Currently, there are no international guidelines for optimal management. For localized tumors, radical resection represents the preferred treatment option, whereas for advanced tumors, systemic therapies recommended for intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are often selected. Emerging information from comparative cohort studies, genomic and transcriptomic data sets are starting to build a case for rationalized approaches to systemic treatment in the advanced setting specific to cHCC-ICC
Spatio-temporal patterns of recent and future climate extremes in the eastern Mediterranean and Middle East region
Recent and future changes in temperature and precipitation climate extremes
are estimated using the Hadley Centre PRECIS ("Providing REgional Climates
for Impacts Studies") climate model for the eastern Mediterranean and Middle
East region. The area of interest is considered vulnerable to extreme
climate events as there is evidence for a temperature rise while
precipitation tends to decline, suggesting likely effects on vital
socioeconomic sectors in the region. Observations have been obtained for the
recent period (1961–1990) and used to evaluate the model output. The spatial
distribution of recent temporal trends in temperature indicates strong
increasing in minimum temperature over the eastern Balkan Peninsula, Turkey
and the Arabian Peninsula. The rate of warming reaches
0.4–0.5 °C decade<sup>−1</sup> in a large part of the domain, while
warming is expected to be strongest in
summer (0.6–0.7 °C decade<sup>−1</sup>) in the eastern Balkans and western Turkey. The trends in
annual and summer maximum temperature are estimated at approximately 0.5 and
0.6 °C decade<sup>−1</sup> respectively. Recent estimates do not indicate
statistically significant trends in precipitation except for individual
sub-regions. Results indicate a future warming trend for the study area over
the last 30 years of the 21st century. Trends are estimated to be positive
and statistically significant in nearly the entire region. The annual trend
patterns for both minimum and maximum temperature show warming rates of
approximately 0.4–0.6 °C decade<sup>−1</sup>, with pronounced warming over the Middle
Eastern countries. Summer temperatures reveal a gradual warming
(0.5–0.9 °C decade<sup>−1</sup>) over much of the region. The model projects drying
trends by 5–30% in annual precipitation towards the end of the 21st
century, with the number of wet days decreasing at the rate of 10–30 days year<sup>−1</sup>,
while heavy precipitation is likely to decrease in the
high-elevation areas by 15 days year<sup>−1</sup>
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Molecular beacon-based real-time PCR detection of primary isolates of Salmonella Typhimurium and Salmonella Enteritidis in environmental and clinical samples
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.Abstract Background A fast and simple two-step multiplex real-time PCR assay has been developed to replace the traditional, laborious Salmonella serotyping procedure. Molecular beacons were incorporated into the assay as probes for target DNA. Target sequences were regions of the invA, prot6E and fliC genes specific for Salmonella spp. Salmonella Enteritidis and Salmonella Typhimurium, respectively, the two most clinically relevant serotypes. An internal amplification positive control was included in the experiment to ensure the optimal functioning of the PCR and detect possible PCR inhibition. Three sets of primers were used for the amplification of the target sequences. The results were compared to those of the Kauffmann-White antigenic classification scheme. Results The assay was 100% sensitive and specific, correctly identifying all 44 Salmonella strains, all 21 samples of S. Enteritidis and all 17 samples of S. Typhimurium tested in this work. Therefore, the entire experiment had specificity and sensitivity of 100%. The detection limit was down to 10 copies of DNA target per 25 μl reaction. Conclusion The assay can amplify and analyse a large number of samples in approximately 8 hours, compared to the 4 to 5 days conventional identification takes, and is thus considered a very promising method for detecting the two major serotypes of Salmonella quickly and accurately from clinical and environmental samples.Published versio
Effects of Meteorology Nudging in Regional Hydroclimatic Simulations of the Eastern Mediterranean
