1,055 research outputs found
catena-Poly[[[triaquaÂcobalt(II)]-ÎŒ-10-methylÂphenothiaÂzine-3,7-dicarboxylÂato] monohydrate]
The polymeric title compound, {[Co(C15H9NO4S)(H2O)3]·H2O}n, consists of chains along [001] made up from Co2+ ions bridged by 10-methylÂphenothiaÂzine-3,7-dicarboxylÂate anions. The Co2+ ion, coordinated by three O atoms from two different carboxylÂate groups and three water molÂecules, displays a distorted octaÂhedral environment. In the crystal, ÏâÏ interÂchain interÂactions, with centroidâcentroid distances of 3.656â
(2) and 3.669â
(2)â
Ă
between the benzene rings of the ligands, assemble the chains into sheets parallel to (100). OâHâŻO hydrogen-bonding interÂactions between the coordinating water molÂecules and carboxylÂate O atoms link the sheets into a three-dimensional network
Even high normal blood pressure affects live birth rate in women undergoing fresh embryo transfer
STUDY QUESTION
Do differences in blood pressure within the normal range have any impacts on the live birth rate (primary outcome) or biochemical pregnancy rate (beta-hCG positivity), clinical pregnancy rate (heart beating in ultrasound), abortion rate and ectopic pregnancy rate (secondary outcomes) of fresh embryo transfer in women undergoing their IVF/ICSI treatment?
SUMMARY ANSWER
Even rather small differences in baseline blood pressure in women with normal blood pressure according to current guidelines undergoing fresh embryo transfer after IVF/ICSI affects substantially the live birth rate.
WHAT IS KNOWN ALREADY
Pre-pregnancy hypertension is a well-known risk factor for adverse pregnancy events such as preeclampsia, fetal growth restriction, placental abruption and adverse neonatal events. It is likewise well known that hypertension during pregnancy in women undergoing ART is associated with adverse pregnancy outcomes. However, whether blood pressure at the high end of the normal range has an impact on ART is unknown.
STUDY DESIGN, SIZE, DURATION
It is a prospective observational cohort study based on a single IVF center between January 2017 and December 2018.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Two thousand four hundred and eighteen women with normal blood pressure undergoing fresh embryo transfer after IVF/ICSI at the Reproductive and Genetic Hospital of CITIC-Xiangya were enrolled in this study.
MAIN RESULTS AND THE ROLE OF CHANCE
Blood pressure was measured at the first visit when women consulted the IVF center due to infertility. In women with a successful pregnancy outcome (1487 live births out of 2418 women undergoing fresh embryo transfer after IVF/ICSI), systolic blood pressure (SBP) (114.1â±â9.48âmmHg versus 115.4â±â9.8âmmHg, Pâ=â0.001) and diastolic blood pressure (DBP) (74.5â±â7.5âmmHg versus 75.3â±â7.34âmmHg, Pâ=â0.006) were lower than in those who did not achieve live births. Multivariate logistic regression analysis revealed that SBP (OR: 0.987, 95% CI: 0.979â0.996, Pâ=â0.004) and DBP (OR: 0.986, 95% CI: 0.975â0.998, Pâ=â0.016) were negatively associated with live birth. Similarly, SBP was significantly negatively related to clinical pregnancy rate (OR: 0.990, 95% CI: 0.981â0.999, Pâ=â0.033), while for DBP the association was not statistically significant (OR: 0.994, 95% CI: 0.982â1.006, Pâ=â0.343). However, both SBP and DBP were positively associated with miscarriage OR: 1.021 (95% CI: 1.004â1.037, Pâ=â0.013) and OR: 1.027 (95% CI: 1.005â1.049, Pâ=â0.014), respectively. Both SBP and DBP were unrelated to biochemical pregnancy (hCG positivity), implantation and ectopic pregnancy rate.
LIMITATIONS, REASONS FOR CAUTION
Whether lowering blood pressure before initiating ART treatment in women with SBP or DBP higher than the thresholds defined in our study will confer a benefit is unknown. Also, we cannot exclude bias due to different ethnicities. Moreover, participants in our study only received fresh embryo transfer, whether the results could apply to frozen embryo transfer is unclear.
WIDER IMPLICATIONS OF THE FINDINGS
Our study challenges the current blood pressure goals in women undergoing fresh embryo transfer after IVF/ICSI. Further studies are needed to figure out the mechanism and effective approach to increase IVF/ICSI pregnancy outcomes.
STUDY FUNDING/COMPETING INTEREST(S)
Hunan Provincial Grant for Innovative Province Construction (2019SK4012). The authors declare that there were no conflicts of interest in this study.
TRIAL REGISTRATION NUMBER
N/A
Dynamic and thermodynamic properties of the generalised diamond chain model for azurite
The natural mineral azurite Cu3(CO3)2(OH)2 is an interesting spin-1/2 quantum
antiferromagnet. Recently, a generalised diamond chain model has been
established as a good description of the magnetic properties of azurite with
parameters placing it in a highly frustrated parameter regime. Here we explore
further properties of this model for azurite. First, we determine the inelastic
neutron scattering spectrum in the absence of a magnetic field and find good
agreement with experiments, thus lending further support to the model.