In this study, we investigated the effects of grid and spectral nudging in regional hydroclimatic simulations over the Eastern Mediterranean climate change hot-spot. We performed year-long simulations for the hydrological year October 2001\u2013September 2002 using the Weather Research and Forecasting (WRF) model at 12-km resolution, driven by the ERA-Interim reanalyses. Six grid and three spectral nudging options were tested using a number of model configurations. Due to the large uncertainty of regional observations, we compared the model with various satelliteand station-based meteorological datasets. The effect of nudging was tested for mean weather conditions and precipitation characteristics and extremes. For certain parts of the study domain, WRF was found to reproduce both aspects of rainfall over the Eastern Mediterranean reasonably well. Our findings highlighted that, for the WRF modeling system, nudging is critical for the simulation of rainfall; however, the application of interior constraint methods was found to have different impacts on various locations and climatic regimes. For the hyperarid parts of the domain, nudging did not improve the simulation of precipitation amounts (about 20% additional drying was introduced), while it added much value for the wetter rainfall regimes of the Eastern Mediterranean (corrections of about 30%). Improvements in the simulated precipitation were mostly introduced by spectral nudging; however, this option required significant computational resources. For these ERA-Interim-driven simulations, grid nudging that involves specific humidity within the planetary boundary layer is not recommended for the simulation of precipitation since it introduces dry biases up to 75\u201380%
Climate Change and Weather Extremes in the Eastern Mediterranean and Middle East
Observation‐based and modeling studies have identified the Eastern Mediterranean and Middle East (EMME) region as a prominent climate change hotspot. While several initiatives have addressed the impacts of climate change in parts of the EMME, here we present an updated assessment, covering a wide range of timescales, phenomena and future pathways. Our assessment is based on a revised analysis of recent observations and projections and an extensive overview of the recent scientific literature on the causes and effects of regional climate change. Greenhouse gas emissions in the EMME are growing rapidly, surpassing those of the European Union, hence contributing significantly to climate change. Over the past half‐century and especially during recent decades, the EMME has warmed significantly faster than other inhabited regions. At the same time, changes in the hydrological cycle have become evident. The observed recent temperature increase of about 0.45°C per decade is projected to continue, although strong global greenhouse gas emission reductions could moderate this trend. In addition to projected changes in mean climate conditions, we call attention to extreme weather events with potentially disruptive societal impacts. These include the strongly increasing severity and duration of heatwaves, droughts and dust storms, as well as torrential rain events that can trigger flash floods. Our review is complemented by a discussion of atmospheric pollution and land‐use change in the region, including urbanization, desertification and forest fires. Finally, we identify sectors that may be critically affected and formulate adaptation and research recommendations toward greater resilience of the EMME region to climate change. The Eastern Mediterranean and Middle East is warming almost two times faster than the global average and other inhabited parts of the world Climate projections indicate a future warming, strongest in summers. Precipitation will likely decrease, particularly in the Mediterranean Virtually all socio‐economic sectors will be critically affected by the projected changes The Eastern Mediterranean and Middle East is warming almost two times faster than the global average and other inhabited parts of the world Climate projections indicate a future warming, strongest in summers. Precipitation will likely decrease, particularly in the Mediterranean Virtually all socio‐economic sectors will be critically affected by the projected change
Climate Change and Weather Extremes in the Eastern Mediterranean and Middle East
Observation-based and modeling studies have identified the Eastern Mediterranean and Middle East (EMME) region as a prominent climate change hotspot. While several initiatives have addressed the impacts of climate change in parts of the EMME, here we present an updated assessment, covering a wide range of timescales, phenomena and future pathways. Our assessment is based on a revised analysis of recent observations and projections and an extensive overview of the recent scientific literature on the causes and effects of regional climate change. Greenhouse gas emissions in the EMME are growing rapidly, surpassing those of the European Union, hence contributing significantly to climate change. Over the past half-century and especially during recent decades, the EMME has warmed significantly faster than other inhabited regions. At the same time, changes in the hydrological cycle have become evident. The observed recent temperature increase of about 0.45 degrees C per decade is projected to continue, although strong global greenhouse gas emission reductions could moderate this trend. In addition to projected changes in mean climate conditions, we call attention to extreme weather events with potentially disruptive societal impacts. These include the strongly increasing severity and duration of heatwaves, droughts and dust storms, as well as torrential rain events that can trigger flash floods. Our review is complemented by a discussion of atmospheric pollution and land-use change in the region, including urbanization, desertification and forest fires. Finally, we identify sectors that may be critically affected and formulate adaptation and research recommendations toward greater resilience of the EMME region to climate change.Peer reviewe