Furthermore, we present numerical data for the magnetocaloric effect and
predict that strong cooling should be observed during adiabatic
(de)magnetisation of azurite in magnetic fields slightly above 30T. Finally,
the presence of a dominant dimer interaction in azurite suggests the use of
effective Hamiltonians for an effective low-energy description and we propose
that such an approach may be useful to fully account for the three-dimensional
coupling geometry.Comment: 19 pages, 6 figures; to appear in: J. Phys.: Condens. Matter (special
issue on geometrically frustrated magnetism
Best clinical practice guidance for treating deep carious lesions in primary teeth: an EAPD policy document.
PURPOSE
The European Academy of Paediatric Dentistry (EAPD) has developed this best clinical practice guidance to help clinicians manage deep carious lesions in primary teeth.
METHODS
Three expert groups conducted systematic reviews of the relevant literature. The topics were: (1) conventional techniques (2) Minimal Intervention Dentistry (MID) and (3) materials. Workshops were held during the corresponding EAPD interim seminar in Oslo in April 2021. Several clinical based recommendations and statements were agreed upon, and gaps in our knowledge were identified.
RESULTS
There is strong evidence that indirect pulp capping and pulpotomy techniques, and 38% Silver Diamine Fluoride are shown to be effective for the management of caries in the primary dentition. Due to the strict criteria, it is not possible to give clear recommendations on which materials are most appropriate for restoring primary teeth with deep carious lesions. Atraumatic Restorative Technique (ART) is not suitable for multi-surface caries, and Pre-formed Metal Crowns (PMCs) using the Hall technique reduce patient discomfort. GIC and RMGIC seem to be more favourable given the lower annual failure rate compared to HVGIC and MRGIC. Glass carbomer cannot be recommended due to inferior marginal adaptation and fractures. Compomers, hybrid composite resins and bulk-fill composite resins demonstrated similar values for annual failure rates.
CONCLUSION
The management of deep carious lesions in primary teeth can be challenging and must consider the patient's compliance, operator skills, materials and costs. There is a clear need to increase the use of MID techniques in managing carious primary teeth as a mainstream rather than a compromise option
Density correlations and dynamical Casimir emission of Bogoliubov phonons in modulated atomic Bose-Einstein condensates
We present a theory of the density correlations that appear in an atomic
Bose-Einstein condensate as a consequence of the dynamical Casimir emission of
pairs of Bogoliubov phonons when the atom-atom scattering length is modulated
in time. Different regimes as a function of the temporal shape of the
modulation are identified and a simple physical picture of the phenomenon is
discussed. Analytical expressions for the density correlation function are
provided for the most significant limiting cases. This theory is able to
explain some unexpected features recently observed in numerical calculations of
Hawking radiation from analog black holes
Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex
The hPrp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome. In order to elucidate the molecular architecture of the hPrp19-CDC5L complex, the crystal structure of CTNNBL1, one of the major components of this complex, was determined. Unlike canonical ARM-repeat proteins such as beta-catenin and importin-alpha, CTNNBL1 was found to contain a twisted and extended ARM-repeat structure at the C-terminal domain and, more importantly, the protein formed a stable dimer. A highly negatively charged patch formed in the N-terminal ARM-repeat domain of CTNNBL1 provides a binding site for CDC5L, a binding partner of the protein in the hPrp19-CDC5L complex, and these two proteins form a complex with a stoichiometry of 2:2. These findings not only present the crystal structure of a novel ARM-repeat protein, CTNNBL1, but also provide insights into the detailed molecular architecture of the hPrp19-CDC5L complex.open0
Has Instagram Fundamentally Altered the 'Family Snapshot'?
This paper considers how parents use the social media platform Instagram to facilitate the capture, curation and sharing of âfamily snapshotsâ. Our work draws upon established cross-disciplinary literature relating to film photography and the composition of family albums in order to establish whether social media has changed the way parents visually present their families. We conducted a qualitative visual analysis of a sample of 4,000 photographs collected from Instagram using hashtags relating to children and parenting. We show that the style and composition of snapshots featuring children remains fundamentally unchanged and continues to be dominated by rather bland and idealised images of the happy family and the cute child. In addition, we find that the frequent taking and sharing of photographs via Instagram has inevitably resulted in a more mundane visual catalogue of daily life. We note a tension in the desire to use social media as a means to evidence good parenting, while trying to effectively manage the social identity of the child and finally, we note the reluctance of parents to use their own snapshots to portray family tension or disharmony, but their willingness to use externally generated content for this purpose
OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials
Machine learning plays an important and growing role in molecular simulation.
The newest version of the OpenMM molecular dynamics toolkit introduces new
features to support the use of machine learning potentials. Arbitrary PyTorch
models can be added to a simulation and used to compute forces and energy. A
higher-level interface allows users to easily model their molecules of interest
with general purpose, pretrained potential functions. A collection of optimized
CUDA kernels and custom PyTorch operations greatly improves the speed of
simulations. We demonstrate these features on simulations of cyclin-dependent
kinase 8 (CDK8) and the green fluorescent protein (GFP) chromophore in water.
Taken together, these features make it practical to use machine learning to
improve the accuracy of simulations at only a modest increase in cost.Comment: 16 pages, 5 figure
- âŠ