Outcome of emergency neurosurgery in patients with refractory and super-refractory status epilepticus: a systematic review and individual participant data meta-analysis
BackgroundRefractory (RSE) and super-refractory status epilepticus (SRSE) are serious neurological conditions requiring aggressive management. Beyond anesthetic agents, there is a lack of evidence guiding management in these patients. This systematic review and individual participant data meta-analysis (IPDMA) seeks to evaluate and compare the currently available surgical techniques for the acute treatment of RSE and SRSE.MethodsA systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Individual Participant Data (PRISMA-IPD). Only patients who underwent surgery while in RSE and SRSE were included. Descriptive statistics were used to compare various subgroups. Multivariable logistic regression models were constructed to identify predictors of status epilepticus (SE) cessation, long-term overall seizure freedom, and favorable functional outcome (i.e., modified Rankin score of 0–2) at last follow-up.ResultsA total of 87 studies including 161 participants were included. Resective surgery tended to achieve better SE cessation rate (93.9%) compared to non-resective techniques (83.9%), but this did not reach significance (p = 0.071). Resective techniques were also more likely to achieve seizure freedom (69.1% vs. 34.4%, p = <0.0001). Older age at SE (OR = 1.384[1.046–1.832], p = 0.023) was associated with increased likelihood of SE cessation, while longer duration of SE (OR = 0.603[0.362–1.003], p = 0.051) and new-onset seizures (OR = 0.244[0.069–0.860], p = 0.028) were associated with lower likelihood of SE cessation, but this did not reach significance for SE duration. Only shorter duration of SE prior to surgery (OR = 1.675[1.168–2.404], p = 0.0060) and immediate termination of SE (OR = 3.736 [1.323–10.548], p = 0.014) were independently associated with long-term seizure status. Rates of favorable functional outcomes (mRS of 0–2) were comparable between resective (44.4%) and non-resective (44.1%) techniques, and no independent predictors of outcome were identified.ConclusionOur findings suggest that emergency neurosurgery may be a safe and effective alternative in patients with RSE/SRSE and may be considered earlier during the disease course. However, the current literature is limited exclusively to small case series and case reports with high risk of publication bias. Larger clinical trials assessing long-term seizure and functional outcomes are warranted to establish robust management guidelines
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Reconciliation of halogen-induced ozone loss with the total-column ozone record
The observed depletion of the ozone layer from the 1980s onwards is attributed to halogen source gases emitted by human activities. However, the precision of this attribution is complicated by year-to-year variations in meteorology, that is, dynamical variability, and by changes in tropospheric ozone concentrations. As such, key aspects of the total-column ozone record, which combines changes in both tropospheric and stratospheric ozone, remain unexplained, such as the apparent absence of a decline in total-column ozone levels before 1980, and of any long-term decline in total-column ozone levels in the tropics. Here we use a chemistry–climate model to estimate changes in halogen-induced ozone loss between 1960 and 2010; the model is constrained by observed meteorology to remove the effects of dynamical variability, and driven by emissions of tropospheric ozone precursors to separate out changes in tropospheric ozone. We show that halogen-induced ozone loss closely followed stratospheric halogen loading over the studied period. Pronounced enhancements in ozone loss were apparent in both hemispheres following the volcanic eruptions of El Chichon and, in particular, Mount Pinatubo, which significantly enhanced stratospheric aerosol loads. We further show that approximately 40% of the long-term non-volcanic ozone loss occurred before 1980, and that long-term ozone loss also occurred in the tropical stratosphere. Finally, we show that halogen-induced ozone loss has declined by over 10% since stratospheric halogen loading peaked in the late 1990s, indicating that the recovery of the ozone layer is well underway
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